Interleukin-5 expression in the bone marrow of sensitized Balb/c mice after allergen challenge.

abstract：:Rationale: Chronic obstructive pulmonary disease (COPD) has been associated with numerous genetic variants, yet the extent to which its genetic risk is mediated by variation in lung structure remains unknown.Objectives: To characterize associations between a genetic risk score (GRS) associated with COPD susceptibility...

journal_title：American journal of respiratory and critical care medicine

authors： Oelsner EC,Ortega VE,Smith BM,Nguyen JN,Manichaikul AW,Hoffman EA,Guo X,Taylor KD,Woodruff PG,Couper DJ,Hansel NN,Martinez FJ,Paine R 3rd,Han MK,Cooper C,Dransfield MT,Criner G,Krishnan JA,Bowler R,Bleecker ER,Pet

更新日期：2019-09-15 00:00:00

abstract：:Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which has been linked to cardiovascular morbidity and mortality. We determined the effects of oral and inhaled corticosteroids on serum markers of inflammation in patients with stable COPD. We recruited 41 patients with mild to moderate ...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Lacy P,York E,Man SF

更新日期：2004-10-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immun...

journal_title：American journal of respiratory and critical care medicine

authors： DeVincenzo JP,Wilkinson T,Vaishnaw A,Cehelsky J,Meyers R,Nochur S,Harrison L,Meeking P,Mann A,Moane E,Oxford J,Pareek R,Moore R,Walsh E,Studholme R,Dorsett P,Alvarez R,Lambkin-Williams R

更新日期：2010-11-15 00:00:00

abstract：:Nitric oxide (NO) produced in the airways can be either detrimental or protective to the host. To investigate the role of NO in the pathogenesis of exercise-induced bronchoconstriction (EIB), we measured exhaled NO (ENO) after exercise challenge in 39 asthmatic and six normal children. FEV(1) and ENO were measured bef...

journal_title：American journal of respiratory and critical care medicine

authors： Terada A,Fujisawa T,Togashi K,Miyazaki T,Katsumata H,Atsuta J,Iguchi K,Kamiya H,Togari H

更新日期：2001-11-15 00:00:00

abstract：:Rationale: Sleep-disordered breathing (SDB) is associated with increased vascular resistance in children and adults. Persistent increased vascular resistance damages vascular endothelial cells-a marker of which is increased platelet activation.Objectives: This study compared whole-blood impedance platelet aggregation ...

journal_title：American journal of respiratory and critical care medicine

authors： Kontos A,Willoughby S,Lushington K,Martin J,Wabnitz D,Dorrian J,Kennedy D

更新日期：2020-12-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) represents an immunologic reaction of the pulmonary parenchyma to an inhaled agent. Since tumor necrosis factor (TNF)-alpha is thought to be involved in the pathogenesis of HP, and polymorphisms in the TNF genes have been associated with variations in the production of TNF-alpha, we i...

journal_title：American journal of respiratory and critical care medicine

authors： Schaaf BM,Seitzer U,Pravica V,Aries SP,Zabel P

更新日期：2001-02-01 00:00:00

abstract：:We reasoned that a prospective assessment of glucocorticoid withdrawal in subjects with asthma would provide insight into the basis for flares of the disease. We therefore enrolled 25 subjects with moderate persistent asthma and treated them for 30 days with inhaled fluticasone propionate (1,760 microg/day) followed b...

journal_title：American journal of respiratory and critical care medicine

authors： Castro M,Bloch SR,Jenkerson MV,DeMartino S,Hamilos DL,Cochran RB,Zhang XE,Wang H,Bradley JP,Schechtman KB,Holtzman MJ

更新日期：2004-04-01 00:00:00

abstract：:The gender-and race-specific effects of asthma/wheeze on pulmonary function level and annual growth velocity were studied in a cohort of 10,792 white and 944 black children 6 to 18 yr of age, examined annually between 1974 and 1989 in six U.S. cities. In comparison with white boys who never reported asthma or wheeze, ...

journal_title：American journal of respiratory and critical care medicine

authors： Gold DR,Wypij D,Wang X,Speizer FE,Pugh M,Ware JH,Ferris BG Jr,Dockery DW

更新日期：1994-05-01 00:00:00

abstract：RATIONALE:Plasma transfusions are frequently prescribed for critically ill children, although their indications lack a strong evidence base. Plasma transfusions are largely driven by physician conceptions of need, and these are poorly documented in pediatric intensive care patients. OBJECTIVES:To identify patient char...

journal_title：American journal of respiratory and critical care medicine

authors： Karam O,Demaret P,Shefler A,Leteurtre S,Spinella PC,Stanworth SJ,Tucci M,Canadian Critical Care Trials Group (CCCTG).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI).,BloodNet.,PlasmaTV Investigators.

更新日期：2015-06-15 00:00:00

abstract：:Nanoparticle-based drug delivery systems have considerable potential for treatment of tuberculosis (TB). The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility ...

journal_title：American journal of respiratory and critical care medicine

authors： Gelperina S,Kisich K,Iseman MD,Heifets L

更新日期：2005-12-15 00:00:00

abstract：RATIONALE:Congenital central hypoventilation syndrome (CCHS) is a genetic disorder mainly characterized by failure of automatic control of breathing, causing alveolar hypoventilation. Little is known regarding cough in CCHS. Parental reports indicate that patients cough normally during airway infections; however, previ...

journal_title：American journal of respiratory and critical care medicine

authors： Lavorini F,Fontana GA,Pantaleo T,Geri P,Piumelli R,Pistolesi M,Widdicombe J

更新日期：2007-10-15 00:00:00

abstract：:Cell death is intertwined with life in development, homeostasis, pathology, and aging. Until recently, apoptosis was the best known form of programmed cell death, whereas necrosis was for a long time considered accidental owing to physicochemical injury. However, identification of crucial signaling and execution molec...

journal_title：American journal of respiratory and critical care medicine

authors： Moreno-Gonzalez G,Vandenabeele P,Krysko DV

更新日期：2016-08-15 00:00:00

abstract：RATIONALE:Donor mesenchymal stromal/stem cell (MSC) expansion and fibrotic differentiation is associated with development of bronchiolitis obliterans syndrome (BOS) in human lung allografts. However, the regulators of fibrotic differentiation of these resident mesenchymal cells are not well understood. OBJECTIVES:This...

journal_title：American journal of respiratory and critical care medicine

authors： Walker NM,Badri LN,Wadhwa A,Wettlaufer S,Peters-Golden M,Lama VN

更新日期：2012-01-01 00:00:00

abstract：:To determine whether the cytokine interleukin (IL)-1 beta directly affects airway smooth muscle functions and, if so, what the mechanism of action is, we studied canine isolated bronchial segments under isometric conditions in vitro. Incubation of tissues with human recombinant IL-1 beta (10 ng/ml) for 150 min decreas...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Yamawaki I,Takeyama K,Chiyotani A,Yamauchi F,Konno K

更新日期：1994-01-01 00:00:00

abstract：RATIONALE:Pulmonary complications (PCs) cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HCT). Shifts in gut microbiota have been linked to HCT outcomes; however, their effect on PCs is unknown. OBJECTIVES:To investigate whether changes in gut microbiota are associate...

journal_title：American journal of respiratory and critical care medicine

authors： Harris B,Morjaria SM,Littmann ER,Geyer AI,Stover DE,Barker JN,Giralt SA,Taur Y,Pamer EG

更新日期：2016-08-15 00:00:00

abstract：:Decision analysis was used to compare three alternative strategies for a 6-mo course of treatment for tuberculosis: directly observed drug therapy (DOT), self-administered fixed-dose combination drug therapy, and self-administered conventional individual drug therapy. Estimates of effectiveness were obtained from the ...

journal_title：American journal of respiratory and critical care medicine

authors： Moore RD,Chaulk CP,Griffiths R,Cavalcante S,Chaisson RE

更新日期：1996-10-01 00:00:00

abstract：:To investigate whether the magnitude of blood flow contributes to ventilator-induced lung injury, 14 sets of isolated rabbit lungs were randomized for perfusion at either 300 (Group A: n = 7) or 900 ml/ min (Group B: n = 7) while ventilated with 30 cm H2O peak static pressure. Control lungs (Group C: n = 7) were venti...

journal_title：American journal of respiratory and critical care medicine

authors： Broccard AF,Hotchkiss JR,Kuwayama N,Olson DA,Jamal S,Wangensteen DO,Marini JJ

更新日期：1998-06-01 00:00:00

abstract：:Studies have shown evidence of significant parent-offspring and sibling correlation in FEV1, but familial aggregation of decline of FEV1 over time has not been reported. Our study population comprised 392 families enrolled in the Tucson Epidemiological Study of Airway Obstructive Diseases. Subjects were older than 18 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kurzius-Spencer M,Sherrill DL,Holberg CJ,Martinez FD,Lebowitz MD

更新日期：2001-10-01 00:00:00

abstract：:POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome is a rare variant of plasma cell dyscrasia with multiple systemic manifestations. We followed the progress of 20 patients with POEMS syndrome in our institution over a 10-yr period. Pulmonary hypertension (PH) was ob...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Godeau B,Authier FJ,Soubrier M,Zuber M,Larroche C,Viard JP,Wechsler B,Gherardi R

更新日期：1998-03-01 00:00:00

abstract：:A dysfunction of pathways that normally cause contraction or relaxation of airways has been proposed to explain heightened levels of responsiveness produced by various insults to the airway. For example, we previously reported (4) that infection of cotton rats with the human respiratory syncytial virus (HRSV) leads to...

journal_title：American journal of respiratory and critical care medicine

authors： Colasurdo GN,Hemming VG,Prince GA,Gelfand AS,Loader JE,Larsen GL

更新日期：1998-05-01 00:00:00

abstract：RATIONALE:An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups. OBJECTIVES:To characterize the asthma and atopy phenotypes in early childhood that associate with the 17q12-21 locus. METHODS:The single nucleotide polymorphism (SNP), rs7216389, was genotyped in ...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Bønnelykke K,Sleiman PM,Brasholt M,Chawes B,Kreiner-Møller E,Stage M,Kim C,Tavendale R,Baty F,Pipper CB,Palmer CN,Hakonarsson H

更新日期：2009-02-01 00:00:00

abstract：:In 11 ventilator-dependent patients, we undertook a head-to-head comparison of patient-ventilator interaction during four ventilator modes: assist-control ventilation (ACV), intermittent mandatory ventilation (IMV), pressure support (PS), and a combination of IMV and PS. Progressive increases in IMV rate and PS level ...

journal_title：American journal of respiratory and critical care medicine

authors： Leung P,Jubran A,Tobin MJ

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:In the normal lung, breathing and deep inspirations potently antagonize bronchoconstriction, but in the asthmatic lung this salutary effect is substantially attenuated or even reversed. To explain these findings, the prevailing hypothesis focuses on contracting airway smooth muscle and posits a nonlinear dyna...

journal_title：American journal of respiratory and critical care medicine

authors： Lavoie TL,Krishnan R,Siegel HR,Maston ED,Fredberg JJ,Solway J,Dowell ML

更新日期：2012-08-01 00:00:00

abstract：RATIONALE:Acute lung injury is a common complication after severe trauma, which predisposes patients to multiple organ failure. This syndrome largely accounts for the late mortality that arises and despite many theories, the pathological mechanism is not fully understood. Discovery of histone-induced toxicity in mice p...

journal_title：American journal of respiratory and critical care medicine

authors： Abrams ST,Zhang N,Manson J,Liu T,Dart C,Baluwa F,Wang SS,Brohi K,Kipar A,Yu W,Wang G,Toh CH

更新日期：2013-01-15 00:00:00

abstract：RATIONALE:Amplification of distal 3q is the most common genomic aberration in squamous lung cancer (SQC). SQC develops in a multistage progression from normal bronchial epithelium through dysplasia to invasive disease. Identifying the key driver events in the early pathogenesis of SQC will facilitate the search for pre...

journal_title：American journal of respiratory and critical care medicine

authors： McCaughan F,Pole JC,Bankier AT,Konfortov BA,Carroll B,Falzon M,Rabbitts TH,George PJ,Dear PH,Rabbitts PH

更新日期：2010-07-01 00:00:00

abstract：:Regular short-acting inhaled beta-agonist therapy is of uncertain benefit in patients with chronic obstructive pulmonary disease (COPD). We conducted a randomized, concealed, double-blind, placebo-controlled crossover trial in two periods, each of 3-mo duration, involving 53 patients with a smoking history of > 20 pac...

journal_title：American journal of respiratory and critical care medicine

authors： Cook D,Guyatt G,Wong E,Goldstein R,Bedard M,Austin P,Ramsdale H,Jaeschke R,Sears M

更新日期：2001-01-01 00:00:00

abstract：:Several modalities of ventilatory support have been proposed to gradually withdraw patients from mechanical ventilation, but their respective effects on the outcome of weaning from mechanical ventilation are not known. We conducted a randomized trial in three intensive care units in mechanically ventilated patients wh...

journal_title：American journal of respiratory and critical care medicine

authors： Brochard L,Rauss A,Benito S,Conti G,Mancebo J,Rekik N,Gasparetto A,Lemaire F

更新日期：1994-10-01 00:00:00

abstract：:Previous studies have shown an increased number of inflammatory cells and, in particular, CD8+ve cells in the airways of smokers with chronic obstructive pulmonary disease (COPD). In this study we investigated whether a similar inflammatory process is also present in the lungs, and particularly in lung parenchyma and ...

journal_title：American journal of respiratory and critical care medicine

authors： Saetta M,Baraldo S,Corbino L,Turato G,Braccioni F,Rea F,Cavallesco G,Tropeano G,Mapp CE,Maestrelli P,Ciaccia A,Fabbri LM

更新日期：1999-08-01 00:00:00

abstract：:The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effectors. We recently reported that both macrophage metalloelastase (MMP-1...

journal_title：American journal of respiratory and critical care medicine

authors： Churg A,Wang RD,Tai H,Wang X,Xie C,Dai J,Shapiro SD,Wright JL

更新日期：2003-04-15 00:00:00

abstract：:We reported that systemic keratinocyte growth factor (KGF) given before bone marrow transplantation (BMT) prevents allogeneic T cell-dependent lung inflammation assessed on Day 7 post-BMT, but the antiinflammatory effects of KGF were impaired in mice injected with both T cells and conditioning regimen of cyclophospham...

journal_title：American journal of respiratory and critical care medicine

authors： Yang S,Panoskaltsis-Mortari A,Ingbar DH,Matalon S,Zhu S,Resnik ER,Farrell CL,Lacey DL,Blazar BR,Haddad IY

更新日期：2000-11-01 00:00:00