Low-dose theophylline reduces eosinophilic inflammation but not exhaled nitric oxide in mild asthma.

abstract：RATIONALE:Despite intensive research, sepsis displays the most prevalent cause of death on intensive care units. The hallmark of sepsis is an overshooting T-cell death that reduces host defense mechanisms and that is associated with poor patient survival. Previous in vitro studies revealed that the expression of the tr...

journal_title：American journal of respiratory and critical care medicine

authors： Schmidt MV,Paulus P,Kuhn AM,Weigert A,Morbitzer V,Zacharowski K,Kempf VA,Brüne B,von Knethen A

更新日期：2011-07-01 00:00:00

abstract：:We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 work...

journal_title：American journal of respiratory and critical care medicine

authors： Senthilselvan A,Pahwa P,Wang P,McDuffie HH,Dosman JA

更新日期：1996-02-01 00:00:00

abstract：:The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...

journal_title：American journal of respiratory and critical care medicine

authors： Ishizaka A,Hasegawa N,Sakamaki F,Tasaka S,Nakamura H,Kishikawa K,Yamada A,Obata T,Sayama K,Urano T

更新日期：1994-11-01 00:00:00

abstract：:Although contraction of human isolated bronchi is mediated mainly by tachykinin NK2 receptors, NK1 receptors, via prostanoid release, contract small-size (approximately 1 mm in diameter) bronchi. Here, we have investigated the presence and biological responses of NK1 receptors in medium-size (2-5 mm in diameter) human...

journal_title：American journal of respiratory and critical care medicine

authors： Amadesi S,Moreau J,Tognetto M,Springer J,Trevisani M,Naline E,Advenier C,Fisher A,Vinci D,Mapp C,Miotto D,Cavallesco G,Geppetti P

更新日期：2001-04-01 00:00:00

abstract：:The lobar and cephalocaudal distribution of aerated and nonaerated lung and of PEEP-induced alveolar recruitment is unknown in acute lung injury (ALI). Dimensions of the lungs and volumes of aerated and nonaerated parts of each pulmonary lobe were measured using a computerized tomographic quantitative analysis and com...

journal_title：American journal of respiratory and critical care medicine

authors： Puybasset L,Cluzel P,Chao N,Slutsky AS,Coriat P,Rouby JJ

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Patients of Hispanic origin with cystic fibrosis (CF) are the largest growing minority, representing 8.5% of patients with CF in the United States. No national survival analysis of this group has ever been undertaken. OBJECTIVES:We aimed to determine whether Hispanic ethnicity within the CF population is ass...

journal_title：American journal of respiratory and critical care medicine

authors： Rho J,Ahn C,Gao A,Sawicki GS,Keller A,Jain R

更新日期：2018-10-15 00:00:00

abstract：:Typical for critical illnesses are substantial alterations within the hypothalamic-anterior pituitary-peripheral hormonal axes that are proportionate to the risk of poor outcome. These neuroendocrine responses to critical illness follow a biphasic pattern. The acute phase (first hours to days) is characterized by an i...

journal_title：American journal of respiratory and critical care medicine

authors： Van den Berghe G

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Chronic infection with Burkholderia cepacia complex bacteria in cystic fibrosis is associated with accelerated decline in pulmonary function and increased mortality. Clinical implications of the recently characterized genomovar VI, B. dolosa, are unknown. OBJECTIVES:Characterization of impact of B. dolosa on...

journal_title：American journal of respiratory and critical care medicine

authors： Kalish LA,Waltz DA,Dovey M,Potter-Bynoe G,McAdam AJ,Lipuma JJ,Gerard C,Goldmann D

更新日期：2006-02-15 00:00:00

abstract：RATIONALE:Roflumilast is a therapeutic agent in the treatment of chronic obstructive pulmonary disease (COPD). It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway implicated in COPD pathogenesis and progression. The self-propagating acetyl-proline-glycine-proline (AcPGP) p...

journal_title：American journal of respiratory and critical care medicine

authors： Wells JM,Jackson PL,Viera L,Bhatt SP,Gautney J,Handley G,King RW,Xu X,Gaggar A,Bailey WC,Dransfield MT,Blalock JE

更新日期：2015-10-15 00:00:00

abstract：:Daily symptom, peak expiratory flow rate (PEFR), and medication diaries are often used in clinical trials of treatments for asthma on the assumption that they provide a better estimate of clinical status than does a questionnaire completed in the clinic. We conducted a study with the aim of comparing the measurement p...

journal_title：American journal of respiratory and critical care medicine

authors： Juniper EF,O'Byrne PM,Ferrie PJ,King DR,Roberts JN

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Ipsilateral recurrence rates of spontaneous pneumothorax after video-assisted thoracoscopic surgery are higher than rates after open thoracotomy. OBJECTIVES:This study was conducted to determine whether additional minocycline pleurodesis would be effective in diminishing recurrence after video-assisted thora...

journal_title：American journal of respiratory and critical care medicine

authors： Chen JS,Hsu HH,Chen RJ,Kuo SW,Huang PM,Tsai PR,Lee JM,Lee YC

更新日期：2006-03-01 00:00:00

abstract：:The potential role of nitric oxide synthase-2 (NOS2) in acute lung injury (ALI) has gained increasing attention. This study evaluates the effects of hypoxia, an important feature of ALI, on NOS2 expression in a rat model of ALI caused by exposure to hypoxia and LPS. Exposure to hypoxia alone had no effect on the expre...

journal_title：American journal of respiratory and critical care medicine

authors： Agorreta J,Garayoa M,Montuenga LM,Zulueta JJ

更新日期：2003-08-01 00:00:00

abstract：RATIONALE:The effects of prenatal cigarette smoke (CS) exposure and hypoxemia on cardiorespiratory control have been investigated in full-term infants. However, few data are available in preterm infants, who form a particularly vulnerable population, with developmentally immature cardiorespiratory control. OBJECTIVES:...

journal_title：American journal of respiratory and critical care medicine

authors： Schneider J,Mitchell I,Singhal N,Kirk V,Hasan SU

更新日期：2008-09-01 00:00:00

abstract：:Studies have shown evidence of significant parent-offspring and sibling correlation in FEV1, but familial aggregation of decline of FEV1 over time has not been reported. Our study population comprised 392 families enrolled in the Tucson Epidemiological Study of Airway Obstructive Diseases. Subjects were older than 18 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kurzius-Spencer M,Sherrill DL,Holberg CJ,Martinez FD,Lebowitz MD

更新日期：2001-10-01 00:00:00

abstract：:Muscle nerve sympathetic activity (MSA), the interval between two R-waves in the ECG, or the interbeat interval (RR-interval), and blood pressure (BP) were recorded in 10 awake patients with obstructive sleep apnea (OSA) and in nine sex- and age-matched controls. Changes in RR-interval and MSA, evoked by sodium nitrop...

journal_title：American journal of respiratory and critical care medicine

authors： Carlson JT,Hedner JA,Sellgren J,Elam M,Wallin BG

更新日期：1996-11-01 00:00:00

abstract：:Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnt...

journal_title：American journal of respiratory and critical care medicine

authors： Tinkle SS,Newman LS

更新日期：1997-12-01 00:00:00

abstract：:Obstructive sleep-disordered breathing is associated with cardiovascular disease in adults, and elevated C-reactive protein (CRP) has been proposed as a link between the two disorders. We hypothesized that children with sleep-disordered breathing have higher CRP values than do control subjects. CRP was measured in 39 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kaditis AG,Alexopoulos EI,Kalampouka E,Kostadima E,Germenis A,Zintzaras E,Gourgoulianis K

更新日期：2005-02-01 00:00:00

abstract：:Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. However, its role in stimulating eosinophil differentiation within the bone marrow following allergen exposure remains to be elucidated. The aims of our study were to deter...

journal_title：American journal of respiratory and critical care medicine

authors： Minshall EM,Schleimer R,Cameron L,Minnicozzi M,Egan RW,Gutierrez-Ramos JC,Eidelman DH,Hamid Q

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:Colonization of lower airways by Staphylococcus aureus is a risk factor for the development of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). However, little is known about the virulence factors of methicillin-sensitive and -resistant S. aureus (MSSA and MRSA) that ma...

journal_title：American journal of respiratory and critical care medicine

authors： Stulik L,Malafa S,Hudcova J,Rouha H,Henics BZ,Craven DE,Sonnevend AM,Nagy E

更新日期：2014-11-15 00:00:00

abstract：:During dynamic hyperinflation, the ventilatory pump is facing increased demand because it must overcome the intrinsic positive end-expiratory pressure (PEEPi) and decreased capacity since it must operate at a dynamically increased end-expiratory lung volume (EELV). The aim of this study was to evaluate the relative pr...

journal_title：American journal of respiratory and critical care medicine

authors： Yan S,Kayser B

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction. OBJECTIVES:We sought to determine if hyponatremia is associated with right heart failure and worse prognosis in patients with pulmonary arterial hypertension (PAH). METHODS:...

journal_title：American journal of respiratory and critical care medicine

authors： Forfia PR,Mathai SC,Fisher MR,Housten-Harris T,Hemnes AR,Champion HC,Girgis RE,Hassoun PM

更新日期：2008-06-15 00:00:00

abstract：RATIONALE:Secondary bacterial infection following rhinovirus (RV) infection has been recognized in chronic obstructive pulmonary disease. OBJECTIVES:We sought to understand mechanisms by which RV infection facilitates secondary bacterial infection. METHODS:Primary human airway epithelial cells grown at air-liquid int...

journal_title：American journal of respiratory and critical care medicine

authors： Sajjan U,Wang Q,Zhao Y,Gruenert DC,Hershenson MB

更新日期：2008-12-15 00:00:00

abstract：:We investigated the relation between IgE reactive with histamine-releasing factor (HRF) and clinical status in patients with asthma or rhinitis. Sera were used to passively sensitize purified, lactic-acid treated basophils. IgE-independent HRF due to chemokines was removed from mononuclear cell supernatants with hepar...

journal_title：American journal of respiratory and critical care medicine

authors： Pasmans SG,Aalbers M,van der Veen MJ,Knol EF,van der Zee JS,Jansen HM,Aalberse RC

更新日期：1996-08-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) is a growth factor that is implicated in fibrosis of many organs. The purpose of this study was to determine the sequential levels of TGF-beta1 in the pleural fluid of rabbits that had undergone empyema induction, as fibrosis of the pleural space develops. Thirty-seven rabb...

journal_title：American journal of respiratory and critical care medicine

authors： Sasse SA,Jadus MR,Kukes GD

更新日期：2003-09-15 00:00:00

abstract：:In order to assess the usefulness of sputum analysis in studying plasma-protein exudation and local secretion of proteins in the airways, we measured specific proteins in the sputum sol phase (SSP) and sputum gel phase (SGP) from patients with stable asthma or chronic obstructive pulmonary disease (COPD). Protein leve...

journal_title：American journal of respiratory and critical care medicine

authors： Schoonbrood DF,Lutter R,Habets FJ,Roos CM,Jansen HM,Out TA

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:Although interferon (IFN)-gamma release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection. OBJECTIVES:To compare tuberculin skin test (TST) results to the commercial IFN-gamma release assay QuantiFERON-TB Gold In-Tub...

journal_title：American journal of respiratory and critical care medicine

authors： Luetkemeyer AF,Charlebois ED,Flores LL,Bangsberg DR,Deeks SG,Martin JN,Havlir DV

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate. OBJECTIVES:Evaluate the accuracy of Doppler echocar...

journal_title：American journal of respiratory and critical care medicine

authors： Fisher MR,Forfia PR,Chamera E,Housten-Harris T,Champion HC,Girgis RE,Corretti MC,Hassoun PM

更新日期：2009-04-01 00:00:00

abstract：:We produced ovalbumin (OVA)-sensitized rats as an animal model of nasal allergy. Intranasal instillation of OVA induced hypertrophic and metaplastic changes of goblet cells in nasal epithelium of OVA- sensitized rats. Intraepithelial mucosubstance in nasal mucosa increased significantly at 24 h after 3 or 7 d of OVA i...

journal_title：American journal of respiratory and critical care medicine

authors： Shimizu T,Hirano H,Majima Y,Sakakura Y

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:The contribution of interferon-gamma release assays (IGRAs) to appropriate risk stratification of active tuberculosis suspects has not been studied. OBJECTIVES:To determine whether the addition of quantitative IGRA results to a prediction model incorporating clinical criteria improves risk stratification of ...

journal_title：American journal of respiratory and critical care medicine

authors： Metcalfe JZ,Cattamanchi A,Vittinghoff E,Ho C,Grinsdale J,Hopewell PC,Kawamura LM,Nahid P

更新日期：2010-01-01 00:00:00

abstract：:Lung transplantation with its attendant life-long immunosuppression contributes to bone loss and its sequelae, fractures and kyphosis, in patients with lung disease, many of whom already suffer from severe osteoporosis. Patients with cystic fibrosis (CF) are one of the most severely affected groups. We conducted a con...

journal_title：American journal of respiratory and critical care medicine

authors： Aris RM,Lester GE,Renner JB,Winders A,Denene Blackwood A,Lark RK,Ontjes DA

更新日期：2000-09-01 00:00:00