Therapy of steroid-induced bone loss in adult asthmatics with calcium, vitamin D, and a diphosphonate.

abstract：RATIONALE:Chronic hypoxia induces pulmonary vascular remodeling, pulmonary hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms driving these responses. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of transcription in hypoxic cells, up-regulating genes involved in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ball MK,Waypa GB,Mungai PT,Nielsen JM,Czech L,Dudley VJ,Beussink L,Dettman RW,Berkelhamer SK,Steinhorn RH,Shah SJ,Schumacker PT

更新日期：2014-02-01 00:00:00

abstract：:This study aimed to examine the performance characteristics of four high-frequency oscillatory-type ventilators, using an in vitro model of the intubated neonatal respiratory system. Each ventilator was examined across its operative range of settings and at varying model lung compliance (C) and resistance. The oscilla...

journal_title：American journal of respiratory and critical care medicine

authors： Pillow JJ,Wilkinson MH,Neil HL,Ramsden CA

更新日期：2001-09-15 00:00:00

abstract：:Characterization of chemokine expression patterns in virus-infected epithelial cells provides important clues to the pathophysiology of such infections. The aim of this study was to determine the chemokine response pattern of respiratory epithelium when infected with respiratory syncytial virus (RSV). Macrophage infla...

journal_title：American journal of respiratory and critical care medicine

authors： Harrison AM,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Mechanical ventilation is known to induce ventilator-induced diaphragm dysfunction. Patients submitted to mechanical ventilation often receive massive doses of corticosteroids that may cause further deterioration of diaphragm function. OBJECTIVES:To examine whether the combination of 24 hours of controlled m...

journal_title：American journal of respiratory and critical care medicine

authors： Maes K,Testelmans D,Cadot P,Deruisseau K,Powers SK,Decramer M,Gayan-Ramirez G

更新日期：2008-12-15 00:00:00

abstract：RATIONALE:Bacterial pneumonia is a major cause of morbidity for HIV-infected persons and contributes to excess mortality in this population. OBJECTIVES:To evaluate the frequency and risk factors for occurrence of bacterial pneumonia in the present era of potent antiretroviral therapy. METHODS:We evaluated data from a...

journal_title：American journal of respiratory and critical care medicine

authors： Gordin FM,Roediger MP,Girard PM,Lundgren JD,Miro JM,Palfreeman A,Rodriguez-Barradas MC,Wolff MJ,Easterbrook PJ,Clezy K,Slater LN

更新日期：2008-09-15 00:00:00

abstract：:We hypothesized that ischemia/reperfusion (I/R) injury of the liver during normotensive gram-negative bacteremic sepsis alters the kinetics of circulating endotoxin, tumor necrosis factor-alpha (TNF-alpha), and coinduced mediators, thereby exacerbating sepsis-induced lung inflammation. Liver and lung dysfunction were ...

journal_title：American journal of respiratory and critical care medicine

authors： Matuschak GM,Henry KA,Johanns CA,Lechner AJ

更新日期：2001-03-01 00:00:00

abstract：:Pulmonary hypertension associated with congestive heart failure carries a risk of right ventricular failure after cardiac transplantation. Few data, however, are available on the hemodynamic behavior of the pulmonary circulation in these patients. We therefore studied mean pulmonary artery pressure minus left atrial p...

journal_title：American journal of respiratory and critical care medicine

authors： Naeije R,Lipski A,Abramowicz M,Lejeune P,Mélot C,Antoine M,De Smet JM,Leclerc JL,Primo G

更新日期：1994-04-01 00:00:00

abstract：:We prospectively investigated the mechanism of airflow limitation before and after targeted emphysematous resection in 12 consecutively studied adult patients 68 +/- 4 yr of age (mean +/- SD) with very severe COPD undergoing bilateral thoracoscopic stapling techniques. Lung function, static lung elastic recoil, and ai...

journal_title：American journal of respiratory and critical care medicine

authors： Gelb AF,Zamel N,McKenna RJ Jr,Brenner M

更新日期：1996-10-01 00:00:00

abstract：:Rapid and selective recruitment of neutrophils into the airspace in response to LPS facilitates the clearance of bacterial pathogens. However, neutrophil infiltration can also participate in the development and progression of environmental airway disease. Previous data have revealed that Toll-like receptor 4 (tlr4) is...

journal_title：American journal of respiratory and critical care medicine

authors： Hollingsworth JW,Chen BJ,Brass DM,Berman K,Gunn MD,Cook DN,Schwartz DA

更新日期：2005-04-15 00:00:00

abstract：:Lung transplantation with its attendant life-long immunosuppression contributes to bone loss and its sequelae, fractures and kyphosis, in patients with lung disease, many of whom already suffer from severe osteoporosis. Patients with cystic fibrosis (CF) are one of the most severely affected groups. We conducted a con...

journal_title：American journal of respiratory and critical care medicine

authors： Aris RM,Lester GE,Renner JB,Winders A,Denene Blackwood A,Lark RK,Ontjes DA

更新日期：2000-09-01 00:00:00

abstract：:Critical illness is not a discrete disease state or syndrome. It is the culmination of a multiplicity of heterogeneous disease states and their varied health trajectories leading to extreme illness that requires advanced life support in a distinct geographic location in the hospital. It is a marker of newly acquired o...

journal_title：American journal of respiratory and critical care medicine

authors： Herridge MS

更新日期：2017-12-01 00:00:00

abstract：:Current evidence suggests that patients with obstructive sleep apnea (OSA) may have augmented pharyngeal dilator muscle activity during wakefulness, to compensate for deficient anatomy. However, the isolated effect of sleep on the activity of these muscles (comparing OSA patients with controls) has not been studied. W...

journal_title：American journal of respiratory and critical care medicine

authors： Mezzanotte WS,Tangel DJ,White DP

更新日期：1996-06-01 00:00:00

abstract：RATIONALE:Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown. OBJECTIVES:To compare lung retransplant patients in the modern era with historical retransplant patients, to compare retransplant patients with initial transplant patients in the modern era, and ...

journal_title：American journal of respiratory and critical care medicine

authors： Kawut SM,Lederer DJ,Keshavjee S,Wilt JS,Daly T,D'Ovidio F,Sonett JR,Arcasoy SM,Barr ML

更新日期：2008-01-01 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on tissue biopsy, which ...

journal_title：American journal of respiratory and critical care medicine

authors： Wei F,Lin CC,Joon A,Feng Z,Troche G,Lira ME,Chia D,Mao M,Ho CL,Su WC,Wong DT

更新日期：2014-11-15 00:00:00

abstract：:The frequency and determinants of exogenous reinfection and of endogenous reactivation of tuberculosis in patients previously treated are poorly understood. In Gran Canaria Island, Spain, between 1991 and 1996, 962 tuberculosis cases were confirmed by culture. Drug susceptibility testing was performed on available bac...

journal_title：American journal of respiratory and critical care medicine

authors： Caminero JA,Pena MJ,Campos-Herrero MI,Rodríguez JC,Afonso O,Martin C,Pavón JM,Torres MJ,Burgos M,Cabrera P,Small PM,Enarson DA

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerous hematopoietic cells, which are central to the pathogenesis of asthma. OBJECTIVES:The contribution of IL-9 to asthma pathogenesis has thus far been unclear, due to conflicting reports in the literature. These earlier st...

journal_title：American journal of respiratory and critical care medicine

authors： Kearley J,Erjefalt JS,Andersson C,Benjamin E,Jones CP,Robichaud A,Pegorier S,Brewah Y,Burwell TJ,Bjermer L,Kiener PA,Kolbeck R,Lloyd CM,Coyle AJ,Humbles AA

更新日期：2011-04-01 00:00:00

abstract：:Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) are prothrombotic. Here, we investigated the time course and the mechanisms. At 1, 6, and 24 hours after instillation ...

journal_title：American journal of respiratory and critical care medicine

authors： Nemmar A,Nemery B,Hoet PH,Vermylen J,Hoylaerts MF

更新日期：2003-12-01 00:00:00

abstract：:Luteolin is a flavonoid that has been shown to reduce proinflammatory molecule expression in vitro. In the present study, we have tested the ability of luteolin to inhibit lipopolysaccharide (LPS)- induced lethal toxicity and proinflammatory molecule expression in vivo. Mice receiving LPS (Salmonella enteriditis LPS, ...

journal_title：American journal of respiratory and critical care medicine

authors： Kotanidou A,Xagorari A,Bagli E,Kitsanta P,Fotsis T,Papapetropoulos A,Roussos C

更新日期：2002-03-15 00:00:00

abstract：RATIONALE:Platelets may interact with the immune system in tuberculosis (TB) to regulate human inflammatory responses that lead to morbidity and spread of infection. OBJECTIVES:To identify a functional role of platelets in the innate inflammatory and matrix-degrading response in TB. METHODS:Markers of platelet activa...

journal_title：American journal of respiratory and critical care medicine

authors： Fox KA,Kirwan DE,Whittington AM,Krishnan N,Robertson BD,Gilman RH,López JW,Singh S,Porter JC,Friedland JS

更新日期：2018-07-15 00:00:00

abstract：RATIONALE:Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition. OBJECTIVES:Our goals were to establish whether epithelial cell and mast cell activation with relea...

journal_title：American journal of respiratory and critical care medicine

authors： Hallstrand TS,Moody MW,Wurfel MM,Schwartz LB,Henderson WR Jr,Aitken ML

更新日期：2005-09-15 00:00:00

abstract：RATIONALE:Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage. OBJECTIVES:To compare damage caused to heart and kidneys on reoxygenation in severely asphyctic term neonates resuscitated with room air (RAR) or 1...

journal_title：American journal of respiratory and critical care medicine

authors： Vento M,Sastre J,Asensi MA,Viña J

更新日期：2005-12-01 00:00:00

abstract：:Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs. We compared the effects of two aspirin-like drugs with different pharmacologic activities, sodium salicylate (SSA) and indomethacin, with the effect of lysine acetylsalicylate (LASA), inhaled 30 min before...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Refini RM,Pieroni MG,Vaghi A,Robuschi M,Bianco S

更新日期：1999-04-01 00:00:00

abstract：:Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

journal_title：American journal of respiratory and critical care medicine

authors： Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

更新日期：2020-12-15 00:00:00

abstract：:In a previous study of older pulp and paper workers in Berlin, New Hampshire, decrements in spirometry results associated with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mill exposure and cigarette smoking. Many of those subjects were older and retired. A new study was ...

journal_title：American journal of respiratory and critical care medicine

authors： Henneberger PK,Lax MB,Ferris BG Jr

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:In cigarette smoking-induced chronic obstructive pulmonary disease, structural and functional derangements are characterized by parenchymal destruction and pulmonary hypertension. Statins are 3-hydroxy-3-methyl-glutaryl-coenzyme-A reductase inhibitors that have been used as lipid-lowering agents. These drugs ...

journal_title：American journal of respiratory and critical care medicine

authors： Lee JH,Lee DS,Kim EK,Choe KH,Oh YM,Shim TS,Kim SE,Lee YS,Lee SD

更新日期：2005-10-15 00:00:00

abstract：RATIONALE:Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases. OBJECTIVES:To study whether arterial Hb-CO is useful to monitor disease activity in patients with chronic obstructive pulmonary disease (COPD) who had stopped smoking. METHOD...

journal_title：American journal of respiratory and critical care medicine

authors： Yasuda H,Yamaya M,Nakayama K,Ebihara S,Sasaki T,Okinaga S,Inoue D,Asada M,Nemoto M,Sasaki H

更新日期：2005-06-01 00:00:00

abstract：:In pleural infection, medical treatment failure (chest-tube drainage and antibiotics) requires surgery and increases mortality. It would be helpful to predict which patients will fail this approach. We examined clinical predictors in 85 consecutive patients with pleural infection receiving chest drainage and intrapleu...

journal_title：American journal of respiratory and critical care medicine

authors： Davies CW,Kearney SE,Gleeson FV,Davies RJ

更新日期：1999-11-01 00:00:00

abstract：:We have previously shown (Am. J. Respir. Crit. Care Med. 1995;152:1248-1255) that in patients needing mechanical ventilation, the load imposed on the inspiratory muscles is excessive relative to their neuromuscular capacity. We have therefore hypothesized that weaning failure may occur because at the time of the trial...

journal_title：American journal of respiratory and critical care medicine

authors： Vassilakopoulos T,Zakynthinos S,Roussos C

更新日期：1998-08-01 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00