The minimal important difference in the 6-minute walk test for patients with pulmonary arterial hypertension.

abstract：:Aeroallergens such as Amb a I from short ragweed are important in the development of allergic airway disease. We tested the ability of a human monoclonal immunoglobulin-A (IgA) antibody specific for Amb a I (A-IgA) to modulate airway responsiveness and lung eosinophilia after airway challenge with nebulized Amb a I or...

journal_title：American journal of respiratory and critical care medicine

authors： Schwarze J,Cieslewicz G,Joetham A,Sun LK,Sun WN,Chang TW,Hamelmann E,Gelfand EW

更新日期：1998-08-01 00:00:00

abstract：:A respiratory therapist-driven weaning protocol incorporating daily screens, spontaneous breathing trials (SBT), and prompts to caregivers has been associated with superior outcomes in mechanically ventilated medical patients. To determine the effectiveness of this approach in neurosurgical (NSY) patients, we conducte...

journal_title：American journal of respiratory and critical care medicine

authors： Namen AM,Ely EW,Tatter SB,Case LD,Lucia MA,Smith A,Landry S,Wilson JA,Glazier SS,Branch CL,Kelly DL,Bowton DL,Haponik EF

更新日期：2001-03-01 00:00:00

abstract：:Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine administration during resuscitation; however, prospective data to support this assertion are scarce. Objectives: To conduct a phase II trial evaluating the hypothesis that early low-dose norepinephrine in adults with sepsis with hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Permpikul C,Tongyoo S,Viarasilpa T,Trainarongsakul T,Chakorn T,Udompanturak S

更新日期：2019-05-01 00:00:00

abstract：:The aim of this prospective study was to determine factors influencing effects of inhaled nitric oxide (NO) on the pulmonary circulation and on gas exchange in critically ill patients with acute lung injury. Twenty-one hypoxemic patients with acute respiratory failure (PaO2 = 127 +/- 69 mm Hg during intermittent posit...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Rouby JJ,Mourgeon E,Cluzel P,Souhil Z,Law-Koune JD,Stewart T,Devilliers C,Lu Q,Roche S

更新日期：1995-07-01 00:00:00

abstract：:Theophylline is well-established in the management of asthma, and there is some evidence of an antiinflammatory effect in asthma. It is not known whether theophylline affects inflammatory markers such as sputum eosinophils and exhaled nitric oxide (NO) in patients with mild asthma not receiving inhaled steroid therapy...

journal_title：American journal of respiratory and critical care medicine

authors： Lim S,Tomita K,Caramori G,Jatakanon A,Oliver B,Keller A,Adcock I,Chung KF,Barnes PJ

更新日期：2001-07-15 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible for movement of sodium. Hyperactivation of ENaC, which creates an osmoti...

journal_title：American journal of respiratory and critical care medicine

authors： Scott DW,Walker MP,Sesma J,Wu B,Stuhlmiller TJ,Sabater JR,Abraham WM,Crowder TM,Christensen DJ,Tarran R

更新日期：2017-09-15 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：:Ten patients with acute respiratory distress syndrome (ARDS) received in random order nitric oxide (NO) inhalation, aerosolized prostaglandin E1 (PGE1), infusion of PGE1, or no intervention. Inhalation of either aerosolized PGE1 (10 +/- 1 ng/kg/min) or NO (7 +/- 1 ppm) reduced pulmonary vascular resistance (PVR) from ...

journal_title：American journal of respiratory and critical care medicine

authors： Putensen C,Hörmann C,Kleinsasser A,Putensen-Himmer G

更新日期：1998-06-01 00:00:00

abstract：:Although all the well-recognized muscles of expiration are paralyzed after traumatic transection of the lower cervical cord, tetraplegic subjects can still empty their lungs actively by contracting the clavicular portion of the pectoralis major. It is not known, however, whether contraction of this muscle bundle may r...

journal_title：American journal of respiratory and critical care medicine

authors： Estenne M,Van Muylem A,Gorini M,Kinnear W,Heilporn A,De Troyer A

更新日期：1994-10-01 00:00:00

abstract：:The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum induction in a two-visit, six-center study in 79 subjects with moderate to severe asthma (mean +/- SD FEV(1) 71 +/- 12% predicted, 67% taking inhaled corticostero...

journal_title：American journal of respiratory and critical care medicine

authors： Fahy JV,Boushey HA,Lazarus SC,Mauger EA,Cherniack RM,Chinchilli VM,Craig TJ,Drazen JM,Ford JG,Fish JE,Israel E,Kraft M,Lemanske RF,Martin RJ,McLean D,Peters SP,Sorkness C,Szefler SJ,NHLBI Asthma Clinical Research Netw

更新日期：2001-05-01 00:00:00

abstract：:Noninflammatory structural alterations, variously referred to as airway remodeling, are well documented in the asthmatic airway. However, the pathogenesis of these alterations, the importance of airway remodeling in generating the asthma phenotype, and the natural history of airway remodeling responses have not been a...

journal_title：American journal of respiratory and critical care medicine

authors： Zhu Z,Lee CG,Zheng T,Chupp G,Wang J,Homer RJ,Noble PW,Hamid Q,Elias JA

更新日期：2001-11-15 00:00:00

abstract：:The role of ventilatory-control abnormalities in predisposing to familial sleep-disordered breathing (SDB) was assessed in 31 subjects 28 +/- 10 yr of age (mean +/- SD). Subjects with (n = 10) and without SDB (n = 12) were recruited from 13 families having two or more members with SDB. Nine age- and gender-matched con...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Leitner J,Arnold J,Tishler PV,Altose MD

更新日期：1997-07-01 00:00:00

abstract：:T cells in the airways are considered to play a key role in orchestrating the inflammatory response of asthma through the elaboration of specific cytokines. Using flow cytometry we have investigated the T-cell response of sensitized asthmatic airways 6 h after local allergen provocation. Twelve subjects with atopic as...

journal_title：American journal of respiratory and critical care medicine

authors： Gratziou C,Carroll M,Montefort S,Teran L,Howarth PH,Holgate ST

更新日期：1996-02-01 00:00:00

abstract：:Nitric oxide (NO) may play a part in pulmonary vascular regulation and bronchomotor control and has been detected in exhaled air. We report the release of NO from airway epithelial cells and its regulation by cyclic adenosine monophosphate (cAMP). To directly measure NO release, a highly specific amperometric sensor f...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Kondo M,Takemura H,Chiyotani A,Yamawaki I,Konno K

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:In clinical trials, patients with cystic fibrosis and a G551D mutation who received ivacaftor experienced improvements in pulmonary and nutritional outcomes. However, whether these improvements reflect a change in disease trajectory cannot be determined without longer-term analyses with an appropriate compara...

journal_title：American journal of respiratory and critical care medicine

authors： Sawicki GS,McKone EF,Pasta DJ,Millar SJ,Wagener JS,Johnson CA,Konstan MW

更新日期：2015-10-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease that persists even during adequate therapy and asymptomatic episodes. We questioned whether "silent" chronic allergen exposure can induce and maintain airway inflammation and whether this still occurs during regular treatment with inhaled steroids. Twenty-six patients with hous...

journal_title：American journal of respiratory and critical care medicine

authors： de Kluijver J,Evertse CE,Schrumpf JA,van der Veen H,Zwinderman AH,Hiemstra PS,Rabe KF,Sterk PJ

更新日期：2002-08-01 00:00:00

abstract：:The lobar and cephalocaudal distribution of aerated and nonaerated lung and of PEEP-induced alveolar recruitment is unknown in acute lung injury (ALI). Dimensions of the lungs and volumes of aerated and nonaerated parts of each pulmonary lobe were measured using a computerized tomographic quantitative analysis and com...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Cluzel P,Chao N,Slutsky AS,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：:Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension in which the vascular changes originate in the small pulmonary veins and venules. The pathogenesis is unknown and any link with primary pulmonary hypertension (PPH) has been speculative. Mutations in the bone morphogenetic protein recepto...

journal_title：American journal of respiratory and critical care medicine

authors： Runo JR,Vnencak-Jones CL,Prince M,Loyd JE,Wheeler L,Robbins IM,Lane KB,Newman JH,Johnson J,Nichols WC,Phillips JA 3rd

更新日期：2003-03-15 00:00:00

abstract：:We produced ovalbumin (OVA)-sensitized rats as an animal model of nasal allergy. Intranasal instillation of OVA induced hypertrophic and metaplastic changes of goblet cells in nasal epithelium of OVA- sensitized rats. Intraepithelial mucosubstance in nasal mucosa increased significantly at 24 h after 3 or 7 d of OVA i...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Majima Y,Sakakura Y

更新日期：2000-05-01 00:00:00

abstract：:Muscle nerve sympathetic activity (MSA), the interval between two R-waves in the ECG, or the interbeat interval (RR-interval), and blood pressure (BP) were recorded in 10 awake patients with obstructive sleep apnea (OSA) and in nine sex- and age-matched controls. Changes in RR-interval and MSA, evoked by sodium nitrop...

journal_title：American journal of respiratory and critical care medicine

authors： Carlson JT,Hedner JA,Sellgren J,Elam M,Wallin BG

更新日期：1996-11-01 00:00:00

abstract：:Regular short-acting inhaled beta-agonist therapy is of uncertain benefit in patients with chronic obstructive pulmonary disease (COPD). We conducted a randomized, concealed, double-blind, placebo-controlled crossover trial in two periods, each of 3-mo duration, involving 53 patients with a smoking history of > 20 pac...

journal_title：American journal of respiratory and critical care medicine

authors： Cook D,Guyatt G,Wong E,Goldstein R,Bedard M,Austin P,Ramsdale H,Jaeschke R,Sears M

更新日期：2001-01-01 00:00:00

abstract：:Rationale: Interstitial macrophages (IMs) and airspace macrophages (AMs) play critical roles in lung homeostasis and host defense, and are central to the pathogenesis of a number of lung diseases. However, the absolute numbers of macrophages and the precise anatomic locations they occupy in the healthy human lung have...

journal_title：American journal of respiratory and critical care medicine

authors： Hume PS,Gibbings SL,Jakubzick CV,Tuder RM,Curran-Everett D,Henson PM,Smith BJ,Janssen WJ

更新日期：2020-05-15 00:00:00

abstract：RATIONALE:Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed duration of antiviral prophylaxis despite the associated cost and...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder LD,Chan C,Kwon D,Yi JS,Martissa JA,Copeland CA,Osborne RJ,Sparks SD,Palmer SM,Weinhold KJ

更新日期：2016-01-01 00:00:00

abstract：:Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thora...

journal_title：American journal of respiratory and critical care medicine

authors： Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Community-acquired pneumonia (CAP) accounts for a major proportion of intensive care unit (ICU) admissions for respiratory failure and sepsis. Diagnostic uncertainty complicates case management, which may delay appropriate cause-specific treatment. OBJECTIVES:To characterize the blood genomic response in pat...

journal_title：American journal of respiratory and critical care medicine

authors： Scicluna BP,Klein Klouwenberg PM,van Vught LA,Wiewel MA,Ong DS,Zwinderman AH,Franitza M,Toliat MR,Nürnberg P,Hoogendijk AJ,Horn J,Cremer OL,Schultz MJ,Bonten MJ,van der Poll T

更新日期：2015-10-01 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00

abstract：:Wheezing in childhood is not a single disorder and different wheezing-associated respiratory illnesses have been recently described. We investigated the association between wheezing conditions and familial, pre-, peri-, and postnatal risk factors. We studied 16,333 children, 6 to 7 yr old, enrolled in a population-bas...

journal_title：American journal of respiratory and critical care medicine

authors： Rusconi F,Galassi C,Corbo GM,Forastiere F,Biggeri A,Ciccone G,Renzoni E

更新日期：1999-11-01 00:00:00

abstract：RATIONALE:The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. OB...

journal_title：American journal of respiratory and critical care medicine

authors： Linch SN,Danielson ET,Kelly AM,Tamakawa RA,Lee JJ,Gold JA

更新日期：2012-08-01 00:00:00

abstract：:The mechanisms of exertional dyspnea relief in response to supplemental oxygen (O2) in chronic airflow limitation (CAL) are not precisely known and are likely multifactorial. To explore factors contributing to the relief of dyspnea after oxygen administration, 11 patients with severe CAL (FEV1.0 = 39 +/- 3% predicted,...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell DE,Bain DJ,Webb KA

更新日期：1997-02-01 00:00:00

abstract：:The physiopathology of chronic cough remains obscure. We evaluated the possibility that chronic cough in nonasthmatic subjects is associated with airway inflammation, and if this is so, what the relationship between this inflammation and the possible etiology of cough might be, as well as its response to inhaled stero...

journal_title：American journal of respiratory and critical care medicine

authors： Boulet LP,Milot J,Boutet M,St Georges F,Laviolette M

更新日期：1994-02-01 00:00:00