Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis.

abstract：RATIONALE:The generation of protective secretory IgA relies on the epithelial polymeric immunoglobulin receptor (pIgR). pIgR expression is reduced in chronic obstructive pulmonary disease (COPD), but correlation to disease severity and underlying mechanisms remains unknown. OBJECTIVES:To address the hypothesis that pI...

journal_title：American journal of respiratory and critical care medicine

authors： Gohy ST,Detry BR,Lecocq M,Bouzin C,Weynand BA,Amatngalim GD,Sibille YM,Pilette C

更新日期：2014-09-01 00:00:00

abstract：:The recruitment of leukocytes to an area of injury or inflammation site is one of the most fundamental host defenses. Pulmonary tuberculosis is characterized by granulomatous inflammation with an extensive infiltration of mononuclear cells. In tuberculous pleurisy pleural mesothelial cells are exposed to mycobacteria ...

journal_title：American journal of respiratory and critical care medicine

authors： Mohammed KA,Nasreen N,Ward MJ,Antony VB

更新日期：1999-05-01 00:00:00

abstract：:Characterization of chemokine expression patterns in virus-infected epithelial cells provides important clues to the pathophysiology of such infections. The aim of this study was to determine the chemokine response pattern of respiratory epithelium when infected with respiratory syncytial virus (RSV). Macrophage infla...

journal_title：American journal of respiratory and critical care medicine

authors： Harrison AM,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：1999-06-01 00:00:00

abstract：:The aim of the study was to investigate the effect of addition of montelukast to inhaled fluticasone propionate (FP) therapy, compared with FP therapy alone (100 microg twice a day) on airway immunopathology in individuals with mild asthma. Twenty-eight subjects received FP (100 microg twice a day) or FP (100 microg t...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan S,Akveld M,Burke CM,Poulter LW

更新日期：2003-03-01 00:00:00

abstract：RATIONALE:Fibroblast growth factor receptor-1alpha(IIIc) [FGF-R1alpha(IIIc)] regulates recovery of neonatal rat lung growth, after 95% oxygen-mediated growth arrest. Its role in normal postnatal alveologenesis is unknown. OBJECTIVE:To determine if FGF-R1alpha(IIIc) regulates normal postnatal alveologenesis. METHODS:T...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Belcastro R,Shek S,Luo D,Post M,Tanswell AK

更新日期：2006-09-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the major pathogen responsible for acute bronchiolitis in infancy. However, evaluation of the relative importance of rhinovirus or multiple viral infections has been hampered by the lack of sensitive diagnostic methodologies. Therefore, in this study we used the reverse transcripti...

journal_title：American journal of respiratory and critical care medicine

authors： Papadopoulos NG,Moustaki M,Tsolia M,Bossios A,Astra E,Prezerakou A,Gourgiotis D,Kafetzis D

更新日期：2002-05-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：RATIONALE:Pure oxygen causes more oxidative stress than room air in resuscitation of asphyctic neonates, and consequently could be associated with increased tissue damage. OBJECTIVES:To compare damage caused to heart and kidneys on reoxygenation in severely asphyctic term neonates resuscitated with room air (RAR) or 1...

journal_title：American journal of respiratory and critical care medicine

authors： Vento M,Sastre J,Asensi MA,Viña J

更新日期：2005-12-01 00:00:00

abstract：:Two distinct types of tumor necrosis factor receptors (TNF-R) have been identified (TNF-R55 and TNF-R75). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR55 and TNF-sR75). TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent...

journal_title：American journal of respiratory and critical care medicine

authors： Humbert M,Roux-Lombard P,Cerrina J,Magnan A,Simonneau G,Dartevelle P,Galanaud P,Dayer JM,Emilie D

更新日期：1994-06-01 00:00:00

abstract：:The aim of this study was to evaluate the effect of two body positions (supine and semirecumbency) on the dynamics of gastroesophageal reflux (GER) in 15 patients requiring mechanical ventilation and having a nasogastric tube in place. Samples of gastric contents, pharyngeal and bronchial secretions, and blood were ob...

journal_title：American journal of respiratory and critical care medicine

authors： Orozco-Levi M,Torres A,Ferrer M,Piera C,el-Ebiary M,de la Bellacasa JP,Rodriguez-Roisin R

更新日期：1995-10-01 00:00:00

abstract：RATIONALE:Because of high mortality, end-of-life care is an important component of intensive care. OBJECTIVES:We evaluated the effectiveness of a quality-improvement intervention to improve intensive care unit (ICU) end-of-life care. METHODS:We conducted a cluster-randomized trial randomizing 12 hospitals. The interv...

journal_title：American journal of respiratory and critical care medicine

authors： Curtis JR,Nielsen EL,Treece PD,Downey L,Dotolo D,Shannon SE,Back AL,Rubenfeld GD,Engelberg RA

更新日期：2011-02-01 00:00:00

abstract：:Elevated levels of ambient particulate matter (PM(10)) have been associated with increased cardiopulmonary morbidity and mortality. We previously showed that the deposition of particles in the lung induces a systemic inflammatory response that includes stimulation of the bone marrow. This marrow response is related to...

journal_title：American journal of respiratory and critical care medicine

authors： van Eeden SF,Tan WC,Suwa T,Mukae H,Terashima T,Fujii T,Qui D,Vincent R,Hogg JC

更新日期：2001-09-01 00:00:00

abstract：:Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which has been linked to cardiovascular morbidity and mortality. We determined the effects of oral and inhaled corticosteroids on serum markers of inflammation in patients with stable COPD. We recruited 41 patients with mild to moderate ...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Lacy P,York E,Man SF

更新日期：2004-10-01 00:00:00

abstract：:Large pleural effusions are typically associated with dyspnea and potential respiratory compromise. Experimental evidence suggests that with large effusions, increased intrapleural pressure may be transmitted to the pericardial space, resulting in impaired cardiac filling and reduced stroke volume. We report two cases...

journal_title：American journal of respiratory and critical care medicine

authors： Kaplan LM,Epstein SK,Schwartz SL,Cao QL,Pandian NG

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Clinical benefits of fixed-dose 100-mg subcutaneous (SC) mepolizumab in prednisone-dependent patients are modest when sputum eosinophilia is not adequately controlled. OBJECTIVES:This study compared treatment response of weight-adjusted intravenous (IV) reslizumab in patients previously treated with 100-mg S...

journal_title：American journal of respiratory and critical care medicine

authors： Mukherjee M,Aleman Paramo F,Kjarsgaard M,Salter B,Nair G,LaVigne N,Radford K,Sehmi R,Nair P

更新日期：2018-01-01 00:00:00

abstract：:Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the National Heart, Lung, and Blood Institute. Decades of clinical research in acute respiratory distress syndrome, acute respiratory failure, pneumonia, and sepsis have...

journal_title：American journal of respiratory and critical care medicine

authors： Semler MW,Bernard GR,Aaron SD,Angus DC,Biros MH,Brower RG,Calfee CS,Colantuoni EA,Ferguson ND,Gong MN,Hopkins RO,Hough CL,Iwashyna TJ,Levy BD,Martin TR,Matthay MA,Mizgerd JP,Moss M,Needham DM,Self WH,Seymour CW,

更新日期：2020-03-09 00:00:00

abstract：:To determine the usefulness of positron emission tomography with fluoro-2-deoxyglucose (PET-FDG) in assessing mediastinal disease in patients with non-small-cell lung cancer (NSCLC) and to compare its yield to that of computed tomography (CT), we performed a prospective consecutive sample investigation in a university...

journal_title：American journal of respiratory and critical care medicine

authors： Chin R Jr,Ward R,Keyes JW,Choplin RH,Reed JC,Wallenhaupt S,Hudspeth AS,Haponik EF

更新日期：1995-12-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part associated with a chronic inflammatory response. The aim of this study was to investigate cross-sectionally and prospectively the potential role of leptin in relation to systemic inflammation in the regulation of the energy balance ...

journal_title：American journal of respiratory and critical care medicine

authors： Schols AM,Creutzberg EC,Buurman WA,Campfield LA,Saris WH,Wouters EF

更新日期：1999-10-01 00:00:00

abstract：:We reasoned that a prospective assessment of glucocorticoid withdrawal in subjects with asthma would provide insight into the basis for flares of the disease. We therefore enrolled 25 subjects with moderate persistent asthma and treated them for 30 days with inhaled fluticasone propionate (1,760 microg/day) followed b...

journal_title：American journal of respiratory and critical care medicine

authors： Castro M,Bloch SR,Jenkerson MV,DeMartino S,Hamilos DL,Cochran RB,Zhang XE,Wang H,Bradley JP,Schechtman KB,Holtzman MJ

更新日期：2004-04-01 00:00:00

abstract：:We describe two reliable methods for high-throughput screening of proteinase inhibitor (PI) S and PI Z alpha(1)-antitrypsin (alpha(1)-AT) deficiency alleles from dried blood spot (DBS) specimens using the LightCycler fluorimetric analyzer. The method was used to study 72 patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Rodriguez F,Jardí R,Costa X,Cotrina M,Galimany R,Vidal R,Miravitlles M

更新日期：2002-09-15 00:00:00

abstract：:The relationship between the severity of obstructive sleep apnea (OSA) (measured by sleep study) and daytime sleepiness is poor. Variation in the degree of arousal accompanying obstructive respiratory events might help explain this poor correlation. Polysomnographic records from patients with OSA were reviewed in orde...

journal_title：American journal of respiratory and critical care medicine

authors： Stradling JR,Pitson DJ,Bennett L,Barbour C,Davies RJ

更新日期：1999-01-01 00:00:00

abstract：:Luteolin is a flavonoid that has been shown to reduce proinflammatory molecule expression in vitro. In the present study, we have tested the ability of luteolin to inhibit lipopolysaccharide (LPS)- induced lethal toxicity and proinflammatory molecule expression in vivo. Mice receiving LPS (Salmonella enteriditis LPS, ...

journal_title：American journal of respiratory and critical care medicine

authors： Kotanidou A,Xagorari A,Bagli E,Kitsanta P,Fotsis T,Papapetropoulos A,Roussos C

更新日期：2002-03-15 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00

abstract：:Interpretation of incremental cardiopulmonary exercise tests (CPET) might be enhanced by considering the simultaneous rates of change of certain key variables, e.g., Delta oxygen uptake/Delta work rate (Delta VO(2)/Delta WR), Delta heart rate/Delta VO(2) (Delta HR/Delta VO(2)), Delta ventilation/Delta carbon dioxide p...

journal_title：American journal of respiratory and critical care medicine

authors： Neder JA,Nery LE,Peres C,Whipp BJ

更新日期：2001-10-15 00:00:00

abstract：RATIONALE:Many authors have suggested that the mechanism by which atelectasis contributes to injury is through the repetitive opening and closing of distal airways in lung regions that are atelectatic. However, neither the topographic nor mechanistic relationships between atelectasis and distribution of lung injury are...

journal_title：American journal of respiratory and critical care medicine

authors： Tsuchida S,Engelberts D,Peltekova V,Hopkins N,Frndova H,Babyn P,McKerlie C,Post M,McLoughlin P,Kavanagh BP

更新日期：2006-08-01 00:00:00

abstract：:We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 work...

journal_title：American journal of respiratory and critical care medicine

authors： Senthilselvan A,Pahwa P,Wang P,McDuffie HH,Dosman JA

更新日期：1996-02-01 00:00:00

abstract：:Patients with severe chronic obstructive pulmonary disease (COPD) do not use the sternocleidomastoid muscles when breathing at rest, but have a greater than normal neural drive to the rib-cage inspiratory muscles, the abdominal muscles, and the diaphragm. Yet the increased activation of the abdominal muscles and diaph...

journal_title：American journal of respiratory and critical care medicine

authors： Estenne M,Derom E,De Troyer A

更新日期：1998-08-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：:To define the mechanisms by which inhaled glucocorticosteroid regulates allergen-induced airway inflammation, a double-blind, placebo-controlled, cross-over study with inhaled budesonide was conducted in 14 subjects with allergic asthma. After baseline bronchoscopy and bronchoalveolar lavage (BAL), subjects were rando...

journal_title：American journal of respiratory and critical care medicine

authors： Kelly EA,Busse WW,Jarjour NN

更新日期：2000-09-01 00:00:00

abstract：:Studies of the hemodynamic effects of nasal continuous positive airway pressure (n-CPAP) in normal subjects have had conflicting results. The largest study (n = 19) found no effect of up to 15 cm H2O on heart rate (HR), cardiac stroke volume (SV), or cardiac index. We hypothesized that n-CPAP, by increasing intrathora...

journal_title：American journal of respiratory and critical care medicine

authors： Montner PK,Greene ER,Murata GH,Stark DM,Timms M,Chick TW

更新日期：1994-06-01 00:00:00