Effects of budesonide and fluticasone on 24-hour plasma cortisol. A dose-response study.

abstract：RATIONALE:Improved ventilation strategies have been the mainstay for reducing mortality in acute respiratory distress syndrome. Their unique clinical effectiveness is, however, unmatched by our understanding of the underlying mechanobiology, and their impact on alveolar dynamics and gas exchange remains largely specula...

journal_title：American journal of respiratory and critical care medicine

authors： Tabuchi A,Nickles HT,Kim M,Semple JW,Koch E,Brochard L,Slutsky AS,Pries AR,Kuebler WM

更新日期：2016-02-15 00:00:00

abstract：:To investigate repair mechanisms in bleomycin-induced pulmonary fibrosis, we used mice deficient in gamma-glutamyl transpeptidase (GGT-/-), a key enzyme in glutathione (GSH) and cysteine metabolism. Seventy-two hours after bleomycin (0.03 U/g), GGT-/- mice displayed a different inflammatory response to wild-type mice ...

journal_title：American journal of respiratory and critical care medicine

authors： Pardo A,Ruiz V,Arreola JL,Ramírez R,Cisneros-Lira J,Gaxiola M,Barrios R,Kala SV,Lieberman MW,Selman M

更新日期：2003-03-15 00:00:00

abstract：:Recently described surgical approaches to the treatment of emphysema, including buttressed stapled volume reduction and laser coagulation, are associated with variable clinical outcomes. We examined objective preoperative factors as predictors of response to treatment in patients enrolled in a randomized trial of stap...

journal_title：American journal of respiratory and critical care medicine

authors： Brenner M,McKenna R Jr,Gelb A,Osann K,Schein MJ,Panzera J,Wong H,Berns MW,Wilson AF

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

journal_title：American journal of respiratory and critical care medicine

authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

更新日期：2019-02-15 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation. OBJECTIVES:We hypothesized tha...

journal_title：American journal of respiratory and critical care medicine

authors： Terragni PP,Rosboch G,Tealdi A,Corno E,Menaldo E,Davini O,Gandini G,Herrmann P,Mascia L,Quintel M,Slutsky AS,Gattinoni L,Ranieri VM

更新日期：2007-01-15 00:00:00

abstract：RATIONALE:Noncommunicable diseases are major causes of morbidity and mortality in sub-Saharan Africa (sSA). Valid burden of disease estimates are lacking for noncommunicable lung disease in sSA. OBJECTIVES:We performed a community-based survey to determine the prevalence of chronic lung disease among adults 18 years o...

journal_title：American journal of respiratory and critical care medicine

authors： Meghji J,Nadeau G,Davis KJ,Wang D,Nyirenda MJ,Gordon SB,Mortimer K

更新日期：2016-07-01 00:00:00

abstract：:A noninvasive method to characterize inflammation and infection in the airways of nonexpectorating children with cystic fibrosis (CF) is needed for clinical and research purposes. Accordingly, we performed sputum inductions by administering 3% saline to 11 healthy control children and 20 children with CF, composed of ...

journal_title：American journal of respiratory and critical care medicine

authors： Sagel SD,Kapsner R,Osberg I,Sontag MK,Accurso FJ

更新日期：2001-10-15 00:00:00

abstract：:Neutrophil infiltration is a major feature in the pathogenesis of the common cold, and respiratory viral infection is the major cause of asthma exacerbations. The factors regulating the neutrophil influx are unknown. Interleukin-8 (IL-8) is a potent neutrophil chemoattractant, which has been implicated in several infl...

journal_title：American journal of respiratory and critical care medicine

authors： Teran LM,Johnston SL,Schröder JM,Church MK,Holgate ST

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain. METHODS:We analyzed computed tomography (CT) lung images and lung function in participants in the Subpopulations and Intermediate Outc...

journal_title：American journal of respiratory and critical care medicine

authors： Dunican EM,Elicker BM,Henry T,Gierada DS,Schiebler ML,Anderson W,Barjaktarevic I,Barr RG,Bleecker ER,Boucher RC,Bowler RP,Christenson SA,Comellas A,Cooper CB,Couper D,Criner GJ,Dransfield M,Doerschuk CM,Drummond MB,

更新日期：2020-11-12 00:00:00

abstract：RATIONALE:Tissue resident memory T cells play a critical role in the defense against inhaled pathogens. The isolation and study of human lung tissue resident memory T cells and lung resident macrophages is limited by experimental constraints. OBJECTIVES:To characterize the spatial and functional relationship between l...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder ME,Sembrat J,Noda K,Myerburg MM,Craig A,Mitash N,Harano T,Furukawa M,Pilewski J,McDyer J,Rojas M,Sanchez P

更新日期：2020-12-11 00:00:00

abstract：RATIONALE:The American Thoracic Society/European Respiratory Society International Consensus Classification panel identified the clinical entity idiopathic nonspecific interstitial pneumonia (NSIP) as a provisional diagnosis and recommended further study. OBJECTIVES:We hypothesized that idiopathic NSIP is an autoimmun...

journal_title：American journal of respiratory and critical care medicine

authors： Kinder BW,Collard HR,Koth L,Daikh DI,Wolters PJ,Elicker B,Jones KD,King TE Jr

更新日期：2007-10-01 00:00:00

abstract：:Despite several codes of research ethics, the issuance of comprehensive rules regarding informed consent by governmental agencies, and numerous writings on the subject of informed consent, many commentators still question the quality of the informed consent process in clinical research. A major concern is that investi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman HJ

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES:The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier st...

journal_title：American journal of respiratory and critical care medicine

authors： Kearley J,Erjefalt JS,Andersson C,Benjamin E,Jones CP,Robichaud A,Pegorier S,Brewah Y,Burwell TJ,Bjermer L,Kiener PA,Kolbeck R,Lloyd CM,Coyle AJ,Humbles AA

更新日期：2011-04-01 00:00:00

abstract：:Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored.Objectives: To elucidate the role of TYKRIL (tyrosine kinase receptor-inducing lncRNA) as a regulator of p53/ PDGFRβ (platelet-derive...

journal_title：American journal of respiratory and critical care medicine

authors： Zehendner CM,Valasarajan C,Werner A,Boeckel JN,Bischoff FC,John D,Weirick T,Glaser SF,Rossbach O,Jaé N,Demolli S,Khassafi F,Yuan K,de Jesus Perez VA,Michalik KM,Chen W,Seeger W,Guenther A,Wasnick RM,Uchida S,Zeihe

更新日期：2020-11-15 00:00:00

abstract：:Pulmonary hypertension is a life-threatening complication of sickle cell disease. L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. This deficiency may play a role in pulmonary hypertension. The enzyme arginase hydrolyzes arginine...

journal_title：American journal of respiratory and critical care medicine

authors： Morris CR,Morris SM Jr,Hagar W,Van Warmerdam J,Claster S,Kepka-Lenhart D,Machado L,Kuypers FA,Vichinsky EP

更新日期：2003-07-01 00:00:00

abstract：:The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV-infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There wer...

journal_title：American journal of respiratory and critical care medicine

authors： Stansell JD,Osmond DH,Charlebois E,LaVange L,Wallace JM,Alexander BV,Glassroth J,Kvale PA,Rosen MJ,Reichman LB,Turner JR,Hopewell PC

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Patients with chronic obstructive pulmonary disease (COPD) show a poor response to corticosteroids. This has been linked to a reduction of histone deacetylase-2 as a result of oxidative stress and is reversed by theophylline. OBJECTIVES:To determine the role of phosphoinositide-3-kinase-delta (PI3K-δ) on the...

journal_title：American journal of respiratory and critical care medicine

authors： To Y,Ito K,Kizawa Y,Failla M,Ito M,Kusama T,Elliott WM,Hogg JC,Adcock IM,Barnes PJ

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. OBJECTIVES:To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically rele...

journal_title：American journal of respiratory and critical care medicine

authors： James AJ,Reinius LE,Verhoek M,Gomes A,Kupczyk M,Hammar U,Ono J,Ohta S,Izuhara K,Bel E,Kere J,Söderhäll C,Dahlén B,Boot RG,Dahlén SE,BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway

更新日期：2016-01-15 00:00:00

abstract：RATIONALE:Breathing supplemental oxygen reduces breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). Replacing nitrogen with helium reduces expiratory flow resistance and may improve lung emptying. Combining these treatments should be independently effective. OBJECTIVES:Study t...

journal_title：American journal of respiratory and critical care medicine

authors： Laude EA,Duffy NC,Baveystock C,Dougill B,Campbell MJ,Lawson R,Jones PW,Calverley PM

更新日期：2006-04-15 00:00:00

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：:Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thora...

journal_title：American journal of respiratory and critical care medicine

authors： Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

更新日期：2020-05-01 00:00:00

abstract：:Luteolin is a flavonoid that has been shown to reduce proinflammatory molecule expression in vitro. In the present study, we have tested the ability of luteolin to inhibit lipopolysaccharide (LPS)- induced lethal toxicity and proinflammatory molecule expression in vivo. Mice receiving LPS (Salmonella enteriditis LPS, ...

journal_title：American journal of respiratory and critical care medicine

authors： Kotanidou A,Xagorari A,Bagli E,Kitsanta P,Fotsis T,Papapetropoulos A,Roussos C

更新日期：2002-03-15 00:00:00

abstract：:Transbronchial biopsies (TBBs) are useful to diagnose acute rejection and infection in patients with lung transplants. The value of routine surveillance biopsies (S-TBBs) is not known, and such biopsies with a clinical indication are not without risk and are expensive. One hundred twenty-six 6-mo survivors of heart-lu...

journal_title：American journal of respiratory and critical care medicine

authors： Tamm M,Sharples LD,Higenbottam TW,Stewart S,Wallwork J

更新日期：1997-05-01 00:00:00

abstract：:We prospectively investigated the mechanism of airflow limitation before and after targeted emphysematous resection in 12 consecutively studied adult patients 68 +/- 4 yr of age (mean +/- SD) with very severe COPD undergoing bilateral thoracoscopic stapling techniques. Lung function, static lung elastic recoil, and ai...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,McKenna RJ Jr,Brenner M

更新日期：1996-10-01 00:00:00

abstract：RATIONALE:Previous investigations have identified several potential predictors of outcomes from lung volume reduction surgery (LVRS). A concern regarding these studies has been their small sample size, which may limit generalizability. We therefore sought to examine radiographic and physiologic predictors of surgical o...

journal_title：American journal of respiratory and critical care medicine

authors： Washko GR,Martinez FJ,Hoffman EA,Loring SH,Estépar RS,Diaz AA,Sciurba FC,Silverman EK,Han MK,Decamp M,Reilly JJ,National Emphysema Treatment Trial Research Group.

更新日期：2010-03-01 00:00:00

abstract：:We prospectively analyzed the diagnostic yield and safety of ultrasound (US)-guided transthoracic needle aspiration biopsy in the histologic diagnosis of 40 patients with superior vena cava (SVC) syndrome. During a 4-yr period, 40 patients with SVC obstruction were admitted to National Taiwan University Hospital. Of t...

journal_title：American journal of respiratory and critical care medicine

authors： Ko JC,Yang PC,Yuan A,Chang DB,Yu CJ,Wu HD,Lee LN,Kuo SH,Luh KT

更新日期：1994-03-01 00:00:00

abstract：:Although impairment of gas exchange caused by ventilation-perfusion (VA/Q) mismatch has been extensively analyzed, there have been no systematic studies focused on determining the distributions of diffusion properties in dose connection with those of VA/Q. We attempted to clarify the simultaneous distributions of VA/Q...

journal_title：American journal of respiratory and critical care medicine

authors： Yamaguchi K,Mori M,Kawai A,Takasugi T,Oyamada Y,Koda E

更新日期：1997-07-01 00:00:00

abstract：:The effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase activity, was evaluated in a rat model of laryngeal injury induced by endotracheal intubation for 1 h. At 1 h after extubation, the laryngeal damage was characterized by areas of mucosal necrosis, submucosal edema, swelling of subglottic glan...

journal_title：American journal of respiratory and critical care medicine

authors： Stern Y,Salzman A,Cotton RT,Zingarelli B

更新日期：1999-11-01 00:00:00

abstract：:In mechanically ventilated patients, pressure and flow tracings can be used to assess respiratory pump muscle activity or rest. When the ventilation is delivered through an endotracheal tube, the respiratory system can be considered a one-compartment model, and activation of the respiratory muscles results in deformat...

journal_title：American journal of respiratory and critical care medicine

authors： Jounieaux V,Parreira VF,Delguste P,Aubert G,Rodenstein DO

更新日期：1997-06-01 00:00:00