Abstract:
:Idiopathic pulmonary fibrosis (IPF) is a progressive, life-threatening, interstitial lung disease of unknown etiology. The median survival of patients with IPF is only 2 to 3 years, yet some patients live much longer. Respiratory failure resulting from disease progression is the most frequent cause of death. To date we have limited information as to predictors of mortality in patients with IPF, and research in this area has failed to yield prediction models that can be reliably used in clinical practice to predict individual risk of mortality. The goal of this concise clinical review is to examine and summarize the current data on the clinical course, individual predictors of survival, and proposed clinical prediction models in IPF. Finally, we will discuss challenges and future directions related to predicting survival in IPF.
journal_name
Am J Respir Crit Care Medauthors
Ley B,Collard HR,King TE Jrdoi
10.1164/rccm.201006-0894CIsubject
Has Abstractpub_date
2011-02-15 00:00:00pages
431-40issue
4eissn
1073-449Xissn
1535-4970pii
201006-0894CIjournal_volume
183pub_type
杂志文章,评审abstract::A major cause of morbidity and mortality following lung transplantation is posttransplant lymphoproliferative disease (PTLD). In a retrospective cohort analysis of pediatric patients, we evaluated the risk factors associated with PTLD in 128 first-time lung transplant recipients from 1990 to 1997. The greatest risk fa...
journal_title:American journal of respiratory and critical care medicine
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