Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease.

abstract：:The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...

journal_title：American journal of respiratory and critical care medicine

authors： Ishizaka A,Hasegawa N,Sakamaki F,Tasaka S,Nakamura H,Kishikawa K,Yamada A,Obata T,Sayama K,Urano T

更新日期：1994-11-01 00:00:00

abstract：:A study was done to compare the efficacy and safety of the coprescription of salmeterol 50 microgram twice daily or 100 microgram twice daily with beclomethasone dipropionate (BDP) 500 micrograms twice daily (SALM 50 and SALM 100) with BDP 1,000 microgram twice daily (BDP 1,000) in patients with asthma not controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Woolcock A,Lundback B,Ringdal N,Jacques LA

更新日期：1996-05-01 00:00:00

abstract：:Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and chronic obstructive pulmonary disease (COPD). IFN-β is a key component of the innate immune response to viral infection. To date, studies of inhaled IFN-β treatment have not demonstrated a significant effect ...

journal_title：American journal of respiratory and critical care medicine

authors： Watson A,Spalluto CM,McCrae C,Cellura D,Burke H,Cunoosamy D,Freeman A,Hicks A,Hühn M,Ostridge K,Staples KJ,Vaarala O,Wilkinson T

更新日期：2020-01-01 00:00:00

abstract：:The inflammatory events in the airways at the time of acute respiratory failure from acute severe asthma are poorly understood. To determine the patterns of cellular inflammation in the airways in acute severe asthma, we analyzed tracheal aspirates collected within 12 h of intubation from patients intubated emergently...

journal_title：American journal of respiratory and critical care medicine

authors： Ordoñez CL,Shaughnessy TE,Matthay MA,Fahy JV

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown. OBJECTIVES:To compare lung retransplant patients in the modern era with historical retransplant patients, to compare retransplant patients with initial transplant patients in the modern era, and ...

journal_title：American journal of respiratory and critical care medicine

authors： Kawut SM,Lederer DJ,Keshavjee S,Wilt JS,Daly T,D'Ovidio F,Sonett JR,Arcasoy SM,Barr ML

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Lung cancer screening (LCS) has the potential to reduce the risk of lung cancer death in healthy individuals, but the impact of coexisting chronic illnesses on LCS outcomes has not been well defined. Consideration of the complex relationship between baseline risk of lung cancer, treatment-related harms, and ...

journal_title：American journal of respiratory and critical care medicine

authors： Rivera MP,Tanner NT,Silvestri GA,Detterbeck FC,Tammemägi MC,Young RP,Slatore CG,Caverly TJ,Boyd CM,Braithwaite D,Fathi JT,Gould MK,Iaccarino JM,Malkoski SP,Mazzone PJ,Tanoue LT,Schoenborn NL,Zulueta JJ,Wiener RS,Ame

更新日期：2018-07-15 00:00:00

abstract：:Although impairment of gas exchange caused by ventilation-perfusion (VA/Q) mismatch has been extensively analyzed, there have been no systematic studies focused on determining the distributions of diffusion properties in dose connection with those of VA/Q. We attempted to clarify the simultaneous distributions of VA/Q...

journal_title：American journal of respiratory and critical care medicine

authors： Yamaguchi K,Mori M,Kawai A,Takasugi T,Oyamada Y,Koda E

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Although commonly used as the primary outcome measure of clinical trials in pulmonary arterial hypertension (PAH), the minimal important difference (MID) of the 6-minute walk test (6MWT) has not been well defined for this population of patients. OBJECTIVES:To estimate the MID in the 6MWT in patients with PAH...

journal_title：American journal of respiratory and critical care medicine

authors： Mathai SC,Puhan MA,Lam D,Wise RA

更新日期：2012-09-01 00:00:00

abstract：:The effects of conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFO) on intraalveolar expression of the tumor necrosis factor-alpha (TNF-alpha) gene were studied in surfactant-depleted rabbits. After lung lavage with saline, 13 rabbits were administered either CMV (n = 6) or HFO (n...

journal_title：American journal of respiratory and critical care medicine

authors： Takata M,Abe J,Tanaka H,Kitano Y,Doi S,Kohsaka T,Miyasaka K

更新日期：1997-07-01 00:00:00

abstract：:Although there is abundant clinical evidence of asthmatic responses to indoor aeroallergens, the symptomatic impacts of other common indoor air pollutants from gas stoves, fireplaces, and environmental tobacco smoke have been less well characterized. These combustion sources produce a complex mixture of pollutants, ma...

journal_title：American journal of respiratory and critical care medicine

authors： Ostro BD,Lipsett MJ,Mann JK,Wiener MB,Selner J

更新日期：1994-06-01 00:00:00

abstract：:Nebulized aerosols are commonly used to deliver drugs into the lungs of patients with cystic fibrosis (CF). The aim of this study was to assess the effectiveness of pressure-support (PS) ventilation in increasing aerosol deposition within the lungs of children with CF. An in vitro study demonstrated the feasibility of...

journal_title：American journal of respiratory and critical care medicine

authors： Fauroux B,Itti E,Pigeot J,Isabey D,Meignan M,Ferry G,Lofaso F,Willemot JM,Clément A,Harf A

更新日期：2000-12-01 00:00:00

abstract：:The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effectors. We recently reported that both macrophage metalloelastase (MMP-1...

journal_title：American journal of respiratory and critical care medicine

authors： Churg A,Wang RD,Tai H,Wang X,Xie C,Dai J,Shapiro SD,Wright JL

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:Standard physiologic assessments of extubation readiness in patients with acute hypoxemic respiratory failure (AHRF) may not reflect lung injury resolution and could adversely affect clinical decision-making and patient outcomes. OBJECTIVES:We hypothesized that elevations in inflammatory plasma biomarkers so...

journal_title：American journal of respiratory and critical care medicine

authors： Alladina J,Levy SD,Cho JL,Brait KL,Rao SR PhD,Camacho A,Hibbert KA,Harris RS,Medoff BD,Januzzi JL,Thompson BT,Bajwa EK

更新日期：2021-01-05 00:00:00

abstract：:Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in lung structure remains unknown.Objectives: To characterize associations between a genetic risk score (GRS) associated with COPD susceptibility...

journal_title：American journal of respiratory and critical care medicine

authors： Oelsner EC,Ortega VE,Smith BM,Nguyen JN,Manichaikul AW,Hoffman EA,Guo X,Taylor KD,Woodruff PG,Couper DJ,Hansel NN,Martinez FJ,Paine R 3rd,Han MK,Cooper C,Dransfield MT,Criner G,Krishnan JA,Bowler R,Bleecker ER,Pet

更新日期：2019-09-15 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:A noninvasive means of detecting airway secretions in ventilator-dependent patients is desirable because endotracheal suctioning can result in life-threatening complications. In a patient who had copious secretions, we observed a sawtooth pattern on his flow-volume curve that disappeared after suctioning. Accordingly,...

journal_title：American journal of respiratory and critical care medicine

authors： Jubran A,Tobin MJ

更新日期：1994-09-01 00:00:00

abstract：RATIONALE:There is consensus on the need to address social determinants of tuberculosis (TB) to achieve TB control, but evidence based on interventions is lacking. OBJECTIVES:We reanalyzed data from the sociomedical experiment performed at the Papworth Village Settlement in England, where the impact of stable employme...

journal_title：American journal of respiratory and critical care medicine

authors： Bhargava A,Pai M,Bhargava M,Marais BJ,Menzies D

更新日期：2012-09-01 00:00:00

abstract：:Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

journal_title：American journal of respiratory and critical care medicine

authors： Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

更新日期：2021-02-01 00:00:00

abstract：:Airway pathology has been extensively investigated in adulthood asthma, whereas only few studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology in children with asthma, we analyzed bronchial biopsies obtained from 23 children undergoing bronchoscopy for clinical indications other tha...

journal_title：American journal of respiratory and critical care medicine

authors： Barbato A,Turato G,Baraldo S,Bazzan E,Calabrese F,Tura M,Zuin R,Beghe B,Maestrelli P,Fabbri LM,Saetta M

更新日期：2003-10-01 00:00:00

abstract：:Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatment) trial demonstrated a significant reduction in all-cause mortality (ACM) risk with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI in patients with chronic obstructive pulmonary disease (COPD) at ris...

journal_title：American journal of respiratory and critical care medicine

authors： Lipson DA,Crim C,Criner GJ,Day NC,Dransfield MT,Halpin DMG,Han MK,Jones CE,Kilbride S,Lange P,Lomas DA,Lettis S,Manchester P,Martin N,Midwinter D,Morris A,Pascoe SJ,Singh D,Wise RA,Martinez FJ

更新日期：2020-06-15 00:00:00

abstract：:Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-l...

journal_title：American journal of respiratory and critical care medicine

authors： Shahar E,Whitney CW,Redline S,Lee ET,Newman AB,Nieto FJ,O'Connor GT,Boland LL,Schwartz JE,Samet JM

更新日期：2001-01-01 00:00:00

abstract：:Pulmonary emphysema and periodontal disease are each characterized by the uncontrolled proteolysis of connective tissue proteins by proteinases derived from human neutrophils. Although these diseases would not appear to be related in terms of the initial insult to individual tissues, the ultimate result in each diseas...

journal_title：American journal of respiratory and critical care medicine

authors： Travis J,Pike R,Imamura T,Potempa J

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:Pulmonary infection in cystic fibrosis (CF) is polymicrobial and it is possible that anaerobic bacteria, not detected by routine aerobic culture methods, reside within infected anaerobic airway mucus. OBJECTIVES:To determine whether anaerobic bacteria are present in the sputum of patients with CF. METHODS:S...

journal_title：American journal of respiratory and critical care medicine

authors： Tunney MM,Field TR,Moriarty TF,Patrick S,Doering G,Muhlebach MS,Wolfgang MC,Boucher R,Gilpin DF,McDowell A,Elborn JS

更新日期：2008-05-01 00:00:00

abstract：:We determined if pulmonary peptidoleukotrienes contribute to the pathogenesis of chronic lung disease of extreme prematurity (CLD) by measuring urinary leukotriene E4 (uLTE4). Study patients had a birth weight < 1000 g and were about 28 d old when they were classified as normal control subjects (n = 8) or as having CL...

journal_title：American journal of respiratory and critical care medicine

authors： Davidson D,Drafta D,Wilkens BA

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:The majority of previous studies investigating asthma genetics have focused on cohorts with stable disease and have not defined mechanisms important during acute asthma. CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region pol...

journal_title：American journal of respiratory and critical care medicine

authors： Martin AC,Laing IA,Khoo SK,Zhang G,Rueter K,Teoh L,Taheri S,Hayden CM,Geelhoed GC,Goldblatt J,LeSouëf PN

更新日期：2006-03-15 00:00:00

abstract：:We tested the hypothesis that in advanced pulmonary fibrosis, edema is redistributed away from the relatively noncompliant interstitium and predominantly floods alveoli. Severe left lung fibrosis was produced in six dogs with radiation and intratracheal bleomycin and, 24 mo later, hydrostatic edema was induced by infu...

journal_title：American journal of respiratory and critical care medicine

authors： Zwikler MP,Iancu D,Michel RP

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped e-liquids are unknown. OBJECTIVES:To determine the effects of chronic vaping on pulmonary epithelia. METHODS:We performed research bronchoscopies on h...

journal_title：American journal of respiratory and critical care medicine

authors： Ghosh A,Coakley RC,Mascenik T,Rowell TR,Davis ES,Rogers K,Webster MJ,Dang H,Herring LE,Sassano MF,Livraghi-Butrico A,Van Buren SK,Graves LM,Herman MA,Randell SH,Alexis NE,Tarran R

更新日期：2018-07-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：:Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it has recently become apparent that cigarette smoking may be a risk factor for cryptogenic fibrosing alveolitis as well as for lung cancer, and so may confound the association between these conditions. ...

journal_title：American journal of respiratory and critical care medicine

authors： Hubbard R,Venn A,Lewis S,Britton J

更新日期：2000-01-01 00:00:00

abstract：:Partial liquid ventilation (PLV) has been shown to be an effective means of improving oxygenation in the injured lung. However, little is known about how approach to ventilation during PLV affects gas exchange and pulmonary mechanics. We hypothesized that gas exchange and pulmonary mechanics would be best with positiv...

journal_title：American journal of respiratory and critical care medicine

authors： Fujino Y,Kirmse M,Hess D,Kacmarek RM

更新日期：1999-04-01 00:00:00