Increased Platelet Aggregation in Children and Adolescents with Sleep-disordered Breathing.

abstract：:Long-term effects of high doses of inhaled corticosteroids (ICS) on bone density and metabolism are still uncertain. Fifty-one patients (37 male, 14 female) using beclomethasone or budesonide at a daily dose > 800 microgram/d (high-dose group [Group HD] mean: 983 microgram/d [prescribed dose x estimated compliance]) o...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Gagnon L,Poubelle PE,Brown J

更新日期：1999-03-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：RATIONALE:Bronchial remodeling, including increased bronchial smooth muscle (BSM) mass, contributes to bronchial obstruction in asthma. However, its mechanisms are complex and remain controversial. Recently, a role of the chitinase 3-like 1 protein (YKL-40) has been evoked in asthma. Indeed, YKL-40 concentration was in...

journal_title：American journal of respiratory and critical care medicine

authors： Bara I,Ozier A,Girodet PO,Carvalho G,Cattiaux J,Begueret H,Thumerel M,Ousova O,Kolbeck R,Coyle AJ,Woods J,Tunon de Lara JM,Marthan R,Berger P

更新日期：2012-04-01 00:00:00

abstract：:The timing and magnitude of airway narrowing in central apneas is unknown. We have developed a method of apnea classification that relies on the transmission of cardiac airflow oscillation to indicate airway patency. Using a theoretical model, we showed that the amplitude of the cardiac airflow oscillation is proporti...

journal_title：American journal of respiratory and critical care medicine

authors： Lemke RP,Idiong N,Al-Saedi S,Kwiatkowski K,Cates DB,Rigatto H

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. OBJECTIVES:To identify prognostic factors of good neurologic outcome in patients admitted to an ...

journal_title：American journal of respiratory and critical care medicine

authors： de Montmollin E,Demeret S,Brulé N,Conrad M,Dailler F,Lerolle N,Navellou JC,Schwebel C,Alves M,Cour M,Engrand N,Tonnelier JM,Maury E,Ruckly S,Picard G,Rogemond V,Magalhaes É,Sharshar T,Timsit JF,Honnorat J,Sonnevil

更新日期：2017-02-15 00:00:00

abstract：RATIONALE:Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions. However, the role of combining these modalities to overcome each individual technique's limitations and, consequently, to further increas...

journal_title：American journal of respiratory and critical care medicine

authors： Eberhardt R,Anantham D,Ernst A,Feller-Kopman D,Herth F

更新日期：2007-07-01 00:00:00

abstract：:To determine the factors contributing to tuberculosis incidence in the U.S.-born and foreign-born populations in San Francisco, California, and to assess the effectiveness of tuberculosis control efforts in these populations, we performed a population-based molecular epidemiologic study using 367 patients with strains...

journal_title：American journal of respiratory and critical care medicine

authors： Chin DP,DeRiemer K,Small PM,de Leon AP,Steinhart R,Schecter GF,Daley CL,Moss AR,Paz EA,Jasmer RM,Agasino CB,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：:Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored.Objectives: To elucidate the role of TYKRIL (tyrosine kinase receptor-inducing lncRNA) as a regulator of p53/ PDGFRβ (platelet-derive...

journal_title：American journal of respiratory and critical care medicine

authors： Zehendner CM,Valasarajan C,Werner A,Boeckel JN,Bischoff FC,John D,Weirick T,Glaser SF,Rossbach O,Jaé N,Demolli S,Khassafi F,Yuan K,de Jesus Perez VA,Michalik KM,Chen W,Seeger W,Guenther A,Wasnick RM,Uchida S,Zeihe

更新日期：2020-11-15 00:00:00

abstract：RATIONALE:The association between aging and idiopathic pulmonary fibrosis is established. The associations between aging-related biomarkers and interstitial lung abnormalities (ILA) have not been comprehensively evaluated. OBJECTIVE:Evaluate associations between aging biomarkers, ILA, and all-cause mortality. METHODS...

journal_title：American journal of respiratory and critical care medicine

authors： Sanders JL,Putman RK,Dupuis J,Xu H,Murabito JM,Araki T,Nishino M,Benjamin EJ,Levy DL,Vasan RS,Washko GR,Curtis JL,Freeman CM,Bowler R,Hatabu H,O'Connor GT,Hunninghake GM

更新日期：2020-10-20 00:00:00

abstract：:Cilomilast (Ariflo), a new oral phosphodiesterase-4 selective inhibitor, improves lung function in chronic obstructive pulmonary disease (COPD). We have evaluated its antiinflammatory effects in 59 patients with COPD randomized to receive cilomilast, 15 mg two times a day, or placebo for 12 weeks. Induced sputum diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Gamble E,Grootendorst DC,Brightling CE,Troy S,Qiu Y,Zhu J,Parker D,Matin D,Majumdar S,Vignola AM,Kroegel C,Morell F,Hansel TT,Rennard SI,Compton C,Amit O,Tat T,Edelson J,Pavord ID,Rabe KF,Barnes NC,Jeffery PK

更新日期：2003-10-15 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is characterized by an extensive alveolar capillary leak, permitting contact between intra-alveolar factors and the endothelium. To investigate whether factors contained in the alveolar milieu induce cell death in human lung microvascular endothelial cells, we exposed these c...

journal_title：American journal of respiratory and critical care medicine

authors： Hamacher J,Lucas R,Lijnen HR,Buschke S,Dunant Y,Wendel A,Grau GE,Suter PM,Ricou B

更新日期：2002-09-01 00:00:00

abstract：:There have been four types of drug treatment of asthma that have been used over the past 100 years. Belladonna alkaloids, derived from the thorn-apple plant were used in 1905, and chemically synthesized entities in this class are still in use today. Western medicine began to use adrenergic stimulants approximately 100...

journal_title：American journal of respiratory and critical care medicine

authors： Chu EK,Drazen JM

更新日期：2005-06-01 00:00:00

abstract：:Luteolin is a flavonoid that has been shown to reduce proinflammatory molecule expression in vitro. In the present study, we have tested the ability of luteolin to inhibit lipopolysaccharide (LPS)- induced lethal toxicity and proinflammatory molecule expression in vivo. Mice receiving LPS (Salmonella enteriditis LPS, ...

journal_title：American journal of respiratory and critical care medicine

authors： Kotanidou A,Xagorari A,Bagli E,Kitsanta P,Fotsis T,Papapetropoulos A,Roussos C

更新日期：2002-03-15 00:00:00

abstract：:Inhaled nitric oxide (NO) improves systemic oxygenation (PaO2/FIO2) in adult patients with acute respiratory distress syndrome (ARDS). However, individual response varies, and previous trials demonstrated no outcome benefit. This prospective, randomized study in 40 ARDS patients analyzed dose-response (DR) characteris...

journal_title：American journal of respiratory and critical care medicine

authors： Gerlach H,Keh D,Semmerow A,Busch T,Lewandowski K,Pappert DM,Rossaint R,Falke KJ

更新日期：2003-04-01 00:00:00

abstract：RATIONALE:High-dose isoniazid is recommended in short-course regimens for multidrug-resistant TB (MDR-TB). The optimal dose of isoniazid and its individual contribution to efficacy against TB strains with inhA or katG mutations are unknown. OBJECTIVE:Define the optimal dose of isoniazid for patients with isoniazid-res...

journal_title：American journal of respiratory and critical care medicine

authors： Dooley KE,Miyahara S,von Groote-Bidlingmaier F,Sun X,Hafner R,Rosenkranz SL,Ignatius EH,Nuermberger EL,Moran L,Donahue K,Swindells S,Vanker N,Diacon AH,A5312 Study Team.

更新日期：2020-01-16 00:00:00

abstract：RATIONALE:The role of computed tomography (CT) screening for lung cancer is controversial, currently under study, and not yet fully elucidated. OBJECTIVES:To report findings from initial and 1-year repeat screening low-radiation-dose CT of the chest and 3-year outcomes for 50- to 79-year-old current and ex-smokers in ...

journal_title：American journal of respiratory and critical care medicine

authors： Wilson DO,Weissfeld JL,Fuhrman CR,Fisher SN,Balogh P,Landreneau RJ,Luketich JD,Siegfried JM

更新日期：2008-11-01 00:00:00

abstract：RATIONALE:Idiopathic pulmonary fibrosis (IPF) is caused by alterations in expression of proteins involved in multiple pathways, including matrix deposition, inflammation, injury, and repair. OBJECTIVES:To understand the pathogenic changes in lung protein expression in IPF and to evaluate apolipoprotein (Apo) A-I as a ...

journal_title：American journal of respiratory and critical care medicine

authors： Kim TH,Lee YH,Kim KH,Lee SH,Cha JY,Shin EK,Jung S,Jang AS,Park SW,Uh ST,Kim YH,Park JS,Sin HG,Youm W,Koh ES,Cho SY,Paik YK,Rhim TY,Park CS

更新日期：2010-09-01 00:00:00

abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

journal_title：American journal of respiratory and critical care medicine

authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

更新日期：1994-08-01 00:00:00

abstract：:The cost effectiveness of asthma care is the first topic of the National Asthma Education and Prevention Program Task Force Report on the Cost Effectiveness, Quality of Care, and Financing of Asthma Care. This working group characterized the role of health economics in understanding optimal asthma management strategie...

journal_title：American journal of respiratory and critical care medicine

authors： Sullivan S,Elixhauser A,Buist AS,Luce BR,Eisenberg J,Weiss KB

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary pressure might limit injury caused by added spontaneous effort. OBJECTIVES:To test the hypothesis that, during spontaneous effort in injured lu...

journal_title：American journal of respiratory and critical care medicine

authors： Yoshida T,Nakahashi S,Nakamura MAM,Koyama Y,Roldan R,Torsani V,De Santis RR,Gomes S,Uchiyama A,Amato MBP,Kavanagh BP,Fujino Y

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. OBJECTIVES:The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) conc...

journal_title：American journal of respiratory and critical care medicine

authors： Hansel NN,McCormack MC,Belli AJ,Matsui EC,Peng RD,Aloe C,Paulin L,Williams DL,Diette GB,Breysse PN

更新日期：2013-05-15 00:00:00

abstract：:We have tested two surfactant preparations with the same phospholipid (PL) composition, containing recombinant surfactant protein-C (rSP-C surfactant) and without SP-C (plain PL surfactant). The effects of rSP-C surfactant were compared with the bovine-derived surfactant preparations Alveofact, bLES, and Infasurf in a...

journal_title：American journal of respiratory and critical care medicine

authors： Häfner D,Germann PG,Hauschke D

更新日期：1998-07-01 00:00:00

abstract：:In mechanically ventilated neonates, the instrumental dead space is a major determinant of total minute ventilation. By flushing this dead space, continuous tracheal gas insufflation (CTGI) may allow reduction of the risk of overinflation. We conducted a randomized trial to evaluate the efficacy of CTGI in reducing ai...

journal_title：American journal of respiratory and critical care medicine

authors： Dassieu G,Brochard L,Benani M,Avenel S,Danan C

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:chronic obstructive pulmonary disease (COPD), characterized by airflow limitation, is a disorder with high phenotypic and genetic heterogeneity. Pulmonary emphysema is a major but variable component of COPD; familial data suggest that different components of COPD, such as emphysema, may be influenced by speci...

journal_title：American journal of respiratory and critical care medicine

authors： Kong X,Cho MH,Anderson W,Coxson HO,Muller N,Washko G,Hoffman EA,Bakke P,Gulsvik A,Lomas DA,Silverman EK,Pillai SG,ECLIPSE Study NETT Investigators.

更新日期：2011-01-01 00:00:00

abstract：RATIONALE:Innate immune responses marked by increases in tumor necrosis factor (TNF)-α have been associated with asthma but whether such alterations are evident before symptoms is not yet clear. OBJECTIVES:To determine if prevalence of childhood asthma or asthma-related traits is predicted by perinatal innate immune s...

journal_title：American journal of respiratory and critical care medicine

authors： Halonen M,Lohman IC,Stern DA,Ellis WL,Rothers J,Wright AL

更新日期：2013-07-01 00:00:00

abstract：:Reexpansion of collapsed lung creates intrapulmonary shear forces. In an earlier study we showed that application of a negative end-expiratory airway pressure (NEEP) to normal rabbit lungs in vivo produced tidal collapse and reexpansion with transient changes in compliance and gas exchange but no histologic damage. In...

journal_title：American journal of respiratory and critical care medicine

authors： Taskar V,John J,Evander E,Robertson B,Jonson B

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. OBJECTIVES:To evaluate the clinical efficacy of intermittent therapy compared with daily therapy for no...

journal_title：American journal of respiratory and critical care medicine

authors： Jeong BH,Jeon K,Park HY,Kim SY,Lee KS,Huh HJ,Ki CS,Lee NY,Shin SJ,Daley CL,Koh WJ

更新日期：2015-01-01 00:00:00

abstract：RATIONALE:Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationsh...

journal_title：American journal of respiratory and critical care medicine

authors： Olsson AC,Gustavsson P,Kromhout H,Peters S,Vermeulen R,Brüske I,Pesch B,Siemiatycki J,Pintos J,Brüning T,Cassidy A,Wichmann HE,Consonni D,Landi MT,Caporaso N,Plato N,Merletti F,Mirabelli D,Richiardi L,Jöckel KH,Ah

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Airways obstruction with thick, adherent mucus is a pathophysiologic and clinical feature of muco-obstructive respiratory diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis (CF). Mucins, the dominant biopolymer in mucus, organize into complex polymeric networks via the form...

journal_title：American journal of respiratory and critical care medicine

authors： Ehre C,Rushton ZL,Wang B,Hothem LN,Morrison CB,Fontana NC,Markovetz MR,Delion MF,Kato T,Villalon D,Thelin WR,Esther CR Jr,Hill DB,Grubb BR,Livraghi-Butrico A,Donaldson SH,Boucher RC

更新日期：2019-01-15 00:00:00

abstract：RATIONALE:Transfusion of erythrocytes stored for prolonged periods is associated with increased mortality. Erythrocytes undergo hemolysis during storage and after transfusion. Plasma hemoglobin scavenges endogenous nitric oxide leading to systemic and pulmonary vasoconstriction. OBJECTIVES:We hypothesized that transfu...

journal_title：American journal of respiratory and critical care medicine

authors： Berra L,Pinciroli R,Stowell CP,Wang L,Yu B,Fernandez BO,Feelisch M,Mietto C,Hod EA,Chipman D,Scherrer-Crosbie M,Bloch KD,Zapol WM

更新日期：2014-10-01 00:00:00