Differential inspiratory muscle pressure contributions to breathing during dynamic hyperinflation.

abstract：RATIONALE:Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. OBJECTIVES:To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically rele...

journal_title：American journal of respiratory and critical care medicine

authors： James AJ,Reinius LE,Verhoek M,Gomes A,Kupczyk M,Hammar U,Ono J,Ohta S,Izuhara K,Bel E,Kere J,Söderhäll C,Dahlén B,Boot RG,Dahlén SE,BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway

更新日期：2016-01-15 00:00:00

abstract：:To compare the effectiveness of information delivered to family members of critically ill patients by junior and senior physicians, we performed a prospective randomized multicenter trial in 11 French intensive care units. Patients (n = 220) were allocated at random to having their family members receive information b...

journal_title：American journal of respiratory and critical care medicine

authors： Moreau D,Goldgran-Toledano D,Alberti C,Jourdain M,Adrie C,Annane D,Garrouste-Orgeas M,Lefrant JY,Papazian L,Quinio P,Pochard F,Azoulay E

更新日期：2004-02-15 00:00:00

abstract：RATIONALE:Cytokine receptors can be markers defining different T-cell subsets and considered as therapeutic targets. The association of IL-6 and IL-6 receptor α (IL-6Rα) with asthma was reported, suggesting their involvement in asthma. OBJECTIVES:To determine whether and how IL-6Rα defines a distinct effector memory (...

journal_title：American journal of respiratory and critical care medicine

authors： Lee N,You S,Shin MS,Lee WW,Kang KS,Kim SH,Kim WU,Homer RJ,Kang MJ,Montgomery RR,Dela Cruz CS,Shaw AC,Lee PJ,Chupp GL,Hwang D,Kang I

更新日期：2014-12-15 00:00:00

abstract：RATIONALE:Brief recurrent apneas in preterm infants and adults can precipitate rapid and severe arterial O(2) desaturation for reasons that remain unclear. OBJECTIVES:We tested a mathematically derived hypothesis that when breathing terminates apnea, mixed-venous hypoxemia continues into the subsequent apnea; as a res...

journal_title：American journal of respiratory and critical care medicine

authors： Sands SA,Edwards BA,Kelly VJ,Skuza EM,Davidson MR,Wilkinson MH,Berger PJ

更新日期：2010-10-01 00:00:00

abstract：:Airway obstruction (AO) in exercise-induced asthma (EIA) is considered a postexercise phenomenon. However, many with EIA complain of respiratory distress during exercise. We evaluated AO in six asthmatic subjects during a short (SX = 6 min) and a long (LX = 20 min) exercise session. We measured peak expiratory flow (P...

journal_title：American journal of respiratory and critical care medicine

authors： Suman OE,Babcock MA,Pegelow DF,Jarjour NN,Reddan WG

更新日期：1995-07-01 00:00:00

abstract：RATIONALE:The effect of graft ischemic time on early graft function and long-term survival of patients who underwent lung transplantation remains controversial. Consequently, graft ischemic time has not been incorporated in the decision-making process at the time of graft acceptance. OBJECTIVES:To investigate the rela...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Mal H,Cerrina J,Dartevelle P,Dromer C,Velly JF,Stern M,Loirat P,Lesèche G,Bertocchi M,Mornex JF,Haloun A,Despins P,Pison C,Blin D,Reynaud-Gaubert M

更新日期：2005-04-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is traditionally diagnosed using overnight polysomnography. Decision rules may provide an alternative to polysomnography. A consecutive series of patients referred to a tertiary sleep center underwent prospective evaluation with the upper airway physical examination protocol, followed by ...

journal_title：American journal of respiratory and critical care medicine

authors： Tsai WH,Remmers JE,Brant R,Flemons WW,Davies J,Macarthur C

更新日期：2003-05-15 00:00:00

abstract：:We reported that systemic keratinocyte growth factor (KGF) given before bone marrow transplantation (BMT) prevents allogeneic T cell-dependent lung inflammation assessed on Day 7 post-BMT, but the antiinflammatory effects of KGF were impaired in mice injected with both T cells and conditioning regimen of cyclophospham...

journal_title：American journal of respiratory and critical care medicine

authors： Yang S,Panoskaltsis-Mortari A,Ingbar DH,Matalon S,Zhu S,Resnik ER,Farrell CL,Lacey DL,Blazar BR,Haddad IY

更新日期：2000-11-01 00:00:00

abstract：:The currently recommended prehospital treatment for carbon monoxide (CO) poisoning is administration of 100% O(2). We have shown in dogs that normocapnic hyperpnea with O(2) further accelerates CO elimination. The purpose of this study was to examine the relation between minute ventilation (V E) and the rate of elimin...

journal_title：American journal of respiratory and critical care medicine

authors： Takeuchi A,Vesely A,Rucker J,Sommer LZ,Tesler J,Lavine E,Slutsky AS,Maleck WH,Volgyesi G,Fedorko L,Iscoe S,Fisher JA

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Mitochondria have important roles in intracellular energy generation, modulation of apoptosis, and redox-dependent intracellular signaling. Although reactive oxygen species (ROS) participate in the regulation of intracellular signaling pathways, including activation of nuclear factor (NF)-kappaB, there is onl...

journal_title：American journal of respiratory and critical care medicine

authors： Zmijewski JW,Lorne E,Zhao X,Tsuruta Y,Sha Y,Liu G,Siegal GP,Abraham E

更新日期：2008-07-15 00:00:00

abstract：:A higher exposure to endotoxin was hypothesized to contribute to lower prevalence of allergic sensitization and hay fever in children growing up on a farm. We studied the association between house dust endotoxin and allergic sensitization. We randomly selected 740 children, aged between 5 and 10 years, from a group of...

journal_title：American journal of respiratory and critical care medicine

authors： Gehring U,Bischof W,Fahlbusch B,Wichmann HE,Heinrich J

更新日期：2002-10-01 00:00:00

abstract：:This study describes the natural history of atopic and wheezy disorders from birth to adult life in a cohort at risk of atopy. One hundred subjects born in Poole, England, were selected at birth in 1976 on the basis that at least one parent was atopic. Subjects were examined annually in the preschool years, and at the...

journal_title：American journal of respiratory and critical care medicine

authors： Rhodes HL,Thomas P,Sporik R,Holgate ST,Cogswell JJ

更新日期：2002-01-15 00:00:00

abstract：:Airway smooth muscle (ASM) accumulation and enrichment of the extracellular matrix (ECM) with type I collagen and fibronectin are major pathologic features of airway remodeling in asthma. These ECM components confer enhanced ASM proliferation in vitro, but a requirement for specific integrin ECM receptors has not been...

journal_title：American journal of respiratory and critical care medicine

authors： Nguyen TT,Ward JP,Hirst SJ

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment of pneumonia. OBJECTIVES:To elucidate clinical features of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), and to clarify risk factors for drug-resistant pathogens in patien...

journal_title：American journal of respiratory and critical care medicine

authors： Shindo Y,Ito R,Kobayashi D,Ando M,Ichikawa M,Shiraki A,Goto Y,Fukui Y,Iwaki M,Okumura J,Yamaguchi I,Yagi T,Tanikawa Y,Sugino Y,Shindoh J,Ogasawara T,Nomura F,Saka H,Yamamoto M,Taniguchi H,Suzuki R,Saito H,Kawa

更新日期：2013-10-15 00:00:00

abstract：:The plasma level of fibrinogen is felt to be an independent risk factor for vascular events. Obstructive sleep apnea (OSA) has a high prevalence in patients with stroke and may also be an independent risk factor. The aim of our study was to determine the association between OSA and plasma levels of fibrinogen in patie...

journal_title：American journal of respiratory and critical care medicine

authors： Wessendorf TE,Thilmann AF,Wang YM,Schreiber A,Konietzko N,Teschler H

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Sarcoidosis is known as a disease with high heterogeneity in clinical severity and inflammatory activity. On the basis of radiologic criteria, John Guyette Scadding developed a classification system, which is widely used, but is insufficient for clinical decision making. Therefore, biomarkers and genetic mark...

journal_title：American journal of respiratory and critical care medicine

authors： Prasse A,Katic C,Germann M,Buchwald A,Zissel G,Müller-Quernheim J

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

更新日期：1997-09-01 00:00:00

abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

journal_title：American journal of respiratory and critical care medicine

authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Daily azithromycin decreases acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but long-term side effects are unknown. OBJECTIVES:To identify the types of exacerbations most likely to be reduced and clinical subgroups most likely to benefit from azithromycin, 250 mg daily, added to usual...

journal_title：American journal of respiratory and critical care medicine

authors： Han MK,Tayob N,Murray S,Dransfield MT,Washko G,Scanlon PD,Criner GJ,Casaburi R,Connett J,Lazarus SC,Albert R,Woodruff P,Martinez FJ

更新日期：2014-06-15 00:00:00

abstract：RATIONALE:Sarcoidosis is a granulomatous disease of unknown etiology, although M. tuberculosis may play a role in the pathogenesis. The traditional view holds that inflammation in sarcoidosis is compartmentalized to involved organs. OBJECTIVES:To determine whether whole blood gene expression signatures reflect inflamm...

journal_title：American journal of respiratory and critical care medicine

authors： Koth LL,Solberg OD,Peng JC,Bhakta NR,Nguyen CP,Woodruff PG

更新日期：2011-11-15 00:00:00

abstract：RATIONALE:There is conflicting information about the development and resolution of airway inflammation and airway hyperresponsiveness (AHR) after repeated airway exposure to allergen in sensitized mice. METHODS:Sensitized BALB/c and C57BL/6 mice were exposed to repeated allergen challenge on 3, 7, or 11 occasions. Air...

journal_title：American journal of respiratory and critical care medicine

authors： Koya T,Kodama T,Takeda K,Miyahara N,Yang ES,Taube C,Joetham A,Park JW,Dakhama A,Gelfand EW

更新日期：2006-01-01 00:00:00

abstract：:Neutrophil adherence to tumor necrosis factor-alpha (TNF-alpha)-treated human pulmonary microvascular endothelial cells (PMECs) induces cytoskeletal changes in endothelial cells that require intercellular adhesion molecule-1 (ICAM-1)-dependent signaling events. This study determined whether similar changes occurred in...

journal_title：American journal of respiratory and critical care medicine

authors： Wang Q,Pfeiffer GR 2nd,Stevens T,Doerschuk CM

更新日期：2002-09-15 00:00:00

abstract：:Studies of the hemodynamic effects of nasal continuous positive airway pressure (n-CPAP) in normal subjects have had conflicting results. The largest study (n = 19) found no effect of up to 15 cm H2O on heart rate (HR), cardiac stroke volume (SV), or cardiac index. We hypothesized that n-CPAP, by increasing intrathora...

journal_title：American journal of respiratory and critical care medicine

authors： Montner PK,Greene ER,Murata GH,Stark DM,Timms M,Chick TW

更新日期：1994-06-01 00:00:00

abstract：:A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases. To find whether inactivation of surfactant could be prevented or reduced by nonionic p...

journal_title：American journal of respiratory and critical care medicine

authors： William Taeusch H,Lu KW,Goerke J,Clements JA

更新日期：1999-05-01 00:00:00

abstract：:The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of p...

journal_title：American journal of respiratory and critical care medicine

authors： Newman LS,Mroz MM,Balkissoon R,Maier LA

更新日期：2005-01-01 00:00:00

abstract：:Rationale: The bHLH (basic helix-loop-helix) transcription factor TWIST1 (Twist-related protein 1) controls cell proliferation and differentiation in tissue development and disease processes. Recently, endothelial TWIST1 has been linked to pulmonary hypertension (PH) and endothelial-to-mesenchymal transition, yet the ...

journal_title：American journal of respiratory and critical care medicine

authors： Fan Y,Gu X,Zhang J,Sinn K,Klepetko W,Wu N,Foris V,Solymosi P,Kwapiszewska G,Kuebler WM

更新日期：2020-11-01 00:00:00

abstract：:The relationship between asthma medication and the perception of asthma symptoms is of interest for daily practice. Poor perception of asthma symptoms might influence patients' health care behavior and subsequently might lead to undertreatment and deterioration of their disease. This study investigated the influence o...

journal_title：American journal of respiratory and critical care medicine

authors： Bijl-Hofland ID,Cloosterman SG,Folgering HT,van den Elshout FJ,van Weel C,van Schayck CP

更新日期：2001-09-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：RATIONALE:Exploring prenatal factors influencing childhood wheeze may inform programming mechanisms. OBJECTIVES:We examined associations among prenatal maternal cortisol profiles, maternal obesity, and repeated wheeze up to age 2 years (n = 261). METHODS:Salivary cortisol was collected five times per day over 3 days ...

journal_title：American journal of respiratory and critical care medicine

authors： Wright RJ,Fisher K,Chiu YH,Wright RO,Fein R,Cohen S,Coull BA

更新日期：2013-06-01 00:00:00

abstract：RATIONALE:In 1989, the United States embarked upon an ambitious path to eliminate tuberculosis (TB) nationwide. Although incidence rates of TB disease in the United States are declining, these cases represent only a tiny fraction of all TB infections. Understanding national trends in TB infection may be important in an...

journal_title：American journal of respiratory and critical care medicine

authors： Khan K,Wang J,Hu W,Bierman A,Li Y,Gardam M

更新日期：2008-02-15 00:00:00