Clinical, echocardiographic, and hemodynamic evidence of cardiac tamponade caused by large pleural effusions.

abstract：:The remarkable success of epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors in patients with EGFR mutations and ALK rearrangements, respectively, introduced the era of targeted therapy in advanced non-small cell lung cancer (NSCLC), shifting treatment from platinum...

journal_title：American journal of respiratory and critical care medicine

authors： Cardarella S,Johnson BE

更新日期：2013-10-01 00:00:00

abstract：RATIONALE:The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood. OBJECTIVES:This study aimed to determine how cells "sense" soluble oxidants and how this is translated into an inflammatory reaction. METHODS:Monocytes, macrophages, or HEK293 cells (stably transfected with ...

journal_title：American journal of respiratory and critical care medicine

authors： Paul-Clark MJ,McMaster SK,Sorrentino R,Sriskandan S,Bailey LK,Moreno L,Ryffel B,Quesniaux VF,Mitchell JA

更新日期：2009-02-15 00:00:00

abstract：:Viral-induced symptomatic respiratory infections (SRI) frequently cause exacerbations of asthma in children. This study investigated the protective effects of 0.5% nedocromil sodium nebulizer solution given three times a day in preventing asthma exacerbations associated with SRI. Ninety-three mild-moderate asthmatic c...

journal_title：American journal of respiratory and critical care medicine

authors： König P,Eigen H,Ellis MH,Ellis E,Blake K,Geller D,Shapiro G,Welch M,Scott C

更新日期：1995-12-01 00:00:00

abstract：:Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and a...

journal_title：American journal of respiratory and critical care medicine

authors： Burgel PR,Munck A,Durieu I,Chiron R,Mely L,Prevotat A,Murris-Espin M,Porzio M,Abely M,Reix P,Marguet C,Macey J,Sermet-Gaudelus I,Corvol H,Bui S,Lemonnier L,Dehillotte C,Da Silva J,Paillasseur JL,Hubert D,French Cy

更新日期：2020-01-15 00:00:00

abstract：RATIONALE:Low blood levels of 25-hydroxyvitamin D (25[OH]D) have been associated with a higher risk of respiratory infections in general populations and higher risk of exacerbations of lung disease in people with asthma. We hypothesized that low blood levels of 25(OH)D in patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Kunisaki KM,Niewoehner DE,Connett JE,COPD Clinical Research Network.

更新日期：2012-02-01 00:00:00

abstract：:In Balb/C mice, painting the skin with ovalbumin (OVA) over a period of 14 days resulted in sensitization of the animals. This was documented by the appearance of OVA-specific IgE and IgG1 antibodies and increased total serum IgE levels. In addition, in regional (inguinal) lymph nodes of sensitized animals, OVA-specif...

journal_title：American journal of respiratory and critical care medicine

authors： Saloga J,Renz H,Larsen GL,Gelfand EW

更新日期：1994-01-01 00:00:00

abstract：:The role of nitric oxide (NO) in the host-defense against human tuberculosis (TB) is controversial. Although experimental evidence indicates that NO may play an important role in controlling TB, its expression in human tuberculous lungs has not been systematically characterized. We therefore investigated the expressio...

journal_title：American journal of respiratory and critical care medicine

authors： Choi HS,Rai PR,Chu HW,Cool C,Chan ED

更新日期：2002-07-15 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：RATIONALE:S. aureus is the most common respiratory pathogen isolated from patients with cystic fibrosis (CF) in the US. While modes of acquisition and genetic adaptation have been described for Pseudomonas aeruginosa, resulting in improved diagnosis and treatment, these features remain more poorly defined for S. aureus...

journal_title：American journal of respiratory and critical care medicine

authors： Long DR,Wolter DJ,Lee M,Precit M,McLean K,Holmes E,Penewit K,Waalkes A,Hoffman LR,Salipante SJ

更新日期：2020-12-09 00:00:00

abstract：:To assess whether there is increased risk of tuberculous infection in children who traveled to or had a household visitor from a country having a high prevalence of tuberculosis, we conducted a case-control study. Children younger than 6 yr of age who had a tuberculin skin test read at public health clinics in areas o...

journal_title：American journal of respiratory and critical care medicine

authors： Lobato MN,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：RATIONALE:Encephalitis caused by anti-N-methyl-d-aspartate receptor (NMDAR) antibodies is the leading cause of immune-mediated encephalitis. There are limited data on intensive care unit (ICU) management of these patients. OBJECTIVES:To identify prognostic factors of good neurologic outcome in patients admitted to an ...

journal_title：American journal of respiratory and critical care medicine

authors： de Montmollin E,Demeret S,Brulé N,Conrad M,Dailler F,Lerolle N,Navellou JC,Schwebel C,Alves M,Cour M,Engrand N,Tonnelier JM,Maury E,Ruckly S,Picard G,Rogemond V,Magalhaes É,Sharshar T,Timsit JF,Honnorat J,Sonnevil

更新日期：2017-02-15 00:00:00

abstract：RATIONALE:Clinical benefits of fixed-dose 100-mg subcutaneous (SC) mepolizumab in prednisone-dependent patients are modest when sputum eosinophilia is not adequately controlled. OBJECTIVES:This study compared treatment response of weight-adjusted intravenous (IV) reslizumab in patients previously treated with 100-mg S...

journal_title：American journal of respiratory and critical care medicine

authors： Mukherjee M,Aleman Paramo F,Kjarsgaard M,Salter B,Nair G,LaVigne N,Radford K,Sehmi R,Nair P

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES:The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier st...

journal_title：American journal of respiratory and critical care medicine

authors： Kearley J,Erjefalt JS,Andersson C,Benjamin E,Jones CP,Robichaud A,Pegorier S,Brewah Y,Burwell TJ,Bjermer L,Kiener PA,Kolbeck R,Lloyd CM,Coyle AJ,Humbles AA

更新日期：2011-04-01 00:00:00

abstract：:We investigated the source of intravascular fat in systemic organs (brain, heart, and kidney) after massive pulmonary fat embolism during cemented arthroplasty. We used a bilateral cemented arthroplasty (BCA) in anesthetized mongrel dogs that simulates a cemented total-hip replacement procedure. We hypothesized that d...

journal_title：American journal of respiratory and critical care medicine

authors： Byrick RJ,Mullen JB,Mazer CD,Guest CB

更新日期：1994-11-01 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by a combination of airways disease (bronchiolitis) and parenchymal destruction (emphysema), whose relative proportion varies from patient to patient. OBJECTIVES:To explore and contrast the molecular pathogenes...

journal_title：American journal of respiratory and critical care medicine

authors： Faner R,Cruz T,Casserras T,López-Giraldo A,Noell G,Coca I,Tal-Singer R,Miller B,Rodriguez-Roisin R,Spira A,Kalko SG,Agustí A

更新日期：2016-06-01 00:00:00

abstract：:The etiology of sleep disruption in patients in intensive care units (ICUs) is poorly understood, but is thought to be related to environmental stimuli, especially noise. We sampled 203 patients (121 males and 82 females) from different ICUs (cardiac [CCU], cardiac stepdown [CICU], medical [MICU], and surgical [SICU])...

journal_title：American journal of respiratory and critical care medicine

authors： Freedman NS,Kotzer N,Schwab RJ

更新日期：1999-04-01 00:00:00

abstract：:The Child Health Questionnaire (CHQ-PF50) is one of several recent efforts to gauge pediatric, health-related quality of life from the patient's (or parent's) perspective. Although tested extensively with healthy children, more information is needed about CHQ performance among children with chronic conditions such as ...

journal_title：American journal of respiratory and critical care medicine

authors： Asmussen L,Olson LM,Grant EN,Landgraf JM,Fagan J,Weiss KB

更新日期：2000-10-01 00:00:00

abstract：:Several modalities of ventilatory support have been proposed to gradually withdraw patients from mechanical ventilation, but their respective effects on the outcome of weaning from mechanical ventilation are not known. We conducted a randomized trial in three intensive care units in mechanically ventilated patients wh...

journal_title：American journal of respiratory and critical care medicine

authors： Brochard L,Rauss A,Benito S,Conti G,Mancebo J,Rekik N,Gasparetto A,Lemaire F

更新日期：1994-10-01 00:00:00

abstract：:Simple tools for discrimination of lung tissues can be useful in a fast machine-aided diagnosis, for example, by tumor-specific microarrays. We demonstrate that an easy ratio technique, based on the expression levels of only two genes differentially expressed in lung tumor and normal lung samples, allows discriminatio...

journal_title：American journal of respiratory and critical care medicine

authors： Hofmann HS,Hansen G,Burdach S,Bartling B,Silber RE,Simm A

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. OBJECTIVES:To determine the effects of chronic vaping on pulmonary epithelia. METHODS:We performed research bronchoscopies on h...

journal_title：American journal of respiratory and critical care medicine

authors： Ghosh A,Coakley RC,Mascenik T,Rowell TR,Davis ES,Rogers K,Webster MJ,Dang H,Herring LE,Sassano MF,Livraghi-Butrico A,Van Buren SK,Graves LM,Herman MA,Randell SH,Alexis NE,Tarran R

更新日期：2018-07-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES:To determine whether continuous positive airway pressure (CPAP) added to trea...

journal_title：American journal of respiratory and critical care medicine

authors： Thunström E,Manhem K,Rosengren A,Peker Y

更新日期：2016-02-01 00:00:00

abstract：RATIONALE:Chronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of these associations could inform prevention strategies for common heart-lung conditions. OBJECTIVES:To use the Coronary Artery Risk ...

journal_title：American journal of respiratory and critical care medicine

authors： Cuttica MJ,Colangelo LA,Shah SJ,Lima J,Kishi S,Arynchyn A,Jacobs DR Jr,Thyagarajan B,Liu K,Lloyd-Jones D,Kalhan R

更新日期：2015-07-01 00:00:00

abstract：:Rationale: Guidelines for vasopressor titration suggest a universal target-mean arterial pressure (MAP) >65 mm Hg. The implications for patients with premorbid low/high blood pressure are unknown.Objectives: To investigate the relationship between premorbid blood pressure and vasopressor duration for patients with sho...

journal_title：American journal of respiratory and critical care medicine

authors： Gershengorn HB,Stelfox HT,Niven DJ,Wunsch H

更新日期：2020-07-01 00:00:00

abstract：:Little is known about the structural response of the diaphragm to controlled mechanical ventilation. We examined effects of this intervention on muscle mass, myosin heavy chain isoforms, and contractile function in the rat diaphragm. Animals were mechanically ventilated for up to 4 days, and comparisons were made with...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Luo J,Bourdon J,Lin MC,Gottfried SB,Petrof BJ

更新日期：2002-10-15 00:00:00

abstract：RATIONALE:Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment of pneumonia. OBJECTIVES:To elucidate clinical features of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), and to clarify risk factors for drug-resistant pathogens in patien...

journal_title：American journal of respiratory and critical care medicine

authors： Shindo Y,Ito R,Kobayashi D,Ando M,Ichikawa M,Shiraki A,Goto Y,Fukui Y,Iwaki M,Okumura J,Yamaguchi I,Yagi T,Tanikawa Y,Sugino Y,Shindoh J,Ogasawara T,Nomura F,Saka H,Yamamoto M,Taniguchi H,Suzuki R,Saito H,Kawa

更新日期：2013-10-15 00:00:00

abstract：:We investigated the influence of pulmonary bacteriology and histology on the yield of diagnostic procedures in a clinically relevant model of ventilator-acquired pneumonia (VAP). Twenty-seven piglets entered a 4-d protocol of ventilatory support under general anesthesia. Endotracheal aspirates (EA), protected specimen...

journal_title：American journal of respiratory and critical care medicine

authors： Wermert D,Marquette CH,Copin MC,Wallet F,Fraticelli A,Ramon P,Tonnel AB

更新日期：1998-07-01 00:00:00

abstract：RATIONALE:Biomass exposure is an important risk factor for chronic obstructive pulmonary disease (COPD). However, the time-course behavior of FEV1 in subjects exposed to biomass is unknown. OBJECTIVES:We undertook this study to determine the FEV1 rate decline in subjects exposed to biomass. METHODS:Pulmonary function...

journal_title：American journal of respiratory and critical care medicine

authors： Ramírez-Venegas A,Sansores RH,Quintana-Carrillo RH,Velázquez-Uncal M,Hernandez-Zenteno RJ,Sánchez-Romero C,Velazquez-Montero A,Flores-Trujillo F

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:Infection with Pneumocystis, an opportunistic fungal pathogen, can result in fulminant pneumonia in the clinical setting of patients with immunosuppression. In murine models, Pneumocystis has previously been shown to induce a CD4+ T cell-dependent eosinophilic response in the lung capable of providing protect...

journal_title：American journal of respiratory and critical care medicine

authors： Eddens T,Campfield BT,Serody K,Manni ML,Horne W,Elsegeiny W,McHugh KJ,Pociask D,Chen K,Zheng M,Alcorn JF,Wenzel S,Kolls JK

更新日期：2016-10-01 00:00:00

abstract：RATIONALE:Spontaneous breathing during mechanical ventilation increases transpulmonary pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary pressure might limit injury caused by added spontaneous effort. OBJECTIVES:To test the hypothesis that, during spontaneous effort in injured lu...

journal_title：American journal of respiratory and critical care medicine

authors： Yoshida T,Nakahashi S,Nakamura MAM,Koyama Y,Roldan R,Torsani V,De Santis RR,Gomes S,Uchiyama A,Amato MBP,Kavanagh BP,Fujino Y

更新日期：2017-09-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00