House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T cells.

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:A noninvasive means of detecting airway secretions in ventilator-dependent patients is desirable because endotracheal suctioning can result in life-threatening complications. In a patient who had copious secretions, we observed a sawtooth pattern on his flow-volume curve that disappeared after suctioning. Accordingly,...

journal_title：American journal of respiratory and critical care medicine

authors： Jubran A,Tobin MJ

更新日期：1994-09-01 00:00:00

abstract：:Nanoparticle-based drug delivery systems have considerable potential for treatment of tuberculosis (TB). The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility ...

journal_title：American journal of respiratory and critical care medicine

authors： Gelperina S,Kisich K,Iseman MD,Heifets L

更新日期：2005-12-15 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES:To determine whether continuous positive airway pressure (CPAP) added to trea...

journal_title：American journal of respiratory and critical care medicine

authors： Thunström E,Manhem K,Rosengren A,Peker Y

更新日期：2016-02-01 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:We evaluated ultrasonic examination as a diagnostic tool for catheter misplacement and pneumothorax after central venous catheter insertion. Physicians in the intensive care unit (ICU) performed the ultrasonic examinations, and the results were compared with those of chest radiography. Eighty-five central venous cathe...

journal_title：American journal of respiratory and critical care medicine

authors： Maury E,Guglielminotti J,Alzieu M,Guidet B,Offenstadt G

更新日期：2001-08-01 00:00:00

abstract：:To elucidate which cells are synthesizing tenascin in usual interstitial pneumonia (UIP) we have analyzed thoracoscopic or open lung biopsies from 30 patients with UIP by mRNA in situ hybridization, using (35)S-labeled tenascin RNA probes. The phenotype of the cells expressing tenascin mRNA was confirmed by immunohist...

journal_title：American journal of respiratory and critical care medicine

authors： Pääkkö P,Kaarteenaho-Wiik R,Pöllänen R,Soini Y

更新日期：2000-03-01 00:00:00

abstract：:The gas exchange threshold (GET) has been used an an index of anaerobic threshold because it can be measured noninvasively. GET is estimated from a breakpoint in breath by breath values of carbon dioxide uptake (Vco2) and oxygen uptake (Vo2) obtained during a progressive exercise test. Three methods of estimating GET ...

journal_title：American journal of respiratory and critical care medicine

authors： Magalang UJ,Grant BJ

更新日期：1995-01-01 00:00:00

abstract：:To determine the usefulness of positron emission tomography with fluoro-2-deoxyglucose (PET-FDG) in assessing mediastinal disease in patients with non-small-cell lung cancer (NSCLC) and to compare its yield to that of computed tomography (CT), we performed a prospective consecutive sample investigation in a university...

journal_title：American journal of respiratory and critical care medicine

authors： Chin R Jr,Ward R,Keyes JW,Choplin RH,Reed JC,Wallenhaupt S,Hudspeth AS,Haponik EF

更新日期：1995-12-01 00:00:00

abstract：:Preeclampsia is the predominant cause of admissions to neonatal intensive care. The diurnal blood pressure pattern is flattened or reversed in preeclampsia. We hypothesized that snoring and partial upper airway obstruction contribute to nocturnal rises in blood pressure. We tested this hypothesis by controlling sleep-...

journal_title：American journal of respiratory and critical care medicine

authors： Edwards N,Blyton DM,Kirjavainen T,Kesby GJ,Sullivan CE

更新日期：2000-07-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease that persists even during adequate therapy and asymptomatic episodes. We questioned whether "silent" chronic allergen exposure can induce and maintain airway inflammation and whether this still occurs during regular treatment with inhaled steroids. Twenty-six patients with hous...

journal_title：American journal of respiratory and critical care medicine

authors： de Kluijver J,Evertse CE,Schrumpf JA,van der Veen H,Zwinderman AH,Hiemstra PS,Rabe KF,Sterk PJ

更新日期：2002-08-01 00:00:00

abstract：:We have undertaken this retrospective study to determine factors associated with in-hospital mortality and morbidity in 80 adult patients with severe Streptococcus pneumoniae meningitis. Clinical characteristics at admission of patients infected with susceptible (n = 54) and nonsusceptible (n = 17) strains to penicill...

journal_title：American journal of respiratory and critical care medicine

authors： Auburtin M,Porcher R,Bruneel F,Scanvic A,Trouillet JL,Bédos JP,Régnier B,Wolff M

更新日期：2002-03-01 00:00:00

abstract：RATIONALE:The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF. OBJECTIVES:To understand the gene expression patterns of acute exacerbations of IPF. METHODS:RNA was extracted ...

journal_title：American journal of respiratory and critical care medicine

authors： Konishi K,Gibson KF,Lindell KO,Richards TJ,Zhang Y,Dhir R,Bisceglia M,Gilbert S,Yousem SA,Song JW,Kim DS,Kaminski N

更新日期：2009-07-15 00:00:00

abstract：:The six-minute walk test is a submaximal exercise test that can be performed even by a patient with heart failure not tolerating maximal exercise testing. To elucidate the clinical significance and prognostic value of the six-minute walk test in patients with primary pulmonary hypertension (PPH), we sought (1) to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Miyamoto S,Nagaya N,Satoh T,Kyotani S,Sakamaki F,Fujita M,Nakanishi N,Miyatake K

更新日期：2000-02-01 00:00:00

abstract：RATIONALE:Neutrophils are usually the first circulating leukocytes to respond during bacterial pneumonia. Their expression of oxidants, proteases, and other mediators present in granules is well documented, but their ability to produce mediators through transcription and translation after migration to an inflammatory s...

journal_title：American journal of respiratory and critical care medicine

authors： Yamada M,Gomez JC,Chugh PE,Lowell CA,Dinauer MC,Dittmer DP,Doerschuk CM

更新日期：2011-05-15 00:00:00

abstract：:Airway obstruction (AO) in exercise-induced asthma (EIA) is considered a postexercise phenomenon. However, many with EIA complain of respiratory distress during exercise. We evaluated AO in six asthmatic subjects during a short (SX = 6 min) and a long (LX = 20 min) exercise session. We measured peak expiratory flow (P...

journal_title：American journal of respiratory and critical care medicine

authors： Suman OE,Babcock MA,Pegelow DF,Jarjour NN,Reddan WG

更新日期：1995-07-01 00:00:00

abstract：:Bronchial overproduction of leukotrienes and inhibition of prostaglandin synthesis are involved in the pathogenesis of aspirin-induced asthma. We investigated whether inhaled prostaglandin E2 (PGE2) attenuates the response to bronchial challenge with lysine acetylsalicylate (LASA) and the associated increase in urinar...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Armetti L,Gambaro G,Pieroni MG,Refini RM,Sala A,Vaghi A,Folco GC,Bianco S,Robuschi M

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:There is growing evidence that alveolar cell apoptosis plays an important role in emphysema pathogenesis, a chronic inflammatory lung disease characterized by alveolar destruction. The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antipr...

journal_title：American journal of respiratory and critical care medicine

authors： Petrache I,Fijalkowska I,Zhen L,Medler TR,Brown E,Cruz P,Choe KH,Taraseviciene-Stewart L,Scerbavicius R,Shapiro L,Zhang B,Song S,Hicklin D,Voelkel NF,Flotte T,Tuder RM

更新日期：2006-06-01 00:00:00

abstract：:A protective role for dietary antioxidants in asthma has been proposed. However, epidemiological evidence to implicate antioxidant vitamins is weak, and data on the role of flavonoid-rich foods and antioxidant trace elements are lacking. We carried out a population-based case-control study in South London, UK, to inve...

journal_title：American journal of respiratory and critical care medicine

authors： Shaheen SO,Sterne JA,Thompson RL,Songhurst CE,Margetts BM,Burney PG

更新日期：2001-11-15 00:00:00

abstract：:In a prospective study, we screened specimens from 190 mechanically ventilated patients hospitalized in a surgical intensive care unit, and from the environment to assess risks and routes of colonization/infection. Specimens from various sites were collected on admission and once a week throughout each patient's stay....

journal_title：American journal of respiratory and critical care medicine

authors： Talon D,Mulin B,Rouget C,Bailly P,Thouverez M,Viel JF

更新日期：1998-03-01 00:00:00

abstract：:Previous studies suggest that lung function tests using monodisperse aerosols can help to identify early stages of lung diseases. We investigated intrapulmonary particle loss and aerosol bolus dispersion-a marker of convective gas transport-in 32 women with asymptomatic nonspecific bronchial hyperresponsiveness (BHR) ...

journal_title：American journal of respiratory and critical care medicine

authors： Kohlhäufl M,Brand P,Scheuch G,Meyer TS,Schulz H,Häussinger K,Heyder J

更新日期：1999-03-01 00:00:00

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：RATIONALE:Neutrophils are key players in chronic obstructive pulmonary disease (COPD), and increased numbers of neutrophils are present in sputum and lung tissue of patients with COPD. Interestingly, immunoglobulin free light chains (IgLC) are able to prolong the life of neutrophils; therefore, IgLC may contribute to t...

journal_title：American journal of respiratory and critical care medicine

authors： Braber S,Thio M,Blokhuis BR,Henricks PA,Koelink PJ,Groot Kormelink T,Bezemer GF,Kerstjens HA,Postma DS,Garssen J,Kraneveld AD,Redegeld FA,Folkerts G

更新日期：2012-04-15 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：:If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin...

journal_title：American journal of respiratory and critical care medicine

authors： Clements NC Jr,Habib MP

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:High-dose isoniazid is recommended in short-course regimens for multidrug-resistant TB (MDR-TB). The optimal dose of isoniazid and its individual contribution to efficacy against TB strains with inhA or katG mutations are unknown. OBJECTIVE:Define the optimal dose of isoniazid for patients with isoniazid-res...

journal_title：American journal of respiratory and critical care medicine

authors： Dooley KE,Miyahara S,von Groote-Bidlingmaier F,Sun X,Hafner R,Rosenkranz SL,Ignatius EH,Nuermberger EL,Moran L,Donahue K,Swindells S,Vanker N,Diacon AH,A5312 Study Team.

更新日期：2020-01-16 00:00:00

abstract：:Burkholderia gladioli has been reported as colonizing the airways of patients with cystic fibrosis (CF) but has not previously been associated with adverse outcome. We describe six patients with CF in whom the same strain of B. gladioli, on the basis of ribotyping and biochemical characteristics, was grown in their sp...

journal_title：American journal of respiratory and critical care medicine

authors： Wilsher ML,Kolbe J,Morris AJ,Welch DF

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:Mast cells have important roles in innate immunity and tissue remodeling but have remained poorly studied in inflammatory airway diseases like chronic obstructive pulmonary disease (COPD). OBJECTIVES:To perform a detailed histological characterization of human lung mast cell populations at different severiti...

journal_title：American journal of respiratory and critical care medicine

authors： Andersson CK,Mori M,Bjermer L,Löfdahl CG,Erjefält JS

更新日期：2010-02-01 00:00:00

abstract：:Endothelins (ET-1, ET-2, ET-3) are potent bronchoconstrictors and growth-promoting mediators. They are released from various cells such as endothelial and epithelial cells. In the airways, ETs are released under basal and stimulated conditions. In patients with status asthmaticus and other pulmonary disorders, the exp...

journal_title：American journal of respiratory and critical care medicine

authors： Yang Q,Battistini B,D'Orléans-Juste P,Jeng AY,Sirois P

更新日期：1997-06-01 00:00:00