Abstract:
:Cigarette smoking causes the development of chronic bronchitis and chronic obstructive pulmonary disease. We hypothesized that exposure to cigarette smoke might initiate release of inflammatory mediators by bronchial epithelial cells. To evaluate this, the effect of cigarette smoke extract (CSE) on IL-8 release from cultured human bronchial epithelial cells was examined. CSE augmented IL-8 release from bronchial epithelial cells in a concentration- and time-dependent manner. Most of the augmenting activity of CSE on IL-8 release from bronchial epithelial cells was lost after volatilization or lyophilization treatment. Two major volatile factors in cigarette smoke, acrolein and acetaldehyde, augmented IL-8 release. Four cell strains were tested and showed increased IL-8 release in response to CSE. In addition, bronchoalveolar lavage was performed on 11 nonsmokers and 12 smokers. IL-8 concentration was greater in the proximal, bronchial samples than in distal, alveolar samples, and IL-8 in BAL from smokers was higher than in BAL from nonsmokers. There was a significant correlation between IL-8 concentration and neutrophil count in bronchial samples of BAL fluid. These data support the hypothesis that exposure to cigarette smoke may induce bronchial epithelial cells to release IL-8 and that this may contribute to airway inflammation in smokers.
journal_name
Am J Respir Crit Care Medauthors
Mio T,Romberger DJ,Thompson AB,Robbins RA,Heires A,Rennard SIdoi
10.1164/ajrccm.155.5.9154890subject
Has Abstractpub_date
1997-05-01 00:00:00pages
1770-6issue
5eissn
1073-449Xissn
1535-4970journal_volume
155pub_type
杂志文章abstract::We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...
journal_title:American journal of respiratory and critical care medicine
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journal_title:American journal of respiratory and critical care medicine
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pub_type: 临床试验,杂志文章
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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更新日期:2014-12-15 00:00:00
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更新日期:2019-09-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-07-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2014-08-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2003-02-15 00:00:00
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更新日期:2011-04-01 00:00:00
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更新日期:2008-03-15 00:00:00
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更新日期:2009-11-15 00:00:00
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更新日期:1995-12-01 00:00:00
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更新日期:2014-08-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-08-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-08-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-10-15 00:00:00