α-Hemolysin activity of methicillin-susceptible Staphylococcus aureus predicts ventilator-associated pneumonia.

abstract：:Rationale: The bHLH (basic helix-loop-helix) transcription factor TWIST1 (Twist-related protein 1) controls cell proliferation and differentiation in tissue development and disease processes. Recently, endothelial TWIST1 has been linked to pulmonary hypertension (PH) and endothelial-to-mesenchymal transition, yet the ...

journal_title：American journal of respiratory and critical care medicine

authors： Fan Y,Gu X,Zhang J,Sinn K,Klepetko W,Wu N,Foris V,Solymosi P,Kwapiszewska G,Kuebler WM

更新日期：2020-11-01 00:00:00

abstract：:Mechanical ventilation may promote overdistension-induced pulmonary lesions in patients with acute respiratory distress syndrome (ARDS). The static pressure-volume (P-V) curve of the respiratory system can be used to determine the lung volume and corresponding static airway pressure at which lung compliance begins to ...

journal_title：American journal of respiratory and critical care medicine

authors： Roupie E,Dambrosio M,Servillo G,Mentec H,el Atrous S,Beydon L,Brun-Buisson C,Lemaire F,Brochard L

更新日期：1995-07-01 00:00:00

abstract：:Genetic factors are likely to contribute to the variable presentation of community-acquired pneumonia (CAP). The purpose of this prospective cohort study was to determine whether the LTalpha+250 (TNFbeta+250) and TNFalpha-308 gene polymorphisms are associated with different presentations of CAP. Septic shock (SS) was ...

journal_title：American journal of respiratory and critical care medicine

authors： Waterer GW,Quasney MW,Cantor RM,Wunderink RG

更新日期：2001-06-01 00:00:00

abstract：RATIONALE:Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of cells contributing to these vascular lesions is uncertain. Endogenous endothelial progenitor cells are potential contributors to this p...

journal_title：American journal of respiratory and critical care medicine

authors： Toshner M,Voswinckel R,Southwood M,Al-Lamki R,Howard LS,Marchesan D,Yang J,Suntharalingam J,Soon E,Exley A,Stewart S,Hecker M,Zhu Z,Gehling U,Seeger W,Pepke-Zaba J,Morrell NW

更新日期：2009-10-15 00:00:00

abstract：:The plasma level of fibrinogen is felt to be an independent risk factor for vascular events. Obstructive sleep apnea (OSA) has a high prevalence in patients with stroke and may also be an independent risk factor. The aim of our study was to determine the association between OSA and plasma levels of fibrinogen in patie...

journal_title：American journal of respiratory and critical care medicine

authors： Wessendorf TE,Thilmann AF,Wang YM,Schreiber A,Konietzko N,Teschler H

更新日期：2000-12-01 00:00:00

abstract：:Comparison of the risk-benefit profiles of different inhaled glucocorticoids has been limited by inadequate information about the dose-response relationships for efficacy relative to side effects. Fluticasone propionate (FP) is twice as effective as budesonide (BUD), but the potency ratio of FP:BUD with respect to sup...

journal_title：American journal of respiratory and critical care medicine

authors： Donnelly R,Williams KM,Baker AB,Badcock CA,Day RO,Seale JP

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:Th2 cytokines play an important role in allergic diseases. These cytokines activate signal transduction pathways, including Janus kinase/signal transducer and activator of transcription (STAT) signaling. Although the suppressor of cytokine signaling (SOCS) family protein, a negative regulator of the Janus kin...

journal_title：American journal of respiratory and critical care medicine

authors： Fukuyama S,Nakano T,Matsumoto T,Oliver BG,Burgess JK,Moriwaki A,Tanaka K,Kubo M,Hoshino T,Tanaka H,McKenzie AN,Matsumoto K,Aizawa H,Nakanishi Y,Yoshimura A,Black JL,Inoue H

更新日期：2009-06-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is characterized by an extensive alveolar capillary leak, permitting contact between intra-alveolar factors and the endothelium. To investigate whether factors contained in the alveolar milieu induce cell death in human lung microvascular endothelial cells, we exposed these c...

journal_title：American journal of respiratory and critical care medicine

authors： Hamacher J,Lucas R,Lijnen HR,Buschke S,Dunant Y,Wendel A,Grau GE,Suter PM,Ricou B

更新日期：2002-09-01 00:00:00

abstract：:The role of nutritional status in the prognosis of subjects with severe chronic obstructive pulmonary disease was studied in a cohort of Canadian men and women followed for 3 to 5 yr. A total of 348 subjects who were recruited for a study of negative pressure ventilation were evaluated for lung function and body weigh...

journal_title：American journal of respiratory and critical care medicine

authors： Gray-Donald K,Gibbons L,Shapiro SH,Macklem PT,Martin JG

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:Although frequent, little is known about early-onset pneumonia that occurs in the postresuscitation period. Although induced hypothermia is recommended as a method of improving neurological outcome, its influence on the occurrence of early-onset pneumonia is not well defined. OBJECTIVES:To describe the incid...

journal_title：American journal of respiratory and critical care medicine

authors： Perbet S,Mongardon N,Dumas F,Bruel C,Lemiale V,Mourvillier B,Carli P,Varenne O,Mira JP,Wolff M,Cariou A

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Conversion from a negative to positive QuantiFERON-TB test is indicative of Mycobacterium tuberculosis (Mtb) infection, which predisposes individuals to tuberculosis disease. Interpretation of serial tests is confounded by immunological and technical variability. OBJECTIVES:To improve the consistency of seri...

journal_title：American journal of respiratory and critical care medicine

authors： Nemes E,Rozot V,Geldenhuys H,Bilek N,Mabwe S,Abrahams D,Makhethe L,Erasmus M,Keyser A,Toefy A,Cloete Y,Ratangee F,Blauenfeldt T,Ruhwald M,Walzl G,Smith B,Loxton AG,Hanekom WA,Andrews JR,Lempicki MD,Ellis R,Ginsb

更新日期：2017-09-01 00:00:00

abstract：:The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL4), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange in premature human infants with respiratory distress syndrome (RDS)....

journal_title：American journal of respiratory and critical care medicine

authors： Cochrane CG,Revak SD,Merritt TA,Heldt GP,Hallman M,Cunningham MD,Easa D,Pramanik A,Edwards DK,Alberts MS

更新日期：1996-01-01 00:00:00

abstract：:Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in t...

journal_title：American journal of respiratory and critical care medicine

authors： Goss CH,Otto K,Aitken ML,Rubenfeld GD

更新日期：2002-08-01 00:00:00

abstract：RATIONALE:To identify infected contacts of tuberculosis (TB) cases, the UK National Institute for Health and Care Excellence (NICE) recommended the addition of IFN-γ release assays (IGRA) to the tuberculin skin test (TST) in its 2006 TB guidelines. Treatment for TB infection was no longer recommended for children who s...

journal_title：American journal of respiratory and critical care medicine

authors： Kampmann B,Seddon JA,Paton J,Nademi Z,Keane D,Williams B,Williams A,Liebeschutz S,Riddell A,Bernatoniene J,Patel S,Martinez N,McMaster P,Basu-Roy R,Welch SB

更新日期：2018-04-15 00:00:00

abstract：:Products of the prostaglandin H synthase (PGHS) metabolic pathway are thought to play a role in the pathogenesis of asthma. We determined the level of expression of the constitutive (PGHS-1) and inducible (PGHS-2) isoforms of the enzyme in induced sputum and bronchial biopsies of patients with asthma, patients with ch...

journal_title：American journal of respiratory and critical care medicine

authors： Taha R,Olivenstein R,Utsumi T,Ernst P,Barnes PJ,Rodger IW,Giaid A

更新日期：2000-02-01 00:00:00

abstract：:It is generally accepted that tuberculosis results from a single infection with a single Mycobacterium tuberculosis strain. Such infections are thought to confer protective immunity against exogenous reinfection. In this study, a novel polymerase chain reaction method was developed to specifically identify M. tubercul...

journal_title：American journal of respiratory and critical care medicine

authors： Warren RM,Victor TC,Streicher EM,Richardson M,Beyers N,Gey van Pittius NC,van Helden PD

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:The incidence of influenza-associated acute respiratory failure is unknown. OBJECTIVES:To estimate the population-based incidence of influenza-associated acute respiratory failure hospitalizations. METHODS:This is a cohort study from January 2003 through March 2009 using hospitalization databases for Arizon...

journal_title：American journal of respiratory and critical care medicine

authors： Ortiz JR,Neuzil KM,Rue TC,Zhou H,Shay DK,Cheng PY,Cooke CR,Goss CH

更新日期：2013-09-15 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variant...

journal_title：American journal of respiratory and critical care medicine

authors： Ragland MF,Benway CJ,Lutz SM,Bowler RP,Hecker J,Hokanson JE,Crapo JD,Castaldi PJ,DeMeo DL,Hersh CP,Hobbs BD,Lange C,Beaty TH,Cho MH,Silverman EK

更新日期：2019-09-15 00:00:00

abstract：:Pulmonary infections are a significant cause of morbidity and mortality in patients with alcohol abuse and human immunodeficiency virus (HIV) infection, two immunocompromising conditions that frequently coexist. This study examined the separate and combined effects of in vivo lentiviral infection and in vitro alcohol ...

journal_title：American journal of respiratory and critical care medicine

authors： Stoltz DA,Nelson S,Kolls JK,Zhang P,Bohm RP Jr,Murphey-Corb M,Bagby GJ

更新日期：2000-01-01 00:00:00

abstract：:Fibrosing alveolitis in systemic sclerosis is histologically identical to lone cryptogenic fibrosing alveolitis (CFA) (idiopathic pulmonary fibrosis). The inflammatory cell content of bronchoalveolar lavage (BAL) samples has been used as a guide to prognosis and treatment in CFA. In this study, the relationship was ex...

journal_title：American journal of respiratory and critical care medicine

authors： Wells AU,Hansell DM,Rubens MB,Cullinan P,Haslam PL,Black CM,Du Bois RM

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Nitric oxide (NO), synthesized by NOSs (NO synthases), plays a role in the development of pulmonary hypertension (PH). However, the role of NO/NOSs in bone marrow (BM) cells in PH remains elusive. OBJECTIVES:To determine the role of NOSs in BM cells in PH. METHODS:Experiments were performed on 36 patients w...

journal_title：American journal of respiratory and critical care medicine

authors： Ogoshi T,Tsutsui M,Kido T,Sakanashi M,Naito K,Oda K,Ishimoto H,Yamada S,Wang KY,Toyohira Y,Izumi H,Masuzaki H,Shimokawa H,Yanagihara N,Yatera K,Mukae H

更新日期：2018-07-15 00:00:00

abstract：:Microscopic examination of tissue sections of mycobacterial lesions frequently results in few or no bacilli seen, even if the lesions appear active histologically. This might be due to the effects of the fixative fluid and/or organic solvent, both of which are conventionally used to make tissue sections for histopatho...

journal_title：American journal of respiratory and critical care medicine

authors： Fukunaga H,Murakami T,Gondo T,Sugi K,Ishihara T

更新日期：2002-10-01 00:00:00

abstract：:When dyspnea must be assessed clinically, there are three methods of assessment: the measurement of dyspnea with activities of daily living using clinical dyspnea ratings such as the modified Medical Research Council (MRC), the Baseline Dyspnea Index (BDI), and the Oxygen Cost Diagram (OCD); the measurement of dyspnea...

journal_title：American journal of respiratory and critical care medicine

authors： Hajiro T,Nishimura K,Tsukino M,Ikeda A,Koyama H,Izumi T

更新日期：1998-10-01 00:00:00

abstract：:Previous work from our laboratory has indicated that mechanoreceptor feedback from the respiratory muscles may play an important role in arousal and apnea termination in obstructive sleep apnea (OSA). Other studies have pointed to a prominent role for chemoreceptor stimuli. We postulated that mechanoreceptor stimuli f...

journal_title：American journal of respiratory and critical care medicine

authors： Kimoff RJ,Cheong TH,Olha AE,Charbonneau M,Levy RD,Cosio MG,Gottfried SB

更新日期：1994-03-01 00:00:00

abstract：RATIONALE:Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on tissue biopsy, which ...

journal_title：American journal of respiratory and critical care medicine

authors： Wei F,Lin CC,Joon A,Feng Z,Troche G,Lira ME,Chia D,Mao M,Ho CL,Su WC,Wong DT

更新日期：2014-11-15 00:00:00

abstract：:Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatment) trial demonstrated a significant reduction in all-cause mortality (ACM) risk with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI in patients with chronic obstructive pulmonary disease (COPD) at ris...

journal_title：American journal of respiratory and critical care medicine

authors： Lipson DA,Crim C,Criner GJ,Day NC,Dransfield MT,Halpin DMG,Han MK,Jones CE,Kilbride S,Lange P,Lomas DA,Lettis S,Manchester P,Martin N,Midwinter D,Morris A,Pascoe SJ,Singh D,Wise RA,Martinez FJ

更新日期：2020-06-15 00:00:00

abstract：:Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-l...

journal_title：American journal of respiratory and critical care medicine

authors： Shahar E,Whitney CW,Redline S,Lee ET,Newman AB,Nieto FJ,O'Connor GT,Boland LL,Schwartz JE,Samet JM

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

更新日期：2014-10-01 00:00:00

abstract：RATIONALE:Recent findings have demonstrated that muscarinic M(3) receptor stimulation enhances airway smooth muscle proliferation to peptide growth factors in vitro. Because both peptide growth factor expression and acetylcholine release are known to be augmented in allergic airway inflammation, it is possible that ant...

journal_title：American journal of respiratory and critical care medicine

authors： Gosens R,Bos IS,Zaagsma J,Meurs H

更新日期：2005-05-15 00:00:00

abstract：:Inhaled corticosteroids are effective antiinflammatory therapy for asthma; however, they do not completely abolish allergen-induced airway inflammation. Leukotriene modifiers attenuate both early and late allergen responses and have antiinflammatory properties. We reasoned that treatment with budesonide and montelukas...

journal_title：American journal of respiratory and critical care medicine

authors： Leigh R,Vethanayagam D,Yoshida M,Watson RM,Rerecich T,Inman MD,O'Byrne PM

更新日期：2002-11-01 00:00:00