Developmental changes in crossbridge properties and myosin isoforms in hamster diaphragm.

abstract：:A study was done to compare the efficacy and safety of the coprescription of salmeterol 50 microgram twice daily or 100 microgram twice daily with beclomethasone dipropionate (BDP) 500 micrograms twice daily (SALM 50 and SALM 100) with BDP 1,000 microgram twice daily (BDP 1,000) in patients with asthma not controlled ...

journal_title：American journal of respiratory and critical care medicine

authors： Woolcock A,Lundback B,Ringdal N,Jacques LA

更新日期：1996-05-01 00:00:00

abstract：:Because interleukin 8 (IL-8) is a potent neutrophil chemotactic and activating cytokine, we investigated IL-8 production in relation to neutrophil migration and elastase release in the human lung during unilateral community-acquired pneumonia (CAP). In 17 patients, the local response in the involved lung was compared ...

journal_title：American journal of respiratory and critical care medicine

authors： Boutten A,Dehoux MS,Seta N,Ostinelli J,Venembre P,Crestani B,Dombret MC,Durand G,Aubier M

更新日期：1996-01-01 00:00:00

abstract：:Most randomized trials in critical care report no mortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true ineffectiveness of interventions. We hypothesize that in acute respiratory distress syndrome (ARDS), randomizing only those patients who show a favorable physiological r...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Kavanagh BP,Rubenfeld GD,Ferguson ND

更新日期：2015-12-15 00:00:00

abstract：:We tested the hypothesis that in advanced pulmonary fibrosis, edema is redistributed away from the relatively noncompliant interstitium and predominantly floods alveoli. Severe left lung fibrosis was produced in six dogs with radiation and intratracheal bleomycin and, 24 mo later, hydrostatic edema was induced by infu...

journal_title：American journal of respiratory and critical care medicine

authors： Zwikler MP,Iancu D,Michel RP

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and increased partial osmotic pressure, in part caused by abnormal purine nucleotide regulation of ion transport, contribute to the pathogenesis of CB. OBJECTIVE...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson WH,Coakley RD,Button B,Henderson AG,Zeman KL,Alexis NE,Peden DB,Lazarowski ER,Davis CW,Bailey S,Fuller F,Almond M,Qaqish B,Bordonali E,Rubinstein M,Bennett WD,Kesimer M,Boucher RC

更新日期：2015-07-15 00:00:00

abstract：:Genetic factors may contribute to the variability of exhaled nitric oxide in healthy individuals. We studied exhaled nitric oxide and genetic variants in both neuronal and endothelial nitric oxide synthases in 105 healthy nonsmoking and smoking subjects. Genomic DNA was screened for a repeat polymorphism in intron 20 ...

journal_title：American journal of respiratory and critical care medicine

authors： Grasemann H,Storm van's Gravesande K,Buscher R,Drazen JM,Ratjen F

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:Fluid accumulation in the legs and its overnight redistribution into the neck appears to play a causative role in obstructive sleep apnea (OSA) in sedentary men. Chronic venous insufficiency (CVI) promotes fluid accumulation in the legs that can be counteracted by compression stockings. OBJECTIVES:To test th...

journal_title：American journal of respiratory and critical care medicine

authors： Redolfi S,Arnulf I,Pottier M,Lajou J,Koskas I,Bradley TD,Similowski T

更新日期：2011-11-01 00:00:00

abstract：RATIONALE:Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. OBJECTIVES:We sought to identify donor, recipient, and perioperative risk factors for PGD. METHODS:We performed a 10-center p...

journal_title：American journal of respiratory and critical care medicine

authors： Diamond JM,Lee JC,Kawut SM,Shah RJ,Localio AR,Bellamy SL,Lederer DJ,Cantu E,Kohl BA,Lama VN,Bhorade SM,Crespo M,Demissie E,Sonett J,Wille K,Orens J,Shah AS,Weinacker A,Arcasoy S,Shah PD,Wilkes DS,Ware LB,Palme

更新日期：2013-03-01 00:00:00

abstract：:The demand for intensivists is increasing around the world, not only to meet the needs of a growing aging population, but also to fill positions in the intensive care unit now occupied by other specialists, since there is compelling evidence that the presence of critical care practitioners improves patient outcomes. N...

journal_title：American journal of respiratory and critical care medicine

authors： Estenssoro E,Valente Barbas CS,Briva A

更新日期：2013-01-15 00:00:00

abstract：:To define the mechanisms by which inhaled glucocorticosteroid regulates allergen-induced airway inflammation, a double-blind, placebo-controlled, cross-over study with inhaled budesonide was conducted in 14 subjects with allergic asthma. After baseline bronchoscopy and bronchoalveolar lavage (BAL), subjects were rando...

journal_title：American journal of respiratory and critical care medicine

authors： Kelly EA,Busse WW,Jarjour NN

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Although research supports a sleep-disordered breathing and atrial fibrillation association, prospective data examining sleep-disordered breathing predicting incident atrial fibrillation are lacking. OBJECTIVES:To investigate sleep-disordered breathing indices as predictors of incident atrial fibrillation. ...

journal_title：American journal of respiratory and critical care medicine

authors： May AM,Blackwell T,Stone PH,Stone KL,Cawthon PM,Sauer WH,Varosy PD,Redline S,Mehra R,MrOS Sleep (Outcomes of Sleep Disorders in Older Men) Study Group.

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:The effect of graft ischemic time on early graft function and long-term survival of patients who underwent lung transplantation remains controversial. Consequently, graft ischemic time has not been incorporated in the decision-making process at the time of graft acceptance. OBJECTIVES:To investigate the rela...

journal_title：American journal of respiratory and critical care medicine

authors： Thabut G,Mal H,Cerrina J,Dartevelle P,Dromer C,Velly JF,Stern M,Loirat P,Lesèche G,Bertocchi M,Mornex JF,Haloun A,Despins P,Pison C,Blin D,Reynaud-Gaubert M

更新日期：2005-04-01 00:00:00

abstract：:Patients with impaired pulmonary function are at increased risk for the development of postoperative complications. Recently exercise testing and predicted postoperative (ppo) function have gained increasing importance in the evaluation of lung resection candidates. We prospectively evaluated an algorithm for the preo...

journal_title：American journal of respiratory and critical care medicine

authors： Wyser C,Stulz P,Solèr M,Tamm M,Müller-Brand J,Habicht J,Perruchoud AP,Bolliger CT

更新日期：1999-05-01 00:00:00

abstract：:The aim of the study was to determine risk factors for severe community-acquired pneumonia (CAP) as well as to compare microbial patterns of severe CAP to a previous study from our respiratory intensive care unit (ICU) originating from 1984 to 1987. Patients admitted to the ICU according to clinical judgment were defi...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Ewig S,Torres A,Arancibia F,Marco F,Mensa J,Sanchez M,Martinez JA

更新日期：1999-09-01 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno K

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Severe pulmonary arterial hypertension (PAH) is characterized by the formation of plexiform lesions and concentric intimal fibrosis in small pulmonary arteries. The origin of cells contributing to these vascular lesions is uncertain. Endogenous endothelial progenitor cells are potential contributors to this p...

journal_title：American journal of respiratory and critical care medicine

authors： Toshner M,Voswinckel R,Southwood M,Al-Lamki R,Howard LS,Marchesan D,Yang J,Suntharalingam J,Soon E,Exley A,Stewart S,Hecker M,Zhu Z,Gehling U,Seeger W,Pepke-Zaba J,Morrell NW

更新日期：2009-10-15 00:00:00

abstract：RATIONALE:Ventilation-perfusion scintigraphy is highly sensitive for pulmonary embolism (PE), but its clinical usefulness is limited by its nondiagnostic rate. Objective analysis of single photon emission computed tomography (SPECT) three-dimensional scintigraphy may improve its diagnostic performance compared with sub...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Bailey D,Miles S,Bailey E,Rogers K,Roach P,Thomas P,Hensley M,King GG

更新日期：2007-06-01 00:00:00

abstract：:An imbalance of proinflammatory cytokines such as TNF-alpha, IL-1 beta, and the neutrophil chemotactic factor IL-8 and inhibitors (e.g., soluble TNF receptors and IL-1ra) in the lung during the first week of life may contribute to prolonged pulmonary inflammation and fibrosis in bronchopulmonary dysplasia (BPD). Disod...

journal_title：American journal of respiratory and critical care medicine

authors： Viscardi RM,Hasday JD,Gumpper KF,Taciak V,Campbell AB,Palmer TW

更新日期：1997-11-01 00:00:00

abstract：:Despite the increasing attention to the relationship between asthma and work exposures, occupational asthma remains underrecognized and its population burden underestimated. This may be due, in part, to the fact that traditional approaches to studying asthma in populations cannot adequately take into account the healt...

journal_title：American journal of respiratory and critical care medicine

authors： Le Moual N,Kauffmann F,Eisen EA,Kennedy SM

更新日期：2008-01-01 00:00:00

abstract：:Phl p5 is a major allergen of timothy grass and causes rhinitis and bronchial asthma in nearly all patients allergic to grass pollen. The biochemical processing of this molecule by the nasal mucosa at its first encounter and possible changes of its biologic activity are unknown. Two isoforms of the allergen were expre...

journal_title：American journal of respiratory and critical care medicine

authors： Bufe A,Gehlhar K,Schramm G,Schlaak M,Becker WM

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults; however, whether mild OSA has significant neurocognitive and cardiovascular complications is uncertain. OBJECTIVES:The specific goals of this Research Statement are to appraise the evidence regarding whether long-term adverse neuro...

journal_title：American journal of respiratory and critical care medicine

authors： Chowdhuri S,Quan SF,Almeida F,Ayappa I,Batool-Anwar S,Budhiraja R,Cruse PE,Drager LF,Griss B,Marshall N,Patel SR,Patil S,Knight SL,Rowley JA,Slyman A,ATS Ad Hoc Committee on Mild Obstructive Sleep Apnea.

更新日期：2016-05-01 00:00:00

abstract：:Rationale: Noninvasive ventilation decreases the need for invasive mechanical ventilation and mortality among patients with chronic obstructive pulmonary disease but has not been well studied in asthma.Objectives: To assess the association between noninvasive ventilation and subsequent need for invasive mechanical ven...

journal_title：American journal of respiratory and critical care medicine

authors： Althoff MD,Holguin F,Yang F,Grunwald GK,Moss M,Vandivier RW,Ho PM,Kiser TH,Burnham EL

更新日期：2020-12-01 00:00:00

abstract：:Noninvasive and invasive diagnostic techniques have been shown to achieve comparable performances in the evaluation of suspected ventilator-associated pneumonia (VAP). We studied the impact of both approaches on outcome in a prospective, open, and randomized study in three intensive care units (ICUs) of a 1,000-bed te...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Torres A,Ewig S,Marcos MA,Alcón A,Lledó R,Asenjo MA,Maldonaldo A

更新日期：2000-07-01 00:00:00

abstract：:Poor adherence to medication regimens may be contributing to the recent increase in asthma morbidity and mortality. We examined patient characteristics that may influence adherence to twice-daily inhaled steroid regimens. Fifty adults with moderate to severe asthma completed questionnaires examining sociodemographics,...

journal_title：American journal of respiratory and critical care medicine

authors： Apter AJ,Reisine ST,Affleck G,Barrows E,ZuWallack RL

更新日期：1998-06-01 00:00:00

abstract：:We have recently demonstrated the development of systemic hypertension in a canine model of obstructive sleep apnea (OSA), but the underlying physiological mechanisms were not identified. Therefore, the purpose of this study was to examine the effect of OSA on arterial baroreceptor control of heart rate (HR) in this c...

journal_title：American journal of respiratory and critical care medicine

authors： Brooks D,Horner RL,Floras JS,Kozar LF,Render-Teixeira CL,Phillipson EA

更新日期：1999-04-01 00:00:00

abstract：:Antimicrobial stewardship involves a multifaceted approach that strives to combat the emergence of resistance, improve clinical outcomes, and control costs by improving antimicrobial use. Therefore, stewardship is of great importance and relevance in the intensive care unit. Clinical decision support systems, biomarke...

journal_title：American journal of respiratory and critical care medicine

authors： Lawrence KL,Kollef MH

更新日期：2009-03-15 00:00:00

abstract：:A continuously mixed series of microbial communities inhabits various points of the respiratory tract, with community composition determined by distance from colonization sources, colonization rates, and extinction rates. Ecology and evolution theory developed in the context of biogeography is relevant to clinical mic...

journal_title：American journal of respiratory and critical care medicine

authors： Whiteson KL,Bailey B,Bergkessel M,Conrad D,Delhaes L,Felts B,Harris JK,Hunter R,Lim YW,Maughan H,Quinn R,Salamon P,Sullivan J,Wagner BD,Rainey PB

更新日期：2014-06-01 00:00:00

abstract：:Rationale: The management of indeterminate pulmonary nodules (IPNs) remains challenging, resulting in invasive procedures and delays in diagnosis and treatment. Strategies to decrease the rate of unnecessary invasive procedures and optimize surveillance regimens are needed.Objectives: To develop and validate a deep le...

journal_title：American journal of respiratory and critical care medicine

authors： Massion PP,Antic S,Ather S,Arteta C,Brabec J,Chen H,Declerck J,Dufek D,Hickes W,Kadir T,Kunst J,Landman BA,Munden RF,Novotny P,Peschl H,Pickup LC,Santos C,Smith GT,Talwar A,Gleeson F

更新日期：2020-07-15 00:00:00

abstract：:The Pulmonary Complications of HIV Infection Study is a prospective, multicenter, observational study evaluating pulmonary disease among HIV-infected persons. For approximately 52 mo, 1,182 HIV-infected subjects were followed. All participants were evaluated for pulmonary disease on a predetermined schedule. There wer...

journal_title：American journal of respiratory and critical care medicine

authors： Stansell JD,Osmond DH,Charlebois E,LaVange L,Wallace JM,Alexander BV,Glassroth J,Kvale PA,Rosen MJ,Reichman LB,Turner JR,Hopewell PC

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00