Network Analysis of Lung Transcriptomics Reveals a Distinct B-Cell Signature in Emphysema.

abstract：RATIONALE:Recent findings have demonstrated that muscarinic M(3) receptor stimulation enhances airway smooth muscle proliferation to peptide growth factors in vitro. Because both peptide growth factor expression and acetylcholine release are known to be augmented in allergic airway inflammation, it is possible that ant...

journal_title：American journal of respiratory and critical care medicine

authors： Gosens R,Bos IS,Zaagsma J,Meurs H

更新日期：2005-05-15 00:00:00

abstract：RATIONALE:Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth-generation bronchi). OBJECTIVES:To define the ontogeny and biology of the human small airway epithelium club cell. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Zuo WL,Shenoy SA,Li S,O'Beirne SL,Strulovici-Barel Y,Leopold PL,Wang G,Staudt MR,Walters MS,Mason C,Kaner RJ,Mezey JG,Crystal RG

更新日期：2018-12-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：:Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

journal_title：American journal of respiratory and critical care medicine

authors： Henke KG,Frantz DE,Kuna ST

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：:This study aimed to examine the performance characteristics of four high-frequency oscillatory-type ventilators, using an in vitro model of the intubated neonatal respiratory system. Each ventilator was examined across its operative range of settings and at varying model lung compliance (C) and resistance. The oscilla...

journal_title：American journal of respiratory and critical care medicine

authors： Pillow JJ,Wilkinson MH,Neil HL,Ramsden CA

更新日期：2001-09-15 00:00:00

abstract：:Ineffective lung repair in patients with unresolving acute respiratory distress syndrome (ARDS) is accompanied by progressive fibroproliferation, inability to improve lung injury score (LIS), progressive multiple organ dysfunction syndrome (MODS), and an unfavorable outcome. Our aim was to investigate the relationship...

journal_title：American journal of respiratory and critical care medicine

authors： Meduri GU,Tolley EA,Chinn A,Stentz F,Postlethwaite A

更新日期：1998-11-01 00:00:00

abstract：:Inhaled corticosteroids are effective antiinflammatory therapy for asthma; however, they do not completely abolish allergen-induced airway inflammation. Leukotriene modifiers attenuate both early and late allergen responses and have antiinflammatory properties. We reasoned that treatment with budesonide and montelukas...

journal_title：American journal of respiratory and critical care medicine

authors： Leigh R,Vethanayagam D,Yoshida M,Watson RM,Rerecich T,Inman MD,O'Byrne PM

更新日期：2002-11-01 00:00:00

abstract：:It has been suggested that in patients with adult respiratory distress syndrome (ARDS), intrinsic positive end-expiratory pressure (PEEPi) is generated by a disproportionate increase in expiratory flow resistance. Using the negative expiratory pressure (NEP) technique, we assessed whether expiratory flow limitation (E...

journal_title：American journal of respiratory and critical care medicine

authors： Koutsoukou A,Armaganidis A,Stavrakaki-Kallergi C,Vassilakopoulos T,Lymberis A,Roussos C,Milic-Emili J

更新日期：2000-05-01 00:00:00

abstract：:Superoxide dismutase (SOD) is a ubiquitous metalloenzyme in aerobic organisms that catalyzes the conversion of superoxide anion to hydrogen peroxide. Mycobacterium tuberculosis is unusual in that it secretes large quantities of iron-cofactored SOD. To determine the role of SOD in pathogenesis, we constructed mutants o...

journal_title：American journal of respiratory and critical care medicine

authors： Edwards KM,Cynamon MH,Voladri RK,Hager CC,DeStefano MS,Tham KT,Lakey DL,Bochan MR,Kernodle DS

更新日期：2001-12-15 00:00:00

abstract：RATIONALE:Infection with Pneumocystis, an opportunistic fungal pathogen, can result in fulminant pneumonia in the clinical setting of patients with immunosuppression. In murine models, Pneumocystis has previously been shown to induce a CD4+ T cell-dependent eosinophilic response in the lung capable of providing protect...

journal_title：American journal of respiratory and critical care medicine

authors： Eddens T,Campfield BT,Serody K,Manni ML,Horne W,Elsegeiny W,McHugh KJ,Pociask D,Chen K,Zheng M,Alcorn JF,Wenzel S,Kolls JK

更新日期：2016-10-01 00:00:00

abstract：:Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used...

journal_title：American journal of respiratory and critical care medicine

authors： Honarmand K,Lalli RS,Priestap F,Chen JL,McIntyre CW,Owen AM,Slessarev M

更新日期：2020-07-15 00:00:00

abstract：:Alveolar epithelial type II cells (AET2) respond with exocytosis of surfactant containing lamellar bodies to stimulation with mechanical stretch and secretagogues, a process that is fundamental for maintaining alveolar stability and lung gas exchange. In the present study in cultured rat AET2, we employed botulinum C2...

journal_title：American journal of respiratory and critical care medicine

authors： Rose F,Kürth-Landwehr C,Sibelius U,Reuner KH,Aktories K,Seeger W,Grimminger F

更新日期：1999-01-01 00:00:00

abstract：:In unilateral lung injury, application of global positive end-expiratory pressure (PEEP) may cause overdistension of normal alveoli and redistribution of blood flow to diseased lung areas, thereby worsening oxygenation. We hypothesized that selective application of tracheal gas insufflation (TGI) will recruit the inju...

journal_title：American journal of respiratory and critical care medicine

authors： Blanch L,Van der Kloot TE,Youngblood AM,Murias G,Naveira A,Adams AB,Romero PV,Nahum A

更新日期：2001-08-15 00:00:00

abstract：:Despite the increasing attention to the relationship between asthma and work exposures, occupational asthma remains underrecognized and its population burden underestimated. This may be due, in part, to the fact that traditional approaches to studying asthma in populations cannot adequately take into account the healt...

journal_title：American journal of respiratory and critical care medicine

authors： Le Moual N,Kauffmann F,Eisen EA,Kennedy SM

更新日期：2008-01-01 00:00:00

abstract：RATIONALE:The majority of patients with sarcoidosis resolve their condition; however 5-10% of patients with sarcoidosis develop pulmonary fibrosis with poor prognosis. Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulatory enzyme in the synthesis of the antifibrotic agent prostaglandin E(2) and is reduced in...

journal_title：American journal of respiratory and critical care medicine

authors： Hill MR,Papafili A,Booth H,Lawson P,Hubner M,Beynon H,Read C,Lindahl G,Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2006-10-15 00:00:00

abstract：:The involvement of platelet-activating factor (PAF) in bronchial hyperresponsiveness (BHR) in bronchial asthma has been controversial. To determine whether PAF is involved in BHR in humans, we carried out a randomized, double-blind, placebo-controlled, two-phase cross-over study on the effects of Y-24180, a potent, sp...

journal_title：American journal of respiratory and critical care medicine

authors： Hozawa S,Haruta Y,Ishioka S,Yamakido M

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Levels of the soluble form of the receptor for advanced glycation end-products (sRAGE) are elevated during acute respiratory distress syndrome (ARDS) and correlate with severity and prognosis. Alveolar fluid clearance (AFC) is necessary for the resolution of lung edema but is impaired in most patients with AR...

journal_title：American journal of respiratory and critical care medicine

authors： Jabaudon M,Blondonnet R,Roszyk L,Bouvier D,Audard J,Clairefond G,Fournier M,Marceau G,Déchelotte P,Pereira B,Sapin V,Constantin JM

更新日期：2015-07-15 00:00:00

abstract：:Isoniazid taken daily for 12 mo and isoniazid and rifampin taken daily for 4 mo are both recommended options for patients with radiographic evidence of previous tuberculosis and positive tuberculin skin tests who have not had prior treatment. We compared the completion rates, number of adverse effects, and cost effect...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Snyder DC,Chin DP,Hopewell PC,Cuthbert SS,Antonio Paz E,Daley CL

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. OBJECTIVES:First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the c...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson ST,Williams AJ,Brown JR,Newton SM,Simsova M,Nicol MP,Sebo P,Levin M,Wilkinson RJ,Wilkinson KA

更新日期：2006-05-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP). OBJECTIVES:To establish the role of intermittent hypoxia in the increased morning BP in patient...

journal_title：American journal of respiratory and critical care medicine

authors： Turnbull CD,Sen D,Kohler M,Petousi N,Stradling JR

更新日期：2019-01-15 00:00:00

abstract：:We present a case of a pulmonary nodular lesion in an immunocompetent patient documented at open lung biopsy to be due to Mycobacterium haemophilum. This organism has recently been recognized as a cause of disease in immunocompromised patients, presenting predominantly as skin lesions, arthritis, and rarely pneumonia....

journal_title：American journal of respiratory and critical care medicine

authors： White DA,Kiehn TE,Bondoc AY,Massarella SA

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Plasma transfusions are frequently prescribed for critically ill children, although their indications lack a strong evidence base. Plasma transfusions are largely driven by physician conceptions of need, and these are poorly documented in pediatric intensive care patients. OBJECTIVES:To identify patient char...

journal_title：American journal of respiratory and critical care medicine

authors： Karam O,Demaret P,Shefler A,Leteurtre S,Spinella PC,Stanworth SJ,Tucci M,Canadian Critical Care Trials Group (CCCTG).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI).,BloodNet.,PlasmaTV Investigators.

更新日期：2015-06-15 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:We produced ovalbumin (OVA)-sensitized rats as an animal model of nasal allergy. Intranasal instillation of OVA induced hypertrophic and metaplastic changes of goblet cells in nasal epithelium of OVA- sensitized rats. Intraepithelial mucosubstance in nasal mucosa increased significantly at 24 h after 3 or 7 d of OVA i...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Majima Y,Sakakura Y

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on tissue biopsy, which ...

journal_title：American journal of respiratory and critical care medicine

authors： Wei F,Lin CC,Joon A,Feng Z,Troche G,Lira ME,Chia D,Mao M,Ho CL,Su WC,Wong DT

更新日期：2014-11-15 00:00:00

abstract：:Wheezing in childhood is not a single disorder and different wheezing-associated respiratory illnesses have been recently described. We investigated the association between wheezing conditions and familial, pre-, peri-, and postnatal risk factors. We studied 16,333 children, 6 to 7 yr old, enrolled in a population-bas...

journal_title：American journal of respiratory and critical care medicine

authors： Rusconi F,Galassi C,Corbo GM,Forastiere F,Biggeri A,Ciccone G,Renzoni E

更新日期：1999-11-01 00:00:00

abstract：:Lung transplant (LTx) recipients have a low peak work rate, peak oxygen consumption (V O2peak), and early lactate threshold on incremental exercise. We hypothesized that LTx recipients have reduced oxidative function and altered fiber type proportion in peripheral skeletal muscle. Seven stable LTx recipients and seven...

journal_title：American journal of respiratory and critical care medicine

authors： Wang XN,Williams TJ,McKenna MJ,Li JL,Fraser SF,Side EA,Snell GI,Walters EH,Carey MF

更新日期：1999-07-01 00:00:00

abstract：:Bradykinin (BK) induces bronchoconstriction in asthmatic but not in normal individuals. Studies in vivo in the human suggest that BK causes cholinergic nerve activation, release of prostanoids, and local axon reflexes with release of tachykinins in the airways. To determine the mechanisms of BK-induced airway narrowin...

journal_title：American journal of respiratory and critical care medicine

authors： Hulsmann AR,Raatgeep HR,Saxena PR,Kerrebijn KF,de Jongste JC

更新日期：1994-10-01 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is a chronic lung disease of very low birth weight infants, associated with oxygen therapy, barotrauma, and/or infections. Improved medical care has led to a paradoxically increased incidence of BPD due to greater infant survival. Early prediction of BPD has proven challenging. Increas...

journal_title：American journal of respiratory and critical care medicine

authors： Cullen A,Van Marter LJ,Allred EN,Moore M,Parad RB,Sunday ME

更新日期：2002-04-15 00:00:00