Continuous tracheal gas insufflation in preterm infants with hyaline membrane disease. A prospective randomized trial.

abstract：:To attain a better understanding of antibiotic cycling and its effects on the epidemiology of antibiotic resistance in gram-negative microorganisms, two different antibiotic classes (quinolone and beta-lactam) were cycled during four 4-month periods in a surgical intensive care unit. Respiratory aspirates and rectal s...

journal_title：American journal of respiratory and critical care medicine

authors： van Loon HJ,Vriens MR,Fluit AC,Troelstra A,van der Werken C,Verhoef J,Bonten MJ

更新日期：2005-03-01 00:00:00

abstract：:Important features of both stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributin...

journal_title：American journal of respiratory and critical care medicine

authors： Abdulai RM,Jensen TJ,Patel NR,Polkey MI,Jansson P,Celli BR,Rennard SI

更新日期：2018-02-15 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible for movement of sodium. Hyperactivation of ENaC, which creates an osmoti...

journal_title：American journal of respiratory and critical care medicine

authors： Scott DW,Walker MP,Sesma J,Wu B,Stuhlmiller TJ,Sabater JR,Abraham WM,Crowder TM,Christensen DJ,Tarran R

更新日期：2017-09-15 00:00:00

abstract：:Phosphatidylglycerol (PG) and phosphatidylinositol (PI) are anionic phospholipids (APLs) present in lung surfactant of virtually all species studied, although their specific contribution to function is unknown. This study examines how APLs influence surfactant monolayer stability and adsorption under static and dynami...

journal_title：American journal of respiratory and critical care medicine

authors： Ingenito EP,Mora R,Mark L

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Exhaled nitric oxide (NO) is a well-known marker of established airway inflammation in asthma. Its role in the disease process before the onset of respiratory symptoms remains unclear. OBJECTIVES:To examine whether elevated NO in newborns with clinically naive airways is associated with subsequent respirator...

journal_title：American journal of respiratory and critical care medicine

authors： Latzin P,Kuehni CE,Baldwin DN,Roiha HL,Casaulta C,Frey U

更新日期：2006-12-15 00:00:00

abstract：:During exercise, children with congenital central hypoventilation syndrome (CCHS) demonstrate coupling of VE to exercise load, despite the absence of a VE response to changes in FICO2. To assess the effect of movement on VE, we studied six CCHS patients and six matched controls during passive motion in a motor-driven ...

journal_title：American journal of respiratory and critical care medicine

authors： Gozal D,Marcus CL,Ward SL,Keens TG

更新日期：1996-02-01 00:00:00

abstract：:Inhaled nitric oxide (NO) improves systemic oxygenation (PaO2/FIO2) in adult patients with acute respiratory distress syndrome (ARDS). However, individual response varies, and previous trials demonstrated no outcome benefit. This prospective, randomized study in 40 ARDS patients analyzed dose-response (DR) characteris...

journal_title：American journal of respiratory and critical care medicine

authors： Gerlach H,Keh D,Semmerow A,Busch T,Lewandowski K,Pappert DM,Rossaint R,Falke KJ

更新日期：2003-04-01 00:00:00

abstract：:Gold-induced pulmonary disease is difficult to diagnose, especially, in the case in which interstitial pneumonia appears in the course of gold therapy for rheumatoid arthritis. We analyzed the literature to define the clinical features and prognosis of gold-induced pulmonary disease, and to identify those features tha...

journal_title：American journal of respiratory and critical care medicine

authors： Tomioka R,King TE Jr

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:Staphylococcus aureus is a major pathogen complicating postsurgical care. OBJECTIVES:To test the effect of sterile laparotomy (LAP) on pulmonary clearance of S. aureus in a murine model. METHODS:Control and LAP mice were infected intranasally with 10(8) cfu of S. aureus. Microbial clearance, pulmonary leuko...

journal_title：American journal of respiratory and critical care medicine

authors： Olszewski MA,Falkowski NR,Surana R,Sonstein J,Hartman A,Moore BB,Huffnagle GB,Toews GB

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:It is controversial whether obstructive sleep apnea (OSA) causes pulmonary hypertension (PH) in the absence of hypoxemic lung disease. To investigate this further we measured awake pulmonary hemodynamics, pulmonary gas exchange, and small airways function in 32 patients with OSA (apnea- hypopnea index, mean +/- SE, 46...

journal_title：American journal of respiratory and critical care medicine

authors： Sajkov D,Wang T,Saunders NA,Bune AJ,Neill AM,Douglas Mcevoy R

更新日期：1999-05-01 00:00:00

abstract：INTRODUCTION:Proteinases with a disintegrin and a metalloproteinase domain (ADAMs) have not been well studied in COPD. We investigated whether ADAM9 is linked to COPD in humans and mice. METHODS:ADAM9 blood and lung levels were measured in COPD patients versus controls, and air- versus cigarette smoke (CS)-exposed wil...

journal_title：American journal of respiratory and critical care medicine

authors： Wang X,Polverino F,Rojas-Quintero J,Zhang D,Sánchez J,Yambayev I,Lindqvist E,Virtala R,Djukanovic R,Davies DE,Wilson S,O'Donnell R,Cunoosamy D,Hazon P,Higham A,Singh D,Olsson H,Owen CA

更新日期：2018-06-04 00:00:00

abstract：:The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR mutations and ALK rearrangements, respectively, introduced the era of targeted therapy in advanced non-small cell lung cancer (NSCLC), shifting treatment from platinum...

journal_title：American journal of respiratory and critical care medicine

authors： Cardarella S,Johnson BE

更新日期：2013-10-01 00:00:00

abstract：:Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to v...

journal_title：American journal of respiratory and critical care medicine

authors： Rasmussen F,Taylor DR,Flannery EM,Cowan JO,Greene JM,Herbison GP,Sears MR

更新日期：2002-06-01 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：:The aim of this study was to clarify the influence of gastroesophageal reflux (GER) on cough threshold in patients with digestive symptoms but free from respiratory involvement. Of 57 consecutive subjects referred for 24-h esophageal pH monitoring because of digestive reflux symptoms, 29 patients free from respiratory...

journal_title：American journal of respiratory and critical care medicine

authors： Ferrari M,Olivieri M,Sembenini C,Benini L,Zuccali V,Bardelli E,Bovo P,Cavallini G,Vantini I,Lo Cascio V

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Traditionally, Mycobacterium avium complex (MAC) has been composed of M. avium and M. intracellulare; however, advances in genetic sequencing have allowed discovery of several novel species. With these discoveries, investigation of differences in risk factors, virulence, and clinical outcomes have emerged. O...

journal_title：American journal of respiratory and critical care medicine

authors： Boyle DP,Zembower TR,Reddy S,Qi C

更新日期：2015-06-01 00:00:00

abstract：:Current evidence suggests that patients with obstructive sleep apnea (OSA) may have augmented pharyngeal dilator muscle activity during wakefulness, to compensate for deficient anatomy. However, the isolated effect of sleep on the activity of these muscles (comparing OSA patients with controls) has not been studied. W...

journal_title：American journal of respiratory and critical care medicine

authors： Mezzanotte WS,Tangel DJ,White DP

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises and despite many theories, the pathological mechanism is not fully understood. Discovery of histone-induced toxicity in mice p...

journal_title：American journal of respiratory and critical care medicine

authors： Abrams ST,Zhang N,Manson J,Liu T,Dart C,Baluwa F,Wang SS,Brohi K,Kipar A,Yu W,Wang G,Toh CH

更新日期：2013-01-15 00:00:00

abstract：RATIONALE:Pulmonary complications (PCs) cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HCT). Shifts in gut microbiota have been linked to HCT outcomes; however, their effect on PCs is unknown. OBJECTIVES:To investigate whether changes in gut microbiota are associate...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Morjaria SM,Littmann ER,Geyer AI,Stover DE,Barker JN,Giralt SA,Taur Y,Pamer EG

更新日期：2016-08-15 00:00:00

abstract：:Although abnormalities of alveolar fibrin turnover have been reported to play a role in the development of idiopathic pulmonary fibrosis (IPF), the pathophysiological relevance remains unclear. We therefore investigated the localization of tissue factor (TF) and fibrin deposition in patients with IPF using immunohisto...

journal_title：American journal of respiratory and critical care medicine

authors： Imokawa S,Sato A,Hayakawa H,Kotani M,Urano T,Takada A

更新日期：1997-08-01 00:00:00

abstract：:Viral respiratory tract infections are associated with an acute increase in airway responsiveness in normal subjects and patients with asthma. Airway responsiveness is also increased at least transiently in animals during acute viral infections. In this article, we discuss possible mechanisms whereby viral infections ...

journal_title：American journal of respiratory and critical care medicine

authors： Hegele RG,Hayashi S,Hogg JC,Paré PD

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Observational studies link statin therapy with improved outcomes in patients with severe sepsis. OBJECTIVES:To test whether atorvastatin therapy affects biologic and clinical outcomes in critically ill patients with severe sepsis. METHODS:Phase II, multicenter, prospective, randomized, double-blind, placebo...

journal_title：American journal of respiratory and critical care medicine

authors： Kruger P,Bailey M,Bellomo R,Cooper DJ,Harward M,Higgins A,Howe B,Jones D,Joyce C,Kostner K,McNeil J,Nichol A,Roberts MS,Syres G,Venkatesh B,ANZ-STATInS Investigators–ANZICS Clinical Trials Group.

更新日期：2013-04-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, fibrotic disorder underlain by aberrant wound healing of repeated lung injury. Environmental triggers and genetic background are likely to act as modifiers of the fibrotic response. Erythrocyte complement receptor 1 is a membrane protein mediating the transport of immu...

journal_title：American journal of respiratory and critical care medicine

authors： Zorzetto M,Ferrarotti I,Trisolini R,Lazzari Agli L,Scabini R,Novo M,De Silvestri A,Patelli M,Martinetti M,Cuccia M,Poletti V,Pozzi E,Luisetti M

更新日期：2003-08-01 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Comparison of the risk-benefit profiles of different inhaled glucocorticoids has been limited by inadequate information about the dose-response relationships for efficacy relative to side effects. Fluticasone propionate (FP) is twice as effective as budesonide (BUD), but the potency ratio of FP:BUD with respect to sup...

journal_title：American journal of respiratory and critical care medicine

authors： Donnelly R,Williams KM,Baker AB,Badcock CA,Day RO,Seale JP

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:Secondhand smoke exposure (SHSe) is a significant modifiable risk for respiratory health in children. Although SHSe is declining overall, it has increased for low-income and minority populations. Implementation of effective SHSe interventions within community organizations has the potential for significant pu...

journal_title：American journal of respiratory and critical care medicine

authors： Eakin MN,Rand CS,Borrelli B,Bilderback A,Hovell M,Riekert KA

更新日期：2014-06-15 00:00:00

abstract：:To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult...

journal_title：American journal of respiratory and critical care medicine

authors： Asch SM,London AS,Barnes PF,Gelberg L

更新日期：1997-01-01 00:00:00

abstract：:We prospectively analyzed the diagnostic yield and safety of ultrasound (US)-guided transthoracic needle aspiration biopsy in the histologic diagnosis of 40 patients with superior vena cava (SVC) syndrome. During a 4-yr period, 40 patients with SVC obstruction were admitted to National Taiwan University Hospital. Of t...

journal_title：American journal of respiratory and critical care medicine

authors： Ko JC,Yang PC,Yuan A,Chang DB,Yu CJ,Wu HD,Lee LN,Kuo SH,Luh KT

更新日期：1994-03-01 00:00:00