Different effects of inhaled aspirinlike drugs on allergen-induced early and late asthmatic responses.

abstract：:Human neutrophil elastase (HNE), an enzyme secreted by activated neutrophils, can bind to and degrade extracellular matrix including human lung elastin. This protease is believed to play an important role in several destructive processes including pulmonary emphysema. In this study, we hypothesized that an alveolar ma...

journal_title：American journal of respiratory and critical care medicine

authors： Fujita J,Sköld CM,Daughton DM,Ertl RF,Takahara J,Rennard SI

更新日期：1999-09-01 00:00:00

abstract：:The blood beryllium lymphocyte proliferation test is used in medical surveillance to identify both beryllium sensitization and chronic beryllium disease. Approximately 50% of individuals with beryllium sensitization have chronic beryllium disease at the time of their initial clinical evaluation; however, the rate of p...

journal_title：American journal of respiratory and critical care medicine

authors： Newman LS,Mroz MM,Balkissoon R,Maier LA

更新日期：2005-01-01 00:00:00

abstract：:The number of patients awaiting lung transplantation (LT) and waiting time for surgery is increasing. In Australia, LT rates are 4. 6/million population/yr, which despite low organ donation rates, are the highest published in the world. The Australian organ allocation system allows identification of marginal donors an...

journal_title：American journal of respiratory and critical care medicine

authors： Gabbay E,Williams TJ,Griffiths AP,Macfarlane LM,Kotsimbos TC,Esmore DS,Snell GI

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:HIV-1-induced interstitial pneumonitis (IP) is a serious complication of HIV-1 infection, characterized by inflammation and cellular infiltration in lungs, often leading to respiratory failure and death. The barrier function of the pulmonary endothelium is caused in part by tight junction (TJ) proteins, such ...

journal_title：American journal of respiratory and critical care medicine

authors： Li H,Singh S,Potula R,Persidsky Y,Kanmogne GD

更新日期：2014-07-01 00:00:00

abstract：:Ethane is a product of lipid peroxidation as a result of oxidative stress and can be detected in the exhaled air. Oxidative stress plays a role in the pathogenesis of asthma. We measured exhaled ethane in 26 asthmatic subjects (mean age +/- SEM, 38 +/- 8 yr; 15 male, FEV(1) 60 +/- 4%) and compared it with exhaled nitr...

journal_title：American journal of respiratory and critical care medicine

authors： Paredi P,Kharitonov SA,Barnes PJ

更新日期：2000-10-01 00:00:00

abstract：RATIONALE:Extensively drug-resistant (XDR) tuberculosis (TB) may arise in individuals on treatment for multidrug-resistant (MDR) TB. Preventing this amplification of resistance will likely improve clinical outcomes and delay the secondary spread of XDR-TB. OBJECTIVES:To measure the proportion of individuals that devel...

journal_title：American journal of respiratory and critical care medicine

authors： Shin SS,Keshavjee S,Gelmanova IY,Atwood S,Franke MF,Mishustin SP,Strelis AK,Andreev YG,Pasechnikov AD,Barnashov A,Tonkel TP,Cohen T

更新日期：2010-08-01 00:00:00

abstract：:Sepsis and cancer share a number of pathophysiological features, and both result from the inability of the host's immune system to cope with the initial insult (tissue invasion by pathogens and malignant cell transformation, respectively). The common coexistence of both disorders and the profound related alterations i...

journal_title：American journal of respiratory and critical care medicine

authors： Mirouse A,Vigneron C,Llitjos JF,Chiche JD,Mira JP,Mokart D,Azoulay E,Pène F

更新日期：2020-12-15 00:00:00

abstract：:Phosphodiesterase (PDE)-5 degrades guanosine 3',5'cyclic monophosphate (cGMP) and its inhibitor sildenafil citrate (Viagra) treats erectile dysfunction by smooth muscle relaxation through elevated cGMP. Sildenafil was examined in two guinea pig models of airways disease: guinea pigs exposed to LPS or sensitized guinea...

journal_title：American journal of respiratory and critical care medicine

authors： Toward TJ,Smith N,Broadley KJ

更新日期：2004-01-15 00:00:00

abstract：:The length of time that blood remains in the pulmonary capillary is an important variable in gas exchange. We have investigated the distribution of capillary transit times in isolated rabbit lungs perfused with a bicarbonate-free buffer. The time course of gas exchange was monitored by enclosing the lungs in a plethys...

journal_title：American journal of respiratory and critical care medicine

authors： Klocke RA,Schünemann HJ,Grant BJ

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:In vivo, IgE production is related to bronchial hyperresponsiveness and, in vitro, passive sensitization of human airways with asthmatic serum containing a high concentration of IgE enhances the contractile response to a variety of agonists. However, cell types implicated in this IgE sensitization are not fully determ...

journal_title：American journal of respiratory and critical care medicine

authors： Berger P,Walls AF,Marthan R,Tunon-de-Lara JM

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. OBJECTIVES:To compare the effects of the Venturi mask and the nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio after extubation. Secondary endpoints were to assess effec...

journal_title：American journal of respiratory and critical care medicine

authors： Maggiore SM,Idone FA,Vaschetto R,Festa R,Cataldo A,Antonicelli F,Montini L,De Gaetano A,Navalesi P,Antonelli M

更新日期：2014-08-01 00:00:00

abstract：:We sought to characterize polymorphisms in the proximal coding region of the lipopolysaccharide binding protein gene and to determine whether a previously reported variant was associated with sepsis complicated by organ failure or shock after trauma. We used multiple analytical methods, including pyrosequencing, restr...

journal_title：American journal of respiratory and critical care medicine

authors： Barber RC,O'Keefe GE

更新日期：2003-05-15 00:00:00

abstract：:A growing body of evidence suggests that neutrophil-derived proteinases play a major role in lung tissue damage in cystic fibrosis (CF). Most previous studies have focused on serine proteinases such as neutrophil elastase, providing no information on the extent to which metalloproteinases participate in proteolytic pr...

journal_title：American journal of respiratory and critical care medicine

authors： Delacourt C,Le Bourgeois M,D'Ortho MP,Doit C,Scheinmann P,Navarro J,Harf A,Hartmann DJ,Lafuma C

更新日期：1995-08-01 00:00:00

abstract：:The respiratory-related evoked potential (RREP) is the electroencephalographic response to brief inspiratory occlusion. The P3 component of the response reflects the active cognitive processing of stimulus information. This study investigated the RREP in 16 subjects with asthma and 16 control subjects. In addition, au...

journal_title：American journal of respiratory and critical care medicine

authors： Webster KE,Colrain IM

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：:To investigate patterns of testing for human immunodeficiency virus (HIV) infection in tuberculosis patients, we obtained data from the tuberculosis registry and from medical records of 500 tuberculosis patients in Los Angeles County. Sixty-three percent of tuberculosis patients were tested for HIV infection, and mult...

journal_title：American journal of respiratory and critical care medicine

authors： Asch SM,London AS,Barnes PF,Gelberg L

更新日期：1997-01-01 00:00:00

abstract：:Although hematopoietic stem cell transplantation (HSCT) can be curative in patients with certain malignancies, survival is poor if the recipient becomes critically ill. This prospective study examined the outcomes of 115 consecutive HSCT patients admitted to the medical intensive care unit (MICU) of a tertiary cancer ...

journal_title：American journal of respiratory and critical care medicine

authors： Price KJ,Thall PF,Kish SK,Shannon VR,Andersson BS

更新日期：1998-09-01 00:00:00

abstract：RATIONALE:In clinical trials, patients with cystic fibrosis and a G551D mutation who received ivacaftor experienced improvements in pulmonary and nutritional outcomes. However, whether these improvements reflect a change in disease trajectory cannot be determined without longer-term analyses with an appropriate compara...

journal_title：American journal of respiratory and critical care medicine

authors： Sawicki GS,McKone EF,Pasta DJ,Millar SJ,Wagener JS,Johnson CA,Konstan MW

更新日期：2015-10-01 00:00:00

abstract：RATIONALE:Cystic fibrosis (CF) lung disease is caused by the loss of function of the cystic fibrosis transmembrane conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC). In the lung, ENaC is responsible for movement of sodium. Hyperactivation of ENaC, which creates an osmoti...

journal_title：American journal of respiratory and critical care medicine

authors： Scott DW,Walker MP,Sesma J,Wu B,Stuhlmiller TJ,Sabater JR,Abraham WM,Crowder TM,Christensen DJ,Tarran R

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:The clinical utility of bronchoalveolar lavage fluid (BAL) cell analysis for the diagnosis and management of patients with interstitial lung disease (ILD) has been a subject of debate and controversy. The American Thoracic Society (ATS) sponsored a committee of international experts to examine all relevant l...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer KC,Raghu G,Baughman RP,Brown KK,Costabel U,du Bois RM,Drent M,Haslam PL,Kim DS,Nagai S,Rottoli P,Saltini C,Selman M,Strange C,Wood B,American Thoracic Society Committee on BAL in Interstitial Lung Disease.

更新日期：2012-05-01 00:00:00

abstract：RATIONALE:The airway surface liquid, the thin layer of liquid covering the airways, is essential for mucociliary clearance and as a barrier against microbial and other noxious agents. Proteins secreted into the airway surface liquid by epithelial and nonepithelial cells may be important in innate immunity and to improv...

journal_title：American journal of respiratory and critical care medicine

authors： Candiano G,Bruschi M,Pedemonte N,Caci E,Liberatori S,Bini L,Pellegrini C,Viganò M,O'Connor BJ,Lee TH,Galietta LJ,Zegarra-Moran O

更新日期：2005-11-01 00:00:00

abstract：:Tracheal gas insufflation (TGI) has been recommended as an adjunct to mechanical ventilation in the presence of elevated Pa CO2. Based on our initial clinical experience with continuous flow TGI and pressure control ventilation (PCV), we were concerned about elevation in peak airway pressure as TGI was applied. In a l...

journal_title：American journal of respiratory and critical care medicine

authors： Imanaka H,Kacmarek RM,Ritz R,Hess D

更新日期：1996-03-01 00:00:00

abstract：:The cells and proteases that mediate cigarette smoke-induced emphysema are controversial, with evidence favoring either neutrophils and neutrophil-derived serine proteases or macrophages and macrophage-derived metalloproteases as the important effectors. We recently reported that both macrophage metalloelastase (MMP-1...

journal_title：American journal of respiratory and critical care medicine

authors： Churg A,Wang RD,Tai H,Wang X,Xie C,Dai J,Shapiro SD,Wright JL

更新日期：2003-04-15 00:00:00

abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

更新日期：2014-10-01 00:00:00

abstract：:Within the last few years, increasing evidence of relative adrenal insufficiency in septic shock evoked a reassessment of hydrocortisone therapy. To evaluate the effects of hydrocortisone on the balance between proinflammatory and antiinflammation, 40 patients with septic shock were randomized in a double-blind crosso...

journal_title：American journal of respiratory and critical care medicine

authors： Keh D,Boehnke T,Weber-Cartens S,Schulz C,Ahlers O,Bercker S,Volk HD,Doecke WD,Falke KJ,Gerlach H

更新日期：2003-02-15 00:00:00

abstract：:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocyte...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan BP,Michelson AD

更新日期：2006-03-01 00:00:00

abstract：:Effective treatment of tuberculosis requires adherence to a minimum of 6 months treatment with multiple drugs. To improve adherence and cure rates, directly observed therapy is recommended for the treatment of pulmonary tuberculosis. We compared treatment outcomes among all culture-positive patients treated for active...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Seaman CB,Gonzalez LC,Kawamura LM,Osmond DH,Daley CL

更新日期：2004-09-01 00:00:00

abstract：:In 35 patients fulfilling the criteria of systemic inflammatory response syndrome (SIRS) of infectious origin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), tumor necrosis factor-soluble receptor (TNF-sR), and interleukin-12 (IL-12), C-reactive protein (CRP) levels and the Acute Physiology, and Chroni...

journal_title：American journal of respiratory and critical care medicine

authors： Presterl E,Staudinger T,Pettermann M,Lassnigg A,Burgmann H,Winkler S,Frass M,Graninger W

更新日期：1997-09-01 00:00:00

abstract：:The nasal mucosal is the first site of contact with inhaled antigens. However, the nature of local immune responses and the role of nasal-associated lymphoid tissue (NALT) in those responses have rarely been studied. To characterize the cells involved in mucosally derived immune responses, NALT and Peyer's patch (PP) ...

journal_title：American journal of respiratory and critical care medicine

authors： Heritage PL,Underdown BJ,Arsenault AL,Snider DP,McDermott MR

更新日期：1997-10-01 00:00:00