Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?

abstract：:We measured in rats the effects of 48 h of mechanical ventilation on the weight, contractile properties, and enzymatic profile of the diaphragm, the soleus and the extensor digitorium longus (EDL) muscles. Eighteen animals were randomly divided into a mechanically ventilated (MV, n = 9) group or a control (C, n = 9) g...

journal_title：American journal of respiratory and critical care medicine

authors： Le Bourdelles G,Viires N,Boczkowski J,Seta N,Pavlovic D,Aubier M

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition. OBJECTIVES:Our goals were to establish whether epithelial cell and mast cell activation with relea...

journal_title：American journal of respiratory and critical care medicine

authors： Hallstrand TS,Moody MW,Wurfel MM,Schwartz LB,Henderson WR Jr,Aitken ML

更新日期：2005-09-15 00:00:00

abstract：:Poor adherence to medication regimens may be contributing to the recent increase in asthma morbidity and mortality. We examined patient characteristics that may influence adherence to twice-daily inhaled steroid regimens. Fifty adults with moderate to severe asthma completed questionnaires examining sociodemographics,...

journal_title：American journal of respiratory and critical care medicine

authors： Apter AJ,Reisine ST,Affleck G,Barrows E,ZuWallack RL

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:Immediate graft performance after lung transplantation is associated with short- and long-term clinical outcomes. However, the biologic mechanism that determines outcomes is not fully understood. OBJECTIVES:To investigate the impact of cell death signals at 24 and 48 hours after lung transplantation on short...

journal_title：American journal of respiratory and critical care medicine

authors： Hashimoto K,Besla R,Zamel R,Juvet S,Kim H,Azad S,Waddell TK,Cypel M,Liu M,Keshavjee S

更新日期：2016-07-01 00:00:00

abstract：:The frequency and determinants of exogenous reinfection and of endogenous reactivation of tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 and 1996, 962 tuberculosis cases were confirmed by culture. Drug susceptibility testing was performed on available bac...

journal_title：American journal of respiratory and critical care medicine

authors： Caminero JA,Pena MJ,Campos-Herrero MI,Rodríguez JC,Afonso O,Martin C,Pavón JM,Torres MJ,Burgos M,Cabrera P,Small PM,Enarson DA

更新日期：2001-03-01 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：:Allergen-induced bronchoconstriction involves mast cell activation. Tryptase is a mast cell serine protease that is released during this process, but little is known about the action of tryptase in the airway. The purpose of this study was to determine: (1) if aerosolized tryptase causes bronchoconstriction, and (2) t...

journal_title：American journal of respiratory and critical care medicine

authors： Molinari JF,Scuri M,Moore WR,Clark J,Tanaka R,Abraham WM

更新日期：1996-09-01 00:00:00

abstract：RATIONALE:Tissue injury and repair involve highly conserved processes governed by mechanisms that can be co-opted in tumors. We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth. OBJECTIVES:To determine whether lung injury promoted growth of orth...

journal_title：American journal of respiratory and critical care medicine

authors： Arenberg D,Luckhardt TR,Carskadon S,Zhao L,Amin MA,Koch AE

更新日期：2010-10-15 00:00:00

abstract：:POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare variant of plasma cell dyscrasia with multiple systemic manifestations. We followed the progress of 20 patients with POEMS syndrome in our institution over a 10-yr period. Pulmonary hypertension (PH) was ob...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Godeau B,Authier FJ,Soubrier M,Zuber M,Larroche C,Viard JP,Wechsler B,Gherardi R

更新日期：1998-03-01 00:00:00

abstract：:Small airway disease is thought to contribute significantly to functional impairment caused by asthma. Functional evidence of airway-parenchyma uncoupling in asthma, such as loss of deep breath bronchodilator effect in bronchoconstrictive episodes and enhanced airway closure, has been previously demonstrated. Elastic ...

journal_title：American journal of respiratory and critical care medicine

authors： Mauad T,Silva LF,Santos MA,Grinberg L,Bernardi FD,Martins MA,Saldiva PH,Dolhnikoff M

更新日期：2004-10-15 00:00:00

abstract：:The stimuli controlling pharyngeal dilator muscles are poorly defined. Local mechanoreceptors are a leading possibility. To address this, we assessed the relationship between two dilator muscle electromyograms (EMGs, i.e., genioglossus [GG-an inspiratory phasic muscle], tensor palatini [TP-a tonically active muscle]) ...

journal_title：American journal of respiratory and critical care medicine

authors： Malhotra A,Pillar G,Fogel RB,Beauregard J,Edwards JK,Slamowitz DI,Shea SA,White DP

更新日期：2000-09-01 00:00:00

abstract：:Although contraction of human isolated bronchi is mediated mainly by tachykinin NK2 receptors, NK1 receptors, via prostanoid release, contract small-size (approximately 1 mm in diameter) bronchi. Here, we have investigated the presence and biological responses of NK1 receptors in medium-size (2-5 mm in diameter) human...

journal_title：American journal of respiratory and critical care medicine

authors： Amadesi S,Moreau J,Tognetto M,Springer J,Trevisani M,Naline E,Advenier C,Fisher A,Vinci D,Mapp C,Miotto D,Cavallesco G,Geppetti P

更新日期：2001-04-01 00:00:00

abstract：:The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The proto...

journal_title：American journal of respiratory and critical care medicine

authors： Grote L,Ploch T,Heitmann J,Knaack L,Penzel T,Peter JH

更新日期：1999-12-01 00:00:00

abstract：:Daily symptom, peak expiratory flow rate (PEFR), and medication diaries are often used in clinical trials of treatments for asthma on the assumption that they provide a better estimate of clinical status than does a questionnaire completed in the clinic. We conducted a study with the aim of comparing the measurement p...

journal_title：American journal of respiratory and critical care medicine

authors： Juniper EF,O'Byrne PM,Ferrie PJ,King DR,Roberts JN

更新日期：2000-10-01 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：:Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated tha...

journal_title：American journal of respiratory and critical care medicine

authors： Balaraman V,Meister J,Ku TL,Sood SL,Tam E,Killeen J,Uyehara CF,Egan E,Easa D

更新日期：1998-07-01 00:00:00

abstract：:To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult...

journal_title：American journal of respiratory and critical care medicine

authors： Asch SM,London AS,Barnes PF,Gelberg L

更新日期：1997-01-01 00:00:00

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：:We produced ovalbumin (OVA)-sensitized rats as an animal model of nasal allergy. Intranasal instillation of OVA induced hypertrophic and metaplastic changes of goblet cells in nasal epithelium of OVA- sensitized rats. Intraepithelial mucosubstance in nasal mucosa increased significantly at 24 h after 3 or 7 d of OVA i...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Majima Y,Sakakura Y

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive syndromes is a significant determinant of short- and long-term outcomes. Although remarkable progress has been made in the understanding of RV function and failure since the meeting of the NIH Working Group on Cellular and Molecula...

journal_title：American journal of respiratory and critical care medicine

authors： Lahm T,Douglas IS,Archer SL,Bogaard HJ,Chesler NC,Haddad F,Hemnes AR,Kawut SM,Kline JA,Kolb TM,Mathai SC,Mercier O,Michelakis ED,Naeije R,Tuder RM,Ventetuolo CE,Vieillard-Baron A,Voelkel NF,Vonk-Noordegraaf A,Hassou

更新日期：2018-08-15 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：:We assessed the influence of current indoor levels of fungi, house dust mite allergen (Der p 1), and cat allergen (Fel d 1) on sensitization and asthma in adults. A total of 485 adults answered a questionnaire and had skin prick tests and lung function tests. Dust and air samples were collected from their bedrooms. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmage S,Bailey M,Raven J,Mitakakis T,Cheng A,Guest D,Rolland J,Forbes A,Thien F,Abramson M,Walters EH

更新日期：2001-07-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. OBJECTIVES:We defined the burden of life-threatening (O(2) saturation [O(2) sat] ≤ ...

journal_title：American journal of respiratory and critical care medicine

authors： Ferolla FM,Hijano DR,Acosta PL,Rodríguez A,Dueñas K,Sancilio A,Barboza E,Caría A,Gago GF,Almeida RE,Castro L,Pozzolo C,Martínez MV,Grimaldi LA,Rebec B,Calvo M,Henrichsen J,Nocito C,González M,Barbero G,Losada JV,

更新日期：2013-05-01 00:00:00

abstract：:In 35 patients fulfilling the criteria of systemic inflammatory response syndrome (SIRS) of infectious origin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), tumor necrosis factor-soluble receptor (TNF-sR), and interleukin-12 (IL-12), C-reactive protein (CRP) levels and the Acute Physiology, and Chroni...

journal_title：American journal of respiratory and critical care medicine

authors： Presterl E,Staudinger T,Pettermann M,Lassnigg A,Burgmann H,Winkler S,Frass M,Graninger W

更新日期：1997-09-01 00:00:00

abstract：:The hereditary thrombophilias are a group of inherited conditions that predispose to thrombosis. Heritable deficiencies of the endogenous anticoagulants protein C, protein S, and antithrombin have been recognized for some years, but their prevalence, even among patients with familial thrombosis, is low. The recent dis...

journal_title：American journal of respiratory and critical care medicine

authors： Murin S,Marelich GP,Arroliga AC,Matthay RA

更新日期：1998-11-01 00:00:00

abstract：:Alveolar macrophages (AMs) are considered major effector cells in host defense against respiratory tract infections by virtue of their potent phagocytic properties. In addition, AMs may regulate the host inflammatory response to infection by production of cytokines and by their capacity to phagocytose apoptotic polymo...

journal_title：American journal of respiratory and critical care medicine

authors： Knapp S,Leemans JC,Florquin S,Branger J,Maris NA,Pater J,van Rooijen N,van der Poll T

更新日期：2003-01-15 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Human T lymphotropic virus type I (HTLV-I) is the etiological agent of adult T cell leukemia, and reports suggest that several other clinical conditions are associated with HTLV-I infection, including myelopathy and inflammatory pulmonary diseases. However, the clinical entity of HTLV-I-associated lung disease remains...

journal_title：American journal of respiratory and critical care medicine

authors： Kawakami K,Miyazato A,Iwakura Y,Saito A

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：RATIONALE:Chronic infection with Burkholderia cepacia complex bacteria in cystic fibrosis is associated with accelerated decline in pulmonary function and increased mortality. Clinical implications of the recently characterized genomovar VI, B. dolosa, are unknown. OBJECTIVES:Characterization of impact of B. dolosa on...

journal_title：American journal of respiratory and critical care medicine

authors： Kalish LA,Waltz DA,Dovey M,Potter-Bynoe G,McAdam AJ,Lipuma JJ,Gerard C,Goldmann D

更新日期：2006-02-15 00:00:00