当前位置： SCI文献检索 > AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE期刊下所有文献 > Tracheal microvascular responses to beta-adrenergic stimulation in anesthetized rats.

Tracheal microvascular responses to beta-adrenergic stimulation in anesthetized rats.

Abstract：

:Previous study of adrenergic control of the tracheal vasculature in rats (1) demonstrated that beta-adrenergic blockade heightened arteriolar and large venular contractile responses to norepinephrine, a nonselective alpha-adrenergic agonist. The present study was undertaken to confirm the presence of functional beta-adrenergic receptors and to determine which beta-adrenergic receptor subtypes mediate vasodilation in this tissue. Tracheal adventitial arterioles (12.0 to 47.0 micro m initial diameter, n=39) and venules (48.0 to 98.5 micrometers initial diameter, n=44) were observed through a video microscope, and vessel diameters were measured. Vessels were preconstricted with 10(-4) M phenylephrine (PHE), a selective alpha 1-adrenergic agonist, to achieve sufficient tone for measurement of dilation responses. When vessels were treated only with PHE, arterioles and venules constricted to 55.9% and 67.6% of their initial diameter, respectively, after 15 min of suffusion. When preconstricted vessels were treated with the nonselective beta-adrenergic agonist isoproterenol (10(-5) M), both arterioles and venules significantly dilated from 63.4% to 82.9% and from 71.5% to 81.3% of their initial diameters. At high concentration (10(-5) M), the putative beta 2-adrenergic agonist terbutaline also caused preconstricted arterioles and venules to significantly dilate from 70.8% to 79.8% and from 71.5% to 83.4% of their initial diameters. The selective beta 1-adrenergic antagonist atenolol (10(-6) M) did not affect terbutaline-induced dilation in preconstricted arterioles, but greatly attenuated dilation in preconstricted venules. From these data, we conclude that beta 2-adrenergic receptors are present in and mediate dilation of tracheal arterioles, and also, that the dilation in large tracheal venules is mediated in large part through beta 1-adrenergic receptors.

journal_name

Am J Respir Crit Care Med

journal_title

American journal of respiratory and critical care medicine

authors

Corboz MR,Ballard ST,Inglis SK,Taylor AE

doi

10.1164/ajrccm.153.3.8630550

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

1093-7

issue

3

eissn

1073-449X

issn

1535-4970

journal_volume

153

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE文献大全
  • Linear dimensions of the upper airway structure during development: assessment by magnetic resonance imaging.

    abstract：:The upper airway undergoes progressive changes during childhood. Using magnetic resonance imaging (MRI), we studied the growth relationships of the tissues surrounding the upper airway (bone and soft tissues) in 92 normal children (47% males; range, 1 to 11 yr) who underwent brain MRI. None had symptoms of sleep-disor...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.165.1.2107140

    authors： Arens R,McDonough JM,Corbin AM,Hernandez ME,Maislin G,Schwab RJ,Pack AI

    更新日期：2002-01-01 00:00:00

  • Surfactant dysfunction makes lungs vulnerable to repetitive collapse and reexpansion.

    abstract：:Reexpansion of collapsed lung creates intrapulmonary shear forces. In an earlier study we showed that application of a negative end-expiratory airway pressure (NEEP) to normal rabbit lungs in vivo produced tidal collapse and reexpansion with transient changes in compliance and gas exchange but no histologic damage. In...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.155.1.9001330

    authors： Taskar V,John J,Evander E,Robertson B,Jonson B

    更新日期：1997-01-01 00:00:00

  • The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis.

    abstract：:Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the 2 days before and for 5 days of monotherapy. Bactericidal activi...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1164/rccm.200305-682OC

    authors： Gosling RD,Uiso LO,Sam NE,Bongard E,Kanduma EG,Nyindo M,Morris RW,Gillespie SH

    更新日期：2003-12-01 00:00:00

  • HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth.

    abstract：RATIONALE:Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described. OBJECTIVES:To determine the molecular mec...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201403-0463OC

    authors： Queisser MA,Dada LA,Deiss-Yehiely N,Angulo M,Zhou G,Kouri FM,Knab LM,Liu J,Stegh AH,DeCamp MM,Budinger GR,Chandel NS,Ciechanover A,Iwai K,Sznajder JI

    更新日期：2014-09-15 00:00:00

  • Tomographic study of the inflection points of the pressure-volume curve in acute lung injury.

    abstract：:The inflection points of the pressure-volume curve have been used for setting mechanical ventilation in patients with acute lung injury. However, the lung status at these points has never been specifically addressed. In 12 patients with early lung injury we traced both limbs of the pressure-volume curve by means of a ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200312-1644OC

    authors： Albaiceta GM,Taboada F,Parra D,Luyando LH,Calvo J,Menendez R,Otero J

    更新日期：2004-11-15 00:00:00

  • Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways.

    abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200409-1185OC

    authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

    更新日期：2005-11-01 00:00:00

  • Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.

    abstract：:Cell death is intertwined with life in development, homeostasis, pathology, and aging. Until recently, apoptosis was the best known form of programmed cell death, whereas necrosis was for a long time considered accidental owing to physicochemical injury. However, identification of crucial signaling and execution molec...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,评审

    doi：10.1164/rccm.201510-2106CI

    authors： Moreno-Gonzalez G,Vandenabeele P,Krysko DV

    更新日期：2016-08-15 00:00:00

  • Prognostic indicators for blood and marrow transplant patients admitted to an intensive care unit.

    abstract：:Although hematopoietic stem cell transplantation (HSCT) can be curative in patients with certain malignancies, survival is poor if the recipient becomes critically ill. This prospective study examined the outcomes of 115 consecutive HSCT patients admitted to the medical intensive care unit (MICU) of a tertiary cancer ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.158.3.9711076

    authors： Price KJ,Thall PF,Kish SK,Shannon VR,Andersson BS

    更新日期：1998-09-01 00:00:00

  • Lung function, bronchial responsiveness, and asthma in a community cohort of 6-year-old children.

    abstract：KEYWORDS:Children as young as 6 years old can perform spirometry, yet the relationship between current asthma, lung function, and bronchial responsiveness has not been described at this age; 2,537 children from a community-based birth cohort were assessed at 6 years of age, with history (n = 2,141), physical examinatio...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200304-556OC

    authors： Joseph-Bowen J,de Klerk NH,Firth MJ,Kendall GE,Holt PG,Sly PD

    更新日期：2004-04-01 00:00:00

  • Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging.

    abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1164/rccm.201310-1825OC

    authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

    更新日期：2014-03-15 00:00:00

  • Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies.

    abstract：RATIONALE:Air pollution is a known asthma trigger and has been associated with short-term asthma symptoms, airway inflammation, decreased lung function, and reduced response to asthma rescue medications. OBJECTIVES:To assess a causal relationship between air pollution and childhood asthma using data that address tempo...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究

    doi：10.1164/rccm.201302-0264OC

    authors： Nishimura KK,Galanter JM,Roth LA,Oh SS,Thakur N,Nguyen EA,Thyne S,Farber HJ,Serebrisky D,Kumar R,Brigino-Buenaventura E,Davis A,LeNoir MA,Meade K,Rodriguez-Cintron W,Avila PC,Borrell LN,Bibbins-Domingo K,Rodriguez-San

    更新日期：2013-08-01 00:00:00

  • Localization of Macrophages in the Human Lung via Design-based Stereology.

    abstract：:Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles in lung homeostasis and host defense, and are central to the pathogenesis of a number of lung diseases. However, the absolute numbers of macrophages and the precise anatomic locations they occupy in the healthy human lung have...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201911-2105OC

    authors： Hume PS,Gibbings SL,Jakubzick CV,Tuder RM,Curran-Everett D,Henson PM,Smith BJ,Janssen WJ

    更新日期：2020-05-15 00:00:00

  • Implications of extubation delay in brain-injured patients meeting standard weaning criteria.

    abstract：:We hypothesized that variation in extubating brain injured patients would affect the incidence of nosocomial pneumonia, length of stay, and hospital charges. In a prospective cohort of consecutive, intubated brain-injured patients, we evaluated daily: intubation status, spontaneous ventilatory parameters, gas exchange...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.161.5.9905102

    authors： Coplin WM,Pierson DJ,Cooley KD,Newell DW,Rubenfeld GD

    更新日期：2000-05-01 00:00:00

  • Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study.

    abstract：:Inhaled nitric oxide (NO) improves systemic oxygenation (PaO2/FIO2) in adult patients with acute respiratory distress syndrome (ARDS). However, individual response varies, and previous trials demonstrated no outcome benefit. This prospective, randomized study in 40 ARDS patients analyzed dose-response (DR) characteris...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1164/rccm.2108121

    authors： Gerlach H,Keh D,Semmerow A,Busch T,Lewandowski K,Pappert DM,Rossaint R,Falke KJ

    更新日期：2003-04-01 00:00:00

  • Linkage analysis of chromosome 12 markers in Italian families with atopic asthmatic children.

    abstract：:We investigated 116 Italian atopic families (560 individuals) for linkage with 13 DNA markers on chromosome 12. All the subjects were phenotyped for asthma, total serum IgE, bronchial hyperresponsiveness, skin-prick positivity to common aeroallergens, and atopy. A relative location map of the markers was prepared from...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.162.4.9909031

    authors： Malerba G,Lauciello MC,Scherpbier T,Trabetti E,Galavotti R,Cusin V,Pescollderungg L,Zanoni G,Martinati LC,Boner AL,Levitt RC,Pignatti PF

    更新日期：2000-10-01 00:00:00

  • Remotely Monitored Therapy and Nitric Oxide Suppression Identifies Nonadherence in Severe Asthma.

    abstract：RATIONALE:Poor adherence is common in difficult-to-control asthma. Distinguishing patients with difficult-to-control asthma who respond to inhaled corticosteroids (ICS) from refractory asthma is an important clinical challenge. OBJECTIVES:Suppression of fractional exhaled nitric oxide (FeNO) with directly observed ICS...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201806-1182OC

    authors： Heaney LG,Busby J,Bradding P,Chaudhuri R,Mansur AH,Niven R,Pavord ID,Lindsay JT,Costello RW,Medical Research Council UK Refractory Asthma Stratification Programme (RASP-UK).

    更新日期：2019-02-15 00:00:00

  • Pleural fluid chemical analysis in parapneumonic effusions. A meta-analysis.

    abstract：:Controversy exists regarding the clinical utility of pleural fluid pH, lactate dehydrogenase (LDH), and glucose for identifying complicated parapneumonic effusions that require drainage. In this report, we performed a meta-analysis of pertinent studies, using receiver operating characteristic (ROC) techniques, to asse...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,meta分析

    doi：10.1164/ajrccm.151.6.7767510

    authors： Heffner JE,Brown LK,Barbieri C,DeLeo JM

    更新日期：1995-06-01 00:00:00

  • Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma.

    abstract：RATIONALE:Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears to resolve by adolescence in nonatopic children. OBJECTIVES:To investigate whether among children with multitrigger wheeze responsive to bronchodilators...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200712-1818OC

    authors： Turato G,Barbato A,Baraldo S,Zanin ME,Bazzan E,Lokar-Oliani K,Calabrese F,Panizzolo C,Snijders D,Maestrelli P,Zuin R,Fabbri LM,Saetta M

    更新日期：2008-09-01 00:00:00

  • Dissociation of lung function changes with humoral immunity during inhaled human insulin therapy.

    abstract：RATIONALE:Inhaled human insulin (INH; Exubera [human insulin (recombinant DNA origin) Inhalation Powder]) causes small changes in pulmonary function and increases in insulin antibodies compared with subcutaneous (SC) insulin. OBJECTIVES:To investigate the relationship between changes in pulmonary function and insulin ...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1164/rccm.200512-1861OC

    authors： Teeter JG,Riese RJ

    更新日期：2006-06-01 00:00:00

  • Effects of allergen challenge on eosinophils, eosinophil cationic protein, and granulocyte-macrophage colony-stimulating factor in mild asthma.

    abstract：:Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challenge on cytokines regulating eosinophil function. We investigated allerg...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.151.6.7767540

    authors： Woolley KL,Adelroth E,Woolley MJ,Ellis R,Jordana M,O'Byrne PM

    更新日期：1995-06-01 00:00:00

  • Transcriptional potencies of inhaled glucocorticoids.

    abstract：:Glucocorticoids (GC) are the most effective anti-inflammatory drugs used in asthma. By a process called trans-activation, they increase the transcription of genes involved in either beneficial processes or certain side effects. Through trans-repression, they inhibit the transcription factors nuclear factor kappa B (NF...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.162.1.9901006

    authors： Jaffuel D,Demoly P,Gougat C,Balaguer P,Mautino G,Godard P,Bousquet J,Mathieu M

    更新日期：2000-07-01 00:00:00

  • Mite and cat allergen levels in homes and severity of asthma.

    abstract：:The relationships between mite and cat allergen levels in the home, skin test reactivity, and severity of asthma were explored in 120 asthmatic subjects, 57 in Vancouver and 63 in Winnipeg. Patients in the two cities were similar in age, gender distribution, and severity of asthma. Skin tests were performed using 13 c...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.152.6.8520740

    authors： Chan-Yeung M,Manfreda J,Dimich-Ward H,Lam J,Ferguson A,Warren P,Simons E,Broder I,Chapman M,Platts-Mills T

    更新日期：1995-12-01 00:00:00

  • Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial.

    abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP). OBJECTIVES:To establish the role of intermittent hypoxia in the increased morning BP in patient...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1164/rccm.201802-0240OC

    authors： Turnbull CD,Sen D,Kohler M,Petousi N,Stradling JR

    更新日期：2019-01-15 00:00:00

  • Ethnic- and sex-free formulae for detection of airway obstruction.

    abstract：RATIONALE:Spirometric detection of airway obstruction in adults requires separate predictive formulae for each ethnicity and sex for percentage of FEV(1)/FVC (%FEV(1)/FVC) and percentage of FEV(3)/FVC (%FEV(3)/FVC), the major measurements for defining airway obstruction. OBJECTIVES:To eliminate the need for multiple f...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200604-517OC

    authors： Hansen JE,Sun XG,Wasserman K

    更新日期：2006-09-01 00:00:00

  • Children's urinary phthalate metabolites and fractional exhaled nitric oxide in an urban cohort.

    abstract：RATIONALE:Phthalates are used widely in consumer products. Exposure to several phthalates has been associated with respiratory symptoms and decreased lung function. Associations between children's phthalate exposures and fractional exhaled nitric oxide (Fe(NO)), a biomarker of airway inflammation, have not been examine...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.201203-0398OC

    authors： Just AC,Whyatt RM,Miller RL,Rundle AG,Chen Q,Calafat AM,Divjan A,Rosa MJ,Zhang H,Perera FP,Goldstein IF,Perzanowski MS

    更新日期：2012-11-01 00:00:00

  • Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study.

    abstract：RATIONALE:Severe asthma is a major public health issue throughout the world. Increased bronchial smooth muscle (BSM) mass, a characteristic feature of airway remodeling in severe asthma, is associated with resistance to high-intensity treatment and poor prognosis. In vitro, the Ca(2+)-channel blocker gallopamil decreas...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章,随机对照试验

    doi：10.1164/rccm.201410-1874OC

    authors： Girodet PO,Dournes G,Thumerel M,Begueret H,Dos Santos P,Ozier A,Dupin I,Trian T,Montaudon M,Laurent F,Marthan R,Berger P

    更新日期：2015-04-15 00:00:00

  • Ultrasonic examination: an alternative to chest radiography after central venous catheter insertion?

    abstract：:We evaluated ultrasonic examination as a diagnostic tool for catheter misplacement and pneumothorax after central venous catheter insertion. Physicians in the intensive care unit (ICU) performed the ultrasonic examinations, and the results were compared with those of chest radiography. Eighty-five central venous cathe...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.164.3.2009042

    authors： Maury E,Guglielminotti J,Alzieu M,Guidet B,Offenstadt G

    更新日期：2001-08-01 00:00:00

  • Sleep-related breathing disorder is an independent risk factor for systemic hypertension.

    abstract：:The exact influence of sleep-related breathing disorder (SRBD) on blood pressure control remains unknown. We investigated the influence of different degrees of SRBD on daytime blood pressure and its association to documented hypertension by examining 1,190 consecutive patients referred for diagnosis of SRBD. The proto...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/ajrccm.160.6.9811054

    authors： Grote L,Ploch T,Heitmann J,Knaack L,Penzel T,Peter JH

    更新日期：1999-12-01 00:00:00

  • Isoniazid-associated hepatitis and antiretroviral drugs during tuberculosis prophylaxis in hiv-infected adults in Botswana.

    abstract：RATIONALE:Little is known about the incidence of isoniazid-associated hepatitis in HIV-infected Africans who receive both isoniazid preventive therapy (IPT) and antiretroviral therapy (ART). OBJECTIVES:To assess the rate of and risk factors for isoniazid (INH)-associated hepatitis in persons living with HIV (PLWH) dur...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 临床试验,杂志文章

    doi：10.1164/rccm.200911-1783OC

    authors： Tedla Z,Nyirenda S,Peeler C,Agizew T,Sibanda T,Motsamai O,Vernon A,Wells CD,Samandari T

    更新日期：2010-07-15 00:00:00

  • The number of alveoli in the human lung.

    abstract：:The number of alveoli is a key structural determinant of lung architecture. A design-based stereologic approach was used for the direct and unbiased estimation of alveolar number in the human lung. The principle is based on two-dimensional topology in three-dimensional space and is free of assumptions on the shape, si...

    journal_title：American journal of respiratory and critical care medicine

    pub_type： 杂志文章

    doi：10.1164/rccm.200308-1107OC

    authors： Ochs M,Nyengaard JR,Jung A,Knudsen L,Voigt M,Wahlers T,Richter J,Gundersen HJ

    更新日期：2004-01-01 00:00:00