Ethnic differences in the effect of asthma on pulmonary function in children.

abstract：:Bradykinin (BK) induces bronchoconstriction in asthmatic but not in normal individuals. Studies in vivo in the human suggest that BK causes cholinergic nerve activation, release of prostanoids, and local axon reflexes with release of tachykinins in the airways. To determine the mechanisms of BK-induced airway narrowin...

journal_title：American journal of respiratory and critical care medicine

authors： Hulsmann AR,Raatgeep HR,Saxena PR,Kerrebijn KF,de Jongste JC

更新日期：1994-10-01 00:00:00

abstract：:Rationale: Chronic cough is characterized by frequent urges to cough and a heightened sensitivity to inhaled irritants. Airway sensory nerves trigger cough. We hypothesized that sensory nerve density is increased in chronic cough, which may contribute to excessive and persistent coughing.Objectives: To measure airway ...

journal_title：American journal of respiratory and critical care medicine

authors： Shapiro CO,Proskocil BJ,Oppegard LJ,Blum ED,Kappel NL,Chang CH,Fryer AD,Jacoby DB,Costello RW,Drake MG

更新日期：2021-02-01 00:00:00

abstract：:To study whether the individual inflammatory response to ozone was reproducible, dose-dependent, and time-dependent, we performed two exposures to 250 ppb ozone, one to 125 ppb and one to filtered air, each for 3 h of intermittent exercise and separated by at least 1 wk. Twenty-one healthy and 15 asthmatic subjects pa...

journal_title：American journal of respiratory and critical care medicine

authors： Holz O,Jörres RA,Timm P,Mücke M,Richter K,Koschyk S,Magnussen H

更新日期：1999-03-01 00:00:00

abstract：:Segmental bronchoprovocation (SBP) with allergen was used in an attempt to study eosinophils recruited to the airway 24 h after challenge. Unexpectedly, in the first four patients, neutrophils (rather than eosinophils) were recruited in the bronchoalveolar lavage (BAL) fluids, and we hypothesized that the allergen ext...

journal_title：American journal of respiratory and critical care medicine

authors： Hunt LW,Gleich GJ,Ohnishi T,Weiler DA,Mansfield ES,Kita H,Sur S

更新日期：1994-06-01 00:00:00

abstract：:A noninvasive means of detecting airway secretions in ventilator-dependent patients is desirable because endotracheal suctioning can result in life-threatening complications. In a patient who had copious secretions, we observed a sawtooth pattern on his flow-volume curve that disappeared after suctioning. Accordingly,...

journal_title：American journal of respiratory and critical care medicine

authors： Jubran A,Tobin MJ

更新日期：1994-09-01 00:00:00

abstract：RATIONALE:Occupational exposure to beryllium (Be) can result in chronic granulomatous inflammation characterized by the presence of Be-specific CD4+ T cells. Studies show that oxidative stress plays a role in the pathogenesis of chronic inflammatory disorders. OBJECTIVES:We hypothesized that Be-induced oxidative stres...

journal_title：American journal of respiratory and critical care medicine

authors： Dobis DR,Sawyer RT,Gillespie MM,Huang J,Newman LS,Maier LA,Day BJ

更新日期：2008-05-01 00:00:00

abstract：:Exposure to fine airborne particulate matter (PM(2.5)) is associated with cardiovascular events and mortality in older and cardiac patients. Potential physiologic effects of in-vehicle, roadside, and ambient PM(2.5) were investigated in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troo...

journal_title：American journal of respiratory and critical care medicine

authors： Riediker M,Cascio WE,Griggs TR,Herbst MC,Bromberg PA,Neas L,Williams RW,Devlin RB

更新日期：2004-04-15 00:00:00

abstract：:The interleukin-1 cluster on human chromosome 2q12-2q14 harbors various promising candidate genes for asthma and other inflammatory diseases. We conducted a systematic association study with single-nucleotide polymorphisms (SNPs) located in candidate genes situated in this cluster. Single-marker, two-locus and three-l...

journal_title：American journal of respiratory and critical care medicine

authors： Gohlke H,Illig T,Bahnweg M,Klopp N,André E,Altmüller J,Herbon N,Werner M,Knapp M,Pescollderungg L,Boner A,Malerba G,Pignatti PF,Wjst M

更新日期：2004-06-01 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：:It is known that the ventilatory response to carbon dioxide (CO2) is increased in asthmatics with airway obstruction. Increased vagal afferent activity as well as increased airway resistance have been postulated as the causative mechanisms. However, whether increased vagal afferent activity without bronchoconstriction...

journal_title：American journal of respiratory and critical care medicine

authors： Midorikawa J,Kikuchi Y,Taguchi O,Hida W,Okabe S,Takishima T,Shirato K

更新日期：1994-12-01 00:00:00

abstract：:To assess whether there is increased risk of tuberculous infection in children who traveled to or had a household visitor from a country having a high prevalence of tuberculosis, we conducted a case-control study. Children younger than 6 yr of age who had a tuberculin skin test read at public health clinics in areas o...

journal_title：American journal of respiratory and critical care medicine

authors： Lobato MN,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：:Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate i...

journal_title：American journal of respiratory and critical care medicine

authors： Casaburi R,Bhasin S,Cosentino L,Porszasz J,Somfay A,Lewis MI,Fournier M,Storer TW

更新日期：2004-10-15 00:00:00

abstract：:Studies of the hemodynamic effects of nasal continuous positive airway pressure (n-CPAP) in normal subjects have had conflicting results. The largest study (n = 19) found no effect of up to 15 cm H2O on heart rate (HR), cardiac stroke volume (SV), or cardiac index. We hypothesized that n-CPAP, by increasing intrathora...

journal_title：American journal of respiratory and critical care medicine

authors： Montner PK,Greene ER,Murata GH,Stark DM,Timms M,Chick TW

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal destruction and pulmonary hypertension. Statins are 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors that have been used as lipid-lowering agents. These drugs ...

journal_title：American journal of respiratory and critical care medicine

authors： Lee JH,Lee DS,Kim EK,Choe KH,Oh YM,Shim TS,Kim SE,Lee YS,Lee SD

更新日期：2005-10-15 00:00:00

abstract：:Although sleep-disordered breathing (SDB) has been shown to be very prevalent in the elderly, little has been done to examine differences between the elderly of different racial groups. It has been well documented that SDB often results in hypertension and that hypertension is more common in African-Americans than in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ancoli-Israel S,Klauber MR,Stepnowsky C,Estline E,Chinn A,Fell R

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:Dysregulation of cellular metabolism has been shown to participate in several pathologic processes. However, the role of metabolic reprogramming is not well appreciated in the pathogenesis of organ fibrosis. OBJECTIVES:To determine if glycolytic reprogramming participates in the pathogenesis of lung fibrosis...

journal_title：American journal of respiratory and critical care medicine

authors： Xie N,Tan Z,Banerjee S,Cui H,Ge J,Liu RM,Bernard K,Thannickal VJ,Liu G

更新日期：2015-12-15 00:00:00

abstract：RATIONALE:Epidemiological studies in older individuals have found an association between the use of angiotensin-converting enzyme (ACE) inhibition (ACE-I) therapy and preserved locomotor muscle mass, strength, and walking speed. ACE-I therapy might therefore have a role in the context of pulmonary rehabilitation (PR). ...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis KJ,Meyrick VM,Mehta B,Haji GS,Li K,Montgomery H,Man WD,Polkey MI,Hopkinson NS

更新日期：2016-12-01 00:00:00

abstract：:Large pleural effusions are typically associated with dyspnea and potential respiratory compromise. Experimental evidence suggests that with large effusions, increased intrapleural pressure may be transmitted to the pericardial space, resulting in impaired cardiac filling and reduced stroke volume. We report two cases...

journal_title：American journal of respiratory and critical care medicine

authors： Kaplan LM,Epstein SK,Schwartz SL,Cao QL,Pandian NG

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Despite increasing evidence about the role of donor-specific human leukocyte antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-specific antibodies (dnDSA) after lung transplantation remains unclear. OBJECTIVES:To describe the incidence, characteristics, and impact of ...

journal_title：American journal of respiratory and critical care medicine

authors： Tikkanen JM,Singer LG,Kim SJ,Li Y,Binnie M,Chaparro C,Chow CW,Martinu T,Azad S,Keshavjee S,Tinckam K

更新日期：2016-09-01 00:00:00

abstract：RATIONALE:Immunophenotypes of antiviral responses, and their relationship with asthma, allergy, and lower respiratory tract infections, are poorly understood. OBJECTIVES:We characterized multiple cytokine responses of peripheral blood mononuclear cells to rhinovirus stimulation, and their relationship with clinical ou...

journal_title：American journal of respiratory and critical care medicine

authors： Custovic A,Belgrave D,Lin L,Bakhsoliani E,Telcian AG,Solari R,Murray CS,Walton RP,Curtin J,Edwards MR,Simpson A,Rattray M,Johnston SL

更新日期：2018-05-15 00:00:00

abstract：:In Balb/C mice, painting the skin with ovalbumin (OVA) over a period of 14 days resulted in sensitization of the animals. This was documented by the appearance of OVA-specific IgE and IgG1 antibodies and increased total serum IgE levels. In addition, in regional (inguinal) lymph nodes of sensitized animals, OVA-specif...

journal_title：American journal of respiratory and critical care medicine

authors： Saloga J,Renz H,Larsen GL,Gelfand EW

更新日期：1994-01-01 00:00:00

abstract：:The rise in childhood asthma prevalence suggests a role for environmental factors in the etiology of this evolving epidemic; however, genetics also influence the occurrence of asthma. Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functi...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Li YF,Dubeau L,Berhane K,Avol E,McConnell R,Gauderman WJ,Peters JM

更新日期：2002-08-15 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：:We investigated the relation between IgE reactive with histamine-releasing factor (HRF) and clinical status in patients with asthma or rhinitis. Sera were used to passively sensitize purified, lactic-acid treated basophils. IgE-independent HRF due to chemokines was removed from mononuclear cell supernatants with hepar...

journal_title：American journal of respiratory and critical care medicine

authors： Pasmans SG,Aalbers M,van der Veen MJ,Knol EF,van der Zee JS,Jansen HM,Aalberse RC

更新日期：1996-08-01 00:00:00

abstract：RATIONALE:In San Francisco, 70% of the tuberculosis cases occur among foreign-born persons, mainly from China, the Philippines, and Mexico. We postulate that there are differences in the characteristics and risk factors for tuberculosis among these populations. OBJECTIVES:To determine the clinical, epidemiological and...

journal_title：American journal of respiratory and critical care medicine

authors： Suwanpimolkul G,Jarlsberg LG,Grinsdale JA,Osmond D,Kawamura LM,Hopewell PC,Kato-Maeda M

更新日期：2013-05-01 00:00:00

abstract：:The present study was undertaken to assess the relationship between health-related quality of life (HRQOL) and bronchiolitis obliterans syndrome (BOS), as both represent important parameters of outcome after lung transplantation. HRQOL was measured both cross-sectionally and longitudinally by standardized patient self...

journal_title：American journal of respiratory and critical care medicine

authors： van Den BERG JW,Geertsma A,van Der BIJ W,Koëter GH,de BOER WJ,Postma DS,ten VERGERT EM

更新日期：2000-06-01 00:00:00

abstract：:Oral mandibular advancement devices are becoming an increasingly important treatment alternative for obstructive sleep apnea (OSA). The first aim of the study was to determine whether a new oral elastic mandibular advancement device (EMA) prevents pharyngeal airway closure during sleep in patients with OSA. The second...

journal_title：American journal of respiratory and critical care medicine

authors： Henke KG,Frantz DE,Kuna ST

更新日期：2000-02-01 00:00:00

abstract：:Premature lungs are highly susceptible to lung injuries, leading to bronchopulmonary dysplasia (BPD). Keratinocyte growth factor (KGF) is produced by the developing lung and may reduce the risk of BPD by preventing injury to the lung epithelium and enhancing its repair. To determine whether KGF concentrations in the a...

journal_title：American journal of respiratory and critical care medicine

authors： Danan C,Franco ML,Jarreau PH,Dassieu G,Chailley-Heu B,Bourbon J,Delacourt C

更新日期：2002-05-15 00:00:00

abstract：RATIONALE:Although interferon (IFN)-gamma release assays are approved for the diagnosis of latent tuberculosis infection (LTBI), limited data exist regarding their performance in HIV infection. OBJECTIVES:To compare tuberculin skin test (TST) results to the commercial IFN-gamma release assay QuantiFERON-TB Gold In-Tub...

journal_title：American journal of respiratory and critical care medicine

authors： Luetkemeyer AF,Charlebois ED,Flores LL,Bangsberg DR,Deeks SG,Martin JN,Havlir DV

更新日期：2007-04-01 00:00:00

abstract：RATIONALE:The majority of patients with sarcoidosis resolve their condition; however 5-10% of patients with sarcoidosis develop pulmonary fibrosis with poor prognosis. Prostaglandin-endoperoxide synthase 2 (PTGS2) is a key regulatory enzyme in the synthesis of the antifibrotic agent prostaglandin E(2) and is reduced in...

journal_title：American journal of respiratory and critical care medicine

authors： Hill MR,Papafili A,Booth H,Lawson P,Hubner M,Beynon H,Read C,Lindahl G,Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2006-10-15 00:00:00