Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease.

abstract：:To determine if gastric intramucosal pH changes during weaning from mechanical ventilation are related to gastric mucosal blood flow modifications, we studied 16 ventilator-supported patients with chronic obstructive pulmonary disease (COPD) who tolerated a 2-h trial of spontaneous breathing with pressure support vent...

journal_title：American journal of respiratory and critical care medicine

authors： Bocquillon N,Mathieu D,Neviere R,Lefebvre N,Marechal X,Wattel F

更新日期：1999-11-01 00:00:00

abstract：:Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in asthmatic subjects from that observed in normal subjects. Increased airway wall thickness has been suggested as a contributing cause f...

journal_title：American journal of respiratory and critical care medicine

authors： Okazawa M,Müller N,McNamara AE,Child S,Verburgt L,Paré PD

更新日期：1996-11-01 00:00:00

abstract：:To define the mechanisms by which inhaled glucocorticosteroid regulates allergen-induced airway inflammation, a double-blind, placebo-controlled, cross-over study with inhaled budesonide was conducted in 14 subjects with allergic asthma. After baseline bronchoscopy and bronchoalveolar lavage (BAL), subjects were rando...

journal_title：American journal of respiratory and critical care medicine

authors： Kelly EA,Busse WW,Jarjour NN

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Although intermittent, three-times-weekly therapy is recommended for the initial treatment of noncavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. OBJECTIVES:To evaluate the clinical efficacy of intermittent therapy compared with daily therapy for no...

journal_title：American journal of respiratory and critical care medicine

authors： Jeong BH,Jeon K,Park HY,Kim SY,Lee KS,Huh HJ,Ki CS,Lee NY,Shin SJ,Daley CL,Koh WJ

更新日期：2015-01-01 00:00:00

abstract：:Although transbronchial lung biopsy (TBBx) is widely acknowledged as the "gold standard" for diagnosis of acute rejection, controversy exists regarding the need to perform follow-up procedures. Over a 5-yr period, we performed 1,142 TBBx of which 173 were follow-up TBBx in 99 patients with pulmonary allograft rejectio...

journal_title：American journal of respiratory and critical care medicine

authors： Aboyoun CL,Tamm M,Chhajed PN,Hopkins P,Malouf MA,Rainer S,Glanville AR

更新日期：2001-08-01 00:00:00

abstract：RATIONALE:The serial computed tomography findings and prognosis of the acute exacerbation of idiopathic pulmonary fibrosis (IPF) are not yet well defined in a larger number of cases. OBJECTIVES:To evaluate the parenchymal abnormalities and prognosis using high-resolution computed tomography (HRCT) in acute exacerbatio...

journal_title：American journal of respiratory and critical care medicine

authors： Akira M,Kozuka T,Yamamoto S,Sakatani M

更新日期：2008-08-15 00:00:00

abstract：:Alveolar epithelial type II cells (AET2) respond with exocytosis of surfactant containing lamellar bodies to stimulation with mechanical stretch and secretagogues, a process that is fundamental for maintaining alveolar stability and lung gas exchange. In the present study in cultured rat AET2, we employed botulinum C2...

journal_title：American journal of respiratory and critical care medicine

authors： Rose F,Kürth-Landwehr C,Sibelius U,Reuner KH,Aktories K,Seeger W,Grimminger F

更新日期：1999-01-01 00:00:00

abstract：:Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

journal_title：American journal of respiratory and critical care medicine

authors： Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

更新日期：2020-12-15 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Sepsis refers to the clinical syndrome of severe systemic inflammation precipitated by infection. Despite appropriate antimicrobial therapy, sepsis-related morbidity and mortality remain intractable problems in critically ill patients. Moreover, there is no specific treatment strategy for the syndrome of seps...

journal_title：American journal of respiratory and critical care medicine

authors： Mei SH,Haitsma JJ,Dos Santos CC,Deng Y,Lai PF,Slutsky AS,Liles WC,Stewart DJ

更新日期：2010-10-15 00:00:00

abstract：:Previous studies have shown that the allergic late airway response (LR) is dependent on the leukotriene (LT) pathway in Brown Norway (BN) rats. In this same model, interleukin-2 (IL-2) has been shown to increase allergic airway responses without increasing LT production. This study examined the relationship between th...

journal_title：American journal of respiratory and critical care medicine

authors： Nag S,Lamkhioued B,Renzi PM

更新日期：2002-06-01 00:00:00

abstract：RATIONALE:Incident pulmonary arterial hypertension was underrepresented in most pulmonary hypertension registries and may have a different disease profile to prevalent disease. OBJECTIVES:To determine the characteristics and outcome of a purely incident, treatment-naive cohort of idiopathic, heritable, and anorexigen-...

journal_title：American journal of respiratory and critical care medicine

authors： Ling Y,Johnson MK,Kiely DG,Condliffe R,Elliot CA,Gibbs JS,Howard LS,Pepke-Zaba J,Sheares KK,Corris PA,Fisher AJ,Lordan JL,Gaine S,Coghlan JG,Wort SJ,Gatzoulis MA,Peacock AJ

更新日期：2012-10-15 00:00:00

abstract：:Collapsibility of the active pharynx, where active contraction of the upper airway muscles is evident, was previously reported to be higher in children with obstructive sleep apnea (OSA) than in those with primary snoring during sleep. Contribution of neuromuscular and anatomic factors to the increased collapsibility,...

journal_title：American journal of respiratory and critical care medicine

authors： Isono S,Shimada A,Utsugi M,Konno A,Nishino T

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:Intensive care unit (ICU) nurses work in a demanding environment where they are repetitively exposed to traumatic situations and stressful events. The psychological effects on nurses as a result of working in the ICU are relatively unknown. OBJECTIVE:To determine whether there is an increased prevalence of p...

journal_title：American journal of respiratory and critical care medicine

authors： Mealer ML,Shelton A,Berg B,Rothbaum B,Moss M

更新日期：2007-04-01 00:00:00

abstract：:Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in lung function in adult life compared with those with asthma. Treatment and cigarette smoking may also influence the rate of decline of lung function. The aim of ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Palmer LJ,Kicic E,Maxwell PS,Lagan SE,Ryan GF,Musk AW

更新日期：2005-01-15 00:00:00

abstract：:Genes for the chemokine receptors CCR5 and CCR2 are characterized by polymorphisms resulting in a nonfunctional receptor expression. Ligands for CCR2 and CCR5 (chemokines monocyte chemotactic protein-1 [MCP-1] and RANTES) are implicated in the pathogenesis of sarcoidosis. We have, therefore, analyzed polymorphisms of ...

journal_title：American journal of respiratory and critical care medicine

authors： Petrek M,Drábek J,Kolek V,Zlámal J,Welsh KI,Bunce M,Weigl E,Du Bois R

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:S100A12 is overexpressed during inflammation and is a marker of inflammatory disease. Furthermore, it has been ascribed to the group of damage-associated molecular pattern molecules that promote inflammation. However, the exact role of human S100A12 during early steps of immune activation and sepsis is only p...

journal_title：American journal of respiratory and critical care medicine

authors： Foell D,Wittkowski H,Kessel C,Lüken A,Weinhage T,Varga G,Vogl T,Wirth T,Viemann D,Björk P,van Zoelen MA,Gohar F,Srikrishna G,Kraft M,Roth J

更新日期：2013-06-15 00:00:00

abstract：RATIONALE:The allergen inhalation challenge is used in clinical trials to test the efficacy of new treatments in attenuating the late-phase asthmatic response (LAR) and associated airway inflammation in subjects with allergic asthma. However, not all subjects with allergic asthma develop the LAR after allergen inhalati...

journal_title：American journal of respiratory and critical care medicine

authors： Singh A,Shannon CP,Kim YW,Yang CX,Balshaw R,Cohen Freue GV,Gauvreau GM,FitzGerald JM,Boulet LP,O'Byrne PM,Tebbutt SJ

更新日期：2018-02-15 00:00:00

abstract：RATIONALE:Genetic alterations on 8p22 have been implicated in multiple cancers, including lung cancer. In this region, genetic variants of the class A scavenger receptor (SR-A) gene have been associated with prostate cancer risk and have been highlighted as a potential susceptibility gene of cancer. OBJECTIVES:To dete...

journal_title：American journal of respiratory and critical care medicine

authors： Ben J,Jin G,Zhang Y,Ma B,Bai H,Chen J,Zhang H,Gong Q,Zhou X,Zhang H,Qian L,Zhu X,Li X,Yang Q,Hu Z,Xu Y,Shen H,Chen Q

更新日期：2012-10-15 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：RATIONALE:Epithelial-mesenchymal transition (EMT) plays a key role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer. OBJECTIVES:There are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, and Twist1) involved in EMT. We hypothesized that germline variants in these genes may in...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Yang X,Ji W,Deng J,Qiu F,Yang R,Fang W,Zhang L,Huang D,Xie C,Zhang H,Zhong N,Ran P,Zhou Y,Lu J

更新日期：2014-01-15 00:00:00

abstract：:Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and a...

journal_title：American journal of respiratory and critical care medicine

authors： Burgel PR,Munck A,Durieu I,Chiron R,Mely L,Prevotat A,Murris-Espin M,Porzio M,Abely M,Reix P,Marguet C,Macey J,Sermet-Gaudelus I,Corvol H,Bui S,Lemonnier L,Dehillotte C,Da Silva J,Paillasseur JL,Hubert D,French Cy

更新日期：2020-01-15 00:00:00

abstract：:In mechanically ventilated patients, pressure and flow tracings can be used to assess respiratory pump muscle activity or rest. When the ventilation is delivered through an endotracheal tube, the respiratory system can be considered a one-compartment model, and activation of the respiratory muscles results in deformat...

journal_title：American journal of respiratory and critical care medicine

authors： Jounieaux V,Parreira VF,Delguste P,Aubert G,Rodenstein DO

更新日期：1997-06-01 00:00:00

abstract：:Positive pressure ventilation with large VTs has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human interleukin-8. The mechanisms regulating ventilation-induced cytokine production are unclear. Based on our previous in vitro model of lung cel...

journal_title：American journal of respiratory and critical care medicine

authors： Li LF,Yu L,Quinn DA

更新日期：2004-02-15 00:00:00

abstract：:Isoniazid taken daily for 12 mo and isoniazid and rifampin taken daily for 4 mo are both recommended options for patients with radiographic evidence of previous tuberculosis and positive tuberculin skin tests who have not had prior treatment. We compared the completion rates, number of adverse effects, and cost effect...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Snyder DC,Chin DP,Hopewell PC,Cuthbert SS,Antonio Paz E,Daley CL

更新日期：2000-11-01 00:00:00

abstract：:This study was designed to evaluate the value and applicability of tidal breathing pattern analysis to assess airflow obstruction in young children. The time needed to reach maximal tidal expiratory flow (TME) divided by total expiratory time (TE) was measured in 228 healthy children 3 to 11 yr of age, 64 patients wit...

journal_title：American journal of respiratory and critical care medicine

authors： van der Ent CK,Brackel HJ,van der Laag J,Bogaard JM

更新日期：1996-04-01 00:00:00

abstract：:Colony-forming units of Mycobacterium tuberculosis in sputum were counted at 2-day intervals in 100 patients treated with 22 regimens of isoniazid, rifampin, pyrazinamide, ethambutol, or streptomycin, given alone or in combinations. The exponential fall in colony-forming units was measured by linear regression coeffic...

journal_title：American journal of respiratory and critical care medicine

authors： Jindani A,Doré CJ,Mitchison DA

更新日期：2003-05-15 00:00:00

abstract：RATIONALE:Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. OBJECTIVES:To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual...

journal_title：American journal of respiratory and critical care medicine

authors： Han MK,Tayob N,Murray S,Dransfield MT,Washko G,Scanlon PD,Criner GJ,Casaburi R,Connett J,Lazarus SC,Albert R,Woodruff P,Martinez FJ

更新日期：2014-06-15 00:00:00

abstract：UNLABELLED:Although local tissue activation of the endothelin (ET) system contributes to the development of pulmonary hypertension, the impact of isolated chronic plasma hyperendothelinemia on the pulmonary circulation is unknown. METHODS:Mini-osmotic pumps were implanted in rats to deliver ET-1 during 7 or 28 days. A...

journal_title：American journal of respiratory and critical care medicine

authors： Migneault A,Sauvageau S,Villeneuve L,Thorin E,Fournier A,Leblanc N,Dupuis J

更新日期：2005-03-01 00:00:00

abstract：RATIONALE:Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness. Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory ...

journal_title：American journal of respiratory and critical care medicine

authors： Rukhadze I,Fenik VB,Benincasa KE,Price A,Kubin L

更新日期：2010-11-15 00:00:00