Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations.

abstract：:The aim of the study was to investigate the effect of addition of montelukast to inhaled fluticasone propionate (FP) therapy, compared with FP therapy alone (100 microg twice a day) on airway immunopathology in individuals with mild asthma. Twenty-eight subjects received FP (100 microg twice a day) or FP (100 microg t...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan S,Akveld M,Burke CM,Poulter LW

更新日期：2003-03-01 00:00:00

abstract：:Although the incidence of pulmonary hypertension is higher in female patients, numerous experimental studies have demonstrated better outcome in female animals, exacerbation of the disease after ovariectomy, and a strong protective effect of estrogen: a phenomenon known as the "estrogen paradox" of pulmonary hypertens...

journal_title：American journal of respiratory and critical care medicine

authors： Umar S,Rabinovitch M,Eghbali M

更新日期：2012-07-15 00:00:00

abstract：:Large pleural effusions are typically associated with dyspnea and potential respiratory compromise. Experimental evidence suggests that with large effusions, increased intrapleural pressure may be transmitted to the pericardial space, resulting in impaired cardiac filling and reduced stroke volume. We report two cases...

journal_title：American journal of respiratory and critical care medicine

authors： Kaplan LM,Epstein SK,Schwartz SL,Cao QL,Pandian NG

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVES:To assess the reliability and the minimal clinically important differences (MCID) for FVC% predicted in the Scleroderma Lung Study I and II. METHODS:Using data from SLS I and II (N=300), we evaluated the test-retest reliability for FVC% predicted (FVC%; screening vs. baseline) using intra-class correlation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kafaja S,Clements PJ,Wilhalme H,Tseng CH,Furst DE,Kim GH,Goldin J,Volkmann ER,Roth MD,Tashkin DP,Khanna D

更新日期：2018-03-01 00:00:00

abstract：:It has been suggested that in patients with adult respiratory distress syndrome (ARDS), intrinsic positive end-expiratory pressure (PEEPi) is generated by a disproportionate increase in expiratory flow resistance. Using the negative expiratory pressure (NEP) technique, we assessed whether expiratory flow limitation (E...

journal_title：American journal of respiratory and critical care medicine

authors： Koutsoukou A,Armaganidis A,Stavrakaki-Kallergi C,Vassilakopoulos T,Lymberis A,Roussos C,Milic-Emili J

更新日期：2000-05-01 00:00:00

abstract：:We measured in rats the effects of 48 h of mechanical ventilation on the weight, contractile properties, and enzymatic profile of the diaphragm, the soleus and the extensor digitorium longus (EDL) muscles. Eighteen animals were randomly divided into a mechanically ventilated (MV, n = 9) group or a control (C, n = 9) g...

journal_title：American journal of respiratory and critical care medicine

authors： Le Bourdelles G,Viires N,Boczkowski J,Seta N,Pavlovic D,Aubier M

更新日期：1994-06-01 00:00:00

abstract：:Used adjunctively during mechanical ventilation, tracheal gas insufflation (TGI) improves CO2 elimination, principally by decreasing effective anatomic dead space. Continuing lung deflation at end- expiration raises the end-expiratory C02 concentration within the proximal airway, and could theoretically reduce the eff...

journal_title：American journal of respiratory and critical care medicine

authors： Ravenscraft SA,Shapiro RS,Nahum A,Burke WC,Adams AB,Nakos G,Marini JJ

更新日期：1996-06-01 00:00:00

abstract：:The distribution of ventilation-perfusion (VA/Q) ratios during bronchoconstriction measured with the multiple inert gases elimination technique is frequently bimodal. However, the topographic basis and the cause of that bimodality remain unknown. In this article, regional VA/Q is quantified by three-dimensional positr...

journal_title：American journal of respiratory and critical care medicine

authors： Melo MF,Harris RS,Layfield JD,Venegas JG

更新日期：2005-04-01 00:00:00

abstract：RATIONALE:Defining the biogeography of bacterial populations in human body habitats is a high priority for understanding microbial-host relationships in health and disease. The healthy lung was traditionally considered sterile, but this notion has been challenged by emerging molecular approaches that enable comprehensi...

journal_title：American journal of respiratory and critical care medicine

authors： Charlson ES,Bittinger K,Haas AR,Fitzgerald AS,Frank I,Yadav A,Bushman FD,Collman RG

更新日期：2011-10-15 00:00:00

abstract：:To assess whether there is increased risk of tuberculous infection in children who traveled to or had a household visitor from a country having a high prevalence of tuberculosis, we conducted a case-control study. Children younger than 6 yr of age who had a tuberculin skin test read at public health clinics in areas o...

journal_title：American journal of respiratory and critical care medicine

authors： Lobato MN,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：:Acute sustained hypoxia causes an early rise in ventilation, followed by a reduction in ventilation ("roll off") after several minutes to levels below the peak but above baseline. The underlying mechanism(s) of this biphasic response is unclear. Hypoxia induces changes in the release and metabolic turnover of glutamat...

journal_title：American journal of respiratory and critical care medicine

authors： Soto-Arape I,Burton MD,Kazemi H

更新日期：1995-04-01 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood. OBJECTIVES:Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) ge...

journal_title：American journal of respiratory and critical care medicine

authors： Simpson A,Maniatis N,Jury F,Cakebread JA,Lowe LA,Holgate ST,Woodcock A,Ollier WE,Collins A,Custovic A,Holloway JW,John SL

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described. OBJECTIVES:To determine the molecular mec...

journal_title：American journal of respiratory and critical care medicine

authors： Queisser MA,Dada LA,Deiss-Yehiely N,Angulo M,Zhou G,Kouri FM,Knab LM,Liu J,Stegh AH,DeCamp MM,Budinger GR,Chandel NS,Ciechanover A,Iwai K,Sznajder JI

更新日期：2014-09-15 00:00:00

abstract：RATIONALE:The role of NADPH oxidase activation in pneumonia is complex because reactive oxygen species contribute to both microbial killing and regulation of the acute pulmonary infiltrate. The relative importance of each role remains poorly defined in community-acquired pneumonia. OBJECTIVES:We evaluated the contribu...

journal_title：American journal of respiratory and critical care medicine

authors： Marriott HM,Jackson LE,Wilkinson TS,Simpson AJ,Mitchell TJ,Buttle DJ,Cross SS,Ince PG,Hellewell PG,Whyte MK,Dockrell DH

更新日期：2008-04-15 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00

abstract：RATIONALE:Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation. OBJECTIVES:We hypothesized tha...

journal_title：American journal of respiratory and critical care medicine

authors： Terragni PP,Rosboch G,Tealdi A,Corno E,Menaldo E,Davini O,Gandini G,Herrmann P,Mascia L,Quintel M,Slutsky AS,Gattinoni L,Ranieri VM

更新日期：2007-01-15 00:00:00

abstract：RATIONALE:Bronchial remodeling, including increased bronchial smooth muscle (BSM) mass, contributes to bronchial obstruction in asthma. However, its mechanisms are complex and remain controversial. Recently, a role of the chitinase 3-like 1 protein (YKL-40) has been evoked in asthma. Indeed, YKL-40 concentration was in...

journal_title：American journal of respiratory and critical care medicine

authors： Bara I,Ozier A,Girodet PO,Carvalho G,Cattiaux J,Begueret H,Thumerel M,Ousova O,Kolbeck R,Coyle AJ,Woods J,Tunon de Lara JM,Marthan R,Berger P

更新日期：2012-04-01 00:00:00

abstract：:Four hundred forty-one subjects 34 to 69 yr of age were recruited from a random sample of the community. The sample was biased in favor of men, snorers, and subjects with subjective sleep complaints. They answered a questionnaire and were monitored in their homes for sleep-disordered breathing (SDB). This report conce...

journal_title：American journal of respiratory and critical care medicine

authors： Olson LG,King MT,Hensley MJ,Saunders NA

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...

journal_title：American journal of respiratory and critical care medicine

authors： Walker NM,Badri LN,Wadhwa A,Wettlaufer S,Peters-Golden M,Lama VN

更新日期：2012-01-01 00:00:00

abstract：RATIONALE:The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of the natural history of asthma. OBJECTIVES:To compare the stability of cluster-based asthma phenotype structures a decad...

journal_title：American journal of respiratory and critical care medicine

authors： Boudier A,Curjuric I,Basagaña X,Hazgui H,Anto JM,Bousquet J,Bridevaux PO,Dupuis-Lozeron E,Garcia-Aymerich J,Heinrich J,Janson C,Künzli N,Leynaert B,de Marco R,Rochat T,Schindler C,Varraso R,Pin I,Probst-Hensch N,Sun

更新日期：2013-09-01 00:00:00

abstract：:The use of noninvasive methods of monitoring airway inflammation, such as exhaled nitric oxide (eNO) and induced sputum, has been shown to improve asthma monitoring and optimize treatment in adult patients with asthma. There is a lack of comparable data in children. Forty children with stable asthma eligible for inhal...

journal_title：American journal of respiratory and critical care medicine

authors： Zacharasiewicz A,Wilson N,Lex C,Erin EM,Li AM,Hansel T,Khan M,Bush A

更新日期：2005-05-15 00:00:00

abstract：RATIONALE:The CD40 protein plays important roles in cell-mediated and humoral immune responses, especially in immunoglobulin class-switching to IgE. OBJECTIVES:We tested the association of CD40 polymorphisms with the risk of asthma and the level of serum IgE and investigated the functional effect of associated polymor...

journal_title：American journal of respiratory and critical care medicine

authors： Park JH,Chang HS,Park CS,Jang AS,Park BL,Rhim TY,Uh ST,Kim YH,Chung IY,Shin HD

更新日期：2007-04-15 00:00:00

abstract：:Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic...

journal_title：American journal of respiratory and critical care medicine

authors： Collard HR,Ryerson CJ,Corte TJ,Jenkins G,Kondoh Y,Lederer DJ,Lee JS,Maher TM,Wells AU,Antoniou KM,Behr J,Brown KK,Cottin V,Flaherty KR,Fukuoka J,Hansell DM,Johkoh T,Kaminski N,Kim DS,Kolb M,Lynch DA,Myers JL,R

更新日期：2016-08-01 00:00:00

abstract：:In Balb/C mice, painting the skin with ovalbumin (OVA) over a period of 14 days resulted in sensitization of the animals. This was documented by the appearance of OVA-specific IgE and IgG1 antibodies and increased total serum IgE levels. In addition, in regional (inguinal) lymph nodes of sensitized animals, OVA-specif...

journal_title：American journal of respiratory and critical care medicine

authors： Saloga J,Renz H,Larsen GL,Gelfand EW

更新日期：1994-01-01 00:00:00

abstract：:Loss of lung elastic recoil causing hyperinflation with increased TLC and decreased diffusing capacity and expiratory airflow are physiologic hallmarks of emphysema. We studied lung mechanics in 10 patients (seven men and three women) aged 69 +/- 9 yr (mean +/- SD) who had fixed, severe expiratory airflow limitation w...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,Hogg JC,Müller NL,Schein MJ

更新日期：1998-09-01 00:00:00

abstract：:The molecular sources of reactive oxygen species (ROS) in skeletal muscles are not well understood. We hypothesized that nonphagocyte NAD(P)H oxidase could be a source of ROS in muscle fibers. We thus investigated the existence, structure, and contribution of nonphagocyte NAD(P)H oxidase to ROS production in rat skele...

journal_title：American journal of respiratory and critical care medicine

authors： Javeshghani D,Magder SA,Barreiro E,Quinn MT,Hussain SN

更新日期：2002-02-01 00:00:00

abstract：RATIONALE:Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions. However, the role of combining these modalities to overcome each individual technique's limitations and, consequently, to further increas...

journal_title：American journal of respiratory and critical care medicine

authors： Eberhardt R,Anantham D,Ernst A,Feller-Kopman D,Herth F

更新日期：2007-07-01 00:00:00

abstract：:Despite several codes of research ethics, the issuance of comprehensive rules regarding informed consent by governmental agencies, and numerous writings on the subject of informed consent, many commentators still question the quality of the informed consent process in clinical research. A major concern is that investi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman HJ

更新日期：1996-09-01 00:00:00

abstract：:The period covered by this update can be considered as the most exciting period in idiopathic pulmonary fibrosis (IPF) research. It started with the identification of genetic variants that are associated with IPF in the majority of patients and continued with discovery of molecular and genetic biomarkers that predict ...

journal_title：American journal of respiratory and critical care medicine

authors： Rosas IO,Kaminski N

更新日期：2015-02-01 00:00:00