Pharmacologic Management of Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Clinical Practice Guideline.

Abstract:

:Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thoracic Society.Methods: Comprehensive evidence syntheses were performed on all relevant studies that addressed the clinical questions and critical patient-centered outcomes agreed upon by the panel of experts. The evidence was appraised, rated, and graded, and recommendations were formulated using the Grading of Recommendations, Assessment, Development, and Evaluation approach.Results: After weighing the quality of evidence and balancing the desirable and undesirable effects, the guideline panel made the following recommendations: 1) a strong recommendation for the use of long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) combination therapy over LABA or LAMA monotherapy in patients with COPD and dyspnea or exercise intolerance; 2) a conditional recommendation for the use of triple therapy with inhaled corticosteroids (ICS)/LABA/LAMA over dual therapy with LABA/LAMA in patients with COPD and dyspnea or exercise intolerance who have experienced one or more exacerbations in the past year; 3) a conditional recommendation for ICS withdrawal for patients with COPD receiving triple therapy (ICS/LABA/LAMA) if the patient has had no exacerbations in the past year; 4) no recommendation for or against ICS as an additive therapy to long-acting bronchodilators in patients with COPD and blood eosinophilia, except for those patients with a history of one or more exacerbations in the past year requiring antibiotics or oral steroids or hospitalization, for whom ICS is conditionally recommended as an additive therapy; 5) a conditional recommendation against the use of maintenance oral corticosteroids in patients with COPD and a history of severe and frequent exacerbations; and 6) a conditional recommendation for opioid-based therapy in patients with COPD who experience advanced refractory dyspnea despite otherwise optimal therapy.Conclusions: The task force made recommendations regarding the pharmacologic treatment of COPD based on currently available evidence. Additional research in populations that are underrepresented in clinical trials is needed, including studies in patients with COPD 80 years of age and older, those with multiple chronic health conditions, and those with a codiagnosis of COPD and asthma.

authors

Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

doi

10.1164/rccm.202003-0625ST

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e56-e69

issue

9

eissn

1073-449X

issn

1535-4970

journal_volume

201

pub_type

杂志文章
  • Hypoxic Pulmonary Vasoconstriction Does Not Explain All Regional Perfusion Redistribution in Asthma.

    abstract:RATIONALE:Regional hypoventilation in bronchoconstricted patients with asthma is spatially associated with reduced perfusion, which is proposed to result from hypoxic pulmonary vasoconstriction (HPV). OBJECTIVES:To determine the role of HPV in the regional perfusion redistribution in bronchoconstricted patients with a...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201612-2438OC

    authors: Kelly VJ,Hibbert KA,Kohli P,Kone M,Greenblatt EE,Venegas JG,Winkler T,Harris RS

    更新日期:2017-10-01 00:00:00

  • Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?

    abstract::Pulmonary hypertension is a life-threatening complication of sickle cell disease. L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. This deficiency may play a role in pulmonary hypertension. The enzyme arginase hydrolyzes arginine...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1164/rccm.200208-967OC

    authors: Morris CR,Morris SM Jr,Hagar W,Van Warmerdam J,Claster S,Kepka-Lenhart D,Machado L,Kuypers FA,Vichinsky EP

    更新日期:2003-07-01 00:00:00

  • The effect of an anti-CD3 monoclonal antibody on bleomycin-induced lymphokine production and lung injury.

    abstract::Acute lung injury was produced in C57BL/6 mice by the intratracheal (i.t.) administration of bleomycin (BLM). Following injection of 0.1 U BLM, CD3+ lymphocytes and the production of the T-helper-1 (Th1) lymphokines interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) were increased in lung and lymph nodes. The produ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.154.1.8680680

    authors: Sharma SK,MacLean JA,Pinto C,Kradin RL

    更新日期:1996-07-01 00:00:00

  • Pulmonary Transplantation of Human Induced Pluripotent Stem Cell-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis.

    abstract:RATIONALE:Although the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC-derived cells in lung disease models are missing. OBJECTIVES:We have tested the therapeuti...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201708-1562OC

    authors: Happle C,Lachmann N,Ackermann M,Mirenska A,Göhring G,Thomay K,Mucci A,Hetzel M,Glomb T,Suzuki T,Chalk C,Glage S,Dittrich-Breiholz O,Trapnell B,Moritz T,Hansen G

    更新日期:2018-08-01 00:00:00

  • Novel action of indoleamine 2,3-dioxygenase attenuating acute lung allograft injury.

    abstract:RATIONALE:Lung allografts are prone to reperfusion injury and acute rejection, which, in addition to infiltrating lymphocytes, are accompanied by neutrophil infiltration and neutrophil-associated oxidative stress. Indoleamine 2,3-dioxygenase (IDO) is a unique cytosolic enzyme that possesses T-cell-suppressive and antio...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200509-1413OC

    authors: Liu H,Liu L,Fletcher BS,Visner GA

    更新日期:2006-03-01 00:00:00

  • Expiratory Resistances Prevent Expiratory Diaphragm Contraction, Flow Limitation, and Lung Collapse.

    abstract::Rationale: Tidal expiratory flow limitation (tidal-EFL) is not completely avoidable by applying positive end-expiratory pressure and may cause respiratory and hemodynamic complications in ventilated patients with lungs prone to collapse. During spontaneous breathing, expiratory diaphragmatic contraction counteracts ti...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201909-1690OC

    authors: Pellegrini M,Gudmundsson M,Bencze R,Segelsjö M,Freden F,Rylander C,Hedenstierna G,Larsson AS,Perchiazzi G

    更新日期:2020-05-15 00:00:00

  • Beryllium sensitization progresses to chronic beryllium disease: a longitudinal study of disease risk.

    abstract::The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of p...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200402-190OC

    authors: Newman LS,Mroz MM,Balkissoon R,Maier LA

    更新日期:2005-01-01 00:00:00

  • T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.

    abstract:RATIONALE:T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-gamma production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III collagen deposition below the bronc...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200503-505OC

    authors: Raby BA,Hwang ES,Van Steen K,Tantisira K,Peng S,Litonjua A,Lazarus R,Giallourakis C,Rioux JD,Sparrow D,Silverman EK,Glimcher LH,Weiss ST

    更新日期:2006-01-01 00:00:00

  • Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.

    abstract:RATIONALE:In cystic fibrosis, abnormal glucose tolerance is associated with decreased lung function and worsened outcomes. Translational evidence indicates that abnormal glucose tolerance may begin in early life. OBJECTIVES:To determine whether very young children with cystic fibrosis have increased abnormal glucose t...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/rccm.201512-2518OC

    authors: Yi Y,Norris AW,Wang K,Sun X,Uc A,Moran A,Engelhardt JF,Ode KL

    更新日期:2016-10-15 00:00:00

  • Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study.

    abstract::Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-l...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1164/ajrccm.163.1.2001008

    authors: Shahar E,Whitney CW,Redline S,Lee ET,Newman AB,Nieto FJ,O'Connor GT,Boland LL,Schwartz JE,Samet JM

    更新日期:2001-01-01 00:00:00

  • Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence.

    abstract:RATIONALE:The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200504-525OC

    authors: Morgan WJ,Stern DA,Sherrill DL,Guerra S,Holberg CJ,Guilbert TW,Taussig LM,Wright AL,Martinez FD

    更新日期:2005-11-15 00:00:00

  • Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids.

    abstract:RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201312-2210OC

    authors: Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

    更新日期:2014-07-15 00:00:00

  • The healthy worker effect in asthma: work may cause asthma, but asthma may also influence work.

    abstract::Despite the increasing attention to the relationship between asthma and work exposures, occupational asthma remains underrecognized and its population burden underestimated. This may be due, in part, to the fact that traditional approaches to studying asthma in populations cannot adequately take into account the healt...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/rccm.200703-415PP

    authors: Le Moual N,Kauffmann F,Eisen EA,Kennedy SM

    更新日期:2008-01-01 00:00:00

  • Ethical considerations of ensuring an informed and autonomous consent in research involving critically ill patients.

    abstract::Despite several codes of research ethics, the issuance of comprehensive rules regarding informed consent by governmental agencies, and numerous writings on the subject of informed consent, many commentators still question the quality of the informed consent process in clinical research. A major concern is that investi...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1164/ajrccm.154.3.8810590

    authors: Silverman HJ

    更新日期:1996-09-01 00:00:00

  • Outcomes after lung retransplantation in the modern era.

    abstract:RATIONALE:Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown. OBJECTIVES:To compare lung retransplant patients in the modern era with historical retransplant patients, to compare retransplant patients with initial transplant patients in the modern era, and ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200707-1132OC

    authors: Kawut SM,Lederer DJ,Keshavjee S,Wilt JS,Daly T,D'Ovidio F,Sonett JR,Arcasoy SM,Barr ML

    更新日期:2008-01-01 00:00:00

  • Angiotensin II is mitogenic for human lung fibroblasts via activation of the type 1 receptor.

    abstract::The expression of renin-angiotensin system components and the elevation of angiotensin-converting enzyme (ACE) in a number of fibrotic lung diseases suggests angiotensin II (AII) could play a role in the pathogenesis of pulmonary fibrosis. However, the effect of AII on lung fibroblasts has not previously been assessed...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.161.6.9907004

    authors: Marshall RP,McAnulty RJ,Laurent GJ

    更新日期:2000-06-01 00:00:00

  • Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children.

    abstract:KEYWORDS:Children as young as 6 years old can perform spirometry, yet the relationship between current asthma, lung function, and bronchial responsiveness has not been described at this age; 2,537 children from a community-based birth cohort were assessed at 6 years of age, with history (n = 2,141), physical examinatio...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200304-556OC

    authors: Joseph-Bowen J,de Klerk NH,Firth MJ,Kendall GE,Holt PG,Sly PD

    更新日期:2004-04-01 00:00:00

  • Neck and abdominal muscle activity in patients with severe thoracic scoliosis.

    abstract::Patients with severe chronic obstructive pulmonary disease (COPD) do not use the sternocleidomastoid muscles when breathing at rest, but have a greater than normal neural drive to the rib-cage inspiratory muscles, the abdominal muscles, and the diaphragm. Yet the increased activation of the abdominal muscles and diaph...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.158.2.9710116

    authors: Estenne M,Derom E,De Troyer A

    更新日期:1998-08-01 00:00:00

  • An oral elastic mandibular advancement device for obstructive sleep apnea.

    abstract::Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.161.2.9903079

    authors: Henke KG,Frantz DE,Kuna ST

    更新日期:2000-02-01 00:00:00

  • Ventilation inhomogeneities in relation to standard lung function in patients with cystic fibrosis.

    abstract::Based on serial lung function measurements performed in 142 children (68 males; 74 females) with cystic fibrosis (CF), prospectively evaluated over an age range of 6 to 20 years, we attempted to determine whether the lung clearance index (LCI) as a measure of ventilation inhomogeneities could be a discriminating facto...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200407-948OC

    authors: Kraemer R,Blum A,Schibler A,Ammann RA,Gallati S

    更新日期:2005-02-15 00:00:00

  • Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release.

    abstract::The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effectors. We recently reported that both macrophage metalloelastase (MMP-1...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200212-1396OC

    authors: Churg A,Wang RD,Tai H,Wang X,Xie C,Dai J,Shapiro SD,Wright JL

    更新日期:2003-04-15 00:00:00

  • Can social interventions prevent tuberculosis?: the Papworth experiment (1918-1943) revisited.

    abstract:RATIONALE:There is consensus on the need to address social determinants of tuberculosis (TB) to achieve TB control, but evidence based on interventions is lacking. OBJECTIVES:We reanalyzed data from the sociomedical experiment performed at the Papworth Village Settlement in England, where the impact of stable employme...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201201-0023OC

    authors: Bhargava A,Pai M,Bhargava M,Marais BJ,Menzies D

    更新日期:2012-09-01 00:00:00

  • Long-term outcome after pulmonary endarterectomy.

    abstract:RATIONALE:There are few follow-up studies on long-term cardiopulmonary function after pulmonary endarterectomy (PEA), the operation of choice for chronic thromboembolic pulmonary hypertension (CTEPH). OBJECTIVES:To prospectively evaluate long-term outcome of patients with CTEPH treated with PEA. METHODS:Between 1994 ...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200801-101OC

    authors: Corsico AG,D'Armini AM,Cerveri I,Klersy C,Ansaldo E,Niniano R,Gatto E,Monterosso C,Morsolini M,Nicolardi S,Tramontin C,Pozzi E,Viganò M

    更新日期:2008-08-15 00:00:00

  • Flow-independent nitric oxide exchange parameters in cystic fibrosis.

    abstract::Exhaled nitric oxide (NO) remains a promising noninvasive index for monitoring inflammatory lung diseases; however, the plateau concentration (C(NO,plat)) is nonspecific and requires a constant exhalation flow rate. We utilized a new technique that employs a variable flow rate to estimate key flow-independent paramete...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.165.3.2105098

    authors: Shin HW,Rose-Gottron CM,Sufi RS,Perez F,Cooper DM,Wilson AF,George SC

    更新日期:2002-02-01 00:00:00

  • Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension.

    abstract:RATIONALE:Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate. OBJECTIVES:Evaluate the accuracy of Doppler echocar...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.200811-1691OC

    authors: Fisher MR,Forfia PR,Chamera E,Housten-Harris T,Champion HC,Girgis RE,Corretti MC,Hassoun PM

    更新日期:2009-04-01 00:00:00

  • Continuous tracheal gas insufflation in preterm infants with hyaline membrane disease. A prospective randomized trial.

    abstract::In mechanically ventilated neonates, the instrumental dead space is a major determinant of total minute ventilation. By flushing this dead space, continuous tracheal gas insufflation (CTGI) may allow reduction of the risk of overinflation. We conducted a randomized trial to evaluate the efficacy of CTGI in reducing ai...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1164/ajrccm.162.3.9910063

    authors: Dassieu G,Brochard L,Benani M,Avenel S,Danan C

    更新日期:2000-09-01 00:00:00

  • Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis.

    abstract::Superoxide dismutase (SOD) is a ubiquitous metalloenzyme in aerobic organisms that catalyzes the conversion of superoxide anion to hydrogen peroxide. Mycobacterium tuberculosis is unusual in that it secretes large quantities of iron-cofactored SOD. To determine the role of SOD in pathogenesis, we constructed mutants o...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.164.12.2106093

    authors: Edwards KM,Cynamon MH,Voladri RK,Hager CC,DeStefano MS,Tham KT,Lakey DL,Bochan MR,Kernodle DS

    更新日期:2001-12-15 00:00:00

  • Aerosol delivery from a metered-dose inhaler during mechanical ventilation. An in vitro model.

    abstract::Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated, mechanically ventilated patients requires adequate delivery of aerosol to the lower respiratory tract. We determined the effect of ventilator mode, inspiratory flow pattern, humidity, and spontaneous respiratory effort on albuterol deliv...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.154.2.8756810

    authors: Fink JB,Dhand R,Duarte AG,Jenne JW,Tobin MJ

    更新日期:1996-08-01 00:00:00

  • Effects of allergen challenge on eosinophils, eosinophil cationic protein, and granulocyte-macrophage colony-stimulating factor in mild asthma.

    abstract::Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challenge on cytokines regulating eosinophil function. We investigated allerg...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/ajrccm.151.6.7767540

    authors: Woolley KL,Adelroth E,Woolley MJ,Ellis R,Jordana M,O'Byrne PM

    更新日期:1995-06-01 00:00:00

  • Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma.

    abstract:RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

    journal_title:American journal of respiratory and critical care medicine

    pub_type: 杂志文章

    doi:10.1164/rccm.201806-1182OC

    authors: Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

    更新日期:2019-02-15 00:00:00