Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats.

abstract：:It is known that the ventilatory response to carbon dioxide (CO2) is increased in asthmatics with airway obstruction. Increased vagal afferent activity as well as increased airway resistance have been postulated as the causative mechanisms. However, whether increased vagal afferent activity without bronchoconstriction...

journal_title：American journal of respiratory and critical care medicine

authors： Midorikawa J,Kikuchi Y,Taguchi O,Hida W,Okabe S,Takishima T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：:Pharyngeal dilator muscle activation (GGEMG) during wakefulness is greater in patients with obstructive sleep apnea (OSA) than in healthy control subjects, representing a neuromuscular compensatory mechanism for a more collapsible airway. As previous work from our laboratory has demonstrated a close relationship betwe...

journal_title：American journal of respiratory and critical care medicine

authors： Fogel RB,Malhotra A,Pillar G,Edwards JK,Beauregard J,Shea SA,White DP

更新日期：2001-12-01 00:00:00

abstract：:Exogenous surfactant therapy is not standard in the acute respiratory distress syndrome (ARDS) because of a lack of proven benefit. Nonuniform surfactant distribution after either bolus or aerosol administration may be an important factor limiting response. In a previous study of acute lung injury, we demonstrated tha...

journal_title：American journal of respiratory and critical care medicine

authors： Balaraman V,Meister J,Ku TL,Sood SL,Tam E,Killeen J,Uyehara CF,Egan E,Easa D

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Asthma is a chronic inflammatory airway disease that affects more than 300 million individuals worldwide. Asthma is caused by interaction of genetic and environmental factors. Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemi...

journal_title：American journal of respiratory and critical care medicine

authors： Koppelman GH,Meyers DA,Howard TD,Zheng SL,Hawkins GA,Ampleford EJ,Xu J,Koning H,Bruinenberg M,Nolte IM,van Diemen CC,Boezen HM,Timens W,Whittaker PA,Stine OC,Barton SJ,Holloway JW,Holgate ST,Graves PE,Martinez FD,

更新日期：2009-11-15 00:00:00

abstract：:Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine administration during resuscitation; however, prospective data to support this assertion are scarce. Objectives: To conduct a phase II trial evaluating the hypothesis that early low-dose norepinephrine in adults with sepsis with hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Permpikul C,Tongyoo S,Viarasilpa T,Trainarongsakul T,Chakorn T,Udompanturak S

更新日期：2019-05-01 00:00:00

abstract：RATIONALE:Although the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC-derived cells in lung disease models are missing. OBJECTIVES:We have tested the therapeuti...

journal_title：American journal of respiratory and critical care medicine

authors： Happle C,Lachmann N,Ackermann M,Mirenska A,Göhring G,Thomay K,Mucci A,Hetzel M,Glomb T,Suzuki T,Chalk C,Glage S,Dittrich-Breiholz O,Trapnell B,Moritz T,Hansen G

更新日期：2018-08-01 00:00:00

abstract：:Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-l...

journal_title：American journal of respiratory and critical care medicine

authors： Shahar E,Whitney CW,Redline S,Lee ET,Newman AB,Nieto FJ,O'Connor GT,Boland LL,Schwartz JE,Samet JM

更新日期：2001-01-01 00:00:00

abstract：:Methodologies used to assess airway responsiveness (AR) in children administer the same dosage schedule to all children despite the great range in the size of subjects. The aim of this study was to examine the hypothesis that the level of AR is size dependent within same-age cohorts and between different ages. Among a...

journal_title：American journal of respiratory and critical care medicine

authors： Le Souëf PN,Sears MR,Sherrill D

更新日期：1995-08-01 00:00:00

abstract：:Recent studies suggest that a nitric oxide (NO) deficiency and elevated arginase activity may play a role in the pathogenesis of asthma. Although much attention has been directed toward measurements of exhaled NO in asthma, no studies to date have evaluated levels of plasma arginase or arginine, the substrate for NO p...

journal_title：American journal of respiratory and critical care medicine

authors： Morris CR,Poljakovic M,Lavrisha L,Machado L,Kuypers FA,Morris SM Jr

更新日期：2004-07-15 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno K

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:The incidence of influenza-associated acute respiratory failure is unknown. OBJECTIVES:To estimate the population-based incidence of influenza-associated acute respiratory failure hospitalizations. METHODS:This is a cohort study from January 2003 through March 2009 using hospitalization databases for Arizon...

journal_title：American journal of respiratory and critical care medicine

authors： Ortiz JR,Neuzil KM,Rue TC,Zhou H,Shay DK,Cheng PY,Cooke CR,Goss CH

更新日期：2013-09-15 00:00:00

abstract：RATIONALE:Lung allografts are prone to reperfusion injury and acute rejection, which, in addition to infiltrating lymphocytes, are accompanied by neutrophil infiltration and neutrophil-associated oxidative stress. Indoleamine 2,3-dioxygenase (IDO) is a unique cytosolic enzyme that possesses T-cell-suppressive and antio...

journal_title：American journal of respiratory and critical care medicine

authors： Liu H,Liu L,Fletcher BS,Visner GA

更新日期：2006-03-01 00:00:00

abstract：:We investigated airway responsiveness to mannitol, a new hyperosmolar challenge, in persons hyperresponsive to airway drying. We studied 36 asthmatic subjects, 18 to 40 yr of age, responsive to exercise (n = 23) and eucapnic hyperventilation (n = 28) defined by a 10% fall in FEV1. Fifteen subjects performed both chall...

journal_title：American journal of respiratory and critical care medicine

authors： Brannan JD,Koskela H,Anderson SD,Chew N

更新日期：1998-10-01 00:00:00

abstract：:Selected events in rhinovirus infection of the normal human airway can be regarded as occurring sequentially. Initial steps in rhinovirus pathogenesis are believed to include viral entry into the nose, mucociliary transport of virus to the posterior pharynx, and initiation of infection in ciliated and non-ciliated epi...

journal_title：American journal of respiratory and critical care medicine

authors： Gwaltney JM Jr

更新日期：1995-10-01 00:00:00

abstract：:CD14 influences postnatal switching of T helper cell responses. CD14 C-159T has been associated with altered CD14 and IgE levels in cross-sectional studies. Identifying whether associations vary with age requires data from children of the same age followed longitudinally over many years. In this study, an unselected p...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell AR,Toelle BG,Marks GB,Hayden CM,Laing IA,Peat JK,Goldblatt J,Le Souëf PN

更新日期：2004-03-01 00:00:00

abstract：:We examined the influence of gender on the polysomnographic features of obstructive sleep apnea (OSA) in a retrospective study of 830 patients with OSA diagnosed by overnight polysomnography (PSG). The severity of OSA was determined from the apnea- hypopnea index (AHI) for total sleep time (AHI(TST)), and was classifi...

journal_title：American journal of respiratory and critical care medicine

authors： O'Connor C,Thornley KS,Hanly PJ

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:When subclavian access is not possible, controversy exists between the internal jugular and femoral sites for the choice of central-venous access in intensive care unit patients. OBJECTIVES:To compare infection and colonization rates of short-term jugular and femoral catheters. METHODS:Using data from two m...

journal_title：American journal of respiratory and critical care medicine

authors： Timsit JF,Bouadma L,Mimoz O,Parienti JJ,Garrouste-Orgeas M,Alfandari S,Plantefeve G,Bronchard R,Troche G,Gauzit R,Antona M,Canet E,Bohe J,Herrault MC,Schwebel C,Ruckly S,Souweine B,Lucet JC

更新日期：2013-11-15 00:00:00

abstract：:Obstructive sleep apnea (OSA) is traditionally diagnosed using overnight polysomnography. Decision rules may provide an alternative to polysomnography. A consecutive series of patients referred to a tertiary sleep center underwent prospective evaluation with the upper airway physical examination protocol, followed by ...

journal_title：American journal of respiratory and critical care medicine

authors： Tsai WH,Remmers JE,Brant R,Flemons WW,Davies J,Macarthur C

更新日期：2003-05-15 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some patients live much longer. Respiratory failure resulting from disease progression is the most frequent cause of death. To date w...

journal_title：American journal of respiratory and critical care medicine

authors： Ley B,Collard HR,King TE Jr

更新日期：2011-02-15 00:00:00

abstract：:Survival is linked to the histopathologic distinction between usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP), the most commonly encountered fibrotic idiopathic interstitial pneumonia. We retrospectively compared the prognostic significance of histopathologic diagnoses, baseline pulmon...

journal_title：American journal of respiratory and critical care medicine

authors： Latsi PI,du Bois RM,Nicholson AG,Colby TV,Bisirtzoglou D,Nikolakopoulou A,Veeraraghavan S,Hansell DM,Wells AU

更新日期：2003-09-01 00:00:00

abstract：:A growing body of evidence suggests that neutrophil-derived proteinases play a major role in lung tissue damage in cystic fibrosis (CF). Most previous studies have focused on serine proteinases such as neutrophil elastase, providing no information on the extent to which metalloproteinases participate in proteolytic pr...

journal_title：American journal of respiratory and critical care medicine

authors： Delacourt C,Le Bourgeois M,D'Ortho MP,Doit C,Scheinmann P,Navarro J,Harf A,Hartmann DJ,Lafuma C

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:The vast majority of children around the world undergoing adenotonsillectomy for obstructive sleep apnea-hypopnea syndrome (OSA) are not objectively diagnosed by nocturnal polysomnography because of access availability and cost issues. Automated analysis of nocturnal oximetry (nSpO2), which is readily and glo...

journal_title：American journal of respiratory and critical care medicine

authors： Hornero R,Kheirandish-Gozal L,Gutiérrez-Tobal GC,Philby MF,Alonso-Álvarez ML,Álvarez D,Dayyat EA,Xu Z,Huang YS,Tamae Kakazu M,Li AM,Van Eyck A,Brockmann PE,Ehsan Z,Simakajornboon N,Kaditis AG,Vaquerizo-Villar F,Crespo S

更新日期：2017-12-15 00:00:00

abstract：:We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SD) of 43.3 (8.6) yr. Pre-exposure spirometry and methacholine challenge tests were performed before beginning the boiler overhaul; postexposure tests were perform...

journal_title：American journal of respiratory and critical care medicine

authors： Hauser R,Elreedy S,Hoppin JA,Christiani DC

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The relative roles of mucus plugs and emphysema in mechanisms of airflow limitation and hypoxemia in smokers with chronic obstructive pulmonary disease (COPD) are uncertain. METHODS:We analyzed computed tomography (CT) lung images and lung function in participants in the Subpopulations and Intermediate Outc...

journal_title：American journal of respiratory and critical care medicine

authors： Dunican EM,Elicker BM,Henry T,Gierada DS,Schiebler ML,Anderson W,Barjaktarevic I,Barr RG,Bleecker ER,Boucher RC,Bowler RP,Christenson SA,Comellas A,Cooper CB,Couper D,Criner GJ,Dransfield M,Doerschuk CM,Drummond MB,

更新日期：2020-11-12 00:00:00

abstract：:Early experience suggests that lung volume reduction surgery improves exercise tolerance as measured by the 6-min walk distance in patients with emphysema. To identify the physiologic mechanism(s) by which lung volume reduction surgery improved exercise, we performed progressive cardiopulmonary exercise testing, inclu...

journal_title：American journal of respiratory and critical care medicine

authors： Benditt JO,Lewis S,Wood DE,Klima L,Albert RK

更新日期：1997-08-01 00:00:00

abstract：:The last century experienced remarkable advances in the classification, diagnosis, and understanding of the pathogenesis of the interstitial lung diseases. Technological advances, particularly physiologic testing, lung imaging studies, bronchoalveolar lavage, surgical lung biopsy, and histopathologic assessment, impro...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr

更新日期：2005-08-01 00:00:00

abstract：:This study investigated the clinico-pathologic correlation of tumor angiogenesis in non-small-cell lung cancers. Formalin-fixed, paraffin-embedded surgical specimens of 55 consecutive patients with primary non-small-cell lung cancers were examined. Included were 26 squamous cell carcinomas and 29 adenocarcinomas. Twen...

journal_title：American journal of respiratory and critical care medicine

authors： Yuan A,Yang PC,Yu CJ,Lee YC,Yao YT,Chen CL,Lee LN,Kuo SH,Luh KT

更新日期：1995-12-01 00:00:00

abstract：:To examine whether diffuse pleural thickening (DPT) causes impairment of pulmonary function independent of other manifestations of asbestos-related disease, we studied individuals selected from 1,150 men with occupational asbestos exposure who had undergone pulmonary function testing and computed tomographic (CT) scan...

journal_title：American journal of respiratory and critical care medicine

authors： Kee ST,Gamsu G,Blanc P

更新日期：1996-09-01 00:00:00