A new tongue advancement technique for sleep-disordered breathing: side effects and efficacy.

abstract：:The role of strain difference in the response to cigarette smoke was investigated in mice. Mice of the strains DBA/2 and C57BL/6J responded to acute cigarette smoke with a decrease of the antioxidant defenses of their bronchoalveolar lavage (BAL) fluids. On the other hand, under these conditions ICR mice increased the...

journal_title：American journal of respiratory and critical care medicine

authors： Cavarra E,Bartalesi B,Lucattelli M,Fineschi S,Lunghi B,Gambelli F,Ortiz LA,Martorana PA,Lungarella G

更新日期：2001-09-01 00:00:00

abstract：RATIONALE:The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF. OBJECTIVES:To understand the gene expression patterns of acute exacerbations of IPF. METHODS:RNA was extracted ...

journal_title：American journal of respiratory and critical care medicine

authors： Konishi K,Gibson KF,Lindell KO,Richards TJ,Zhang Y,Dhir R,Bisceglia M,Gilbert S,Yousem SA,Song JW,Kim DS,Kaminski N

更新日期：2009-07-15 00:00:00

abstract：:Normoxic lung ischemia/reperfusion (I/R) leads to oxidative injury of the pulmonary tissue. We analyzed angiotensin-converting enzyme (ACE) in perfused rat lungs upon I/R in order to assess the endothelial injury produced. I/R led to a time-dependent increase in ACE activity in the perfusate, from 145+/-14 mU to 252+/...

journal_title：American journal of respiratory and critical care medicine

authors： Atochina EN,Muzykantov VR,Al-Mehdi AB,Danilov SM,Fisher AB

更新日期：1997-10-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00

abstract：:Genes for the chemokine receptors CCR5 and CCR2 are characterized by polymorphisms resulting in a nonfunctional receptor expression. Ligands for CCR2 and CCR5 (chemokines monocyte chemotactic protein-1 [MCP-1] and RANTES) are implicated in the pathogenesis of sarcoidosis. We have, therefore, analyzed polymorphisms of ...

journal_title：American journal of respiratory and critical care medicine

authors： Petrek M,Drábek J,Kolek V,Zlámal J,Welsh KI,Bunce M,Weigl E,Du Bois R

更新日期：2000-09-01 00:00:00

abstract：:At the time of diagnosis, many sarcoidosis patients have no clinical indication for corticosteroid therapy, and prognostic parameters predicting deterioration are missing. In the present study, we investigated parameters derived from bronchoalveolar lavage (BAL) and serum in 77 patients with recently diagnosed sarcoid...

journal_title：American journal of respiratory and critical care medicine

authors： Ziegenhagen MW,Benner UK,Zissel G,Zabel P,Schlaak M,Müller-Quernheim J

更新日期：1997-11-01 00:00:00

abstract：:Rationale: To detect pulmonary arterial hypertension (PAH) at any early stage is a promising approach to optimize the outcome. Objectives: To investigate the impact of school ECG-based screening on detecting idiopathic or heritable (I/H)-PAH in the general pediatric population. Methods: This was a nationwide survey of...

journal_title：American journal of respiratory and critical care medicine

authors： Sawada H,Mitani Y,Nakayama T,Fukushima H,Kogaki S,Igarashi T,Ichida F,Ono Y,Nakanishi T,Doi S,Ishikawa S,Matsushima M,Yamada O,Saji T

更新日期：2019-06-01 00:00:00

abstract：:There is a need for quick, reliable, and noninvasive lung function tests to assess airway obstruction in preschool children both for pediatric pulmonary care as well as for research purposes. We studied feasibility, reproducibility, and validity of measurements of the respiratory system using the interrupter technique...

journal_title：American journal of respiratory and critical care medicine

authors： Merkus PJ,Mijnsbergen JY,Hop WC,de Jongste JC

更新日期：2001-05-01 00:00:00

abstract：:We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SD) of 43.3 (8.6) yr. Pre-exposure spirometry and methacholine challenge tests were performed before beginning the boiler overhaul; postexposure tests were perform...

journal_title：American journal of respiratory and critical care medicine

authors： Hauser R,Elreedy S,Hoppin JA,Christiani DC

更新日期：1995-11-01 00:00:00

abstract：:The aim of the study was to determine whether closing pressures or vascular distensibility can be used to describe liver venous hemodynamics when right atrial pressure is raised. The study was performed using a vascularly isolated pig liver preparation that allowed the independent control of portal vein and hepatic ar...

journal_title：American journal of respiratory and critical care medicine

authors： Brienza N,Ayuse T,O'Donnell CP,Permutt S,Robotham JL

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Mitochondria have important roles in intracellular energy generation, modulation of apoptosis, and redox-dependent intracellular signaling. Although reactive oxygen species (ROS) participate in the regulation of intracellular signaling pathways, including activation of nuclear factor (NF)-kappaB, there is onl...

journal_title：American journal of respiratory and critical care medicine

authors： Zmijewski JW,Lorne E,Zhao X,Tsuruta Y,Sha Y,Liu G,Siegal GP,Abraham E

更新日期：2008-07-15 00:00:00

abstract：RATIONALE:Although it is widely assumed that the incidence of childhood respiratory allergies to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVES:To assess...

journal_title：American journal of respiratory and critical care medicine

authors： Torrent M,Sunyer J,Garcia R,Harris J,Iturriaga MV,Puig C,Vall O,Anto JM,Newman Taylor AJ,Cullinan P

更新日期：2007-09-01 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) is a life-threatening disease, characterized by vascular remodeling and vasoconstriction. Evidence suggests that oxidative stress may contribute to the pathogenesis and/or development of PH. OBJECTIVES:In the present study, we examined whether intratracheal gene transfer of human ...

journal_title：American journal of respiratory and critical care medicine

authors： Kamezaki F,Tasaki H,Yamashita K,Tsutsui M,Koide S,Nakata S,Tanimoto A,Okazaki M,Sasaguri Y,Adachi T,Otsuji Y

更新日期：2008-01-15 00:00:00

abstract：:Great emphasis is placed on educating asthmatics to use action plans to achieve better control of symptoms. The use of peak flow meters (PFM) has been recommended as an important part of self-management plans. We studied 92 (47 F) adult patients with asthma in a primary care setting to compare the effectiveness of act...

journal_title：American journal of respiratory and critical care medicine

authors： Turner MO,Taylor D,Bennett R,Fitzgerald JM

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poo...

journal_title：American journal of respiratory and critical care medicine

authors： Kiwamoto T,Ishii Y,Morishima Y,Yoh K,Maeda A,Ishizaki K,Iizuka T,Hegab AE,Matsuno Y,Homma S,Nomura A,Sakamoto T,Takahashi S,Sekizawa K

更新日期：2006-07-15 00:00:00

abstract：:The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of p...

journal_title：American journal of respiratory and critical care medicine

authors： Newman LS,Mroz MM,Balkissoon R,Maier LA

更新日期：2005-01-01 00:00:00

abstract：:Increased serum levels of mucin-associated antigen have been previously demonstrated in patients with cystic fibrosis (CF) and interstitial pneumonia, and in lung-transplant recipients. The present study assessed the serum airway mucin levels in patients with acute respiratory distress syndrome (ARDS). An enzyme-linke...

journal_title：American journal of respiratory and critical care medicine

authors： Shih JY,Yang SC,Yu CJ,Wu HD,Liaw YS,Wu R,Yang PC

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Systemic steroids are the standard treatment for bronchiolitis obliterans syndrome (BOS) after allogeneic hematopoietic stem cell transplantation (HSCT) despite their poor efficacy and disabling side effects. OBJECTIVES:To evaluate the effectiveness and tolerance of budesonide/formoterol as an alternative tr...

journal_title：American journal of respiratory and critical care medicine

authors： Bergeron A,Chevret S,Chagnon K,Godet C,Bergot E,Peffault de Latour R,Dominique S,de Revel T,Juvin K,Maillard N,Reman O,Contentin N,Robin M,Buzyn A,Socié G,Tazi A

更新日期：2015-06-01 00:00:00

abstract：:A study was done to compare the efficacy and safety of the coprescription of salmeterol 50 microgram twice daily or 100 microgram twice daily with beclomethasone dipropionate (BDP) 500 micrograms twice daily (SALM 50 and SALM 100) with BDP 1,000 microgram twice daily (BDP 1,000) in patients with asthma not controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Woolcock A,Lundback B,Ringdal N,Jacques LA

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:An increasing number of persons, exposed to high altitude for leisure, sport, or work, may suffer from severe high-altitude illness. OBJECTIVES:To assess, in a large cohort of subjects, the association between physiological parameters and the risk of altitude illness and their discrimination ability in a ris...

journal_title：American journal of respiratory and critical care medicine

authors： Richalet JP,Larmignat P,Poitrine E,Letournel M,Canouï-Poitrine F

更新日期：2012-01-15 00:00:00

abstract：:A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical mic...

journal_title：American journal of respiratory and critical care medicine

authors： Whiteson KL,Bailey B,Bergkessel M,Conrad D,Delhaes L,Felts B,Harris JK,Hunter R,Lim YW,Maughan H,Quinn R,Salamon P,Sullivan J,Wagner BD,Rainey PB

更新日期：2014-06-01 00:00:00

abstract：RATIONALE:Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage. OBJECTIVES:To compare damage caused to heart and kidneys on reoxygenation in severely asphyctic term neonates resuscitated with room air (RAR) or 1...

journal_title：American journal of respiratory and critical care medicine

authors： Vento M,Sastre J,Asensi MA,Viña J

更新日期：2005-12-01 00:00:00

abstract：RATIONALE:Inhibition of pharyngeal motoneurons accompanies REM sleep and is a cause of hypoventilation and obstructive sleep apnea in humans. One explanation posits that the neurotransmitters glycine and γ-aminobutyric acid are responsible for REM sleep motor inhibition. However, blockade of that mechanism at cranial m...

journal_title：American journal of respiratory and critical care medicine

authors： Grace KP,Hughes SW,Horner RL

更新日期：2013-02-01 00:00:00

abstract：:To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 asthmatic subjects pa...

journal_title：American journal of respiratory and critical care medicine

authors： Holz O,Jörres RA,Timm P,Mücke M,Richter K,Koschyk S,Magnussen H

更新日期：1999-03-01 00:00:00

abstract：:Lone cryptogenic fibrosing alveolitis (CFA) is a progressive interstitial lung disease, with a median survival of 3 to 6 yr from the onset of dyspnea. CFA can be subdivided into prognostically significant histopathologic patterns, including nonspecific interstitial pneumonia (NSIP). We reviewed 78 patients with a clin...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholson AG,Colby TV,du Bois RM,Hansell DM,Wells AU

更新日期：2000-12-01 00:00:00

abstract：:Chronic bacterial infection and neutrophilic inflammation characterize cystic fibrosis (CF) pulmonary disease. In many disorders, inflammation and angiogenesis are codependent phenomena. We previously noted excessive angiogenesis in CF tissues and elevated vascular endothelial growth factor (VEGF) in random serum samp...

journal_title：American journal of respiratory and critical care medicine

authors： McColley SA,Stellmach V,Boas SR,Jain M,Crawford SE

更新日期：2000-06-01 00:00:00

abstract：:In a prospective, controlled, and randomized clinical trial, we examined the effects of treatment with vitamin D (1,000 IU/d), calcium (1 g/d), and ethane-1-hydroxy-1,1-diphosphonate (EHDP; 7.5 mg/kg body weight) on vertebral bone mass in fourteen asthmatics undergoing long-term treatment with systemically applied cor...

journal_title：American journal of respiratory and critical care medicine

authors： Worth H,Stammen D,Keck E

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:In a high-tuberculosis (TB) incidence area of Cape Town, South Africa, there is a very high rate of unexplained recurrent TB. The incidence of new bacteriologically confirmed disease in the area is 313 per 100,000 individuals. OBJECTIVE:To estimate the rate of recurrent TB attributable to reinfection after s...

journal_title：American journal of respiratory and critical care medicine

authors： Verver S,Warren RM,Beyers N,Richardson M,van der Spuy GD,Borgdorff MW,Enarson DA,Behr MA,van Helden PD

更新日期：2005-06-15 00:00:00

abstract：RATIONALE:Patients with severe asthma (SA) are less responsive to the beneficial effects of corticosteroid (CS) therapy, and relative CS insensitivity has been shown in airway smooth muscle cells (ASMC) from patients with SA. OBJECTIVES:We investigated whether there was a defect in the actions of the glucocorticoid re...

journal_title：American journal of respiratory and critical care medicine

authors： Chang PJ,Michaeloudes C,Zhu J,Shaikh N,Baker J,Chung KF,Bhavsar PK

更新日期：2015-01-01 00:00:00

abstract：:Comparison of the risk-benefit profiles of different inhaled glucocorticoids has been limited by inadequate information about the dose-response relationships for efficacy relative to side effects. Fluticasone propionate (FP) is twice as effective as budesonide (BUD), but the potency ratio of FP:BUD with respect to sup...

journal_title：American journal of respiratory and critical care medicine

authors： Donnelly R,Williams KM,Baker AB,Badcock CA,Day RO,Seale JP

更新日期：1997-12-01 00:00:00