Abstract:
:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mTc-diethylenetriamine pentaacetic acid (99mTc-DTPA) lung scans after abstaining from smoking for 12 h (chronic smoking) and 1 h after smoking two cigarettes (acute smoking). Each smoker also underwent bronchoscopy and bronchoalveolar lavage (BAL) after either chronic (n = 8) or acute smoking (n = 7). Seven nonsmokers also underwent bronchoscopy and BAL. The time to 50% clearance of 99mTc-DTPA (t50) after chronic smoking was 16.7 +/- 1. 3 min (mean +/- SE), and was further reduced after acute smoking to 14.8 +/- 1.0 min (p < 0.01). Neutrophil numbers were increased in bronchoalveolar lavage fluid (BALF) in the acute smoking group as compared with the nonsmokers (p < 0.05). Superoxide release from mixed BAL leukocytes was increased after chronic (p < 0.01) and acute (p < 0.001) smoking, as were thiobarbituric acid-reactive species (TBARS), providing evidence of lipid peroxidation in plasma (chronic, p < 0.05; acute, p < 0.05). Trolox equivalent antioxidant capacity (TEAC) was reduced in plasma (p < 0.001) and increased in BALF (p < 0.05) in both smoking groups. The study therefore showed an acute increase in epithelial permeability and an increase in the number of neutrophils in the air spaces of cigarette smokers concomitant with evidence of increased oxidant stress.
journal_name
Am J Respir Crit Care Medauthors
Morrison D,Rahman I,Lannan S,MacNee Wdoi
10.1164/ajrccm.159.2.9804080subject
Has Abstractpub_date
1999-02-01 00:00:00pages
473-9issue
2eissn
1073-449Xissn
1535-4970journal_volume
159pub_type
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2005-12-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2015-04-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
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更新日期:2020-12-15 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-02-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-07-15 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:2008-08-15 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2014-06-15 00:00:00
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更新日期:2005-04-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
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更新日期:1996-02-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2015-10-01 00:00:00
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更新日期:2006-12-15 00:00:00
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更新日期:2005-02-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章
doi:10.1164/rccm.200210-1188OC
更新日期:2003-10-15 00:00:00
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pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-11-15 00:00:00