Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways.

abstract：RATIONALE:Comorbidities contribute to disease severity and mortality in patients with chronic obstructive pulmonary disease (COPD). Comorbidities have been studied individually and were mostly based on self-reports. The coexistence of objectively identified comorbidities and the role of low-grade systemic inflammation ...

journal_title：American journal of respiratory and critical care medicine

authors： Vanfleteren LE,Spruit MA,Groenen M,Gaffron S,van Empel VP,Bruijnzeel PL,Rutten EP,Op 't Roodt J,Wouters EF,Franssen FM

更新日期：2013-04-01 00:00:00

abstract：:Nebulized aerosols are commonly used to deliver drugs into the lungs of patients with cystic fibrosis (CF). The aim of this study was to assess the effectiveness of pressure-support (PS) ventilation in increasing aerosol deposition within the lungs of children with CF. An in vitro study demonstrated the feasibility of...

journal_title：American journal of respiratory and critical care medicine

authors： Fauroux B,Itti E,Pigeot J,Isabey D,Meignan M,Ferry G,Lofaso F,Willemot JM,Clément A,Harf A

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown. OBJECTIVES:To describe the evolution of diaphragm th...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Fan E,Herridge MS,Murray A,Vorona S,Brace D,Rittayamai N,Lanys A,Tomlinson G,Singh JM,Bolz SS,Rubenfeld GD,Kavanagh BP,Brochard LJ,Ferguson ND

更新日期：2015-11-01 00:00:00

abstract：:Changes in dynamic lung compliance during inspiration and expiration cannot be modeled accurately with conventional algorithms. We developed a simple method to analyze pressure-volume (P/V) relationships under condition of nonlinearity (APVNL) and tested it in a lung model with known resistance and nonlinear P/V relat...

journal_title：American journal of respiratory and critical care medicine

authors： Nikischin W,Gerhardt T,Everett R,Bancalari E

更新日期：1998-10-01 00:00:00

abstract：:Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in asthmatic subjects from that observed in normal subjects. Increased airway wall thickness has been suggested as a contributing cause f...

journal_title：American journal of respiratory and critical care medicine

authors： Okazawa M,Müller N,McNamara AE,Child S,Verburgt L,Paré PD

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:It is hypothesized that the affective dimension of dyspnea (unpleasantness, emotional response) is not strictly dependent on the intensity of dyspnea. OBJECTIVES:We tested the hypothesis that the ratio of immediate unpleasantness (A(1)) to sensory intensity (SI) varies depending on the type of dyspnea. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Banzett RB,Pedersen SH,Schwartzstein RM,Lansing RW

更新日期：2008-06-15 00:00:00

abstract：RATIONALE:Transfusion of erythrocytes stored for prolonged periods is associated with increased mortality. Erythrocytes undergo hemolysis during storage and after transfusion. Plasma hemoglobin scavenges endogenous nitric oxide leading to systemic and pulmonary vasoconstriction. OBJECTIVES:We hypothesized that transfu...

journal_title：American journal of respiratory and critical care medicine

authors： Berra L,Pinciroli R,Stowell CP,Wang L,Yu B,Fernandez BO,Feelisch M,Mietto C,Hod EA,Chipman D,Scherrer-Crosbie M,Bloch KD,Zapol WM

更新日期：2014-10-01 00:00:00

abstract：:If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin...

journal_title：American journal of respiratory and critical care medicine

authors： Clements NC Jr,Habib MP

更新日期：1995-03-01 00:00:00

abstract：:Four hundred forty-one subjects 34 to 69 yr of age were recruited from a random sample of the community. The sample was biased in favor of men, snorers, and subjects with subjective sleep complaints. They answered a questionnaire and were monitored in their homes for sleep-disordered breathing (SDB). This report conce...

journal_title：American journal of respiratory and critical care medicine

authors： Olson LG,King MT,Hensley MJ,Saunders NA

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:North American occupational health programs that switched from the tuberculin skin test (TST) to IFN-γ release assays for latent tuberculosis screening are reporting challenges with interpretation of serial testing results in healthcare workers (HCWs). However, limited data exist on the reproducibility of ser...

journal_title：American journal of respiratory and critical care medicine

authors： Slater ML,Welland G,Pai M,Parsonnet J,Banaei N

更新日期：2013-10-15 00:00:00

abstract：RATIONALE:Surfactant protein D (SP-D), a 43-kD collectin, is synthesized and secreted by airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have previously shown that the quaternary structure of SP-D can be altered during inflammatory lung injury through its modification by S-nitrosylation...

journal_title：American journal of respiratory and critical care medicine

authors： Atochina-Vasserman EN,Winkler C,Abramova H,Schaumann F,Krug N,Gow AJ,Beers MF,Hohlfeld JM

更新日期：2011-04-01 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：:Snoring and sleeping apnea are reportedly associated with morbidity. We used home monitoring (MESAM IV) to measure snoring and sleep apnea in 294 men aged 40 to 65 yr from the volunteer register of the Busselton (Australia) Health Survey. In this group, 81% snored for more than 10% of the night and 22% for more than h...

journal_title：American journal of respiratory and critical care medicine

authors： Bearpark H,Elliott L,Grunstein R,Cullen S,Schneider H,Althaus W,Sullivan C

更新日期：1995-05-01 00:00:00

abstract：:We investigated 116 Italian atopic families (560 individuals) for linkage with 13 DNA markers on chromosome 12. All the subjects were phenotyped for asthma, total serum IgE, bronchial hyperresponsiveness, skin-prick positivity to common aeroallergens, and atopy. A relative location map of the markers was prepared from...

journal_title：American journal of respiratory and critical care medicine

authors： Malerba G,Lauciello MC,Scherpbier T,Trabetti E,Galavotti R,Cusin V,Pescollderungg L,Zanoni G,Martinati LC,Boner AL,Levitt RC,Pignatti PF

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA), a treatable sleep disorder that is associated with alterations in glucose metabolism in individuals without diabetes, is a highly prevalent comorbidity of type 2 diabetes. However, it is not known whether the severity of OSA is a predictor of glycemic control in patients with di...

journal_title：American journal of respiratory and critical care medicine

authors： Aronsohn RS,Whitmore H,Van Cauter E,Tasali E

更新日期：2010-03-01 00:00:00

abstract：:We found that continuous eosinophilic inflammation after repeated antigen instillation into the nose was observed only in A/J mice, not in three other strains. Histologic analysis of tissues from A/J mice revealed features typical of airway remodeling, i.e., airway wall thickening and increased collagen depositions we...

journal_title：American journal of respiratory and critical care medicine

authors： Shinagawa K,Kojima M

更新日期：2003-10-15 00:00:00

abstract：:The potent bronchoconstrictor and mitogenic actions of the peptide endothelin-1 (ET-1) on airway smooth muscle may contribute significantly to the bronchial obstruction observed in asthma. However, the status of the receptor-effector systems that mediate these actions of ET-1 in asthmatic airways is currently unknown....

journal_title：American journal of respiratory and critical care medicine

authors： Goldie RG,Henry PJ,Knott PG,Self GJ,Luttmann MA,Hay DW

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is a highly prevalent disorder in children, in which enlarged adenotonsillar tissues (AT) play a major pathophysiologic role. Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is a...

journal_title：American journal of respiratory and critical care medicine

authors： Khalyfa A,Gharib SA,Kim J,Dayyat E,Snow AB,Bhattacharjee R,Kheirandish-Gozal L,Goldman JL,Gozal D

更新日期：2010-05-15 00:00:00

abstract：:Disordered breathing during sleep is associated with acute, unfavorable effects on cardiovascular physiology, but few studies have examined its postulated association with cardiovascular disease (CVD). We examined the cross-sectional association between sleep- disordered breathing and self-reported CVD in 6,424 free-l...

journal_title：American journal of respiratory and critical care medicine

authors： Shahar E,Whitney CW,Redline S,Lee ET,Newman AB,Nieto FJ,O'Connor GT,Boland LL,Schwartz JE,Samet JM

更新日期：2001-01-01 00:00:00

abstract：:The distribution of ventilation-perfusion (VA/Q) ratios during bronchoconstriction measured with the multiple inert gases elimination technique is frequently bimodal. However, the topographic basis and the cause of that bimodality remain unknown. In this article, regional VA/Q is quantified by three-dimensional positr...

journal_title：American journal of respiratory and critical care medicine

authors： Melo MF,Harris RS,Layfield JD,Venegas JG

更新日期：2005-04-01 00:00:00

abstract：:Inhaled corticosteroids are effective antiinflammatory therapy for asthma; however, they do not completely abolish allergen-induced airway inflammation. Leukotriene modifiers attenuate both early and late allergen responses and have antiinflammatory properties. We reasoned that treatment with budesonide and montelukas...

journal_title：American journal of respiratory and critical care medicine

authors： Leigh R,Vethanayagam D,Yoshida M,Watson RM,Rerecich T,Inman MD,O'Byrne PM

更新日期：2002-11-01 00:00:00

abstract：:Background: This document provides clinical recommendations for the pharmacologic treatment of chronic obstructive pulmonary disease (COPD). It represents a collaborative effort on the part of a panel of expert COPD clinicians and researchers along with a team of methodologists under the guidance of the American Thora...

journal_title：American journal of respiratory and critical care medicine

authors： Nici L,Mammen MJ,Charbek E,Alexander PE,Au DH,Boyd CM,Criner GJ,Donaldson GC,Dreher M,Fan VS,Gershon AS,Han MK,Krishnan JA,Martinez FJ,Meek PM,Morgan M,Polkey MI,Puhan MA,Sadatsafavi M,Sin DD,Washko GR,Wedzicha

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:The impact of asthma on chronic lung function deficits is well known. However, there has been little study of ethnic differences in these asthma-associated deficits. OBJECTIVES:To examine whether there are ethnic differences in the effects of asthma on children's lung function. METHODS:We evaluated the impa...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,McConnell R,Gilliland F,Berhane K

更新日期：2011-03-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that both embryonic stem cells and adult bone marrow stem cells can participate in the regeneration and repair of diseased adult organs, including the lungs. However, the extent of airway epithelial remodeling with adult marrow stem cells is low, and there are no available in viv...

journal_title：American journal of respiratory and critical care medicine

authors： Sueblinvong V,Loi R,Eisenhauer PL,Bernstein IM,Suratt BT,Spees JL,Weiss DJ

更新日期：2008-04-01 00:00:00

abstract：:Phl p5 is a major allergen of timothy grass and causes rhinitis and bronchial asthma in nearly all patients allergic to grass pollen. The biochemical processing of this molecule by the nasal mucosa at its first encounter and possible changes of its biologic activity are unknown. Two isoforms of the allergen were expre...

journal_title：American journal of respiratory and critical care medicine

authors： Bufe A,Gehlhar K,Schramm G,Schlaak M,Becker WM

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:There is conflicting information about the development and resolution of airway inflammation and airway hyperresponsiveness (AHR) after repeated airway exposure to allergen in sensitized mice. METHODS:Sensitized BALB/c and C57BL/6 mice were exposed to repeated allergen challenge on 3, 7, or 11 occasions. Air...

journal_title：American journal of respiratory and critical care medicine

authors： Koya T,Kodama T,Takeda K,Miyahara N,Yang ES,Taube C,Joetham A,Park JW,Dakhama A,Gelfand EW

更新日期：2006-01-01 00:00:00

abstract：:It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cell cultures morphologically and physiologically and determined whether cytokine production or nuclear factor-kappaB activat...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MN,Sauer MS,Muhlebach MS,Hirsh AJ,Wu Q,Verghese MW,Randell SH

更新日期：2004-03-01 00:00:00

abstract：:Interleukin-5 (IL-5) is a potent eosinophilopoietic factor implicated in the chronic inflammatory cell accumulation accompanying bronchial asthma. However, its role in stimulating eosinophil differentiation within the bone marrow following allergen exposure remains to be elucidated. The aims of our study were to deter...

journal_title：American journal of respiratory and critical care medicine

authors： Minshall EM,Schleimer R,Cameron L,Minnicozzi M,Egan RW,Gutierrez-Ramos JC,Eidelman DH,Hamid Q

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The use of biomass as a cooking fuel is commonplace in developing countries and has been associated with chronic bronchitis and obstructive airway disease. METHODS:A cross-sectional survey was done in the village of Solis, close to Mexico City. Lifelong nonsmoking women 38 yr of age or older (n=841) complet...

journal_title：American journal of respiratory and critical care medicine

authors： Regalado J,Pérez-Padilla R,Sansores R,Páramo Ramirez JI,Brauer M,Paré P,Vedal S

更新日期：2006-10-15 00:00:00

abstract：:We present a case of a pulmonary nodular lesion in an immunocompetent patient documented at open lung biopsy to be due to Mycobacterium haemophilum. This organism has recently been recognized as a cause of disease in immunocompromised patients, presenting predominantly as skin lesions, arthritis, and rarely pneumonia....

journal_title：American journal of respiratory and critical care medicine

authors： White DA,Kiehn TE,Bondoc AY,Massarella SA

更新日期：1999-10-01 00:00:00