Relaxation is impaired in the diaphragm muscle of the cardiomyopathic Syrian hamster.

abstract：OBJECTIVES:To assess the reliability and the minimal clinically important differences (MCID) for FVC% predicted in the Scleroderma Lung Study I and II. METHODS:Using data from SLS I and II (N=300), we evaluated the test-retest reliability for FVC% predicted (FVC%; screening vs. baseline) using intra-class correlation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kafaja S,Clements PJ,Wilhalme H,Tseng CH,Furst DE,Kim GH,Goldin J,Volkmann ER,Roth MD,Tashkin DP,Khanna D

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Studies in patients and experimental animals provide compelling evidence of the involvement of the major thrombin receptor, proteinase-activated receptor-1 (PAR(1)), and the potent chemokine, chemokine (CC motif) ligand-2 (CCL2)/monocyte chemotactic protein-1, in the pathogenesis of idiopathic pulmonary fibro...

journal_title：American journal of respiratory and critical care medicine

authors： Mercer PF,Johns RH,Scotton CJ,Krupiczojc MA,Königshoff M,Howell DC,McAnulty RJ,Das A,Thorley AJ,Tetley TD,Eickelberg O,Chambers RC

更新日期：2009-03-01 00:00:00

abstract：RATIONALE:Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment of pneumonia. OBJECTIVES:To elucidate clinical features of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), and to clarify risk factors for drug-resistant pathogens in patien...

journal_title：American journal of respiratory and critical care medicine

authors： Shindo Y,Ito R,Kobayashi D,Ando M,Ichikawa M,Shiraki A,Goto Y,Fukui Y,Iwaki M,Okumura J,Yamaguchi I,Yagi T,Tanikawa Y,Sugino Y,Shindoh J,Ogasawara T,Nomura F,Saka H,Yamamoto M,Taniguchi H,Suzuki R,Saito H,Kawa

更新日期：2013-10-15 00:00:00

abstract：:The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk factors and describe the complications of UEX. We followed 426 ventilated patients over a 2-mo period. C...

journal_title：American journal of respiratory and critical care medicine

authors： Boulain T

更新日期：1998-04-01 00:00:00

abstract：:Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in lung structure remains unknown.Objectives: To characterize associations between a genetic risk score (GRS) associated with COPD susceptibility...

journal_title：American journal of respiratory and critical care medicine

authors： Oelsner EC,Ortega VE,Smith BM,Nguyen JN,Manichaikul AW,Hoffman EA,Guo X,Taylor KD,Woodruff PG,Couper DJ,Hansel NN,Martinez FJ,Paine R 3rd,Han MK,Cooper C,Dransfield MT,Criner G,Krishnan JA,Bowler R,Bleecker ER,Pet

更新日期：2019-09-15 00:00:00

abstract：:Guidelines, protocols, and checklists (together called "protocols") can be immensely helpful in the clinical arena. However, clinicians and health care systems relying on protocols must assess whether benefits are being accrued, whether such "benefits" are real, and whether harm can be detected. These concerns are imp...

journal_title：American journal of respiratory and critical care medicine

authors： Kavanagh BP,Nurok M

更新日期：2016-01-01 00:00:00

abstract：:Diseases of the respiratory tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary ...

journal_title：American journal of respiratory and critical care medicine

authors： Opitz B,van Laak V,Eitel J,Suttorp N

更新日期：2010-06-15 00:00:00

abstract：:Snoring and sleeping apnea are reportedly associated with morbidity. We used home monitoring (MESAM IV) to measure snoring and sleep apnea in 294 men aged 40 to 65 yr from the volunteer register of the Busselton (Australia) Health Survey. In this group, 81% snored for more than 10% of the night and 22% for more than h...

journal_title：American journal of respiratory and critical care medicine

authors： Bearpark H,Elliott L,Grunstein R,Cullen S,Schneider H,Althaus W,Sullivan C

更新日期：1995-05-01 00:00:00

abstract：:Many patients with acute asthma do not respond adequately to currently accepted therapy, including oxygen, beta-agonists, and corticosteroids. Leukotriene receptor antagonists such as montelukast have demonstrated efficacy in chronic asthma, but their efficacy in acute asthma is unknown. In this randomized, double-bli...

journal_title：American journal of respiratory and critical care medicine

authors： Camargo CA Jr,Smithline HA,Malice MP,Green SA,Reiss TF

更新日期：2003-02-15 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：:The period covered by this update can be considered as the most exciting period in idiopathic pulmonary fibrosis (IPF) research. It started with the identification of genetic variants that are associated with IPF in the majority of patients and continued with discovery of molecular and genetic biomarkers that predict ...

journal_title：American journal of respiratory and critical care medicine

authors： Rosas IO,Kaminski N

更新日期：2015-02-01 00:00:00

abstract：:The role of nitric oxide (NO) in the host-defense against human tuberculosis (TB) is controversial. Although experimental evidence indicates that NO may play an important role in controlling TB, its expression in human tuberculous lungs has not been systematically characterized. We therefore investigated the expressio...

journal_title：American journal of respiratory and critical care medicine

authors： Choi HS,Rai PR,Chu HW,Cool C,Chan ED

更新日期：2002-07-15 00:00:00

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：:Morphologic changes in pulmonary muscular arteries may modify the mechanisms that regulate the pulmonary vascular tone and contribute to maintaining an adequate ventilation-perfusion (VA/Q) matching in patients with chronic obstructive pulmonary disease (COPD). To analyze the relationships between the abnormalities of...

journal_title：American journal of respiratory and critical care medicine

authors： Barberà JA,Riverola A,Roca J,Ramirez J,Wagner PD,Ros D,Wiggs BR,Rodriguez-Roisin R

更新日期：1994-02-01 00:00:00

abstract：:The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as part of an inflammatory response, may play a pivotal role in the development of BPD. A neutrophil chemokine, cytokine-induced...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Jankov RP,Belcastro R,Humes D,Copland I,Shek S,Sweezey NB,Post M,Albertine KH,Auten RL,Tanswell AK

更新日期：2004-12-01 00:00:00

abstract：:Isoniazid taken daily for 12 mo and isoniazid and rifampin taken daily for 4 mo are both recommended options for patients with radiographic evidence of previous tuberculosis and positive tuberculin skin tests who have not had prior treatment. We compared the completion rates, number of adverse effects, and cost effect...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Snyder DC,Chin DP,Hopewell PC,Cuthbert SS,Antonio Paz E,Daley CL

更新日期：2000-11-01 00:00:00

abstract：:We described here an original device for laser Doppler (LD) flowmetry measurements of gastric mucosal perfusion, which was used here in healthy volunteers. A modified nasogastric tube containing the LD probe was inserted. Aspiration via a catheter, fixed in parallel to the probe, held the probe against the gastric wal...

journal_title：American journal of respiratory and critical care medicine

authors： Duranteau J,Sitbon P,Vicaut E,Descorps-Declère A,Vigue B,Samii K

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Exploring prenatal factors influencing childhood wheeze may inform programming mechanisms. OBJECTIVES:We examined associations among prenatal maternal cortisol profiles, maternal obesity, and repeated wheeze up to age 2 years (n = 261). METHODS:Salivary cortisol was collected five times per day over 3 days ...

journal_title：American journal of respiratory and critical care medicine

authors： Wright RJ,Fisher K,Chiu YH,Wright RO,Fein R,Cohen S,Coull BA

更新日期：2013-06-01 00:00:00

abstract：:Stimulation of the airways of asthmatic individuals causes severe bronchoconstriction, which is in part neurally mediated via the vagus nerve. Local anesthetics are commonly administered to prevent this reflex-induced bronchoconstriction. Therefore, in a double-blind, placebo-controlled prospective study, we tested th...

journal_title：American journal of respiratory and critical care medicine

authors： Groeben H,Foster WM,Brown RH

更新日期：1996-10-01 00:00:00

abstract：:Genetic susceptibility to asthma is due to multiple genes that interact with each other and the environment. There are many known environmental influences, such as viral and other respiratory infections and exposure to allergens, air pollutants, and active or passive cigarette smoke (1). Genome-wide screens for asthma...

journal_title：American journal of respiratory and critical care medicine

authors： Bleecker ER,Postma DS,Meyers DA

更新日期：1997-10-01 00:00:00

abstract：:Not all asthma can be adequately controlled, despite the use of high-dose inhaled corticosteroids. Because cysteinyl-leukotrienes (Cys-LT) have been implicated in the pathogenesis of asthma, we hypothesized that the leukotriene receptor antagonist zafirlukast, in combination with high-doses of inhaled corticosteroids,...

journal_title：American journal of respiratory and critical care medicine

authors： Virchow JC Jr,Prasse A,Naya I,Summerton L,Harris A

更新日期：2000-08-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a condition in which continuous bronchodilation may have clinical advantages. This study evaluated salmeterol, a beta-agonist bronchodilator with a duration of action substantially longer than that of short-acting beta-agonists, compared with ipratropium, an anticholiner...

journal_title：American journal of respiratory and critical care medicine

authors： Rennard SI,Anderson W,ZuWallack R,Broughton J,Bailey W,Friedman M,Wisniewski M,Rickard K

更新日期：2001-04-01 00:00:00

abstract：:Pulmonary hypertension associated with congestive heart failure carries a risk of right ventricular failure after cardiac transplantation. Few data, however, are available on the hemodynamic behavior of the pulmonary circulation in these patients. We therefore studied mean pulmonary artery pressure minus left atrial p...

journal_title：American journal of respiratory and critical care medicine

authors： Naeije R,Lipski A,Abramowicz M,Lejeune P,Mélot C,Antoine M,De Smet JM,Leclerc JL,Primo G

更新日期：1994-04-01 00:00:00

abstract：:Previous study of adrenergic control of the tracheal vasculature in rats (1) demonstrated that beta-adrenergic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective alpha-adrenergic agonist. The present study was undertaken to confirm the presence of functional beta-a...

journal_title：American journal of respiratory and critical care medicine

authors： Corboz MR,Ballard ST,Inglis SK,Taylor AE

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:The determinants of immunoglobulin G (IgG) level and the risk of hypogammaglobulinemia (HGG) in patients with severe lung disease before and after lung transplantation are unknown. OBJECTIVES:We aimed to identify predictors of low IgG levels before and after lung transplantation. METHODS:We performed a retr...

journal_title：American journal of respiratory and critical care medicine

authors： Yip NH,Lederer DJ,Kawut SM,Wilt JS,D'Ovidio F,Wang Y,Dwyer E,Sonett JR,Arcasoy SM

更新日期：2006-04-15 00:00:00

abstract：RATIONALE:In clinical trials, patients with cystic fibrosis and a G551D mutation who received ivacaftor experienced improvements in pulmonary and nutritional outcomes. However, whether these improvements reflect a change in disease trajectory cannot be determined without longer-term analyses with an appropriate compara...

journal_title：American journal of respiratory and critical care medicine

authors： Sawicki GS,McKone EF,Pasta DJ,Millar SJ,Wagener JS,Johnson CA,Konstan MW

更新日期：2015-10-01 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：RATIONALE:Implementation of intervention strategies to prevent lung damage in early cystic fibrosis (CF) requires objective outcome measures that capture and track lung disease. OBJECTIVES:To define the utility of the Lung Clearance Index (LCI), measured by multiple breath washout, as a means to track disease progress...

journal_title：American journal of respiratory and critical care medicine

authors： Stanojevic S,Davis SD,Retsch-Bogart G,Webster H,Davis M,Johnson RC,Jensen R,Pizarro ME,Kane M,Clem CC,Schornick L,Subbarao P,Ratjen FA

更新日期：2017-05-01 00:00:00

abstract：:Many time series studies have found that individuals with primary cardiac conditions were susceptible to the adverse effects associated with increased ambient particle levels. However, the mechanism(s) of these associations is not yet understood. In this study, we evaluate whether individuals with nonrespiratory prima...

journal_title：American journal of respiratory and critical care medicine

authors： De Leon SF,Thurston GD,Ito K

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate. OBJECTIVES:Evaluate the accuracy of Doppler echocar...

journal_title：American journal of respiratory and critical care medicine

authors： Fisher MR,Forfia PR,Chamera E,Housten-Harris T,Champion HC,Girgis RE,Corretti MC,Hassoun PM

更新日期：2009-04-01 00:00:00