Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation.

abstract：:Effects of cigarette smoking and smoking cessation on rate of FEV1 decline over 6 yr were examined in 4,451 Japanese-American men from the Honolulu Heart Program who were 45 to 68 yr of age at baseline (1965-1968). Within-person regression was used to calculate annual change in FEV1. Rates of FEV1 decline varied stron...

journal_title：American journal of respiratory and critical care medicine

authors： Burchfiel CM,Marcus EB,Curb JD,Maclean CJ,Vollmer WM,Johnson LR,Fong KO,Rodriguez BL,Masaki KH,Buist AS

更新日期：1995-06-01 00:00:00

abstract：:The mechanisms of exertional dyspnea relief in response to supplemental oxygen (O2) in chronic airflow limitation (CAL) are not precisely known and are likely multifactorial. To explore factors contributing to the relief of dyspnea after oxygen administration, 11 patients with severe CAL (FEV1.0 = 39 +/- 3% predicted,...

journal_title：American journal of respiratory and critical care medicine

authors： O'Donnell DE,Bain DJ,Webb KA

更新日期：1997-02-01 00:00:00

abstract：:Pulmonary hypertension associated with congestive heart failure carries a risk of right ventricular failure after cardiac transplantation. Few data, however, are available on the hemodynamic behavior of the pulmonary circulation in these patients. We therefore studied mean pulmonary artery pressure minus left atrial p...

journal_title：American journal of respiratory and critical care medicine

authors： Naeije R,Lipski A,Abramowicz M,Lejeune P,Mélot C,Antoine M,De Smet JM,Leclerc JL,Primo G

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults; however, whether mild OSA has significant neurocognitive and cardiovascular complications is uncertain. OBJECTIVES:The specific goals of this Research Statement are to appraise the evidence regarding whether long-term adverse neuro...

journal_title：American journal of respiratory and critical care medicine

authors： Chowdhuri S,Quan SF,Almeida F,Ayappa I,Batool-Anwar S,Budhiraja R,Cruse PE,Drager LF,Griss B,Marshall N,Patel SR,Patil S,Knight SL,Rowley JA,Slyman A,ATS Ad Hoc Committee on Mild Obstructive Sleep Apnea.

更新日期：2016-05-01 00:00:00

abstract：:Transbronchial biopsies (TBBs) are useful to diagnose acute rejection and infection in patients with lung transplants. The value of routine surveillance biopsies (S-TBBs) is not known, and such biopsies with a clinical indication are not without risk and are expensive. One hundred twenty-six 6-mo survivors of heart-lu...

journal_title：American journal of respiratory and critical care medicine

authors： Tamm M,Sharples LD,Higenbottam TW,Stewart S,Wallwork J

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Tissue resident memory T cells play a critical role in the defense against inhaled pathogens. The isolation and study of human lung tissue resident memory T cells and lung resident macrophages is limited by experimental constraints. OBJECTIVES:To characterize the spatial and functional relationship between l...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder ME,Sembrat J,Noda K,Myerburg MM,Craig A,Mitash N,Harano T,Furukawa M,Pilewski J,McDyer J,Rojas M,Sanchez P

更新日期：2020-12-11 00:00:00

abstract：:Neutrophil infiltration is a major feature in the pathogenesis of the common cold, and respiratory viral infection is the major cause of asthma exacerbations. The factors regulating the neutrophil influx are unknown. Interleukin-8 (IL-8) is a potent neutrophil chemoattractant, which has been implicated in several infl...

journal_title：American journal of respiratory and critical care medicine

authors： Teran LM,Johnston SL,Schröder JM,Church MK,Holgate ST

更新日期：1997-04-01 00:00:00

abstract：RATIONALE:The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major challenge due to lack of effective drug therapy or accurate indicators for disease progression. Fibrocytes are circulating mesenchymal cell progenitors that are involved in tissue repair and fibrosis. OBJECTIVES:To test the hypoth...

journal_title：American journal of respiratory and critical care medicine

authors： Moeller A,Gilpin SE,Ask K,Cox G,Cook D,Gauldie J,Margetts PJ,Farkas L,Dobranowski J,Boylan C,O'Byrne PM,Strieter RM,Kolb M

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Many authors have suggested that the mechanism by which atelectasis contributes to injury is through the repetitive opening and closing of distal airways in lung regions that are atelectatic. However, neither the topographic nor mechanistic relationships between atelectasis and distribution of lung injury are...

journal_title：American journal of respiratory and critical care medicine

authors： Tsuchida S,Engelberts D,Peltekova V,Hopkins N,Frndova H,Babyn P,McKerlie C,Post M,McLoughlin P,Kavanagh BP

更新日期：2006-08-01 00:00:00

abstract：:To help assess short-term respiratory responses to summertime air pollution, we exposed 24 asthmatic volunteers aged 11-18 in a chamber to respirable acid aerosol (mass median aerodynamic diameter 0.66 micron) plus 0.3 ppm nitrogen dioxide (NO2) plus 0.2 ppm ozone (O3). The aerosol contained available hydrogen ions (H...

journal_title：American journal of respiratory and critical care medicine

authors： Linn WS,Anderson KR,Shamoo DA,Edwards SA,Webb TL,Hackney JD,Gong H Jr

更新日期：1995-09-01 00:00:00

abstract：:Allergen inhalation challenge is associated with increases in eosinophil number and activation, and provides a useful model for investigating airway inflammation in asthma. Limited information, however, is available on the effect of allergen challenge on cytokines regulating eosinophil function. We investigated allerg...

journal_title：American journal of respiratory and critical care medicine

authors： Woolley KL,Adelroth E,Woolley MJ,Ellis R,Jordana M,O'Byrne PM

更新日期：1995-06-01 00:00:00

abstract：:The absence of standardized assessment protocols with well- defined measurement properties limits comparison of outcomes among those receiving long-term oxygen therapy (LTOT). We describe simple protocols for a hospital test, a simulated home test, and an actual home test, their reliability and relationship to each ot...

journal_title：American journal of respiratory and critical care medicine

authors： Guyatt GH,McKim DA,Weaver B,Austin PA,Bryan RE,Walter SD,Nonoyama ML,Ferreira IM,Goldstein RS

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:Because of high mortality, end-of-life care is an important component of intensive care. OBJECTIVES:We evaluated the effectiveness of a quality-improvement intervention to improve intensive care unit (ICU) end-of-life care. METHODS:We conducted a cluster-randomized trial randomizing 12 hospitals. The interv...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis JR,Nielsen EL,Treece PD,Downey L,Dotolo D,Shannon SE,Back AL,Rubenfeld GD,Engelberg RA

更新日期：2011-02-01 00:00:00

abstract：:We examined the efficacy and the acceptance of an oral device (SnorEx) causing a forward displacement of the tongue for the treatment of sleep-disordered breathing (SDB). Twenty-three consecutive subjects with SDB were investigated. Noncompliance (NC) of use of the oral appliance was observed in 74% (17 of 23) of the ...

journal_title：American journal of respiratory and critical care medicine

authors： Schönhofer B,Stoohs RA,Rager H,Wenzel M,Wenzel G,Köhler D

更新日期：1997-02-01 00:00:00

abstract：:Although airway inflammation is recognized as a key feature of asthma, the characteristics of airway inflammation in children with acute severe asthma are not well defined. The aim of this study was to describe the characteristics of airway inflammation in children with an acute exacerbation of asthma using sputum cel...

journal_title：American journal of respiratory and critical care medicine

authors： Norzila MZ,Fakes K,Henry RL,Simpson J,Gibson PG

更新日期：2000-03-01 00:00:00

abstract：:The present study was undertaken to assess the relationship between health-related quality of life (HRQOL) and bronchiolitis obliterans syndrome (BOS), as both represent important parameters of outcome after lung transplantation. HRQOL was measured both cross-sectionally and longitudinally by standardized patient self...

journal_title：American journal of respiratory and critical care medicine

authors： van Den BERG JW,Geertsma A,van Der BIJ W,Koëter GH,de BOER WJ,Postma DS,ten VERGERT EM

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Exacerbation of chronic obstructive pulmonary disease commonly causes hospitalization. The change in lung mechanics during exacerbation and its relationship to symptoms in spontaneously breathing individuals has not been described. OBJECTIVE:We hypothesized that changes in both airflow and lung volumes would...

journal_title：American journal of respiratory and critical care medicine

authors： Stevenson NJ,Walker PP,Costello RW,Calverley PM

更新日期：2005-12-15 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：:In 11 ventilator-dependent patients, we undertook a head-to-head comparison of patient-ventilator interaction during four ventilator modes: assist-control ventilation (ACV), intermittent mandatory ventilation (IMV), pressure support (PS), and a combination of IMV and PS. Progressive increases in IMV rate and PS level ...

journal_title：American journal of respiratory and critical care medicine

authors： Leung P,Jubran A,Tobin MJ

更新日期：1997-06-01 00:00:00

abstract：:Genetic susceptibility to asthma is due to multiple genes that interact with each other and the environment. There are many known environmental influences, such as viral and other respiratory infections and exposure to allergens, air pollutants, and active or passive cigarette smoke (1). Genome-wide screens for asthma...

journal_title：American journal of respiratory and critical care medicine

authors： Bleecker ER,Postma DS,Meyers DA

更新日期：1997-10-01 00:00:00

abstract：:We present a case of a pulmonary nodular lesion in an immunocompetent patient documented at open lung biopsy to be due to Mycobacterium haemophilum. This organism has recently been recognized as a cause of disease in immunocompromised patients, presenting predominantly as skin lesions, arthritis, and rarely pneumonia....

journal_title：American journal of respiratory and critical care medicine

authors： White DA,Kiehn TE,Bondoc AY,Massarella SA

更新日期：1999-10-01 00:00:00

abstract：:The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum induction in a two-visit, six-center study in 79 subjects with moderate to severe asthma (mean +/- SD FEV(1) 71 +/- 12% predicted, 67% taking inhaled corticostero...

journal_title：American journal of respiratory and critical care medicine

authors： Fahy JV,Boushey HA,Lazarus SC,Mauger EA,Cherniack RM,Chinchilli VM,Craig TJ,Drazen JM,Ford JG,Fish JE,Israel E,Kraft M,Lemanske RF,Martin RJ,McLean D,Peters SP,Sorkness C,Szefler SJ,NHLBI Asthma Clinical Research Netw

更新日期：2001-05-01 00:00:00

abstract：RATIONALE:There is growing evidence that alveolar cell apoptosis plays an important role in emphysema pathogenesis, a chronic inflammatory lung disease characterized by alveolar destruction. The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antipr...

journal_title：American journal of respiratory and critical care medicine

authors： Petrache I,Fijalkowska I,Zhen L,Medler TR,Brown E,Cruz P,Choe KH,Taraseviciene-Stewart L,Scerbavicius R,Shapiro L,Zhang B,Song S,Hicklin D,Voelkel NF,Flotte T,Tuder RM

更新日期：2006-06-01 00:00:00

abstract：:Preeclampsia is the predominant cause of admissions to neonatal intensive care. The diurnal blood pressure pattern is flattened or reversed in preeclampsia. We hypothesized that snoring and partial upper airway obstruction contribute to nocturnal rises in blood pressure. We tested this hypothesis by controlling sleep-...

journal_title：American journal of respiratory and critical care medicine

authors： Edwards N,Blyton DM,Kirjavainen T,Kesby GJ,Sullivan CE

更新日期：2000-07-01 00:00:00

abstract：:The effects of glutathione-S-transferase (GST) M1, GSTT1, and GSTP1 genotypes on lung function growth were investigated in 1,940 children enrolled in the Children's Health Study as fourth graders (aged 8-11 years) in two cohorts during 1993 and 1996 and were followed annually over a 4-year period. Genotypes for GSTM1 ...

journal_title：American journal of respiratory and critical care medicine

authors： Gilliland FD,Gauderman WJ,Vora H,Rappaport E,Dubeau L

更新日期：2002-09-01 00:00:00

abstract：RATIONALE:Platelets are essential for pulmonary leukocyte recruitment, airway hyperresponsiveness, and bronchial remodeling in animals with allergic inflammation and can be found in bronchoalveolar lavage of sensitized animals. No studies, however, have explored the direct migration of platelets to lungs. OBJECTIVES:T...

journal_title：American journal of respiratory and critical care medicine

authors： Pitchford SC,Momi S,Baglioni S,Casali L,Giannini S,Rossi R,Page CP,Gresele P

更新日期：2008-03-15 00:00:00

abstract：RATIONALE:Fibroblast growth factor receptor-1alpha(IIIc) [FGF-R1alpha(IIIc)] regulates recovery of neonatal rat lung growth, after 95% oxygen-mediated growth arrest. Its role in normal postnatal alveologenesis is unknown. OBJECTIVE:To determine if FGF-R1alpha(IIIc) regulates normal postnatal alveologenesis. METHODS:T...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Belcastro R,Shek S,Luo D,Post M,Tanswell AK

更新日期：2006-09-01 00:00:00

abstract：:Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy. To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in a double-blind crosso...

journal_title：American journal of respiratory and critical care medicine

authors： Keh D,Boehnke T,Weber-Cartens S,Schulz C,Ahlers O,Bercker S,Volk HD,Doecke WD,Falke KJ,Gerlach H

更新日期：2003-02-15 00:00:00

abstract：:Rationale: Diagnosis and monitoring of patients with pulmonary artery hypertension (PAH) is currently difficult.Objectives: We aimed to develop a noninvasive imaging modality for PAH that tracks the infiltration of macrophages into the pulmonary vasculature, using a positron emission tomography (PET) agent, 68Ga-2-(p-...

journal_title：American journal of respiratory and critical care medicine

authors： Park JB,Suh M,Park JY,Park JK,Kim YI,Kim H,Cho YS,Kang H,Kim K,Choi JH,Nam JW,Kim HK,Lee YS,Jeong JM,Kim YJ,Paeng JC,Lee SP

更新日期：2020-01-01 00:00:00

abstract：:In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members of families with an individual with known sleep apnea (85 inde...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Tishler PV,Hans MG,Tosteson TD,Strohl KP,Spry K

更新日期：1997-01-01 00:00:00