Dissociation of lung function changes with humoral immunity during inhaled human insulin therapy.

abstract：:The involvement of platelet-activating factor (PAF) in bronchial hyperresponsiveness (BHR) in bronchial asthma has been controversial. To determine whether PAF is involved in BHR in humans, we carried out a randomized, double-blind, placebo-controlled, two-phase cross-over study on the effects of Y-24180, a potent, sp...

journal_title：American journal of respiratory and critical care medicine

authors： Hozawa S,Haruta Y,Ishioka S,Yamakido M

更新日期：1995-10-01 00:00:00

abstract：:The interleukin-1 cluster on human chromosome 2q12-2q14 harbors various promising candidate genes for asthma and other inflammatory diseases. We conducted a systematic association study with single-nucleotide polymorphisms (SNPs) located in candidate genes situated in this cluster. Single-marker, two-locus and three-l...

journal_title：American journal of respiratory and critical care medicine

authors： Gohlke H,Illig T,Bahnweg M,Klopp N,André E,Altmüller J,Herbon N,Werner M,Knapp M,Pescollderungg L,Boner A,Malerba G,Pignatti PF,Wjst M

更新日期：2004-06-01 00:00:00

abstract：:Asthma is a common chronic disease without cure. Our understanding of asthma onset, pathobiology, classification, and management has evolved substantially over the past decade; however, significant asthma-related morbidity and excess healthcare use and costs persist. To address this important clinical condition, the N...

journal_title：American journal of respiratory and critical care medicine

authors： Levy BD,Noel PJ,Freemer MM,Cloutier MM,Georas SN,Jarjour NN,Ober C,Woodruff PG,Barnes KC,Bender BG,Camargo CA Jr,Chupp GL,Denlinger LC,Fahy JV,Fitzpatrick AM,Fuhlbrigge A,Gaston BM,Hartert TV,Kolls JK,Lynch SV,Moo

更新日期：2015-12-01 00:00:00

abstract：:During exercise, children with congenital central hypoventilation syndrome (CCHS) demonstrate coupling of VE to exercise load, despite the absence of a VE response to changes in FICO2. To assess the effect of movement on VE, we studied six CCHS patients and six matched controls during passive motion in a motor-driven ...

journal_title：American journal of respiratory and critical care medicine

authors： Gozal D,Marcus CL,Ward SL,Keens TG

更新日期：1996-02-01 00:00:00

abstract：:Cigarette smoking causes the development of chronic bronchitis and chronic obstructive pulmonary disease. We hypothesized that exposure to cigarette smoke might initiate release of inflammatory mediators by bronchial epithelial cells. To evaluate this, the effect of cigarette smoke extract (CSE) on IL-8 release from c...

journal_title：American journal of respiratory and critical care medicine

authors： Mio T,Romberger DJ,Thompson AB,Robbins RA,Heires A,Rennard SI

更新日期：1997-05-01 00:00:00

abstract：:Nebulized aerosols are commonly used to deliver drugs into the lungs of patients with cystic fibrosis (CF). The aim of this study was to assess the effectiveness of pressure-support (PS) ventilation in increasing aerosol deposition within the lungs of children with CF. An in vitro study demonstrated the feasibility of...

journal_title：American journal of respiratory and critical care medicine

authors： Fauroux B,Itti E,Pigeot J,Isabey D,Meignan M,Ferry G,Lofaso F,Willemot JM,Clément A,Harf A

更新日期：2000-12-01 00:00:00

abstract：:Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy. To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in a double-blind crosso...

journal_title：American journal of respiratory and critical care medicine

authors： Keh D,Boehnke T,Weber-Cartens S,Schulz C,Ahlers O,Bercker S,Volk HD,Doecke WD,Falke KJ,Gerlach H

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Current classification of pulmonary hypertension (PH) is based on a relatively simple combination of patient characteristics and hemodynamics. This limits customization of treatment, and lacks the clarity of a more granular identification based on individual patient phenotypes. Rapid advances in mechanistic ...

journal_title：American journal of respiratory and critical care medicine

authors： Dweik RA,Rounds S,Erzurum SC,Archer S,Fagan K,Hassoun PM,Hill NS,Humbert M,Kawut SM,Krowka M,Michelakis E,Morrell NW,Stenmark K,Tuder RM,Newman J,ATS Committee on Pulmonary Hypertension Phenotypes.

更新日期：2014-02-01 00:00:00

abstract：:In a previous study of older pulp and paper workers in Berlin, New Hampshire, decrements in spirometry results associated with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mill exposure and cigarette smoking. Many of those subjects were older and retired. A new study was ...

journal_title：American journal of respiratory and critical care medicine

authors： Henneberger PK,Lax MB,Ferris BG Jr

更新日期：1996-01-01 00:00:00

abstract：:The mechanism responsible for diminished exercise performance in cystic fibrosis (CF) is not clear. We hypothesized that reduced muscle size, rather than an intrinsic muscle defect, was the primary factor in such diminished exercise performance. Twenty-two subjects with CF (14 females and eight males, aged 6.5 to 17.7...

journal_title：American journal of respiratory and critical care medicine

authors： Moser C,Tirakitsoontorn P,Nussbaum E,Newcomb R,Cooper DM

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation. OBJECTIVES:We hypothesized tha...

journal_title：American journal of respiratory and critical care medicine

authors： Terragni PP,Rosboch G,Tealdi A,Corno E,Menaldo E,Davini O,Gandini G,Herrmann P,Mascia L,Quintel M,Slutsky AS,Gattinoni L,Ranieri VM

更新日期：2007-01-15 00:00:00

abstract：RATIONALE:Mast cells have important roles in innate immunity and tissue remodeling but have remained poorly studied in inflammatory airway diseases like chronic obstructive pulmonary disease (COPD). OBJECTIVES:To perform a detailed histological characterization of human lung mast cell populations at different severiti...

journal_title：American journal of respiratory and critical care medicine

authors： Andersson CK,Mori M,Bjermer L,Löfdahl CG,Erjefält JS

更新日期：2010-02-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immun...

journal_title：American journal of respiratory and critical care medicine

authors： DeVincenzo JP,Wilkinson T,Vaishnaw A,Cehelsky J,Meyers R,Nochur S,Harrison L,Meeking P,Mann A,Moane E,Oxford J,Pareek R,Moore R,Walsh E,Studholme R,Dorsett P,Alvarez R,Lambkin-Williams R

更新日期：2010-11-15 00:00:00

abstract：:Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are important for disease pathogenesis. Objectives: To determine whether s...

journal_title：American journal of respiratory and critical care medicine

authors： Reyfman PA,Walter JM,Joshi N,Anekalla KR,McQuattie-Pimentel AC,Chiu S,Fernandez R,Akbarpour M,Chen CI,Ren Z,Verma R,Abdala-Valencia H,Nam K,Chi M,Han S,Gonzalez-Gonzalez FJ,Soberanes S,Watanabe S,Williams KJN,Flozak

更新日期：2019-06-15 00:00:00

abstract：:The severity of breathlessness at given degrees of airway obstruction varies between patients with asthma. It has been postulated that the symptoms during bronchoconstriction are determined in part by involvement of airway inflammation. We compared the severity of breathlessness at various degrees of acute airway obst...

journal_title：American journal of respiratory and critical care medicine

authors： Sont JK,Booms P,Bel EH,Vandenbroucke JP,Sterk PJ

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：RATIONALE:FVC has emerged as a standard primary endpoint in clinical trials evaluating novel therapies for patients with idiopathic pulmonary fibrosis (IPF). However, it has recently been proposed that all-cause mortality or a composite comprised of all-cause mortality and all-cause nonelective hospitalization be adopt...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr,Albera C,Bradford WZ,Costabel U,du Bois RM,Leff JA,Nathan SD,Sahn SA,Valeyre D,Noble PW

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Tissue resident memory T cells play a critical role in the defense against inhaled pathogens. The isolation and study of human lung tissue resident memory T cells and lung resident macrophages is limited by experimental constraints. OBJECTIVES:To characterize the spatial and functional relationship between l...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder ME,Sembrat J,Noda K,Myerburg MM,Craig A,Mitash N,Harano T,Furukawa M,Pilewski J,McDyer J,Rojas M,Sanchez P

更新日期：2020-12-11 00:00:00

abstract：:Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the 2 days before and for 5 days of monotherapy. Bactericidal activi...

journal_title：American journal of respiratory and critical care medicine

authors： Gosling RD,Uiso LO,Sam NE,Bongard E,Kanduma EG,Nyindo M,Morris RW,Gillespie SH

更新日期：2003-12-01 00:00:00

abstract：:The lobar and cephalocaudal distribution of aerated and nonaerated lung and of PEEP-induced alveolar recruitment is unknown in acute lung injury (ALI). Dimensions of the lungs and volumes of aerated and nonaerated parts of each pulmonary lobe were measured using a computerized tomographic quantitative analysis and com...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Cluzel P,Chao N,Slutsky AS,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Epithelial-mesenchymal transition (EMT) plays a key role in the development of chronic obstructive pulmonary disease (COPD) and lung cancer. OBJECTIVES:There are five major EMT regulatory genes (Snai1, Slug, Zeb1, Zeb2, and Twist1) involved in EMT. We hypothesized that germline variants in these genes may in...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Yang X,Ji W,Deng J,Qiu F,Yang R,Fang W,Zhang L,Huang D,Xie C,Zhang H,Zhong N,Ran P,Zhou Y,Lu J

更新日期：2014-01-15 00:00:00

abstract：:Lung transplantation with its attendant life-long immunosuppression contributes to bone loss and its sequelae, fractures and kyphosis, in patients with lung disease, many of whom already suffer from severe osteoporosis. Patients with cystic fibrosis (CF) are one of the most severely affected groups. We conducted a con...

journal_title：American journal of respiratory and critical care medicine

authors： Aris RM,Lester GE,Renner JB,Winders A,Denene Blackwood A,Lark RK,Ontjes DA

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:T-bet (TBX21 or T-box 21) is a critical regulator of T-helper 1 lineage commitment and IFN-gamma production. Knockout mice lacking T-bet develop airway hyperresponsiveness (AHR) to methacholine, peribronchial eosinophilic and lymphocytic inflammation, and increased type III collagen deposition below the bronc...

journal_title：American journal of respiratory and critical care medicine

authors： Raby BA,Hwang ES,Van Steen K,Tantisira K,Peng S,Litonjua A,Lazarus R,Giallourakis C,Rioux JD,Sparrow D,Silverman EK,Glimcher LH,Weiss ST

更新日期：2006-01-01 00:00:00

abstract：:To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess the effects of the combination of positive end-expiratory pressure (PEEP) and pressure-support ventilation (PSV) on inspiratory muscle effort, we investigated respiratory mechanic...

journal_title：American journal of respiratory and critical care medicine

authors： Appendini L,Purro A,Patessio A,Zanaboni S,Carone M,Spada E,Donner CF,Rossi A

更新日期：1996-11-01 00:00:00

abstract：:The place of surgical treatment in obstructive sleep apnea syndrome (OSAS) remains unclear. Uvulopalatopharyngoplasty (UPPP) has a response rate of 41% overall and only 5% when retrolingual narrowing is present. Thus, in cases with suspected hypopharyngeal collapse maxillofacial surgery has been proposed with improved...

journal_title：American journal of respiratory and critical care medicine

authors： Bettega G,Pépin JL,Veale D,Deschaux C,Raphaël B,Lévy P

更新日期：2000-08-01 00:00:00

abstract：RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...

journal_title：American journal of respiratory and critical care medicine

authors： Walker NM,Badri LN,Wadhwa A,Wettlaufer S,Peters-Golden M,Lama VN

更新日期：2012-01-01 00:00:00

abstract：:Although abnormalities of alveolar fibrin turnover have been reported to play a role in the development of idiopathic pulmonary fibrosis (IPF), the pathophysiological relevance remains unclear. We therefore investigated the localization of tissue factor (TF) and fibrin deposition in patients with IPF using immunohisto...

journal_title：American journal of respiratory and critical care medicine

authors： Imokawa S,Sato A,Hayakawa H,Kotani M,Urano T,Takada A

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:The effect of indoor air pollutants on respiratory morbidity among patients with chronic obstructive pulmonary disease (COPD) in developed countries is uncertain. OBJECTIVES:The first longitudinal study to investigate the independent effects of indoor particulate matter (PM) and nitrogen dioxide (NO(2)) conc...

journal_title：American journal of respiratory and critical care medicine

authors： Hansel NN,McCormack MC,Belli AJ,Matsui EC,Peng RD,Aloe C,Paulin L,Williams DL,Diette GB,Breysse PN

更新日期：2013-05-15 00:00:00

abstract：:The effects of conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFO) on intraalveolar expression of the tumor necrosis factor-alpha (TNF-alpha) gene were studied in surfactant-depleted rabbits. After lung lavage with saline, 13 rabbits were administered either CMV (n = 6) or HFO (n...

journal_title：American journal of respiratory and critical care medicine

authors： Takata M,Abe J,Tanaka H,Kitano Y,Doi S,Kohsaka T,Miyasaka K

更新日期：1997-07-01 00:00:00

abstract：:Keratinocyte growth factor (KGF) induces transient proliferation of alveolar type II cells (AEII) associated with surfactant alterations. To test the hypothesis that homeostasis of intracellular phospholipid stores is maintained under KGF-induced hyperplasia, we (1) collected tissue from adult rat lungs, fixed for lig...

journal_title：American journal of respiratory and critical care medicine

authors： Fehrenbach A,Bube C,Hohlfeld JM,Stevens P,Tschernig T,Hoymann HG,Krug N,Fehrenbach H

更新日期：2003-05-01 00:00:00