Abstract:
:Pulmonary hypertension associated with congestive heart failure carries a risk of right ventricular failure after cardiac transplantation. Few data, however, are available on the hemodynamic behavior of the pulmonary circulation in these patients. We therefore studied mean pulmonary artery pressure minus left atrial pressure (estimated by pulmonary artery occluded pressure) versus cardiac output relationships in 20 patients with congestive heart failure evaluated for orthotopic cardiac transplantation, and we repeated this study either within the first 3 days postoperatively (n = 10) or 1 month postoperatively (n = 11). Cardiac output was increased by physical exercise or (in the early postoperative period) by an infusion of dobutamine. Reversibility of pulmonary hypertension was tested by an infusion of prostaglandin E1. At preoperative evaluation, the extrapolated pressure intercept of pulmonary vascular pressure:flow plots was negative in 10 of the patients, suggesting active exercise-induced pulmonary vasoconstriction. In the other 10 patients, the extrapolated pressure intercept was positive, suggesting that an increased closing pressure contributed to pulmonary hypertension. However, transplantation was constantly associated with proportional decreases of pulmonary artery pressure and left atrial pressure. On the other hand, pulmonary vascular pressure:flow plots were displaced to equal or lower pressures and to higher flows by prostaglandin E1 before as well as after transplantation. We conclude that in patients with congestive heart failure evaluated for cardiac transplantation, an increased pulmonary venous pressure more than a reversible increase in closing pressure determines the severity of pulmonary hypertension.
journal_name
Am J Respir Crit Care Medauthors
Naeije R,Lipski A,Abramowicz M,Lejeune P,Mélot C,Antoine M,De Smet JM,Leclerc JL,Primo Gdoi
10.1164/ajrccm.149.4.8143050subject
Has Abstractpub_date
1994-04-01 00:00:00pages
881-7issue
4 Pt 1eissn
1073-449Xissn
1535-4970journal_volume
149pub_type
杂志文章abstract::Diseases of the respiratory tract are among the leading causes of death in the world population. Increasing evidence points to a key role of the innate immune system with its pattern recognition receptors (PRRs) in both infectious and noninfectious lung diseases, which include pneumonia, chronic obstructive pulmonary ...
journal_title:American journal of respiratory and critical care medicine
pub_type: 杂志文章,评审
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doi:10.1164/ajrccm.154.3.8810620
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-08-01 00:00:00
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更新日期:1998-11-01 00:00:00
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journal_title:American journal of respiratory and critical care medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-10-15 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-09-15 00:00:00
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更新日期:1996-03-01 00:00:00
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更新日期:2000-12-01 00:00:00
abstract:RATIONALE:The role of computed tomography (CT) screening for lung cancer is controversial, currently under study, and not yet fully elucidated. OBJECTIVES:To report findings from initial and 1-year repeat screening low-radiation-dose CT of the chest and 3-year outcomes for 50- to 79-year-old current and ex-smokers in ...
journal_title:American journal of respiratory and critical care medicine
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更新日期:2008-11-01 00:00:00