In vitro performance characteristics of high-frequency oscillatory ventilators.

abstract：RATIONALE:The rapid diagnosis of pulmonary tuberculosis (TB) is difficult when acid fast bacilli (AFB) cannot be detected in sputum smears. OBJECTIVES:Following a proof of principle study, we examined in routine clinical practice whether individuals with sputum AFB smear-negative TB can be discriminated from those wit...

journal_title：American journal of respiratory and critical care medicine

authors： Jafari C,Thijsen S,Sotgiu G,Goletti D,Domínguez Benítez JA,Losi M,Eberhardt R,Kirsten D,Kalsdorf B,Bossink A,Latorre I,Migliori GB,Strassburg A,Winteroll S,Greinert U,Richeldi L,Ernst M,Lange C,Tuberculosis Network Eu

更新日期：2009-10-01 00:00:00

abstract：RATIONALE:Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises and despite many theories, the pathological mechanism is not fully understood. Discovery of histone-induced toxicity in mice p...

journal_title：American journal of respiratory and critical care medicine

authors： Abrams ST,Zhang N,Manson J,Liu T,Dart C,Baluwa F,Wang SS,Brohi K,Kipar A,Yu W,Wang G,Toh CH

更新日期：2013-01-15 00:00:00

abstract：:The objective of this study was to evaluate the effectiveness of an asthma education program on morbidity, knowledge, and compliance with inhaled corticosteroid treatment using a prospective, randomized, controlled, one-year-before/one-year-after protocol. After rigorous optimization of asthma therapy under the care o...

journal_title：American journal of respiratory and critical care medicine

authors： Coté J,Cartier A,Robichaud P,Boutin H,Malo JL,Rouleau M,Fillion A,Lavallée M,Krusky M,Boulet LP

更新日期：1997-05-01 00:00:00

abstract：:Ahead of Print article withdrawn by publisher. ...

journal_title：American journal of respiratory and critical care medicine

authors： Kanwar BA

更新日期：2020-10-07 00:00:00

abstract：:To compare the effectiveness of information delivered to family members of critically ill patients by junior and senior physicians, we performed a prospective randomized multicenter trial in 11 French intensive care units. Patients (n = 220) were allocated at random to having their family members receive information b...

journal_title：American journal of respiratory and critical care medicine

authors： Moreau D,Goldgran-Toledano D,Alberti C,Jourdain M,Adrie C,Annane D,Garrouste-Orgeas M,Lefrant JY,Papazian L,Quinio P,Pochard F,Azoulay E

更新日期：2004-02-15 00:00:00

abstract：:We assessed the influence of current indoor levels of fungi, house dust mite allergen (Der p 1), and cat allergen (Fel d 1) on sensitization and asthma in adults. A total of 485 adults answered a questionnaire and had skin prick tests and lung function tests. Dust and air samples were collected from their bedrooms. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmage S,Bailey M,Raven J,Mitakakis T,Cheng A,Guest D,Rolland J,Forbes A,Thien F,Abramson M,Walters EH

更新日期：2001-07-01 00:00:00

abstract：RATIONALE:North American occupational health programs that switched from the tuberculin skin test (TST) to IFN-γ release assays for latent tuberculosis screening are reporting challenges with interpretation of serial testing results in healthcare workers (HCWs). However, limited data exist on the reproducibility of ser...

journal_title：American journal of respiratory and critical care medicine

authors： Slater ML,Welland G,Pai M,Parsonnet J,Banaei N

更新日期：2013-10-15 00:00:00

abstract：:Although numerous reports have described the improvement in PAO2 in patients in the prone position, the underlying mechanism has yet to be determined. Some authors have suggested this phenomenon may be related to an increase in functional residual capacity (FRC); however, no previous studies have described positional ...

journal_title：American journal of respiratory and critical care medicine

authors： Numa AH,Hammer J,Newth CJ

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood. OBJECTIVES:Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) ge...

journal_title：American journal of respiratory and critical care medicine

authors： Simpson A,Maniatis N,Jury F,Cakebread JA,Lowe LA,Holgate ST,Woodcock A,Ollier WE,Collins A,Custovic A,Holloway JW,John SL

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:Extracellular nucleotides have recently been identified as proinflammatory mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the role of the purinergic receptor type 6 (P2Y6R) has not been previously investigated. OBJECTIVES:To investigate the role of P2Y6R in asthma pathog...

journal_title：American journal of respiratory and critical care medicine

authors： Vieira RP,Müller T,Grimm M,von Gernler V,Vetter B,Dürk T,Cicko S,Ayata CK,Sorichter S,Robaye B,Zeiser R,Ferrari D,Kirschbaum A,Zissel G,Virchow JC,Boeynaems JM,Idzko M

更新日期：2011-07-15 00:00:00

abstract：:Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the rats were killed at timed intervals ranging from 2 to 430 d fr...

journal_title：American journal of respiratory and critical care medicine

authors： Fraire AE,Greenberg SD,Spjut HJ,Roggli VL,Dodson RF,Cartwright J,Williams G,Baker S

更新日期：1994-08-01 00:00:00

abstract：:To determine the status of activation of lymphocytes and the role of cytokines on the inflammatory response of the bronchial mucosa in toluene diisocyanate (TDI) asthma, we performed a quantitative analysis of bronchial biopsies obtained from 15 subjects with TDI-induced asthma and seven normal control subjects. Marke...

journal_title：American journal of respiratory and critical care medicine

authors： Maestrelli P,di Stefano A,Occari P,Turato G,Milani G,Pivirotto F,Mapp CE,Fabbri LM,Saetta M

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:The contribution of interferon-gamma release assays (IGRAs) to appropriate risk stratification of active tuberculosis suspects has not been studied. OBJECTIVES:To determine whether the addition of quantitative IGRA results to a prediction model incorporating clinical criteria improves risk stratification of ...

journal_title：American journal of respiratory and critical care medicine

authors： Metcalfe JZ,Cattamanchi A,Vittinghoff E,Ho C,Grinsdale J,Hopewell PC,Kawamura LM,Nahid P

更新日期：2010-01-01 00:00:00

abstract：:To elucidate which cells are synthesizing tenascin in usual interstitial pneumonia (UIP) we have analyzed thoracoscopic or open lung biopsies from 30 patients with UIP by mRNA in situ hybridization, using (35)S-labeled tenascin RNA probes. The phenotype of the cells expressing tenascin mRNA was confirmed by immunohist...

journal_title：American journal of respiratory and critical care medicine

authors： Pääkkö P,Kaarteenaho-Wiik R,Pöllänen R,Soini Y

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Studies in humans and rodents have indicated a causative role for CD8(+) T cells in IgE-mediated allergic inflammation, but their function is still controversial. OBJECTIVES:To analyze the role of allergen-specific CD8(+) T cells during the development of allergic airway inflammation in two parallel but dive...

journal_title：American journal of respiratory and critical care medicine

authors： Aguilar-Pimentel JA,Alessandrini F,Huster KM,Jakob T,Schulz H,Behrendt H,Ring J,de Angelis MH,Busch DH,Mempel M,Ollert M

更新日期：2010-01-01 00:00:00

abstract：:Cigarette smoking causes the development of chronic bronchitis and chronic obstructive pulmonary disease. We hypothesized that exposure to cigarette smoke might initiate release of inflammatory mediators by bronchial epithelial cells. To evaluate this, the effect of cigarette smoke extract (CSE) on IL-8 release from c...

journal_title：American journal of respiratory and critical care medicine

authors： Mio T,Romberger DJ,Thompson AB,Robbins RA,Heires A,Rennard SI

更新日期：1997-05-01 00:00:00

abstract：:The absence of standardized assessment protocols with well- defined measurement properties limits comparison of outcomes among those receiving long-term oxygen therapy (LTOT). We describe simple protocols for a hospital test, a simulated home test, and an actual home test, their reliability and relationship to each ot...

journal_title：American journal of respiratory and critical care medicine

authors： Guyatt GH,McKim DA,Weaver B,Austin PA,Bryan RE,Walter SD,Nonoyama ML,Ferreira IM,Goldstein RS

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is increasingly recognized as a multicomponent disease with systemic consequences and effects on quality of life. Single measures such as lung function provide a limited reflection of how the disease affects patients. Composite measures have the potential to accoun...

journal_title：American journal of respiratory and critical care medicine

authors： Jones RC,Donaldson GC,Chavannes NH,Kida K,Dickson-Spillmann M,Harding S,Wedzicha JA,Price D,Hyland ME

更新日期：2009-12-15 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is used to ameliorate neutropenia in patients after antineoplastic treatment. It has also been suggested as an adjunct treatment in septic patients; however, the recruitment and priming of leukocytes by GM-CSF bears the hazard of a hyperinflammatory response. I...

journal_title：American journal of respiratory and critical care medicine

authors： Wollin L,Uhlig S,Nüsing R,Wendel A

更新日期：2001-02-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：RATIONALE:Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation caused by a combination of airways disease (bronchiolitis) and parenchymal destruction (emphysema), whose relative proportion varies from patient to patient. OBJECTIVES:To explore and contrast the molecular pathogenes...

journal_title：American journal of respiratory and critical care medicine

authors： Faner R,Cruz T,Casserras T,López-Giraldo A,Noell G,Coca I,Tal-Singer R,Miller B,Rodriguez-Roisin R,Spira A,Kalko SG,Agustí A

更新日期：2016-06-01 00:00:00

abstract：:The virulence of Pseudomonas aeruginosa is partly controlled by the las quorum-sensing system. A rat model of acute pneumonia was used to investigate the pathophysiological impact of this system by comparing the virulence of the wild-type virulent laboratory strain PAO1 with that of its lasR-deleted mutant PAOR. In co...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Faurisson F,Join-Lambert O,Roudot-Thoraval F,Foglino M,Vissuzaine C,Carbon C

更新日期：2003-06-01 00:00:00

abstract：:Airway remodeling may lead to irreversible loss of lung function in asthma. The impact of childhood asthma, airway responsiveness, atopy, and smoking on airway remodeling was investigated in a birth cohort studied longitudinally to age 26. A low postbronchodilator ratio of forced exhaled volume in 1 second (FEV1) to v...

journal_title：American journal of respiratory and critical care medicine

authors： Rasmussen F,Taylor DR,Flannery EM,Cowan JO,Greene JM,Herbison GP,Sears MR

更新日期：2002-06-01 00:00:00

abstract：RATIONALE:Asthma is a chronic inflammatory airway disease that affects more than 300 million individuals worldwide. Asthma is caused by interaction of genetic and environmental factors. Bronchial hyperresponsiveness (BHR) is a hallmark of asthma and results from increased sensitivity of the airways to physical or chemi...

journal_title：American journal of respiratory and critical care medicine

authors： Koppelman GH,Meyers DA,Howard TD,Zheng SL,Hawkins GA,Ampleford EJ,Xu J,Koning H,Bruinenberg M,Nolte IM,van Diemen CC,Boezen HM,Timens W,Whittaker PA,Stine OC,Barton SJ,Holloway JW,Holgate ST,Graves PE,Martinez FD,

更新日期：2009-11-15 00:00:00

abstract：:We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 work...

journal_title：American journal of respiratory and critical care medicine

authors： Senthilselvan A,Pahwa P,Wang P,McDuffie HH,Dosman JA

更新日期：1996-02-01 00:00:00

abstract：:Ventilation was measured in 31 difficult-to-wean patients while pressure support (PS) was reduced by 5 cm H2O every 20 min. Weaning had to be aborted in 14 of 31 patients (Group F) because they met predefined distress criteria. The remaining 17 patients who were able to complete the "weaning test" (Group S) had larger...

journal_title：American journal of respiratory and critical care medicine

authors： Stroetz RW,Hubmayr RD

更新日期：1995-09-01 00:00:00

abstract：:The effect of a dental appliance (DA) is usually evaluated in a single mandibular position reached after several weeks and corresponding to either improvement of symptoms or intolerance to any further advancement. The purpose of this study was to test the feasibility of one-night evaluation of the efficacy of a DA. Th...

journal_title：American journal of respiratory and critical care medicine

authors： Pételle B,Vincent G,Gagnadoux F,Rakotonanahary D,Meyer B,Fleury B

更新日期：2002-04-15 00:00:00

abstract：:Pleural disease both before and after organ transplantation has important implications. Pleural effusions are common in candidates for heart, liver, and kidney transplantation. A thoracentesis is not mandatory in these patients, but it should be performed if clinical or radiologic features suggest that the effusion is...

journal_title：American journal of respiratory and critical care medicine

authors： Judson MA,Sahn SA

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) has been associated with kidney function loss, which may be related to changes in the renin-angiotensin system (RAS). OBJECTIVES:We sought to determine the effect of continuous positive airway pressure (CPAP) of patients with OSA on renal hemodynamics at baseline and in response...

journal_title：American journal of respiratory and critical care medicine

authors： Nicholl DD,Hanly PJ,Poulin MJ,Handley GB,Hemmelgarn BR,Sola DY,Ahmed SB

更新日期：2014-09-01 00:00:00

abstract：RATIONALE:Inflammation is now recognized as an integral part of the pathogenesis of chronic obstructive pulmonary disease (COPD). In contrast to the sterile airways of normal lungs, bacterial pathogens are often isolated from the airways in stable COPD. This "colonization" of the tracheobronchial tree, currently believ...

journal_title：American journal of respiratory and critical care medicine

authors： Sethi S,Maloney J,Grove L,Wrona C,Berenson CS

更新日期：2006-05-01 00:00:00