Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs.

abstract：RATIONALE:The discovery that retinoic acid-related orphan receptor (Rora)-α is highly expressed in lungs of patients with COPD led us to hypothesize that Rora may contribute to the pathogenesis of emphysema. OBJECTIVES:To determine the role of Rora in smoke-induced emphysema. METHODS:Cigarette smoke extract in vitro ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi Y,Cao J,Gao J,Zheng L,Goodwin A,An CH,Patel A,Lee JS,Duncan SR,Kaminski N,Pandit KV,Rosas IO,Choi AM,Morse D

更新日期：2012-09-01 00:00:00

abstract：:E-selectin, an early mediator of leukocyte-endothelial adhesion, is expressed on activated endothelium. Soluble E-selectin is present in the supernatant of cytokine-activated endothelial cells and elevated serum levels are found in a variety of inflammatory conditions. We documented elevated E-selectin serum levels in...

journal_title：American journal of respiratory and critical care medicine

authors： Cummings CJ,Sessler CN,Beall LD,Fisher BJ,Best AM,Fowler AA 3rd

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood. OBJECTIVES:Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) ge...

journal_title：American journal of respiratory and critical care medicine

authors： Simpson A,Maniatis N,Jury F,Cakebread JA,Lowe LA,Holgate ST,Woodcock A,Ollier WE,Collins A,Custovic A,Holloway JW,John SL

更新日期：2005-07-01 00:00:00

abstract：UNLABELLED:Although local tissue activation of the endothelin (ET) system contributes to the development of pulmonary hypertension, the impact of isolated chronic plasma hyperendothelinemia on the pulmonary circulation is unknown. METHODS:Mini-osmotic pumps were implanted in rats to deliver ET-1 during 7 or 28 days. A...

journal_title：American journal of respiratory and critical care medicine

authors： Migneault A,Sauvageau S,Villeneuve L,Thorin E,Fournier A,Leblanc N,Dupuis J

更新日期：2005-03-01 00:00:00

abstract：:A number of new observations have added to our understanding of mast cell biology and the relevance of this cell to the genesis of asthma. The purpose of this review has been to highlight this new information and to refer the reader to extensive reviews where previously documented and well-known data are available. Of...

journal_title：American journal of respiratory and critical care medicine

authors： Wasserman SI

更新日期：1994-11-01 00:00:00

abstract：RATIONALE:Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear. OBJECTIVES:We hypothesized that formation of a fibrin mesh retains plasma protei...

journal_title：American journal of respiratory and critical care medicine

authors： Takabayashi T,Kato A,Peters AT,Hulse KE,Suh LA,Carter R,Norton J,Grammer LC,Cho SH,Tan BK,Chandra RK,Conley DB,Kern RC,Fujieda S,Schleimer RP

更新日期：2013-01-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a chronic lung disease of very low birth weight infants, associated with oxygen therapy, barotrauma, and/or infections. Improved medical care has led to a paradoxically increased incidence of BPD due to greater infant survival. Early prediction of BPD has proven challenging. Increas...

journal_title：American journal of respiratory and critical care medicine

authors： Cullen A,Van Marter LJ,Allred EN,Moore M,Parad RB,Sunday ME

更新日期：2002-04-15 00:00:00

abstract：:The interleukin-1 cluster on human chromosome 2q12-2q14 harbors various promising candidate genes for asthma and other inflammatory diseases. We conducted a systematic association study with single-nucleotide polymorphisms (SNPs) located in candidate genes situated in this cluster. Single-marker, two-locus and three-l...

journal_title：American journal of respiratory and critical care medicine

authors： Gohlke H,Illig T,Bahnweg M,Klopp N,André E,Altmüller J,Herbon N,Werner M,Knapp M,Pescollderungg L,Boner A,Malerba G,Pignatti PF,Wjst M

更新日期：2004-06-01 00:00:00

abstract：:There is intriguing evidence suggesting pathophysiologic relationships among dyspnea, hyperventilation, and panic anxiety. The symptoms of panic attacks and pulmonary disease overlap, so that panic anxiety can reflect underlying cardiopulmonary disease and dyspnea can reflect an underlying anxiety disorder. The pathog...

journal_title：American journal of respiratory and critical care medicine

authors： Smoller JW,Pollack MH,Otto MW,Rosenbaum JF,Kradin RL

更新日期：1996-07-01 00:00:00

abstract：:We describe two reliable methods for high-throughput screening of proteinase inhibitor (PI) S and PI Z alpha(1)-antitrypsin (alpha(1)-AT) deficiency alleles from dried blood spot (DBS) specimens using the LightCycler fluorimetric analyzer. The method was used to study 72 patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Rodriguez F,Jardí R,Costa X,Cotrina M,Galimany R,Vidal R,Miravitlles M

更新日期：2002-09-15 00:00:00

abstract：:The purpose of this study was to evaluate the physiologic responses to endurance training in patients with moderate to severe airflow obstruction by specifically looking at changes in skeletal muscle enzymatic activities. Eleven patients (age = 65 +/- 7 yr, mean +/- SD, FEV1 = 36 +/- 11% of predicted value, range = 24...

journal_title：American journal of respiratory and critical care medicine

authors： Maltais F,LeBlanc P,Simard C,Jobin J,Bérubé C,Bruneau J,Carrier L,Belleau R

更新日期：1996-08-01 00:00:00

abstract：:To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult...

journal_title：American journal of respiratory and critical care medicine

authors： Asch SM,London AS,Barnes PF,Gelberg L

更新日期：1997-01-01 00:00:00

abstract：:We investigated ventilation inhomogeneity in patients with chronic obstructive pulmonary disease (COPD) through use of the multiple breath N2 washout test (MBW). From an alveolar slope analysis throughout the MBW, we derived two indices, S(cond) and S(acin), as a measure of ventilation inhomogeneity in conductive and ...

journal_title：American journal of respiratory and critical care medicine

authors： Verbanck S,Schuermans D,Van Muylem A,Melot C,Noppen M,Vincken W,Paiva M

更新日期：1998-05-01 00:00:00

abstract：:This is a study of the reliability of peak expiratory flow (PEF) monitoring using a portable computerized peak flow meter, the VMX Mini-log, in 17 subjects referred for suspected occupational asthma. Subjects were requested to monitor their PEF six times daily using the VMX Mini-Log for 2 wk at work and at least 10 d ...

journal_title：American journal of respiratory and critical care medicine

authors： Quirce S,Contreras G,Dybuncio A,Chan-Yeung M

更新日期：1995-09-01 00:00:00

abstract：:Colony-forming units of Mycobacterium tuberculosis in sputum were counted at 2-day intervals in 100 patients treated with 22 regimens of isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, given alone or in combinations. The exponential fall in colony-forming units was measured by linear regression coeffic...

journal_title：American journal of respiratory and critical care medicine

authors： Jindani A,Doré CJ,Mitchison DA

更新日期：2003-05-15 00:00:00

abstract：RATIONALE:An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups. OBJECTIVES:To characterize the asthma and atopy phenotypes in early childhood that associate with the 17q12-21 locus. METHODS:The single nucleotide polymorphism (SNP), rs7216389, was genotyped in ...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Bønnelykke K,Sleiman PM,Brasholt M,Chawes B,Kreiner-Møller E,Stage M,Kim C,Tavendale R,Baty F,Pipper CB,Palmer CN,Hakonarsson H

更新日期：2009-02-01 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：RATIONALE:Susceptibility to tuberculosis is not only determined by Mycobacterium tuberculosis infection, but also by the genetic component of the host. The pleiotropic cytokine tumor necrosis factor-alpha is essential to control tuberculosis infection, and various tumor necrosis factor family members and their respecti...

journal_title：American journal of respiratory and critical care medicine

authors： Möller M,Flachsbart F,Till A,Thye T,Horstmann RD,Meyer CG,Osei I,van Helden PD,Hoal EG,Schreiber S,Nebel A,Franke A

更新日期：2010-02-15 00:00:00

abstract：:Nitric oxide (NO) may play a part in pulmonary vascular regulation and bronchomotor control and has been detected in exhaled air. We report the release of NO from airway epithelial cells and its regulation by cyclic adenosine monophosphate (cAMP). To directly measure NO release, a highly specific amperometric sensor f...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Kondo M,Takemura H,Chiyotani A,Yamawaki I,Konno K

更新日期：1995-10-01 00:00:00

abstract：:Most patients with cystic fibrosis (CF) are infected by Pseudomonas aeruginosa. Dextran exhibits anti-adhesive effects in preventing attachment of P. aeruginosa to epithelial cells (1). The initial purpose of this study was to evaluate the potential of dextran to alter the rheology and ciliary transportability of CF s...

journal_title：American journal of respiratory and critical care medicine

authors： Feng W,Garrett H,Speert DP,King M

更新日期：1998-03-01 00:00:00

abstract：RATIONALE:Severe asthma is a major public health issue throughout the world. Increased bronchial smooth muscle (BSM) mass, a characteristic feature of airway remodeling in severe asthma, is associated with resistance to high-intensity treatment and poor prognosis. In vitro, the Ca(2+)-channel blocker gallopamil decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Girodet PO,Dournes G,Thumerel M,Begueret H,Dos Santos P,Ozier A,Dupin I,Trian T,Montaudon M,Laurent F,Marthan R,Berger P

更新日期：2015-04-15 00:00:00

abstract：:We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

journal_title：American journal of respiratory and critical care medicine

authors： Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

更新日期：1997-02-01 00:00:00

abstract：:The relationship between asthma medication and the perception of asthma symptoms is of interest for daily practice. Poor perception of asthma symptoms might influence patients' health care behavior and subsequently might lead to undertreatment and deterioration of their disease. This study investigated the influence o...

journal_title：American journal of respiratory and critical care medicine

authors： Bijl-Hofland ID,Cloosterman SG,Folgering HT,van den Elshout FJ,van Weel C,van Schayck CP

更新日期：2001-09-01 00:00:00

abstract：RATIONALE:Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary pressure might limit injury caused by added spontaneous effort. OBJECTIVES:To test the hypothesis that, during spontaneous effort in injured lu...

journal_title：American journal of respiratory and critical care medicine

authors： Yoshida T,Nakahashi S,Nakamura MAM,Koyama Y,Roldan R,Torsani V,De Santis RR,Gomes S,Uchiyama A,Amato MBP,Kavanagh BP,Fujino Y

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:Defective efferocytosis (phagocytic clearance of apoptotic cells) in the airway may perpetuate inflammation via secondary necrosis in chronic obstructive pulmonary disease (COPD). We have previously reported that low-dose azithromycin improved alveolar macrophage (AM) phagocytic function in vitro. OBJECTIVES...

journal_title：American journal of respiratory and critical care medicine

authors： Hodge S,Hodge G,Jersmann H,Matthews G,Ahern J,Holmes M,Reynolds PN

更新日期：2008-07-15 00:00:00

abstract：:Most of the studies linking chronic obstructive pulmonary disease (COPD) with oxidative stress are in vitro, using invasive techniques, or measuring systemic oxidative stress. The aim of this study was to quantify oxidative stress in the lungs in patients with COPD and in healthy smokers, as reflected by 8-isoprostane...

journal_title：American journal of respiratory and critical care medicine

authors： Montuschi P,Collins JV,Ciabattoni G,Lazzeri N,Corradi M,Kharitonov SA,Barnes PJ

更新日期：2000-09-01 00:00:00

abstract：:Snoring and sleeping apnea are reportedly associated with morbidity. We used home monitoring (MESAM IV) to measure snoring and sleep apnea in 294 men aged 40 to 65 yr from the volunteer register of the Busselton (Australia) Health Survey. In this group, 81% snored for more than 10% of the night and 22% for more than h...

journal_title：American journal of respiratory and critical care medicine

authors： Bearpark H,Elliott L,Grunstein R,Cullen S,Schneider H,Althaus W,Sullivan C

更新日期：1995-05-01 00:00:00

abstract：:Lung transplantation with its attendant life-long immunosuppression contributes to bone loss and its sequelae, fractures and kyphosis, in patients with lung disease, many of whom already suffer from severe osteoporosis. Patients with cystic fibrosis (CF) are one of the most severely affected groups. We conducted a con...

journal_title：American journal of respiratory and critical care medicine

authors： Aris RM,Lester GE,Renner JB,Winders A,Denene Blackwood A,Lark RK,Ontjes DA

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Tissue injury and repair involve highly conserved processes governed by mechanisms that can be co-opted in tumors. We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth. OBJECTIVES:To determine whether lung injury promoted growth of orth...

journal_title：American journal of respiratory and critical care medicine

authors： Arenberg D,Luckhardt TR,Carskadon S,Zhao L,Amin MA,Koch AE

更新日期：2010-10-15 00:00:00

abstract：:Ventilation was measured in 31 difficult-to-wean patients while pressure support (PS) was reduced by 5 cm H2O every 20 min. Weaning had to be aborted in 14 of 31 patients (Group F) because they met predefined distress criteria. The remaining 17 patients who were able to complete the "weaning test" (Group S) had larger...

journal_title：American journal of respiratory and critical care medicine

authors： Stroetz RW,Hubmayr RD

更新日期：1995-09-01 00:00:00