Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease.

abstract：:A 21-yr-old man with multiple pulmonary AV fistulae presented with moderate hypoxemia with chronic hyperventilation, which continued even after sufficient oxygenation by 100% O2 inhalation. The infusion of aminophylline, an adenosine receptor blocker, not only increased PaCO2 from 35 to 39 mm Hg but also depressed the...

journal_title：American journal of respiratory and critical care medicine

authors： Kobayashi S,Nishimura M,Nasuhara Y,Miyamoto K,Kawakami Y

更新日期：1994-12-01 00:00:00

abstract：RATIONALE:Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH. OBJECTIVES:To assess the effect of the adrenergic receptor blocker carvedilol on ...

journal_title：American journal of respiratory and critical care medicine

authors： Bogaard HJ,Natarajan R,Mizuno S,Abbate A,Chang PJ,Chau VQ,Hoke NN,Kraskauskas D,Kasper M,Salloum FN,Voelkel NF

更新日期：2010-09-01 00:00:00

abstract：:In humans, respiratory viral infections lead to increased airway responsiveness and exacerbations of asthma. In the present study, the role of interleukin-5 (IL-5) in virus-induced airway hyperresponsiveness and inflammation was examined in guinea pigs. In animals treated with control antibody, parainfluenza-3 virus s...

journal_title：American journal of respiratory and critical care medicine

authors： van Oosterhout AJ,van Ark I,Folkerts G,van der Linde HJ,Savelkoul HF,Verheyen AK,Nijkamp FP

更新日期：1995-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor that was recently shown to exhibit bronchoconstrictive properties in vitro. In asthmatic patients, the expression of ET-1 peptide was also shown to be increased in endobronchial biopsies. Thus, we postulated that ET-1 could be higher in subjects with nocturnal...

journal_title：American journal of respiratory and critical care medicine

authors： Kraft M,Beam WR,Wenzel SE,Zamora MR,O'Brien RF,Martin RJ

更新日期：1994-04-01 00:00:00

abstract：:The epithelium of the paranasal sinuses produces nitric oxide (NO), which probably plays a major role in the nonspecific defense of these cavities through its bacteriostatic and cilia motility stimulation properties. Abundant eosinophils of nasal polyps potentially generate superoxide anion (O2-*), but NO and O2-* ina...

journal_title：American journal of respiratory and critical care medicine

authors： Pasto M,Serrano E,Urocoste E,Barbacanne MA,Guissani A,Didier A,Delisle MB,Rami J,Arnal JF

更新日期：2001-01-01 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：:The present study was designed to examine whether clenbuterol (CLEN) could reduce dexamethasone (DEX)-induced diaphragm dysfunction. We studied four groups of New Zealand white (NZW) rabbits, each receiving one of the following daily injections subcutaneously for 2 wk: saline (control), DEX 3 mg/kg, DEX 3 mg/kg + CLEN...

journal_title：American journal of respiratory and critical care medicine

authors： Jiang TX,Cairns A,Road JD,Wilcox PG

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Colonization of lower airways by Staphylococcus aureus is a risk factor for the development of ventilator-associated tracheobronchitis (VAT) and ventilator-associated pneumonia (VAP). However, little is known about the virulence factors of methicillin-sensitive and -resistant S. aureus (MSSA and MRSA) that ma...

journal_title：American journal of respiratory and critical care medicine

authors： Stulik L,Malafa S,Hudcova J,Rouha H,Henics BZ,Craven DE,Sonnevend AM,Nagy E

更新日期：2014-11-15 00:00:00

abstract：:Lung cancer is a significant disease with survival rates remaining poor despite numerous therapeutic advances during the last 30 years. Understanding lung cancer pathogenesis through murine modeling may improve future human therapies, and new data indicate that mutations within different endogenous stem cells situated...

journal_title：American journal of respiratory and critical care medicine

authors： Giangreco A,Groot KR,Janes SM

更新日期：2007-03-15 00:00:00

abstract：:We hypothesized that a leukotriene receptor antagonist (LTRA) could provide bronchoprotection against the cold, dry air-induced response in asthmatic preschool children. In a randomized, double-blind, placebo-controlled crossover study, we examined the effect of the specific LTRA montelukast at 5 mg/d for 2 d on the b...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Nielsen KG

更新日期：2000-07-01 00:00:00

abstract：:The demand for intensivists is increasing around the world, not only to meet the needs of a growing aging population, but also to fill positions in the intensive care unit now occupied by other specialists, since there is compelling evidence that the presence of critical care practitioners improves patient outcomes. N...

journal_title：American journal of respiratory and critical care medicine

authors： Estenssoro E,Valente Barbas CS,Briva A

更新日期：2013-01-15 00:00:00

abstract：:Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia.Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and applied Grading of Recommendations, Assessment, Development, and Ev...

journal_title：American journal of respiratory and critical care medicine

authors： Metlay JP,Waterer GW,Long AC,Anzueto A,Brozek J,Crothers K,Cooley LA,Dean NC,Fine MJ,Flanders SA,Griffin MR,Metersky ML,Musher DM,Restrepo MI,Whitney CG

更新日期：2019-10-01 00:00:00

abstract：:The aim of this prospective study was to detect subjects in the general population with objective signs of chronic obstructive pulmonary disease (COPD) or asthma at an early stage. This was done by means of a two-stage protocol involving screening and a subsequent 2-yr monitoring of all subjects with positive results ...

journal_title：American journal of respiratory and critical care medicine

authors： van den Boom G,van Schayck CP,van Möllen MP,Tirimanna PR,den Otter JJ,van Grunsven PM,Buitendijk MJ,van Herwaarden CL,van Weel C

更新日期：1998-12-01 00:00:00

abstract：:This prospective and controlled pilot study evaluates the long-term effects of nocturnal oxygen therapy (NOT) on exercise endurance, hematology variables, quality of life, and survival of 23 adult patients (mean age, 32 +/- 6 yr) with post-tricuspid congenital heart defects (ventricular septal defect = 10; patent duct...

journal_title：American journal of respiratory and critical care medicine

authors： Sandoval J,Aguirre JS,Pulido T,Martinez-Guerra ML,Santos E,Alvarado P,Rosas M,Bautista E

更新日期：2001-11-01 00:00:00

abstract：:In order to examine the dose-dependence of the airway response to animal allergens we performed environmental challenges on 17 workers with documented IgE-mediated allergic reactions to laboratory rats. The 1-h environmental challenges were conducted in a vivarium during cage cleaning (high-allergen challenge), quiet ...

journal_title：American journal of respiratory and critical care medicine

authors： Eggleston PA,Ansari AA,Adkinson NF Jr,Wood RA

更新日期：1995-03-01 00:00:00

abstract：:In anaphylactic shock (AS), the relative effects of the autacoids including histamine, prostaglandins, and leukotrienes on causing cardiovascular collapse and the extent to which receptor blocking agents and pathway inhibitors may prevent this collapse are not clear. In a ragweed model of anaphylaxis, we examined whet...

journal_title：American journal of respiratory and critical care medicine

authors： Chrusch C,Sharma S,Unruh H,Bautista E,Duke K,Becker A,Kepron W,Mink SN

更新日期：1999-10-01 00:00:00

abstract：:Sarcoidosis is a systemic, granulomatous disorder with a high rate of spontaneous remission indicating the presence of antiinflammatory mechanisms. Antiinflammatory mediators such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-beta) should be able to induce spontaneous remission of sarcoidosis. By ...

journal_title：American journal of respiratory and critical care medicine

authors： Zissel G,Homolka J,Schlaak J,Schlaak M,Müller-Quernheim J

更新日期：1996-09-01 00:00:00

abstract：:Clinically, the spread of infectious agents between subjects undergoing spirometry is quite uncommon. There is almost no documentation in the medical literature on this subject. We studied the retrieval of nonpathogenic Escherichia coli after aerosolizing organisms into standard pulmonary function tubing of a type tha...

journal_title：American journal of respiratory and critical care medicine

authors： Hiebert T,Miles J,Okeson GC

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Tumor-infiltrating immune cells affect lung cancer outcome. However, the factors that influence the composition and function of the tumor immune environment remain poorly defined and need investigation, particularly in the era of immunotherapy. OBJECTIVES:To determine whether the tumoral immune environment i...

journal_title：American journal of respiratory and critical care medicine

authors： Mansuet-Lupo A,Alifano M,Pécuchet N,Biton J,Becht E,Goc J,Germain C,Ouakrim H,Régnard JF,Cremer I,Laurent-Puig P,Dieu-Nosjean MC,Blons H,Damotte D

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES:To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular dise...

journal_title：American journal of respiratory and critical care medicine

authors： Loffler KA,Heeley E,Freed R,Anderson CS,Brockway B,Corbett A,Chang CL,Douglas JA,Ferrier K,Graham N,Hamilton GS,Hlavac M,McArdle N,McLachlan J,Mukherjee S,Naughton MT,Thien F,Young A,Grunstein RR,Palmer LJ,Woodman

更新日期：2017-12-01 00:00:00

abstract：RATIONALE:The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based methods may provide novel insights in the study of the natural history of asthma. OBJECTIVES:To compare the stability of cluster-based asthma phenotype structures a decad...

journal_title：American journal of respiratory and critical care medicine

authors： Boudier A,Curjuric I,Basagaña X,Hazgui H,Anto JM,Bousquet J,Bridevaux PO,Dupuis-Lozeron E,Garcia-Aymerich J,Heinrich J,Janson C,Künzli N,Leynaert B,de Marco R,Rochat T,Schindler C,Varraso R,Pin I,Probst-Hensch N,Sun

更新日期：2013-09-01 00:00:00

abstract：:Bronchial dehiscence after lung transplantation is difficult to treat and associated with high mortality. We describe our experience using self-expanding metallic stents to treat post-lung transplant bronchial dehiscence. From January 1995 to June 2004, 189 single and 118 double lung transplants were performed in our ...

journal_title：American journal of respiratory and critical care medicine

authors： Mughal MM,Gildea TR,Murthy S,Pettersson G,DeCamp M,Mehta AC

更新日期：2005-09-15 00:00:00

abstract：:Pulmonary tuberculosis, one of the granulomatous diseases, has few serological markers for its activity. Recently, an increased serum level of vascular endothelial growth factor (VEGF) was detected in patients with Crohn's disease, also a granulomatous disease. We hypothesized that VEGF might be associated with the pa...

journal_title：American journal of respiratory and critical care medicine

authors： Matsuyama W,Hashiguchi T,Matsumuro K,Iwami F,Hirotsu Y,Kawabata M,Arimura K,Osame M

更新日期：2000-09-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11beta-HSD) are responsible for the conversion of bioactive glucocorticoids to and from inactive metabolites. 11beta-HSD2 is generally considered a high-affinity inactivator of natural glucocorticoids, although its activity with synthetic compounds in vivo is unknown. Inhaled cort...

journal_title：American journal of respiratory and critical care medicine

authors： Orsida BE,Krozowski ZS,Walters EH

更新日期：2002-04-01 00:00:00

abstract：:In 35 patients fulfilling the criteria of systemic inflammatory response syndrome (SIRS) of infectious origin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), tumor necrosis factor-soluble receptor (TNF-sR), and interleukin-12 (IL-12), C-reactive protein (CRP) levels and the Acute Physiology, and Chroni...

journal_title：American journal of respiratory and critical care medicine

authors： Presterl E,Staudinger T,Pettermann M,Lassnigg A,Burgmann H,Winkler S,Frass M,Graninger W

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:In clinical trials, patients with cystic fibrosis and a G551D mutation who received ivacaftor experienced improvements in pulmonary and nutritional outcomes. However, whether these improvements reflect a change in disease trajectory cannot be determined without longer-term analyses with an appropriate compara...

journal_title：American journal of respiratory and critical care medicine

authors： Sawicki GS,McKone EF,Pasta DJ,Millar SJ,Wagener JS,Johnson CA,Konstan MW

更新日期：2015-10-01 00:00:00

abstract：:Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs. We compared the effects of two aspirin-like drugs with different pharmacologic activities, sodium salicylate (SSA) and indomethacin, with the effect of lysine acetylsalicylate (LASA), inhaled 30 min before...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Refini RM,Pieroni MG,Vaghi A,Robuschi M,Bianco S

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Secondary bacterial infection following rhinovirus (RV) infection has been recognized in chronic obstructive pulmonary disease. OBJECTIVES:We sought to understand mechanisms by which RV infection facilitates secondary bacterial infection. METHODS:Primary human airway epithelial cells grown at air-liquid int...

journal_title：American journal of respiratory and critical care medicine

authors： Sajjan U,Wang Q,Zhao Y,Gruenert DC,Hershenson MB

更新日期：2008-12-15 00:00:00

abstract：RATIONALE:Diesel motor exhaust is classified by the International Agency for Research on Cancer as probably carcinogenic to humans. The epidemiologic evidence is evaluated as limited because most studies lack adequate control for potential confounders and only a few studies have reported on exposure-response relationsh...

journal_title：American journal of respiratory and critical care medicine

authors： Olsson AC,Gustavsson P,Kromhout H,Peters S,Vermeulen R,Brüske I,Pesch B,Siemiatycki J,Pintos J,Brüning T,Cassidy A,Wichmann HE,Consonni D,Landi MT,Caporaso N,Plato N,Merletti F,Mirabelli D,Richiardi L,Jöckel KH,Ah

更新日期：2011-04-01 00:00:00