Cycle ergometer and inspiratory muscle training in chronic obstructive pulmonary disease.

abstract：:Isoniazid taken daily for 12 mo and isoniazid and rifampin taken daily for 4 mo are both recommended options for patients with radiographic evidence of previous tuberculosis and positive tuberculin skin tests who have not had prior treatment. We compared the completion rates, number of adverse effects, and cost effect...

journal_title：American journal of respiratory and critical care medicine

authors： Jasmer RM,Snyder DC,Chin DP,Hopewell PC,Cuthbert SS,Antonio Paz E,Daley CL

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

更新日期：2014-10-01 00:00:00

abstract：:Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or oxygen use. Discriminating between these two mechanisms may be relevant for the early fluid resuscitation strategy.Objectives: To understand the relationship among central venous oxygen saturation (ScvO2), lactat...

journal_title：American journal of respiratory and critical care medicine

authors： Gattinoni L,Vasques F,Camporota L,Meessen J,Romitti F,Pasticci I,Duscio E,Vassalli F,Forni LG,Payen D,Cressoni M,Zanella A,Latini R,Quintel M,Marini JJ

更新日期：2019-09-01 00:00:00

abstract：:Smoking is the major risk factor for chronic respiratory symptoms, but dietary factors may also play a role. Most studies of diet and lung disease have been cross-sectional and conducted in populations with a Western-style diet. We analyzed the relation between dietary intake at baseline and new onset of cough with ph...

journal_title：American journal of respiratory and critical care medicine

authors： Butler LM,Koh WP,Lee HP,Yu MC,London SJ

更新日期：2004-08-01 00:00:00

abstract：RATIONALE:Traditionally, Mycobacterium avium complex (MAC) has been composed of M. avium and M. intracellulare; however, advances in genetic sequencing have allowed discovery of several novel species. With these discoveries, investigation of differences in risk factors, virulence, and clinical outcomes have emerged. O...

journal_title：American journal of respiratory and critical care medicine

authors： Boyle DP,Zembower TR,Reddy S,Qi C

更新日期：2015-06-01 00:00:00

abstract：:Normative spirometric values were derived from 5,042 white (of mainly European ancestry) and black (of mainly African ancestry) men and women paper plant workers who are never-smokers, with no respiratory symptoms or diagnoses and no history of occupational exposure to fibrogenic dusts or irritant chemicals. This coho...

journal_title：American journal of respiratory and critical care medicine

authors： Glindmeyer HW,Lefante JJ,McColloster C,Jones RN,Weill H

更新日期：1995-02-01 00:00:00

abstract：:Current evidence suggests that patients with obstructive sleep apnea (OSA) may have augmented pharyngeal dilator muscle activity during wakefulness, to compensate for deficient anatomy. However, the isolated effect of sleep on the activity of these muscles (comparing OSA patients with controls) has not been studied. W...

journal_title：American journal of respiratory and critical care medicine

authors： Mezzanotte WS,Tangel DJ,White DP

更新日期：1996-06-01 00:00:00

abstract：:The German reunification offers a unique opportunity to study the impact of environmental factors on the development of childhood respiratory and allergic disorders in ethnically similar populations. We investigated the prevalence of asthma, hay fever, atopy, and bronchial hyperresponsiveness (BHR) in 9- to 11-year ol...

journal_title：American journal of respiratory and critical care medicine

authors： von Mutius E,Martinez FD,Fritzsch C,Nicolai T,Roell G,Thiemann HH

更新日期：1994-02-01 00:00:00

abstract：RATIONALE:Roflumilast is a therapeutic agent in the treatment of chronic obstructive pulmonary disease (COPD). It has antiinflammatory effects; however, it is not known whether it can affect a biologic pathway implicated in COPD pathogenesis and progression. The self-propagating acetyl-proline-glycine-proline (AcPGP) p...

journal_title：American journal of respiratory and critical care medicine

authors： Wells JM,Jackson PL,Viera L,Bhatt SP,Gautney J,Handley G,King RW,Xu X,Gaggar A,Bailey WC,Dransfield MT,Blalock JE

更新日期：2015-10-15 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variant...

journal_title：American journal of respiratory and critical care medicine

authors： Ragland MF,Benway CJ,Lutz SM,Bowler RP,Hecker J,Hokanson JE,Crapo JD,Castaldi PJ,DeMeo DL,Hersh CP,Hobbs BD,Lange C,Beaty TH,Cho MH,Silverman EK

更新日期：2019-09-15 00:00:00

abstract：:Reduced diaphragm contractility has been described in normal subjects after whole body endurance exercise, and it indicates low frequency fatigue (LFF); it is unknown whether LFF is of clinical importance. We therefore studied the effect of treadmill exercise to exhaustion on diaphragm contractility in six patients wi...

journal_title：American journal of respiratory and critical care medicine

authors： Polkey MI,Kyroussis D,Keilty SE,Hamnegard CH,Mills GH,Green M,Moxham J

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:There is a need to develop novel noninvasive imaging biomarkers that help to evaluate antiinflammatory asthma treatments. OBJECTIVES:To investigate whether the extent of the segmental lung edema measured noninvasively using turbo-inversion recovery-magnitude magnetic resonance imaging (TIRM MRI) corresponds ...

journal_title：American journal of respiratory and critical care medicine

authors： Vogel-Claussen J,Renne J,Hinrichs J,Schönfeld C,Gutberlet M,Schaumann F,Winkler C,Faulenbach C,Krug N,Wacker FK,Hohlfeld JM

更新日期：2014-03-15 00:00:00

abstract：RATIONALE:Cigarette smoking is a risk factor for diffuse parenchymal lung disease. Risk factors for subclinical parenchymal lung disease have not been described. OBJECTIVES:To determine if cigarette smoking is associated with subclinical parenchymal lung disease, as measured by spirometric restriction and regions of h...

journal_title：American journal of respiratory and critical care medicine

authors： Lederer DJ,Enright PL,Kawut SM,Hoffman EA,Hunninghake G,van Beek EJ,Austin JH,Jiang R,Lovasi GS,Barr RG

更新日期：2009-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is associated with significant morbidity and mortality despite aggressive therapy. Thirty-eight patients with biopsy-proven IPF were studied to identify pretreatment features that could be used to predict short-term improvement in pulmonary function and improved longer term survival...

journal_title：American journal of respiratory and critical care medicine

authors： Gay SE,Kazerooni EA,Toews GB,Lynch JP 3rd,Gross BH,Cascade PN,Spizarny DL,Flint A,Schork MA,Whyte RI,Popovich J,Hyzy R,Martinez FJ

更新日期：1998-04-01 00:00:00

abstract：:We measured in rats the effects of 48 h of mechanical ventilation on the weight, contractile properties, and enzymatic profile of the diaphragm, the soleus and the extensor digitorium longus (EDL) muscles. Eighteen animals were randomly divided into a mechanically ventilated (MV, n = 9) group or a control (C, n = 9) g...

journal_title：American journal of respiratory and critical care medicine

authors： Le Bourdelles G,Viires N,Boczkowski J,Seta N,Pavlovic D,Aubier M

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Chronic exposure to indoor nitrogen dioxide (NO2) is a public health concern. Over half of U.S. households have a source of NO2, and experimental data suggest potential for adverse respiratory effects. OBJECTIVE:To examine associations of indoor NO2 exposure with respiratory symptoms among children with asth...

journal_title：American journal of respiratory and critical care medicine

authors： Belanger K,Gent JF,Triche EW,Bracken MB,Leaderer BP

更新日期：2006-02-01 00:00:00

abstract：:The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk factors and describe the complications of UEX. We followed 426 ventilated patients over a 2-mo period. C...

journal_title：American journal of respiratory and critical care medicine

authors： Boulain T

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown. OBJECTIVES:To compare lung retransplant patients in the modern era with historical retransplant patients, to compare retransplant patients with initial transplant patients in the modern era, and ...

journal_title：American journal of respiratory and critical care medicine

authors： Kawut SM,Lederer DJ,Keshavjee S,Wilt JS,Daly T,D'Ovidio F,Sonett JR,Arcasoy SM,Barr ML

更新日期：2008-01-01 00:00:00

abstract：:It is controversial whether obstructive sleep apnea (OSA) causes pulmonary hypertension (PH) in the absence of hypoxemic lung disease. To investigate this further we measured awake pulmonary hemodynamics, pulmonary gas exchange, and small airways function in 32 patients with OSA (apnea- hypopnea index, mean +/- SE, 46...

journal_title：American journal of respiratory and critical care medicine

authors： Sajkov D,Wang T,Saunders NA,Bune AJ,Neill AM,Douglas Mcevoy R

更新日期：1999-05-01 00:00:00

abstract：:Retrospective studies have suggested that combination antibiotic therapy for severe bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a prospective, multicenter, international observational study of 844 adult patients with bacteremia due to Streptococcus pneumoniae. The effect of combin...

journal_title：American journal of respiratory and critical care medicine

authors： Baddour LM,Yu VL,Klugman KP,Feldman C,Ortqvist A,Rello J,Morris AJ,Luna CM,Snydman DR,Ko WC,Chedid MB,Hui DS,Andremont A,Chiou CC,International Pneumococcal Study Group.

更新日期：2004-08-15 00:00:00

abstract：:Sarcoidosis is a systemic disorder of unknown origin, primarily affecting the lungs. The granulomatous inflammation is driven by the interplay between various molecules and cells, including T cells. Previously, our group reported a close correlation between lung-restricted T-cell receptor (TCR) AV2S3 CD4-positive T-ce...

journal_title：American journal of respiratory and critical care medicine

authors： Katchar K,Wahlström J,Eklund A,Grunewald J

更新日期：2001-06-01 00:00:00

abstract：RATIONALE:Inhaled human insulin (INH; Exubera [human insulin (recombinant DNA origin) Inhalation Powder]) causes small changes in pulmonary function and increases in insulin antibodies compared with subcutaneous (SC) insulin. OBJECTIVES:To investigate the relationship between changes in pulmonary function and insulin ...

journal_title：American journal of respiratory and critical care medicine

authors： Teeter JG,Riese RJ

更新日期：2006-06-01 00:00:00

abstract：:Ventilation was measured in 31 difficult-to-wean patients while pressure support (PS) was reduced by 5 cm H2O every 20 min. Weaning had to be aborted in 14 of 31 patients (Group F) because they met predefined distress criteria. The remaining 17 patients who were able to complete the "weaning test" (Group S) had larger...

journal_title：American journal of respiratory and critical care medicine

authors： Stroetz RW,Hubmayr RD

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES:To identify novel asthma phenotypes using an unsupervised hierarchical clu...

journal_title：American journal of respiratory and critical care medicine

authors： Moore WC,Meyers DA,Wenzel SE,Teague WG,Li H,Li X,D'Agostino R Jr,Castro M,Curran-Everett D,Fitzpatrick AM,Gaston B,Jarjour NN,Sorkness R,Calhoun WJ,Chung KF,Comhair SA,Dweik RA,Israel E,Peters SP,Busse WW,Erzurum

更新日期：2010-02-15 00:00:00

abstract：:Rationale: Guidelines for vasopressor titration suggest a universal target-mean arterial pressure (MAP) >65 mm Hg. The implications for patients with premorbid low/high blood pressure are unknown.Objectives: To investigate the relationship between premorbid blood pressure and vasopressor duration for patients with sho...

journal_title：American journal of respiratory and critical care medicine

authors： Gershengorn HB,Stelfox HT,Niven DJ,Wunsch H

更新日期：2020-07-01 00:00:00

abstract：:The human pleural space is lined by a single layer of mesothelial cells, the intracellular pH (pH(i)) of which has never been investigated. In the present study, the intrinsic buffering power of H+ ions (beta(i)) and the pH(i) regulatory systems were investigated in primary cultures of human pleural mesothelial cells ...

journal_title：American journal of respiratory and critical care medicine

authors： Liaw YS,Yang PC,Yu CJ,Kuo SH,Luh KT,Lin YJ,Wu ML

更新日期：1997-02-01 00:00:00

abstract：:In a prospective study, we screened specimens from 190 mechanically ventilated patients hospitalized in a surgical intensive care unit, and from the environment to assess risks and routes of colonization/infection. Specimens from various sites were collected on admission and once a week throughout each patient's stay....

journal_title：American journal of respiratory and critical care medicine

authors： Talon D,Mulin B,Rouget C,Bailly P,Thouverez M,Viel JF

更新日期：1998-03-01 00:00:00

abstract：:The present prospective study was designed to determine the prevalence of pleural effusion at approximately 28 days after cardiac surgery and their subsequent course. This consecutive case study included 389 patients; 312 had only coronary artery bypass graft surgery (CABG) surgery, 37 had both valve and CABG surgery,...

journal_title：American journal of respiratory and critical care medicine

authors： Light RW,Rogers JT,Moyers JP,Lee YC,Rodriguez RM,Alford WC Jr,Ball SK,Burrus GR,Coltharp WH,Glassford DM Jr,Hoff SJ,Lea JW 4th,Nesbitt JC,Petracek MR,Starkey TD,Stoney WS,Tedder M

更新日期：2002-12-15 00:00:00

abstract：:In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians. A total of 225 African-Americans and 622 Caucasians, ages 2 to 86 yr, recruited as members of families with an individual with known sleep apnea (85 inde...

journal_title：American journal of respiratory and critical care medicine

authors： Redline S,Tishler PV,Hans MG,Tosteson TD,Strohl KP,Spry K

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:Tissue injury and repair involve highly conserved processes governed by mechanisms that can be co-opted in tumors. We hypothesized that soluble factors released during the repair response to lung injury would promote orthotopic tumor growth. OBJECTIVES:To determine whether lung injury promoted growth of orth...

journal_title：American journal of respiratory and critical care medicine

authors： Arenberg D,Luckhardt TR,Carskadon S,Zhao L,Amin MA,Koch AE

更新日期：2010-10-15 00:00:00