Indoor air pollution and asthma. Results from a panel study.

abstract：RATIONALE:Obstructive sleep apnea (OSA) is common in people with hypertension, particularly resistant hypertension. Treatment with an antihypertensive agent alone is often insufficient to control hypertension in patients with OSA. OBJECTIVES:To determine whether continuous positive airway pressure (CPAP) added to trea...

journal_title：American journal of respiratory and critical care medicine

authors： Thunström E,Manhem K,Rosengren A,Peker Y

更新日期：2016-02-01 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:The majority of previous studies investigating asthma genetics have focused on cohorts with stable disease and have not defined mechanisms important during acute asthma. CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region pol...

journal_title：American journal of respiratory and critical care medicine

authors： Martin AC,Laing IA,Khoo SK,Zhang G,Rueter K,Teoh L,Taheri S,Hayden CM,Geelhoed GC,Goldblatt J,LeSouëf PN

更新日期：2006-03-15 00:00:00

abstract：:T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as...

journal_title：American journal of respiratory and critical care medicine

authors： Gratziou C,Carroll M,Montefort S,Teran L,Howarth PH,Holgate ST

更新日期：1996-02-01 00:00:00

abstract：:We sought to describe pulmonary fibrosis mortality in the United States from 1979 through 1991 by analyzing death certificate reports compiled by the National Center for Health Statistics. Of the 26,866,600 people who died during the study period, 107,292 had a diagnosis of pulmonary fibrosis listed on their death cer...

journal_title：American journal of respiratory and critical care medicine

authors： Mannino DM,Etzel RA,Parrish RG

更新日期：1996-05-01 00:00:00

abstract：:We evaluated positron emission tomographic imaging of pulmonary transgene expression, using an enhanced mutant herpes simplex virus-1 thymidine kinase as the reporter gene, in the lungs of normal rats. Sixteen rats were studied 3 days after an intratracheal administration of 5 x 10(9) to 1 x 10(11) viral particles of ...

journal_title：American journal of respiratory and critical care medicine

authors： Richard JC,Zhou Z,Ponde DE,Dence CS,Factor P,Reynolds PN,Luker GD,Sharma V,Ferkol T,Piwnica-Worms D,Schuster DP

更新日期：2003-05-01 00:00:00

abstract：:The pathophysiology of impaired exercise tolerance in patients with cystic fibrosis (CF) is not completely understood. The objective of this study was to compare exercise ability (at clinical and cellular levels) and resting energy expenditure in female athletes with CF compared with matched control subjects. Sixteen ...

journal_title：American journal of respiratory and critical care medicine

authors： Selvadurai HC,Allen J,Sachinwalla T,Macauley J,Blimkie CJ,Van Asperen PP

更新日期：2003-12-15 00:00:00

abstract：:In normal airways, invasion of small numbers of pathogenic bacteria will not give rise to injury or local colonization. In chronic obstructive pulmonary disease, however, local conditions are changed, which may impair local defense systems and facilitate infection. These include: (1) factors promoting bacterial adhere...

journal_title：American journal of respiratory and critical care medicine

authors： Jansen HM,Sachs AP,van Alphen L

更新日期：1995-06-01 00:00:00

abstract：:The effect of long-term exposure to air pollutants was studied in a cross-sectional population-based sample of adults (aged 18 to 60 yr; n = 9,651) residing in eight different areas in Switzerland. Standardized medical examination included questionnaire data, lung function tests, skin-prick testing, and end-expiratory...

journal_title：American journal of respiratory and critical care medicine

authors： Ackermann-Liebrich U,Leuenberger P,Schwartz J,Schindler C,Monn C,Bolognini G,Bongard JP,Brändli O,Domenighetti G,Elsasser S,Grize L,Karrer W,Keller R,Keller-Wossidlo H,Künzli N,Martin BW,Medici TC,Perruchoud AP,Schöni

更新日期：1997-01-01 00:00:00

abstract：:In animal models of endotoxemia, sepsis is associated with the accumulation of leukocytes and altered microvascular perfusion. In order to test the hypothesis that bacterial sepsis upregulates leukocyte-endothelial adhesion, we used intravital microscopy to examine the flow behavior of leukocytes in the postcapillary ...

journal_title：American journal of respiratory and critical care medicine

authors： Piper RD,Pitt-Hyde ML,Anderson LA,Sibbald WJ,Potter RF

更新日期：1998-01-01 00:00:00

abstract：:To attain a better understanding of antibiotic cycling and its effects on the epidemiology of antibiotic resistance in gram-negative microorganisms, two different antibiotic classes (quinolone and beta-lactam) were cycled during four 4-month periods in a surgical intensive care unit. Respiratory aspirates and rectal s...

journal_title：American journal of respiratory and critical care medicine

authors： van Loon HJ,Vriens MR,Fluit AC,Troelstra A,van der Werken C,Verhoef J,Bonten MJ

更新日期：2005-03-01 00:00:00

abstract：:Nitric oxide (NO) may play a part in pulmonary vascular regulation and bronchomotor control and has been detected in exhaled air. We report the release of NO from airway epithelial cells and its regulation by cyclic adenosine monophosphate (cAMP). To directly measure NO release, a highly specific amperometric sensor f...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Kondo M,Takemura H,Chiyotani A,Yamawaki I,Konno K

更新日期：1995-10-01 00:00:00

abstract：:We reasoned that a prospective assessment of glucocorticoid withdrawal in subjects with asthma would provide insight into the basis for flares of the disease. We therefore enrolled 25 subjects with moderate persistent asthma and treated them for 30 days with inhaled fluticasone propionate (1,760 microg/day) followed b...

journal_title：American journal of respiratory and critical care medicine

authors： Castro M,Bloch SR,Jenkerson MV,DeMartino S,Hamilos DL,Cochran RB,Zhang XE,Wang H,Bradley JP,Schechtman KB,Holtzman MJ

更新日期：2004-04-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of the natural history of asthma. OBJECTIVES:To compare the stability of cluster-based asthma phenotype structures a decad...

journal_title：American journal of respiratory and critical care medicine

authors： Boudier A,Curjuric I,Basagaña X,Hazgui H,Anto JM,Bousquet J,Bridevaux PO,Dupuis-Lozeron E,Garcia-Aymerich J,Heinrich J,Janson C,Künzli N,Leynaert B,de Marco R,Rochat T,Schindler C,Varraso R,Pin I,Probst-Hensch N,Sun

更新日期：2013-09-01 00:00:00

abstract：RATIONALE:The development of tuberculin skin test (TST) positivity following infection by Mycobacterium tuberculosis is not invariable and may depend on bacillary as well as host factors. OBJECTIVES:First, to compare the diagnostic performance of the TST and a form of in vitro IFN-gamma release assay (IFNGRA) in the c...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson ST,Williams AJ,Brown JR,Newton SM,Simsova M,Nicol MP,Sebo P,Levin M,Wilkinson RJ,Wilkinson KA

更新日期：2006-05-01 00:00:00

abstract：RATIONALE:Although commonly used as the primary outcome measure of clinical trials in pulmonary arterial hypertension (PAH), the minimal important difference (MID) of the 6-minute walk test (6MWT) has not been well defined for this population of patients. OBJECTIVES:To estimate the MID in the 6MWT in patients with PAH...

journal_title：American journal of respiratory and critical care medicine

authors： Mathai SC,Puhan MA,Lam D,Wise RA

更新日期：2012-09-01 00:00:00

abstract：:Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. However, its role in stimulating eosinophil differentiation within the bone marrow following allergen exposure remains to be elucidated. The aims of our study were to deter...

journal_title：American journal of respiratory and critical care medicine

authors： Minshall EM,Schleimer R,Cameron L,Minnicozzi M,Egan RW,Gutierrez-Ramos JC,Eidelman DH,Hamid Q

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:The sympathetic nervous system has been reported to be activated in pulmonary arterial hypertension (PAH). OBJECTIVES:We investigated the prognostic significance of muscle sympathetic nervous system activity (MSNA) in PAH. METHODS:Thirty-two patients with PAH were included in the study and underwent a measu...

journal_title：American journal of respiratory and critical care medicine

authors： Ciarka A,Doan V,Velez-Roa S,Naeije R,van de Borne P

更新日期：2010-06-01 00:00:00

abstract：:Although overproduction of proinflammatory 5-lipoxygenase (5-LO)-derived leukotrienes (LTs) has been demonstrated in the lungs of patients with pulmonary fibrosis, their causal involvement in this condition has not been established. Bleomycin-induced pulmonary fibrosis was studied in mice rendered LT deficient by knoc...

journal_title：American journal of respiratory and critical care medicine

authors： Peters-Golden M,Bailie M,Marshall T,Wilke C,Phan SH,Toews GB,Moore BB

更新日期：2002-01-15 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immun...

journal_title：American journal of respiratory and critical care medicine

authors： DeVincenzo JP,Wilkinson T,Vaishnaw A,Cehelsky J,Meyers R,Nochur S,Harrison L,Meeking P,Mann A,Moane E,Oxford J,Pareek R,Moore R,Walsh E,Studholme R,Dorsett P,Alvarez R,Lambkin-Williams R

更新日期：2010-11-15 00:00:00

abstract：:The impact of methicillin resistance on morbidity and mortality of patients suffering from severe Staphylococcus aureus infections remains highly controversial. We analyzed a retrospective cohort of 97 patients with methicillin-susceptible and 74 patients with methicillin-resistant Staphylococcus aureus ventilator-ass...

journal_title：American journal of respiratory and critical care medicine

authors： Combes A,Luyt CE,Fagon JY,Wollf M,Trouillet JL,Gibert C,Chastre J,PNEUMA Trial Group.

更新日期：2004-10-01 00:00:00

abstract：RATIONALE:Our understanding of how airway remodeling affects regional airway elastic properties is limited due to technical difficulties in quantitatively measuring dynamic, in vivo airway dimensions. Such knowledge could help elucidate mechanisms of excessive airway narrowing. OBJECTIVES:To use anatomical optical coh...

journal_title：American journal of respiratory and critical care medicine

authors： Williamson JP,McLaughlin RA,Noffsinger WJ,James AL,Baker VA,Curatolo A,Armstrong JJ,Regli A,Shepherd KL,Marks GB,Sampson DD,Hillman DR,Eastwood PR

更新日期：2011-03-01 00:00:00

abstract：:This study investigated the clinico-pathologic correlation of tumor angiogenesis in non-small-cell lung cancers. Formalin-fixed, paraffin-embedded surgical specimens of 55 consecutive patients with primary non-small-cell lung cancers were examined. Included were 26 squamous cell carcinomas and 29 adenocarcinomas. Twen...

journal_title：American journal of respiratory and critical care medicine

authors： Yuan A,Yang PC,Yu CJ,Lee YC,Yao YT,Chen CL,Lee LN,Kuo SH,Luh KT

更新日期：1995-12-01 00:00:00

abstract：:Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, and the natural history of airway remodeling responses have not been a...

journal_title：American journal of respiratory and critical care medicine

authors： Zhu Z,Lee CG,Zheng T,Chupp G,Wang J,Homer RJ,Noble PW,Hamid Q,Elias JA

更新日期：2001-11-15 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Air pollution is a known asthma trigger and has been associated with short-term asthma symptoms, airway inflammation, decreased lung function, and reduced response to asthma rescue medications. OBJECTIVES:To assess a causal relationship between air pollution and childhood asthma using data that address tempo...

journal_title：American journal of respiratory and critical care medicine

authors： Nishimura KK,Galanter JM,Roth LA,Oh SS,Thakur N,Nguyen EA,Thyne S,Farber HJ,Serebrisky D,Kumar R,Brigino-Buenaventura E,Davis A,LeNoir MA,Meade K,Rodriguez-Cintron W,Avila PC,Borrell LN,Bibbins-Domingo K,Rodriguez-San

更新日期：2013-08-01 00:00:00

abstract：:Although considerable evidence indicates a role for CD4(+) T lymphocytes (T cells) in airway inflammation, little data exist regarding the mechanisms underlying the induction and regulation of CD4(+) T cell reactivity to lung-specific antigens. To dissect the immunologic and molecular mechanisms of CD4(+) T cell dysre...

journal_title：American journal of respiratory and critical care medicine

authors： Bruder D,Westendorf AM,Geffers R,Gruber AD,Gereke M,Enelow RI,Buer J

更新日期：2004-12-01 00:00:00

abstract：RATIONALE:Congenital central hypoventilation syndrome (CCHS) is a genetic disorder mainly characterized by failure of automatic control of breathing, causing alveolar hypoventilation. Little is known regarding cough in CCHS. Parental reports indicate that patients cough normally during airway infections; however, previ...

journal_title：American journal of respiratory and critical care medicine

authors： Lavorini F,Fontana GA,Pantaleo T,Geri P,Piumelli R,Pistolesi M,Widdicombe J

更新日期：2007-10-15 00:00:00

abstract：:The aim of the study was to determine risk factors for severe community-acquired pneumonia (CAP) as well as to compare microbial patterns of severe CAP to a previous study from our respiratory intensive care unit (ICU) originating from 1984 to 1987. Patients admitted to the ICU according to clinical judgment were defi...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Ewig S,Torres A,Arancibia F,Marco F,Mensa J,Sanchez M,Martinez JA

更新日期：1999-09-01 00:00:00