The early pattern of conjugated dienes in liver and lung after endotoxin exposure.

abstract：:Patients with impaired pulmonary function are at increased risk for the development of postoperative complications. Recently exercise testing and predicted postoperative (ppo) function have gained increasing importance in the evaluation of lung resection candidates. We prospectively evaluated an algorithm for the preo...

journal_title：American journal of respiratory and critical care medicine

authors： Wyser C,Stulz P,Solèr M,Tamm M,Müller-Brand J,Habicht J,Perruchoud AP,Bolliger CT

更新日期：1999-05-01 00:00:00

abstract：:We developed a bronchial provocation test (BPT) with a dry powder preparation of mannitol. The mannitol was inhaled from gelatin capsules containing 5, 10, 20, or 40 mg to a cumulative dose of 635 mg, and was delivered via an inhalator, Halermatic, or Dinkihaler device. We studied the airway sensitivity to inhaled man...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson SD,Brannan J,Spring J,Spalding N,Rodwell LT,Chan K,Gonda I,Walsh A,Clark AR

更新日期：1997-09-01 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:In pleural infection, medical treatment failure (chest-tube drainage and antibiotics) requires surgery and increases mortality. It would be helpful to predict which patients will fail this approach. We examined clinical predictors in 85 consecutive patients with pleural infection receiving chest drainage and intrapleu...

journal_title：American journal of respiratory and critical care medicine

authors： Davies CW,Kearney SE,Gleeson FV,Davies RJ

更新日期：1999-11-01 00:00:00

abstract：:Fibrosing alveolitis in systemic sclerosis is histologically identical to lone cryptogenic fibrosing alveolitis (CFA) (idiopathic pulmonary fibrosis). The inflammatory cell content of bronchoalveolar lavage (BAL) samples has been used as a guide to prognosis and treatment in CFA. In this study, the relationship was ex...

journal_title：American journal of respiratory and critical care medicine

authors： Wells AU,Hansell DM,Rubens MB,Cullinan P,Haslam PL,Black CM,Du Bois RM

更新日期：1994-08-01 00:00:00

abstract：:Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy. To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in a double-blind crosso...

journal_title：American journal of respiratory and critical care medicine

authors： Keh D,Boehnke T,Weber-Cartens S,Schulz C,Ahlers O,Bercker S,Volk HD,Doecke WD,Falke KJ,Gerlach H

更新日期：2003-02-15 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) develops after inhalation of many different environmental antigens, causing variable clinical symptoms that often make diagnosis uncertain. The prevalence of HP is higher than recognized, especially its chronic form. Mechanisms of disease are still incompletely known. Strategies to im...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JN,Ortega HG,Reynolds HY,Cormier YF,Fan LL,Franks TJ,Kreiss K,Kunkel S,Lynch D,Quirce S,Rose C,Schleimer RP,Schuyler MR,Selman M,Trout D,Yoshizawa Y

更新日期：2005-04-01 00:00:00

abstract：:In Balb/C mice, painting the skin with ovalbumin (OVA) over a period of 14 days resulted in sensitization of the animals. This was documented by the appearance of OVA-specific IgE and IgG1 antibodies and increased total serum IgE levels. In addition, in regional (inguinal) lymph nodes of sensitized animals, OVA-specif...

journal_title：American journal of respiratory and critical care medicine

authors： Saloga J,Renz H,Larsen GL,Gelfand EW

更新日期：1994-01-01 00:00:00

abstract：:Most randomized trials in critical care report no mortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true ineffectiveness of interventions. We hypothesize that in acute respiratory distress syndrome (ARDS), randomizing only those patients who show a favorable physiological r...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Kavanagh BP,Rubenfeld GD,Ferguson ND

更新日期：2015-12-15 00:00:00

abstract：:We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects c...

journal_title：American journal of respiratory and critical care medicine

authors： Louis R,Shute J,Biagi S,Stanciu L,Marrelli F,Tenor H,Hidi R,Djukanović R

更新日期：1997-02-01 00:00:00

abstract：:This prospective and controlled pilot study evaluates the long-term effects of nocturnal oxygen therapy (NOT) on exercise endurance, hematology variables, quality of life, and survival of 23 adult patients (mean age, 32 +/- 6 yr) with post-tricuspid congenital heart defects (ventricular septal defect = 10; patent duct...

journal_title：American journal of respiratory and critical care medicine

authors： Sandoval J,Aguirre JS,Pulido T,Martinez-Guerra ML,Santos E,Alvarado P,Rosas M,Bautista E

更新日期：2001-11-01 00:00:00

abstract：:Tracheal gas insufflation (TGI) has been recommended as an adjunct to mechanical ventilation in the presence of elevated Pa CO2. Based on our initial clinical experience with continuous flow TGI and pressure control ventilation (PCV), we were concerned about elevation in peak airway pressure as TGI was applied. In a l...

journal_title：American journal of respiratory and critical care medicine

authors： Imanaka H,Kacmarek RM,Ritz R,Hess D

更新日期：1996-03-01 00:00:00

abstract：:In order to determine the long-term sequelae of prune belly syndrome (PBS) and whether the absence of abdominal wall musculature impairs exercise performance we studied nine patients 6 to 31 yr of age with PBS. Conventional spirometry, lung volumes, DLCO, and respiratory muscle strength were measured. A progressive 1-...

journal_title：American journal of respiratory and critical care medicine

authors： Ewig JM,Griscom NT,Wohl ME

更新日期：1996-04-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11beta-HSD) are responsible for the conversion of bioactive glucocorticoids to and from inactive metabolites. 11beta-HSD2 is generally considered a high-affinity inactivator of natural glucocorticoids, although its activity with synthetic compounds in vivo is unknown. Inhaled cort...

journal_title：American journal of respiratory and critical care medicine

authors： Orsida BE,Krozowski ZS,Walters EH

更新日期：2002-04-01 00:00:00

abstract：:Phosphodiesterase (PDE)-5 degrades guanosine 3',5'cyclic monophosphate (cGMP) and its inhibitor sildenafil citrate (Viagra) treats erectile dysfunction by smooth muscle relaxation through elevated cGMP. Sildenafil was examined in two guinea pig models of airways disease: guinea pigs exposed to LPS or sensitized guinea...

journal_title：American journal of respiratory and critical care medicine

authors： Toward TJ,Smith N,Broadley KJ

更新日期：2004-01-15 00:00:00

abstract：:The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV-infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There wer...

journal_title：American journal of respiratory and critical care medicine

authors： Stansell JD,Osmond DH,Charlebois E,LaVange L,Wallace JM,Alexander BV,Glassroth J,Kvale PA,Rosen MJ,Reichman LB,Turner JR,Hopewell PC

更新日期：1997-01-01 00:00:00

abstract：:We have investigated the efficacy of a clarithromycin-containing four-drug regimen for Mycobacterium avium complex (MAC) pulmonary disease in 46 patients without acquired immunodeficiency syndrome (AIDS). The patients were 14 males and 32 females with a mean age of 60.9 +/- 11.5 yr. Patients received 10 mg/kg/d of cla...

journal_title：American journal of respiratory and critical care medicine

authors： Tanaka E,Kimoto T,Tsuyuguchi K,Watanabe I,Matsumoto H,Niimi A,Suzuki K,Murayama T,Amitani R,Kuze F

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:The incidence of influenza-associated acute respiratory failure is unknown. OBJECTIVES:To estimate the population-based incidence of influenza-associated acute respiratory failure hospitalizations. METHODS:This is a cohort study from January 2003 through March 2009 using hospitalization databases for Arizon...

journal_title：American journal of respiratory and critical care medicine

authors： Ortiz JR,Neuzil KM,Rue TC,Zhou H,Shay DK,Cheng PY,Cooke CR,Goss CH

更新日期：2013-09-15 00:00:00

abstract：RATIONALE:The development of host-targeted, prophylactic, and therapeutic interventions against tuberculosis requires a better understanding of the immune mechanisms that determine the outcome of infection with Mycobacterium tuberculosis. OBJECTIVES:To identify T-cell-dependent mechanisms that are protective in tuberc...

journal_title：American journal of respiratory and critical care medicine

authors： Busch M,Herzmann C,Kallert S,Zimmermann A,Höfer C,Mayer D,Zenk SF,Muche R,Lange C,Bloom BR,Modlin RL,Stenger S,TBornotTB Network.

更新日期：2016-08-01 00:00:00

abstract：:We prospectively investigated the lower airway response in boilermakers overhauling an oil-powered boiler. We studied 26 male boilermakers with a mean age (SD) of 43.3 (8.6) yr. Pre-exposure spirometry and methacholine challenge tests were performed before beginning the boiler overhaul; postexposure tests were perform...

journal_title：American journal of respiratory and critical care medicine

authors： Hauser R,Elreedy S,Hoppin JA,Christiani DC

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00

abstract：:Previous studies reported linkage between maternally inherited atopy and the beta subunit of the high affinity IgE receptor (Fc epsilon RI-beta) located on chromosome 11q13. We have investigated 45 Italian families with atopic asthmatic children, for a total of 213 subjects, including 148 patients. Genotyping was carr...

journal_title：American journal of respiratory and critical care medicine

authors： Martinati LC,Trabetti E,Casartelli A,Boner AL,Pignatti PF

更新日期：1996-05-01 00:00:00

abstract：:The human pleural space is lined by a single layer of mesothelial cells, the intracellular pH (pH(i)) of which has never been investigated. In the present study, the intrinsic buffering power of H+ ions (beta(i)) and the pH(i) regulatory systems were investigated in primary cultures of human pleural mesothelial cells ...

journal_title：American journal of respiratory and critical care medicine

authors： Liaw YS,Yang PC,Yu CJ,Kuo SH,Luh KT,Lin YJ,Wu ML

更新日期：1997-02-01 00:00:00

abstract：:We have investigated the influence of the cytokine tumor necrosis factor alpha (TNF alpha), an important mediator of sepsis, on in vitro hamster diaphragm contractility. Costal diaphragm strips were excised and mounted on an experimental apparatus consisting of a force transducer and servomotor. Preparations were rand...

journal_title：American journal of respiratory and critical care medicine

authors： Wilcox P,Milliken C,Bressler B

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Allergic bronchopulmonary aspergillosis (ABPA) is characterized by a Th2 immune response. Mouse models suggest a critical role for the Th2 chemokines thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) in ABPA. OBJECTIVES:To determine whether serum levels of TARC and MDC ...

journal_title：American journal of respiratory and critical care medicine

authors： Hartl D,Latzin P,Zissel G,Krane M,Krauss-Etschmann S,Griese M

更新日期：2006-06-15 00:00:00

abstract：:Because interleukin 8 (IL-8) is a potent neutrophil chemotactic and activating cytokine, we investigated IL-8 production in relation to neutrophil migration and elastase release in the human lung during unilateral community-acquired pneumonia (CAP). In 17 patients, the local response in the involved lung was compared ...

journal_title：American journal of respiratory and critical care medicine

authors： Boutten A,Dehoux MS,Seta N,Ostinelli J,Venembre P,Crestani B,Dombret MC,Durand G,Aubier M

更新日期：1996-01-01 00:00:00

abstract：:In addition to its central role in hemostasis, thrombin may play a role in inflammation and remodeling. To investigate the contribution of thrombin to allergic airway inflammation in asthma, we used an enzymatic assay to determine thrombin activity in bronchoalveolar lavage fluid obtained from 19 subjects with atopic ...

journal_title：American journal of respiratory and critical care medicine

authors： Terada M,Kelly EA,Jarjour NN

更新日期：2004-02-01 00:00:00

abstract：RATIONALE:Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in immunocompromised patients. OBJECTIVES:We hypothesize that galactomannan (GM), a component of fungal cell wall, as measured in bronchoalveolar lavage (BAL) might be a diagnostic adjunct in hematologic malignancies. METHODS:A ...

journal_title：American journal of respiratory and critical care medicine

authors： Affolter K,Tamm M,Jahn K,Halter J,Passweg J,Hirsch HH,Stolz D

更新日期：2014-08-01 00:00:00

abstract：:At the time of diagnosis, many sarcoidosis patients have no clinical indication for corticosteroid therapy, and prognostic parameters predicting deterioration are missing. In the present study, we investigated parameters derived from bronchoalveolar lavage (BAL) and serum in 77 patients with recently diagnosed sarcoid...

journal_title：American journal of respiratory and critical care medicine

authors： Ziegenhagen MW,Benner UK,Zissel G,Zabel P,Schlaak M,Müller-Quernheim J

更新日期：1997-11-01 00:00:00