Fibroblast growth factor-2 and receptor-1alpha(IIIc) regulate postnatal rat lung cell apoptosis.

abstract：:The last century experienced remarkable advances in the classification, diagnosis, and understanding of the pathogenesis of the interstitial lung diseases. Technological advances, particularly physiologic testing, lung imaging studies, bronchoalveolar lavage, surgical lung biopsy, and histopathologic assessment, impro...

journal_title：American journal of respiratory and critical care medicine

authors： King TE Jr

更新日期：2005-08-01 00:00:00

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：:The relationship between asthma medication and the perception of asthma symptoms is of interest for daily practice. Poor perception of asthma symptoms might influence patients' health care behavior and subsequently might lead to undertreatment and deterioration of their disease. This study investigated the influence o...

journal_title：American journal of respiratory and critical care medicine

authors： Bijl-Hofland ID,Cloosterman SG,Folgering HT,van den Elshout FJ,van Weel C,van Schayck CP

更新日期：2001-09-01 00:00:00

abstract：:Regular short-acting inhaled beta-agonist therapy is of uncertain benefit in patients with chronic obstructive pulmonary disease (COPD). We conducted a randomized, concealed, double-blind, placebo-controlled crossover trial in two periods, each of 3-mo duration, involving 53 patients with a smoking history of > 20 pac...

journal_title：American journal of respiratory and critical care medicine

authors： Cook D,Guyatt G,Wong E,Goldstein R,Bedard M,Austin P,Ramsdale H,Jaeschke R,Sears M

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The clinical utility of bronchoalveolar lavage fluid (BAL) cell analysis for the diagnosis and management of patients with interstitial lung disease (ILD) has been a subject of debate and controversy. The American Thoracic Society (ATS) sponsored a committee of international experts to examine all relevant l...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer KC,Raghu G,Baughman RP,Brown KK,Costabel U,du Bois RM,Drent M,Haslam PL,Kim DS,Nagai S,Rottoli P,Saltini C,Selman M,Strange C,Wood B,American Thoracic Society Committee on BAL in Interstitial Lung Disease.

更新日期：2012-05-01 00:00:00

abstract：:The role of strain difference in the response to cigarette smoke was investigated in mice. Mice of the strains DBA/2 and C57BL/6J responded to acute cigarette smoke with a decrease of the antioxidant defenses of their bronchoalveolar lavage (BAL) fluids. On the other hand, under these conditions ICR mice increased the...

journal_title：American journal of respiratory and critical care medicine

authors： Cavarra E,Bartalesi B,Lucattelli M,Fineschi S,Lunghi B,Gambelli F,Ortiz LA,Martorana PA,Lungarella G

更新日期：2001-09-01 00:00:00

abstract：:Although hematopoietic stem cell transplantation (HSCT) can be curative in patients with certain malignancies, survival is poor if the recipient becomes critically ill. This prospective study examined the outcomes of 115 consecutive HSCT patients admitted to the medical intensive care unit (MICU) of a tertiary cancer ...

journal_title：American journal of respiratory and critical care medicine

authors： Price KJ,Thall PF,Kish SK,Shannon VR,Andersson BS

更新日期：1998-09-01 00:00:00

abstract：:While signal transducer and activator of transcription protein 6 (STAT6) is important in interleukin-4 (IL-4)-induced commitment of CD4(+) T cells to the T helper cell, type 2 (Th2) phenotype and IgE isotype switching in B cells, its role in other IL-4-mediated events and their impact upon the allergic response is les...

journal_title：American journal of respiratory and critical care medicine

authors： Tomkinson A,Kanehiro A,Rabinovitch N,Joetham A,Cieslewicz G,Gelfand EW

更新日期：1999-10-01 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：:Most randomized trials in critical care report no mortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true ineffectiveness of interventions. We hypothesize that in acute respiratory distress syndrome (ARDS), randomizing only those patients who show a favorable physiological r...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Kavanagh BP,Rubenfeld GD,Ferguson ND

更新日期：2015-12-15 00:00:00

abstract：:The role of nutritional status in the prognosis of subjects with severe chronic obstructive pulmonary disease was studied in a cohort of Canadian men and women followed for 3 to 5 yr. A total of 348 subjects who were recruited for a study of negative pressure ventilation were evaluated for lung function and body weigh...

journal_title：American journal of respiratory and critical care medicine

authors： Gray-Donald K,Gibbons L,Shapiro SH,Macklem PT,Martin JG

更新日期：1996-03-01 00:00:00

abstract：:We investigated the influence of pulmonary bacteriology and histology on the yield of diagnostic procedures in a clinically relevant model of ventilator-acquired pneumonia (VAP). Twenty-seven piglets entered a 4-d protocol of ventilatory support under general anesthesia. Endotracheal aspirates (EA), protected specimen...

journal_title：American journal of respiratory and critical care medicine

authors： Wermert D,Marquette CH,Copin MC,Wallet F,Fraticelli A,Ramon P,Tonnel AB

更新日期：1998-07-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00

abstract：:Measurement of cardiac output using thermodilution technique in mechanically ventilated patients is associated with significant morbidity. The goal of the present study was to assess the validity of cardiac output measurement using transesophageal Doppler in critically ill patients. Forty-six patients from three diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Valtier B,Cholley BP,Belot JP,de la Coussaye JE,Mateo J,Payen DM

更新日期：1998-07-01 00:00:00

abstract：:Airway hyperresponsiveness in asthma has been attributed to impaired ability of deep inspiration (DI) to stretch airway smooth muscle. We have retested this hypothesis by comparing the responses to methacholine of 10 asthmatic and 10 control subjects. After each dose subjects breathed tidally without deep inspiration ...

journal_title：American journal of respiratory and critical care medicine

authors： Burns GP,Gibson GJ

更新日期：1998-07-01 00:00:00

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationsh...

journal_title：American journal of respiratory and critical care medicine

authors： Olsson AC,Gustavsson P,Kromhout H,Peters S,Vermeulen R,Brüske I,Pesch B,Siemiatycki J,Pintos J,Brüning T,Cassidy A,Wichmann HE,Consonni D,Landi MT,Caporaso N,Plato N,Merletti F,Mirabelli D,Richiardi L,Jöckel KH,Ah

更新日期：2011-04-01 00:00:00

abstract：RATIONALE:Spirometric detection of airway obstruction in adults requires separate predictive formulae for each ethnicity and sex for percentage of FEV(1)/FVC (%FEV(1)/FVC) and percentage of FEV(3)/FVC (%FEV(3)/FVC), the major measurements for defining airway obstruction. OBJECTIVES:To eliminate the need for multiple f...

journal_title：American journal of respiratory and critical care medicine

authors： Hansen JE,Sun XG,Wasserman K

更新日期：2006-09-01 00:00:00

abstract：:Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population dat...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Carcillo JA,Linde-Zwirble WT,Clermont G,Lidicker J,Angus DC

更新日期：2003-03-01 00:00:00

abstract：:The management of children with drug-resistant tuberculosis (DR-TB) is challenging, and it is likely that in many places, the roll-out of molecular diagnostic testing will lead to more children being diagnosed. There is a limited evidence base to guide optimal treatment and follow-up in the pediatric population; in ex...

journal_title：American journal of respiratory and critical care medicine

authors： Seddon JA,Furin JJ,Gale M,Del Castillo Barrientos H,Hurtado RM,Amanullah F,Ford N,Starke JR,Schaaf HS,Sentinel Project on Pediatric Drug-Resistant Tuberculosis.

更新日期：2012-11-15 00:00:00

abstract：RATIONALE:Comorbidities contribute to disease severity and mortality in patients with chronic obstructive pulmonary disease (COPD). Comorbidities have been studied individually and were mostly based on self-reports. The coexistence of objectively identified comorbidities and the role of low-grade systemic inflammation ...

journal_title：American journal of respiratory and critical care medicine

authors： Vanfleteren LE,Spruit MA,Groenen M,Gaffron S,van Empel VP,Bruijnzeel PL,Rutten EP,Op 't Roodt J,Wouters EF,Franssen FM

更新日期：2013-04-01 00:00:00

abstract：:The molecular sources of reactive oxygen species (ROS) in skeletal muscles are not well understood. We hypothesized that nonphagocyte NAD(P)H oxidase could be a source of ROS in muscle fibers. We thus investigated the existence, structure, and contribution of nonphagocyte NAD(P)H oxidase to ROS production in rat skele...

journal_title：American journal of respiratory and critical care medicine

authors： Javeshghani D,Magder SA,Barreiro E,Quinn MT,Hussain SN

更新日期：2002-02-01 00:00:00

abstract：:Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha released from alveolar macrophages (AM) in pulmonary tuberculosis (TB) are important in host defense against mycobacterial infection. Nitric oxide (NO) production is enhanced in AM of TB patients. We examined whether NO was implicated in (IL)-1beta and TNF-a...

journal_title：American journal of respiratory and critical care medicine

authors： Kuo HP,Wang CH,Huang KS,Lin HC,Yu CT,Liu CY,Lu LC

更新日期：2000-01-01 00:00:00

abstract：:Exposure to fine airborne particulate matter (PM(2.5)) is associated with cardiovascular events and mortality in older and cardiac patients. Potential physiologic effects of in-vehicle, roadside, and ambient PM(2.5) were investigated in young, healthy, nonsmoking, male North Carolina Highway Patrol troopers. Nine troo...

journal_title：American journal of respiratory and critical care medicine

authors： Riediker M,Cascio WE,Griggs TR,Herbst MC,Bromberg PA,Neas L,Williams RW,Devlin RB

更新日期：2004-04-15 00:00:00

abstract：:Erythromycin inhibits mucus glycoconjugate secretion from airway cells in vitro and may increase mucus clearance in patients with asthma or diffuse panbronchiolitis. Because mucus hypersecretion is common in purulent rhinitis, we questioned whether clarithromycin would change the properties of nasal mucus from subject...

journal_title：American journal of respiratory and critical care medicine

authors： Rubin BK,Druce H,Ramirez OE,Palmer R

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Improved ventilation strategies have been the mainstay for reducing mortality in acute respiratory distress syndrome. Their unique clinical effectiveness is, however, unmatched by our understanding of the underlying mechanobiology, and their impact on alveolar dynamics and gas exchange remains largely specula...

journal_title：American journal of respiratory and critical care medicine

authors： Tabuchi A,Nickles HT,Kim M,Semple JW,Koch E,Brochard L,Slutsky AS,Pries AR,Kuebler WM

更新日期：2016-02-15 00:00:00

abstract：RATIONALE:Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. OBJECTIVES:To identify additional risk loci for sarcoidosis and its acute and chronic subforms, we a...

journal_title：American journal of respiratory and critical care medicine

authors： Fischer A,Schmid B,Ellinghaus D,Nothnagel M,Gaede KI,Schürmann M,Lipinski S,Rosenstiel P,Zissel G,Höhne K,Petrek M,Kolek V,Pabst S,Grohé C,Grunewald J,Ronninger M,Eklund A,Padyukov L,Gieger C,Wichmann HE,Nebel A,

更新日期：2012-11-01 00:00:00

abstract：RATIONALE:Inhaled human insulin (INH; Exubera [human insulin (recombinant DNA origin) Inhalation Powder]) causes small changes in pulmonary function and increases in insulin antibodies compared with subcutaneous (SC) insulin. OBJECTIVES:To investigate the relationship between changes in pulmonary function and insulin ...

journal_title：American journal of respiratory and critical care medicine

authors： Teeter JG,Riese RJ

更新日期：2006-06-01 00:00:00

abstract：:Bronchial hyperresponsiveness (BHR), the increased sensitivity to a wide variety of stimuli that narrow the airways, is a central abnormality in patients with asthma, and is frequently observed in patients with chronic obstructive pulmonary disease. In the study of the underlying mechanisms of BHR, various animal mode...

journal_title：American journal of respiratory and critical care medicine

authors： Rabe KF

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically...

journal_title：American journal of respiratory and critical care medicine

authors： Hallberg J,Dominicus A,Eriksson UK,Gerhardsson de Verdier M,Pedersen NL,Dahlbäck M,Nihlén U,Higenbottam T,Svartengren M

更新日期：2008-03-01 00:00:00