Effects of pulmonary fibrosis on the distribution of edema. Morphometric analysis.

abstract：RATIONALE:Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES:To examine the functional and transcriptional profiles of pa...

journal_title：American journal of respiratory and critical care medicine

authors： Juss JK,House D,Amour A,Begg M,Herre J,Storisteanu DM,Hoenderdos K,Bradley G,Lennon M,Summers C,Hessel EM,Condliffe A,Chilvers ER

更新日期：2016-10-15 00:00:00

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF. OBJECTIVES:To understand the gene expression patterns of acute exacerbations of IPF. METHODS:RNA was extracted ...

journal_title：American journal of respiratory and critical care medicine

authors： Konishi K,Gibson KF,Lindell KO,Richards TJ,Zhang Y,Dhir R,Bisceglia M,Gilbert S,Yousem SA,Song JW,Kim DS,Kaminski N

更新日期：2009-07-15 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：:To better understand strategies for recruiting and maintaining lung volume in acute lung injury, we examined relationships between steady-state lung volume and cumulative cyclic recruitment/derecruitment volume history and the quasi-static pressure-volume curve, in an animal saline lavage lung injury model. Small-volu...

journal_title：American journal of respiratory and critical care medicine

authors： Downie JM,Nam AJ,Simon BA

更新日期：2004-04-15 00:00:00

abstract：:We investigated the influence of pulmonary bacteriology and histology on the yield of diagnostic procedures in a clinically relevant model of ventilator-acquired pneumonia (VAP). Twenty-seven piglets entered a 4-d protocol of ventilatory support under general anesthesia. Endotracheal aspirates (EA), protected specimen...

journal_title：American journal of respiratory and critical care medicine

authors： Wermert D,Marquette CH,Copin MC,Wallet F,Fraticelli A,Ramon P,Tonnel AB

更新日期：1998-07-01 00:00:00

abstract：:The intestinal immune system discriminates between potentially harmful and harmless foreign proteins. The basis for this differential response may be related to the conditions of antigen presentation by antigen-presenting cells, as determined by their phenotype or activation state. How these conditions affect specific...

journal_title：American journal of respiratory and critical care medicine

authors： Smith KM,Eaton AD,Finlayson LM,Garside P

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment of pneumonia. OBJECTIVES:To elucidate clinical features of community-acquired pneumonia (CAP) and healthcare-associated pneumonia (HCAP), and to clarify risk factors for drug-resistant pathogens in patien...

journal_title：American journal of respiratory and critical care medicine

authors： Shindo Y,Ito R,Kobayashi D,Ando M,Ichikawa M,Shiraki A,Goto Y,Fukui Y,Iwaki M,Okumura J,Yamaguchi I,Yagi T,Tanikawa Y,Sugino Y,Shindoh J,Ogasawara T,Nomura F,Saka H,Yamamoto M,Taniguchi H,Suzuki R,Saito H,Kawa

更新日期：2013-10-15 00:00:00

abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

journal_title：American journal of respiratory and critical care medicine

authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：:Positive pressure ventilation with large VTs has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human interleukin-8. The mechanisms regulating ventilation-induced cytokine production are unclear. Based on our previous in vitro model of lung cel...

journal_title：American journal of respiratory and critical care medicine

authors： Li LF,Yu L,Quinn DA

更新日期：2004-02-15 00:00:00

abstract：:The last century experienced remarkable advances in the classification, diagnosis, and understanding of the pathogenesis of the interstitial lung diseases. Technological advances, particularly physiologic testing, lung imaging studies, bronchoalveolar lavage, surgical lung biopsy, and histopathologic assessment, impro...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr

更新日期：2005-08-01 00:00:00

abstract：:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocyte...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan BP,Michelson AD

更新日期：2006-03-01 00:00:00

abstract：RATIONALE:Mechanical ventilation is known to induce ventilator-induced diaphragm dysfunction. Patients submitted to mechanical ventilation often receive massive doses of corticosteroids that may cause further deterioration of diaphragm function. OBJECTIVES:To examine whether the combination of 24 hours of controlled m...

journal_title：American journal of respiratory and critical care medicine

authors： Maes K,Testelmans D,Cadot P,Deruisseau K,Powers SK,Decramer M,Gayan-Ramirez G

更新日期：2008-12-15 00:00:00

abstract：:A protective role for dietary antioxidants in asthma has been proposed. However, epidemiological evidence to implicate antioxidant vitamins is weak, and data on the role of flavonoid-rich foods and antioxidant trace elements are lacking. We carried out a population-based case-control study in South London, UK, to inve...

journal_title：American journal of respiratory and critical care medicine

authors： Shaheen SO,Sterne JA,Thompson RL,Songhurst CE,Margetts BM,Burney PG

更新日期：2001-11-15 00:00:00

abstract：:Asthma is a chronic inflammatory disease that persists even during adequate therapy and asymptomatic episodes. We questioned whether "silent" chronic allergen exposure can induce and maintain airway inflammation and whether this still occurs during regular treatment with inhaled steroids. Twenty-six patients with hous...

journal_title：American journal of respiratory and critical care medicine

authors： de Kluijver J,Evertse CE,Schrumpf JA,van der Veen H,Zwinderman AH,Hiemstra PS,Rabe KF,Sterk PJ

更新日期：2002-08-01 00:00:00

abstract：:It is controversial whether obstructive sleep apnea (OSA) causes pulmonary hypertension (PH) in the absence of hypoxemic lung disease. To investigate this further we measured awake pulmonary hemodynamics, pulmonary gas exchange, and small airways function in 32 patients with OSA (apnea- hypopnea index, mean +/- SE, 46...

journal_title：American journal of respiratory and critical care medicine

authors： Sajkov D,Wang T,Saunders NA,Bune AJ,Neill AM,Douglas Mcevoy R

更新日期：1999-05-01 00:00:00

abstract：:Alveolar macrophages (AMs) are considered major effector cells in host defense against respiratory tract infections by virtue of their potent phagocytic properties. In addition, AMs may regulate the host inflammatory response to infection by production of cytokines and by their capacity to phagocytose apoptotic polymo...

journal_title：American journal of respiratory and critical care medicine

authors： Knapp S,Leemans JC,Florquin S,Branger J,Maris NA,Pater J,van Rooijen N,van der Poll T

更新日期：2003-01-15 00:00:00

abstract：:We hypothesized that a leukotriene receptor antagonist (LTRA) could provide bronchoprotection against the cold, dry air-induced response in asthmatic preschool children. In a randomized, double-blind, placebo-controlled crossover study, we examined the effect of the specific LTRA montelukast at 5 mg/d for 2 d on the b...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Nielsen KG

更新日期：2000-07-01 00:00:00

abstract：:This study was carried out to determine if the bronchoconstrictive effect of cigarette smoke (CS) is enhanced when airway hyperresponsiveness is induced by ovalbumin (Ova) sensitization, and if so, whether an increase in endogenously released tachykinins is involved. The bronchoconstrictive effects of an acute CS inha...

journal_title：American journal of respiratory and critical care medicine

authors： Wu ZX,Zhou D,Chen G,Lee LY

更新日期：2000-01-01 00:00:00

abstract：:The frequency and determinants of exogenous reinfection and of endogenous reactivation of tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 and 1996, 962 tuberculosis cases were confirmed by culture. Drug susceptibility testing was performed on available bac...

journal_title：American journal of respiratory and critical care medicine

authors： Caminero JA,Pena MJ,Campos-Herrero MI,Rodríguez JC,Afonso O,Martin C,Pavón JM,Torres MJ,Burgos M,Cabrera P,Small PM,Enarson DA

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:The majority of previous studies investigating asthma genetics have focused on cohorts with stable disease and have not defined mechanisms important during acute asthma. CD14 and CC16 each play a key role in biologically important inflammatory pathways and the gene of each has a functional promoter-region pol...

journal_title：American journal of respiratory and critical care medicine

authors： Martin AC,Laing IA,Khoo SK,Zhang G,Rueter K,Teoh L,Taheri S,Hayden CM,Geelhoed GC,Goldblatt J,LeSouëf PN

更新日期：2006-03-15 00:00:00

abstract：RATIONALE:Traditionally, Mycobacterium avium complex (MAC) has been composed of M. avium and M. intracellulare; however, advances in genetic sequencing have allowed discovery of several novel species. With these discoveries, investigation of differences in risk factors, virulence, and clinical outcomes have emerged. O...

journal_title：American journal of respiratory and critical care medicine

authors： Boyle DP,Zembower TR,Reddy S,Qi C

更新日期：2015-06-01 00:00:00

abstract：:Rationale: Decisions in medicine are made on the basis of knowledge and reasoning, often in shared conversations with patients and families in consideration of clinical practice guideline recommendations, individual preferences, and individual goals. Observational studies can provide valuable knowledge to inform guide...

journal_title：American journal of respiratory and critical care medicine

authors： Gershon AS,Lindenauer PK,Wilson KC,Rose L,Walkey AJ,Sadatsafavi M,Anstrom KJ,Au DH,Bender BG,Brookhart MA,Dweik RA,Han MK,Joo MJ,Lavergne V,Mehta AB,Miravitlles M,Mularski RA,Roche N,Oren E,Riekert KA,Schoenberg N

更新日期：2021-01-01 00:00:00

abstract：:Little is known about the structural response of the diaphragm to controlled mechanical ventilation. We examined effects of this intervention on muscle mass, myosin heavy chain isoforms, and contractile function in the rat diaphragm. Animals were mechanically ventilated for up to 4 days, and comparisons were made with...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Luo J,Bourdon J,Lin MC,Gottfried SB,Petrof BJ

更新日期：2002-10-15 00:00:00

abstract：RATIONALE:Recent cohort studies in chronic obstructive pulmonary disease (COPD) have questioned the validity of previously reported associations between inhaled corticosteroids (ICS) and reductions in mortality and rehospitalization in observational studies. Using time-dependent versions of statistical survival models,...

journal_title：American journal of respiratory and critical care medicine

authors： Kiri VA,Pride NB,Soriano JB,Vestbo J

更新日期：2005-08-15 00:00:00

abstract：:The purpose of this study was to evaluate the physiologic responses to endurance training in patients with moderate to severe airflow obstruction by specifically looking at changes in skeletal muscle enzymatic activities. Eleven patients (age = 65 +/- 7 yr, mean +/- SD, FEV1 = 36 +/- 11% of predicted value, range = 24...

journal_title：American journal of respiratory and critical care medicine

authors： Maltais F,LeBlanc P,Simard C,Jobin J,Bérubé C,Bruneau J,Carrier L,Belleau R

更新日期：1996-08-01 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00

abstract：:It is generally accepted that tuberculosis results from a single infection with a single Mycobacterium tuberculosis strain. Such infections are thought to confer protective immunity against exogenous reinfection. In this study, a novel polymerase chain reaction method was developed to specifically identify M. tubercul...

journal_title：American journal of respiratory and critical care medicine

authors： Warren RM,Victor TC,Streicher EM,Richardson M,Beyers N,Gey van Pittius NC,van Helden PD

更新日期：2004-03-01 00:00:00

abstract：:Many patients with acute asthma do not respond adequately to currently accepted therapy, including oxygen, beta-agonists, and corticosteroids. Leukotriene receptor antagonists such as montelukast have demonstrated efficacy in chronic asthma, but their efficacy in acute asthma is unknown. In this randomized, double-bli...

journal_title：American journal of respiratory and critical care medicine

authors： Camargo CA Jr,Smithline HA,Malice MP,Green SA,Reiss TF

更新日期：2003-02-15 00:00:00