Effect of the addition of montelukast to inhaled fluticasone propionate on airway inflammation.

abstract：:Important features of both stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributin...

journal_title：American journal of respiratory and critical care medicine

authors： Abdulai RM,Jensen TJ,Patel NR,Polkey MI,Jansson P,Celli BR,Rennard SI

更新日期：2018-02-15 00:00:00

abstract：RATIONALE:Reactivation tuberculosis (TB) occurs as a result of reactivation of latent TB infection (LTBI), and was reported to occur in the United States at a rate of 0.10 to 0.16 cases per 100 person-years in the 1950s; it has not been measured since. OBJECTIVES:To calculate the rate of reactivation TB in a U.S. comm...

journal_title：American journal of respiratory and critical care medicine

authors： Horsburgh CR Jr,O'Donnell M,Chamblee S,Moreland JL,Johnson J,Marsh BJ,Narita M,Johnson LS,von Reyn CF

更新日期：2010-08-01 00:00:00

abstract：:Obstructive apneas and hypopneas during sleep are a well recognized cause of excessive daytime sleepiness. Snoring is also associated with excess sleepiness, although it is not known whether this reflects an independent effect of snoring or whether snoring is simply a marker for obstructive sleep apnea. To further exp...

journal_title：American journal of respiratory and critical care medicine

authors： Gottlieb DJ,Yao Q,Redline S,Ali T,Mahowald MW

更新日期：2000-10-01 00:00:00

abstract：:In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was s...

journal_title：American journal of respiratory and critical care medicine

authors： Piirilä PL,Nordman H,Keskinen HM,Luukkonen R,Salo SP,Tuomi TO,Tuppurainen M

更新日期：2000-08-01 00:00:00

abstract：:Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnt...

journal_title：American journal of respiratory and critical care medicine

authors： Tinkle SS,Newman LS

更新日期：1997-12-01 00:00:00

abstract：:In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members of families with an individual with known sleep apnea (85 inde...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Tishler PV,Hans MG,Tosteson TD,Strohl KP,Spry K

更新日期：1997-01-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：:We investigated the relationship between the extent of pulmonary emphysema, assessed by quantitative high-resolution computed tomography (HRCT), and lung mechanics in 24 patients with chronic obstructive pulmonary disease (COPD). The extent of emphysema was quantified as the relative lung area with CT numbers < -950 H...

journal_title：American journal of respiratory and critical care medicine

authors： Baldi S,Miniati M,Bellina CR,Battolla L,Catapano G,Begliomini E,Giustini D,Giuntini C

更新日期：2001-08-15 00:00:00

abstract：:Diabetes mellitus has been inconsistently associated with a reduced level of pulmonary function. To elucidate this association further, we analyzed the relationship of diabetes and of fasting blood glucose to the level of pulmonary function assessed by spirometry in the 3,254 members of the Framingham Offspring Cohort...

journal_title：American journal of respiratory and critical care medicine

authors： Walter RE,Beiser A,Givelber RJ,O'Connor GT,Gottlieb DJ

更新日期：2003-03-15 00:00:00

abstract：:Erythromycin inhibits mucus glycoconjugate secretion from airway cells in vitro and may increase mucus clearance in patients with asthma or diffuse panbronchiolitis. Because mucus hypersecretion is common in purulent rhinitis, we questioned whether clarithromycin would change the properties of nasal mucus from subject...

journal_title：American journal of respiratory and critical care medicine

authors： Rubin BK,Druce H,Ramirez OE,Palmer R

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible for movement of sodium. Hyperactivation of ENaC, which creates an osmoti...

journal_title：American journal of respiratory and critical care medicine

authors： Scott DW,Walker MP,Sesma J,Wu B,Stuhlmiller TJ,Sabater JR,Abraham WM,Crowder TM,Christensen DJ,Tarran R

更新日期：2017-09-15 00:00:00

abstract：:We have undertaken this retrospective study to determine factors associated with in-hospital mortality and morbidity in 80 adult patients with severe Streptococcus pneumoniae meningitis. Clinical characteristics at admission of patients infected with susceptible (n = 54) and nonsusceptible (n = 17) strains to penicill...

journal_title：American journal of respiratory and critical care medicine

authors： Auburtin M,Porcher R,Bruneel F,Scanvic A,Trouillet JL,Bédos JP,Régnier B,Wolff M

更新日期：2002-03-01 00:00:00

abstract：:Two distinct types of tumor necrosis factor receptors (TNF-R) have been identified (TNF-R55 and TNF-R75). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR55 and TNF-sR75). TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent...

journal_title：American journal of respiratory and critical care medicine

authors： Humbert M,Roux-Lombard P,Cerrina J,Magnan A,Simonneau G,Dartevelle P,Galanaud P,Dayer JM,Emilie D

更新日期：1994-06-01 00:00:00

abstract：:It has long been known that there are cyclic changes in arterial pressure during mechanical ventilation. They are caused by cyclic changes in both the right and left ventricular stroke output, occurring in opposite phases. As a result, arterial pulse pressure is increased during inspiration and decreased during expira...

journal_title：American journal of respiratory and critical care medicine

authors： Vieillard-Baron A,Chergui K,Augarde R,Prin S,Page B,Beauchet A,Jardin F

更新日期：2003-09-15 00:00:00

abstract：:Knowledge of the local and regional doses of inhaled particulates is crucial for inhalation therapy and for understanding the progression of pulmonary disease. We studied the deposition pattern of radioactively tagged particles in rats with chronic bronchitis. Rats were exposed to sulfur dioxide (SO2; 236 +/- 14 ppm) ...

journal_title：American journal of respiratory and critical care medicine

authors： Sweeney TD,Skornik WA,Brain JD,Hatch V,Godleski JJ

更新日期：1995-02-01 00:00:00

abstract：:Normoxic lung ischemia/reperfusion (I/R) leads to oxidative injury of the pulmonary tissue. We analyzed angiotensin-converting enzyme (ACE) in perfused rat lungs upon I/R in order to assess the endothelial injury produced. I/R led to a time-dependent increase in ACE activity in the perfusate, from 145+/-14 mU to 252+/...

journal_title：American journal of respiratory and critical care medicine

authors： Atochina EN,Muzykantov VR,Al-Mehdi AB,Danilov SM,Fisher AB

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poo...

journal_title：American journal of respiratory and critical care medicine

authors： Kiwamoto T,Ishii Y,Morishima Y,Yoh K,Maeda A,Ishizaki K,Iizuka T,Hegab AE,Matsuno Y,Homma S,Nomura A,Sakamoto T,Takahashi S,Sekizawa K

更新日期：2006-07-15 00:00:00

abstract：:We developed clonal cell lines of human bronchial smooth muscle origin by retroviral transduction of temperature-sensitive simian virus 40 large tumor (T) antigen. These cells show increased growth potential at 33 degrees C, but on shift to the nonpermissive temperature (39 degrees C), they show diminished or arrested...

journal_title：American journal of respiratory and critical care medicine

authors： Zhou L,Li J,Goldsmith AM,Newcomb DC,Giannola DM,Vosk RG,Eves EM,Rosner MR,Solway J,Hershenson MB

更新日期：2004-03-15 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Chronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of these associations could inform prevention strategies for common heart-lung conditions. OBJECTIVES:To use the Coronary Artery Risk ...

journal_title：American journal of respiratory and critical care medicine

authors： Cuttica MJ,Colangelo LA,Shah SJ,Lima J,Kishi S,Arynchyn A,Jacobs DR Jr,Thyagarajan B,Liu K,Lloyd-Jones D,Kalhan R

更新日期：2015-07-01 00:00:00

abstract：:Relaxation was examined in diaphragm muscle strips of cardiomyopathic Syrian hamsters and control hamsters. Isotonic lengthening velocity and isometric tension decay were analyzed over the load continuum in response to twitch. For each load level (P), we measured the maximum extent of shortening (deltaL), the peak len...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Chemla D,Pourny JC,Lambert F,Riou B,Lecarpentier Y

更新日期：1997-05-01 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Venous thromboembolism is difficult to diagnose in critically ill patients and may increase morbidity and mortality. OBJECTIVES:To evaluate the cost-effectiveness of strategies to reduce morbidity from venous thromboembolism in critically ill patients. METHODS:A Markov decision analytic model to compare wee...

journal_title：American journal of respiratory and critical care medicine

authors： Sud S,Mittmann N,Cook DJ,Geerts W,Chan B,Dodek P,Gould MK,Guyatt G,Arabi Y,Fowler RA,Canadian Critical Care Trials Group.,E-PROTECT Investigators.

更新日期：2011-12-01 00:00:00

abstract：:Ineffective lung repair in patients with unresolving acute respiratory distress syndrome (ARDS) is accompanied by progressive fibroproliferation, inability to improve lung injury score (LIS), progressive multiple organ dysfunction syndrome (MODS), and an unfavorable outcome. Our aim was to investigate the relationship...

journal_title：American journal of respiratory and critical care medicine

authors： Meduri GU,Tolley EA,Chinn A,Stentz F,Postlethwaite A

更新日期：1998-11-01 00:00:00

abstract：:Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

journal_title：American journal of respiratory and critical care medicine

authors： Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

更新日期：2021-02-01 00:00:00

abstract：RATIONALE:Congenital central hypoventilation syndrome (CCHS), a unique disorder of respiratory control associated with Hirschsprung disease (HSCR) and tumors of neural crest origin, results from polyalanine repeat expansion mutations in the paired-like homeobox (PHOX)2B gene in more than 90% of cases, and alternative P...

journal_title：American journal of respiratory and critical care medicine

authors： Berry-Kravis EM,Zhou L,Rand CM,Weese-Mayer DE

更新日期：2006-11-15 00:00:00

abstract：:Guidelines, protocols, and checklists (together called "protocols") can be immensely helpful in the clinical arena. However, clinicians and health care systems relying on protocols must assess whether benefits are being accrued, whether such "benefits" are real, and whether harm can be detected. These concerns are imp...

journal_title：American journal of respiratory and critical care medicine

authors： Kavanagh BP,Nurok M

更新日期：2016-01-01 00:00:00

abstract：:Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are important for disease pathogenesis. Objectives: To determine whether s...

journal_title：American journal of respiratory and critical care medicine

authors： Reyfman PA,Walter JM,Joshi N,Anekalla KR,McQuattie-Pimentel AC,Chiu S,Fernandez R,Akbarpour M,Chen CI,Ren Z,Verma R,Abdala-Valencia H,Nam K,Chi M,Han S,Gonzalez-Gonzalez FJ,Soberanes S,Watanabe S,Williams KJN,Flozak

更新日期：2019-06-15 00:00:00

abstract：:The present studies were designed to assess the pattern of activity and the frequency of activation of the neck muscles in patients with chronic obstructive pulmonary disease (COPD). Using concentric needle electrodes, we thus recorded the electromyograms of the scalene, sternocleidomastoid, and trapezius muscles duri...

journal_title：American journal of respiratory and critical care medicine

authors： De Troyer A,Peche R,Yernault JC,Estenne M

更新日期：1994-07-01 00:00:00

abstract：:From an Aspergillus fumigatus complementary deoxyribonucleic acid (cDNA) library displayed on phage surface, an allergen formally termed rAsp f 3 was cloned. The open-reading frame of the cloned gene for the allergen encodes a protein of 168 amino acids with a predicted molecular mass of 18.5 kD, showing 36% identity ...

journal_title：American journal of respiratory and critical care medicine

authors： Hemmann S,Blaser K,Crameri R

更新日期：1997-12-01 00:00:00