Effect of clarithromycin regimen for Mycobacterium avium complex pulmonary disease.

abstract：RATIONALE:Spirometric detection of airway obstruction in adults requires separate predictive formulae for each ethnicity and sex for percentage of FEV(1)/FVC (%FEV(1)/FVC) and percentage of FEV(3)/FVC (%FEV(3)/FVC), the major measurements for defining airway obstruction. OBJECTIVES:To eliminate the need for multiple f...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen JE,Sun XG,Wasserman K

更新日期：2006-09-01 00:00:00

abstract：:Airway smooth muscle (ASM) accumulation and enrichment of the extracellular matrix (ECM) with type I collagen and fibronectin are major pathologic features of airway remodeling in asthma. These ECM components confer enhanced ASM proliferation in vitro, but a requirement for specific integrin ECM receptors has not been...

journal_title：American journal of respiratory and critical care medicine

authors： Nguyen TT,Ward JP,Hirst SJ

更新日期：2005-02-01 00:00:00

abstract：:Long-term effects of high doses of inhaled corticosteroids (ICS) on bone density and metabolism are still uncertain. Fifty-one patients (37 male, 14 female) using beclomethasone or budesonide at a daily dose > 800 microgram/d (high-dose group [Group HD] mean: 983 microgram/d [prescribed dose x estimated compliance]) o...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Gagnon L,Poubelle PE,Brown J

更新日期：1999-03-01 00:00:00

abstract：:Methodologies used to assess airway responsiveness (AR) in children administer the same dosage schedule to all children despite the great range in the size of subjects. The aim of this study was to examine the hypothesis that the level of AR is size dependent within same-age cohorts and between different ages. Among a...

journal_title：American journal of respiratory and critical care medicine

authors： Le Souëf PN,Sears MR,Sherrill D

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Patients with severe asthma (SA) are less responsive to the beneficial effects of corticosteroid (CS) therapy, and relative CS insensitivity has been shown in airway smooth muscle cells (ASMC) from patients with SA. OBJECTIVES:We investigated whether there was a defect in the actions of the glucocorticoid re...

journal_title：American journal of respiratory and critical care medicine

authors： Chang PJ,Michaeloudes C,Zhu J,Shaikh N,Baker J,Chung KF,Bhavsar PK

更新日期：2015-01-01 00:00:00

abstract：:We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 work...

journal_title：American journal of respiratory and critical care medicine

authors： Senthilselvan A,Pahwa P,Wang P,McDuffie HH,Dosman JA

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:Studies in humans and rodents have indicated a causative role for CD8(+) T cells in IgE-mediated allergic inflammation, but their function is still controversial. OBJECTIVES:To analyze the role of allergen-specific CD8(+) T cells during the development of allergic airway inflammation in two parallel but dive...

journal_title：American journal of respiratory and critical care medicine

authors： Aguilar-Pimentel JA,Alessandrini F,Huster KM,Jakob T,Schulz H,Behrendt H,Ring J,de Angelis MH,Busch DH,Mempel M,Ollert M

更新日期：2010-01-01 00:00:00

abstract：:The purpose of the study was to examine risk factors for nosocomial pneumonia in the surgical and medical/respiratory intensive care unit (ICU) populations. In a public teaching hospital, all cases of nosocomial pneumonia in the surgical and medical/respiratory ICUs (n = 20, respectively) were identified by prospectiv...

journal_title：American journal of respiratory and critical care medicine

authors： Cunnion KM,Weber DJ,Broadhead WE,Hanson LC,Pieper CF,Rutala WA

更新日期：1996-01-01 00:00:00

abstract：:It has been suggested that in patients with adult respiratory distress syndrome (ARDS), intrinsic positive end-expiratory pressure (PEEPi) is generated by a disproportionate increase in expiratory flow resistance. Using the negative expiratory pressure (NEP) technique, we assessed whether expiratory flow limitation (E...

journal_title：American journal of respiratory and critical care medicine

authors： Koutsoukou A,Armaganidis A,Stavrakaki-Kallergi C,Vassilakopoulos T,Lymberis A,Roussos C,Milic-Emili J

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is hypothesized to be influenced by genes within pathways involved with obesity, craniofacial development, inflammation, and ventilatory control. OBJECTIVES:We conducted the first candidate gene study of OSA using family data from European Americans and African Americans, select...

journal_title：American journal of respiratory and critical care medicine

authors： Larkin EK,Patel SR,Goodloe RJ,Li Y,Zhu X,Gray-McGuire C,Adams MD,Redline S

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Drug-resistant tuberculosis transmission in hospitals threatens staff and patient health. Surgical face masks used by patients with tuberculosis (TB) are believed to reduce transmission but have not been rigorously tested. OBJECTIVES:We sought to quantify the efficacy of surgical face masks when worn by pati...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmadhikari AS,Mphahlele M,Stoltz A,Venter K,Mathebula R,Masotla T,Lubbe W,Pagano M,First M,Jensen PA,van der Walt M,Nardell EA

更新日期：2012-05-15 00:00:00

abstract：:Knowledge of the local and regional doses of inhaled particulates is crucial for inhalation therapy and for understanding the progression of pulmonary disease. We studied the deposition pattern of radioactively tagged particles in rats with chronic bronchitis. Rats were exposed to sulfur dioxide (SO2; 236 +/- 14 ppm) ...

journal_title：American journal of respiratory and critical care medicine

authors： Sweeney TD,Skornik WA,Brain JD,Hatch V,Godleski JJ

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Increased thickness of the airway smooth muscle (ASM) layer in asthma may result from hyperplasia or hypertrophy of muscle cells or increased extracellular matrix (ECM). OBJECTIVES:To relate ASM hypertrophy, ASM hyperplasia, and deposition of ECM to the severity and duration of asthma. METHODS:Airways from ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Elliot JG,Jones RL,Carroll ML,Mauad T,Bai TR,Abramson MJ,McKay KO,Green FH

更新日期：2012-05-15 00:00:00

abstract：:Rationale: Chronic hypersensitivity pneumonitis (CHP) is caused by an immune response to antigen inhalation and is characterized by variable histopathological and clinical features. A subset of subjects with CHP have usual interstitial pneumonia and appear to be clinically similar to subjects with idiopathic pulmonary...

journal_title：American journal of respiratory and critical care medicine

authors： Furusawa H,Cardwell JH,Okamoto T,Walts AD,Konigsberg IR,Kurche JS,Bang TJ,Schwarz MI,Brown KK,Kropski JA,Rojas M,Cool CD,Lee JS,Wolters PJ,Yang IV,Schwartz DA

更新日期：2020-11-15 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Measurements of upper airway size and shape are important in investigating the pathophysiology of obstructive sleep apnea (OSA) and in devising, applying, and determining the effectiveness of treatment modalities. We describe an endoscopic optical technique (anatomic optical coherence tomography, aOCT) that ...

journal_title：American journal of respiratory and critical care medicine

authors： Armstrong JJ,Leigh MS,Sampson DD,Walsh JH,Hillman DR,Eastwood PR

更新日期：2006-01-15 00:00:00

abstract：:Hepatopulmonary syndrome (HPS) is characterized by intrapulmonary vascular dilatations and an increased alveoloarterial oxygen difference (AaPO(2)). These abnormalities are related to augmented pulmonary nitric oxide (NO) production, dependent primarily on increases in the expression and activity of inducible NO-synth...

journal_title：American journal of respiratory and critical care medicine

authors： Rabiller A,Nunes H,Lebrec D,Tazi KA,Wartski M,Dulmet E,Libert JM,Mougeot C,Moreau R,Mazmanian M,Humbert M,Hervé P

更新日期：2002-08-15 00:00:00

abstract：:We surveyed pulmonologists to determine which procedures they do in practice, where they learned the procedures, and how much training they recommend to attain and maintain clinical competence in each. We mailed a survey to a random sample of 1,000 members of the American College of Physicians who were identified as p...

journal_title：American journal of respiratory and critical care medicine

authors： Tape TG,Blank LL,Wigton RS

更新日期：1995-02-01 00:00:00

abstract：:T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as...

journal_title：American journal of respiratory and critical care medicine

authors： Gratziou C,Carroll M,Montefort S,Teran L,Howarth PH,Holgate ST

更新日期：1996-02-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11beta-HSD) are responsible for the conversion of bioactive glucocorticoids to and from inactive metabolites. 11beta-HSD2 is generally considered a high-affinity inactivator of natural glucocorticoids, although its activity with synthetic compounds in vivo is unknown. Inhaled cort...

journal_title：American journal of respiratory and critical care medicine

authors： Orsida BE,Krozowski ZS,Walters EH

更新日期：2002-04-01 00:00:00

abstract：:It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cell cultures morphologically and physiologically and determined whether cytokine production or nuclear factor-kappaB activat...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MN,Sauer MS,Muhlebach MS,Hirsh AJ,Wu Q,Verghese MW,Randell SH

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES:To identify novel asthma phenotypes using an unsupervised hierarchical clu...

journal_title：American journal of respiratory and critical care medicine

authors： Moore WC,Meyers DA,Wenzel SE,Teague WG,Li H,Li X,D'Agostino R Jr,Castro M,Curran-Everett D,Fitzpatrick AM,Gaston B,Jarjour NN,Sorkness R,Calhoun WJ,Chung KF,Comhair SA,Dweik RA,Israel E,Peters SP,Busse WW,Erzurum

更新日期：2010-02-15 00:00:00

abstract：RATIONALE:Cigarette smoke is the major risk factor in the development of chronic obstructive pulmonary disease (COPD). Lipidomics is a novel and emerging research field that may provide new insights in the origins of chronic inflammatory diseases, such as COPD. OBJECTIVES:To investigate whether expression of the sputu...

journal_title：American journal of respiratory and critical care medicine

authors： Telenga ED,Hoffmann RF,Ruben t'Kindt,Hoonhorst SJ,Willemse BW,van Oosterhout AJ,Heijink IH,van den Berge M,Jorge L,Sandra P,Postma DS,Sandra K,ten Hacken NH

更新日期：2014-07-15 00:00:00

abstract：RATIONALE:Patients with obstructive sleep apnea (OSA) adapt to the anatomical vulnerability of their upper airway by generating increased activity in upper airway-dilating muscles during wakefulness. Norepinephrine (NE) and serotonin (5-HT) mediate, through α₁-adrenergic and 5-HT₂A receptors, a wake-related excitatory ...

journal_title：American journal of respiratory and critical care medicine

authors： Rukhadze I,Fenik VB,Benincasa KE,Price A,Kubin L

更新日期：2010-11-15 00:00:00

abstract：:Alveolar epithelial type II cells (AET2) respond with exocytosis of surfactant containing lamellar bodies to stimulation with mechanical stretch and secretagogues, a process that is fundamental for maintaining alveolar stability and lung gas exchange. In the present study in cultured rat AET2, we employed botulinum C2...

journal_title：American journal of respiratory and critical care medicine

authors： Rose F,Kürth-Landwehr C,Sibelius U,Reuner KH,Aktories K,Seeger W,Grimminger F

更新日期：1999-01-01 00:00:00

abstract：:The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effectors. We recently reported that both macrophage metalloelastase (MMP-1...

journal_title：American journal of respiratory and critical care medicine

authors： Churg A,Wang RD,Tai H,Wang X,Xie C,Dai J,Shapiro SD,Wright JL

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:Current thinking accredits eosinophils with preeminent contributions to allergic airway responses, including a major role in the development of airway remodeling, a process thought to significantly contribute to airway dysfunction. However, direct evidence in support of this notion is limited and often contro...

journal_title：American journal of respiratory and critical care medicine

authors： Fattouh R,Al-Garawi A,Fattouh M,Arias K,Walker TD,Goncharova S,Coyle AJ,Humbles AA,Jordana M

更新日期：2011-01-15 00:00:00

abstract：:Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

journal_title：American journal of respiratory and critical care medicine

authors： Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

更新日期：2003-10-01 00:00:00

abstract：RATIONALE:Inhaled corticosteroids are commonly prescribed to patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES:To examine whether these medications might be associated with an excess risk of pneumonia. METHODS:We conducted a nested case-control study within a cohort of patients with COPD from Que...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst P,Gonzalez AV,Brassard P,Suissa S

更新日期：2007-07-15 00:00:00

abstract：:To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess the effects of the combination of positive end-expiratory pressure (PEEP) and pressure-support ventilation (PSV) on inspiratory muscle effort, we investigated respiratory mechanic...

journal_title：American journal of respiratory and critical care medicine

authors： Appendini L,Purro A,Patessio A,Zanaboni S,Carone M,Spada E,Donner CF,Rossi A

更新日期：1996-11-01 00:00:00