Abstract:
:A number of new observations have added to our understanding of mast cell biology and the relevance of this cell to the genesis of asthma. The purpose of this review has been to highlight this new information and to refer the reader to extensive reviews where previously documented and well-known data are available. Of particular current interest is the knowledge that mast cell growth and differentiation is regulated by a specific molecule, stem cell factor, which interacts with a receptor on the surface of the mast cell (a tyrosine kinase) and that mast cell phenotype may be modulated by exposure to stem cell factor as well as to a host of inflammatory cytokines. In addition to the ability to release vasoactive/spasmogenic mediators characterized by histamine, the slow-reacting substance of anaphylaxis (sulfidopeptide leukotrienes), platelet-activating factor, and adenosine, the mast cell can release a unique family of enzymes and generate a cassette of cytokines with critically important pro-inflammatory potential. The enzymes that are unique to the mast cell can potentiate a number of inflammatory events central to asthma, including fibroblast activation, mucus secretion, smooth muscle contraction, and neuropeptide degradation, while the cytokines may directly influence the influx, persistence, and activity of inflammatory cells, particularly eosinophilis and basophils, through the ability of the cytokines to modulate endothelial expression of leukocyte adhesion receptors and to prevent target cell apoptosis.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Am J Respir Crit Care Medauthors
Wasserman SIdoi
10.1164/ajrccm/150.5_Pt_2.S39subject
Has Abstractpub_date
1994-11-01 00:00:00pages
S39-41issue
5 Pt 2eissn
1073-449Xissn
1535-4970journal_volume
150pub_type
杂志文章,评审abstract::The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...
journal_title:American journal of respiratory and critical care medicine
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doi:10.1164/ajrccm.150.5.7952560
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2003-05-15 00:00:00
abstract::Ahead of Print article withdrawn by publisher. ...
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pub_type: 临床试验,杂志文章
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doi:10.1164/ajrccm.158.2.9710116
更新日期:1998-08-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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doi:10.1164/ajrccm.156.2.9608047
更新日期:1997-08-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1164/ajrccm.154.2.8756830
更新日期:1996-08-01 00:00:00
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更新日期:2019-09-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1164/ajrccm.153.4.8616580
更新日期:1996-04-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00