Rapid screening for alpha1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood specimens.

abstract：:There is a need for quick, reliable, and noninvasive lung function tests to assess airway obstruction in preschool children both for pediatric pulmonary care as well as for research purposes. We studied feasibility, reproducibility, and validity of measurements of the respiratory system using the interrupter technique...

journal_title：American journal of respiratory and critical care medicine

authors： Merkus PJ,Mijnsbergen JY,Hop WC,de Jongste JC

更新日期：2001-05-01 00:00:00

abstract：:Collapsibility of the active pharynx, where active contraction of the upper airway muscles is evident, was previously reported to be higher in children with obstructive sleep apnea (OSA) than in those with primary snoring during sleep. Contribution of neuromuscular and anatomic factors to the increased collapsibility,...

journal_title：American journal of respiratory and critical care medicine

authors： Isono S,Shimada A,Utsugi M,Konno A,Nishino T

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation and have suggested that treatment of patients with severe d...

journal_title：American journal of respiratory and critical care medicine

authors： Spragg RG,Taut FJ,Lewis JF,Schenk P,Ruppert C,Dean N,Krell K,Karabinis A,Günther A

更新日期：2011-04-15 00:00:00

abstract：:Chronic beryllium disease (CBD) provides a model system in which to evaluate the antigen-stimulated, cell-mediated, immune response that leads to granulomatous lung disease. We hypothesized that beryllium salts would stimulate bronchoalveolar lavage (BAL) cell release of tumor necrosis factor-alpha (TNF-alpha) and lnt...

journal_title：American journal of respiratory and critical care medicine

authors： Tinkle SS,Newman LS

更新日期：1997-12-01 00:00:00

abstract：:We surveyed pulmonologists to determine which procedures they do in practice, where they learned the procedures, and how much training they recommend to attain and maintain clinical competence in each. We mailed a survey to a random sample of 1,000 members of the American College of Physicians who were identified as p...

journal_title：American journal of respiratory and critical care medicine

authors： Tape TG,Blank LL,Wigton RS

更新日期：1995-02-01 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:Dobutamine has been proposed as a means of disclosing a pathologic oxygen supply (DO2) dependency in critically ill patients. Like other catecholamines, however, dobutamine might increase cellular metabolism, so that oxygen consumption (VO2) would increase regardless of the presence or absence of a supply dependency. ...

journal_title：American journal of respiratory and critical care medicine

authors： De Backer D,Moraine JJ,Berre J,Kahn RJ,Vincent JL

更新日期：1994-07-01 00:00:00

abstract：:Interleukin (IL)-2 has a central role in regulating T cell responses to Mycobacterium tuberculosis. Adjunctive immunotherapy with recombinant human IL-2 was studied in a randomized, placebo-controlled, double-blinded trial in 110 human immunodeficiency virus-seronegative adults in whom smear-positive, drug-susceptible...

journal_title：American journal of respiratory and critical care medicine

authors： Johnson JL,Ssekasanvu E,Okwera A,Mayanja H,Hirsch CS,Nakibali JG,Jankus DD,Eisenach KD,Boom WH,Ellner JJ,Mugerwa RD,Uganda-Case Western Reserve University Research Collaboration.

更新日期：2003-07-15 00:00:00

abstract：RATIONALE:Density-based morphometric studies have demonstrated decreased capillary density in infants with bronchopulmonary dysplasia (BPD) and in BPD-like animal models, leading to the prevailing view that microvascular development is disrupted in BPD. OBJECTIVE:To perform a comprehensive analysis of the early and la...

journal_title：American journal of respiratory and critical care medicine

authors： De Paepe ME,Mao Q,Powell J,Rubin SE,DeKoninck P,Appel N,Dixon M,Gundogan F

更新日期：2006-01-15 00:00:00

abstract：:Little is known about the structural response of the diaphragm to controlled mechanical ventilation. We examined effects of this intervention on muscle mass, myosin heavy chain isoforms, and contractile function in the rat diaphragm. Animals were mechanically ventilated for up to 4 days, and comparisons were made with...

journal_title：American journal of respiratory and critical care medicine

authors： Yang L,Luo J,Bourdon J,Lin MC,Gottfried SB,Petrof BJ

更新日期：2002-10-15 00:00:00

abstract：:Central airway obstruction is a problem facing all medical and surgical subspecialists caring for patients with chest diseases. The incidence of this disorder appears to be rising because of the epidemic of lung cancer; however, benign causes of central airway obstruction are being seen more frequently as well. The mo...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst A,Feller-Kopman D,Becker HD,Mehta AC

更新日期：2004-06-15 00:00:00

abstract：:Increased serum levels of mucin-associated antigen have been previously demonstrated in patients with cystic fibrosis (CF) and interstitial pneumonia, and in lung-transplant recipients. The present study assessed the serum airway mucin levels in patients with acute respiratory distress syndrome (ARDS). An enzyme-linke...

journal_title：American journal of respiratory and critical care medicine

authors： Shih JY,Yang SC,Yu CJ,Wu HD,Liaw YS,Wu R,Yang PC

更新日期：1997-11-01 00:00:00

abstract：:The inheritance of asthma, evident from its high family concordance, is not well understood. To investigate whether asthma may be inherited through a major gene with two alleles, segregation analyses were conducted in 3,369 individuals from 906 nuclear families enrolled, without selection, in a longitudinal study of r...

journal_title：American journal of respiratory and critical care medicine

authors： Holberg CJ,Elston RC,Halonen M,Wright AL,Taussig LM,Morgan WJ,Martinez FD

更新日期：1996-07-01 00:00:00

abstract：RATIONALE:Recent cohort studies in chronic obstructive pulmonary disease (COPD) have questioned the validity of previously reported associations between inhaled corticosteroids (ICS) and reductions in mortality and rehospitalization in observational studies. Using time-dependent versions of statistical survival models,...

journal_title：American journal of respiratory and critical care medicine

authors： Kiri VA,Pride NB,Soriano JB,Vestbo J

更新日期：2005-08-15 00:00:00

abstract：RATIONALE:The use of high-frequency oscillatory ventilation (HFOV) for acute respiratory failure in children is prevalent despite the lack of efficacy data. OBJECTIVES:To compare the outcomes of patients with acute respiratory failure managed with HFOV within 24-48 hours of endotracheal intubation with those receiving...

journal_title：American journal of respiratory and critical care medicine

authors： Bateman ST,Borasino S,Asaro LA,Cheifetz IM,Diane S,Wypij D,Curley MA,RESTORE Study Investigators.

更新日期：2016-03-01 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：:Although there is abundant clinical evidence of asthmatic responses to indoor aeroallergens, the symptomatic impacts of other common indoor air pollutants from gas stoves, fireplaces, and environmental tobacco smoke have been less well characterized. These combustion sources produce a complex mixture of pollutants, ma...

journal_title：American journal of respiratory and critical care medicine

authors： Ostro BD,Lipsett MJ,Mann JK,Wiener MB,Selner J

更新日期：1994-06-01 00:00:00

abstract：:The role of nutritional status in the prognosis of subjects with severe chronic obstructive pulmonary disease was studied in a cohort of Canadian men and women followed for 3 to 5 yr. A total of 348 subjects who were recruited for a study of negative pressure ventilation were evaluated for lung function and body weigh...

journal_title：American journal of respiratory and critical care medicine

authors： Gray-Donald K,Gibbons L,Shapiro SH,Macklem PT,Martin JG

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that both embryonic stem cells and adult bone marrow stem cells can participate in the regeneration and repair of diseased adult organs, including the lungs. However, the extent of airway epithelial remodeling with adult marrow stem cells is low, and there are no available in viv...

journal_title：American journal of respiratory and critical care medicine

authors： Sueblinvong V,Loi R,Eisenhauer PL,Bernstein IM,Suratt BT,Spees JL,Weiss DJ

更新日期：2008-04-01 00:00:00

abstract：:Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used...

journal_title：American journal of respiratory and critical care medicine

authors： Honarmand K,Lalli RS,Priestap F,Chen JL,McIntyre CW,Owen AM,Slessarev M

更新日期：2020-07-15 00:00:00

abstract：:Decreases in gastric mucosal pH (pHi) are associated with splanchnic hypoxia in animals and with increased mortality in patients. In the present study we measured changes in gastric pHi with a tonometer in septic patients after a short-term infusion of dobutamine. These changes were compared with concurrent alteration...

journal_title：American journal of respiratory and critical care medicine

authors： Gutierrez G,Clark C,Brown SD,Price K,Ortiz L,Nelson C

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:There is conflicting information about the development and resolution of airway inflammation and airway hyperresponsiveness (AHR) after repeated airway exposure to allergen in sensitized mice. METHODS:Sensitized BALB/c and C57BL/6 mice were exposed to repeated allergen challenge on 3, 7, or 11 occasions. Air...

journal_title：American journal of respiratory and critical care medicine

authors： Koya T,Kodama T,Takeda K,Miyahara N,Yang ES,Taube C,Joetham A,Park JW,Dakhama A,Gelfand EW

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:It is hypothesized that the affective dimension of dyspnea (unpleasantness, emotional response) is not strictly dependent on the intensity of dyspnea. OBJECTIVES:We tested the hypothesis that the ratio of immediate unpleasantness (A(1)) to sensory intensity (SI) varies depending on the type of dyspnea. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Banzett RB,Pedersen SH,Schwartzstein RM,Lansing RW

更新日期：2008-06-15 00:00:00

abstract：:We hypothesized that variation in extubating brain injured patients would affect the incidence of nosocomial pneumonia, length of stay, and hospital charges. In a prospective cohort of consecutive, intubated brain-injured patients, we evaluated daily: intubation status, spontaneous ventilatory parameters, gas exchange...

journal_title：American journal of respiratory and critical care medicine

authors： Coplin WM,Pierson DJ,Cooley KD,Newell DW,Rubenfeld GD

更新日期：2000-05-01 00:00:00

abstract：:To investigate whether the language of dyspnea provides relevant clinical information in addition to that provided by ratings of overall dyspnea intensity when assessing subjective response to therapy, we conducted a prospective study in a cohort of 25 patients with acute asthma presenting to the emergency department ...

journal_title：American journal of respiratory and critical care medicine

authors： Moy ML,Lantin ML,Harver A,Schwartzstein RM

更新日期：1998-09-01 00:00:00

abstract：:The absence of standardized assessment protocols with well- defined measurement properties limits comparison of outcomes among those receiving long-term oxygen therapy (LTOT). We describe simple protocols for a hospital test, a simulated home test, and an actual home test, their reliability and relationship to each ot...

journal_title：American journal of respiratory and critical care medicine

authors： Guyatt GH,McKim DA,Weaver B,Austin PA,Bryan RE,Walter SD,Nonoyama ML,Ferreira IM,Goldstein RS

更新日期：2001-03-01 00:00:00

abstract：:This study aimed to compare O2 consumption (VO2) determination by the gas-exchange (VO2GE) and Fick (VO2F) methods in cardiac surgical patients. A total of 10 mechanically ventilated postoperative patients were studied prospectively. Thermodilution was performed using three randomly applied techniques: room temperatur...

journal_title：American journal of respiratory and critical care medicine

authors： Chioléro R,Mavrocordatos P,Bracco D,Schutz Y,Cayeux C,Revelly JP

更新日期：1994-05-01 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN), also called basigin, is present in the lung during development, but its expression in normal adult lung is minimal. Increases of EMMPRIN have been found in various forms of experimental lung injury. To determine whether EMMPRIN might be involved in alveolar inj...

journal_title：American journal of respiratory and critical care medicine

authors： Betsuyaku T,Tanino M,Nagai K,Nasuhara Y,Nishimura M,Senior RM

更新日期：2003-07-15 00:00:00

abstract：:Measurement of cardiac output using thermodilution technique in mechanically ventilated patients is associated with significant morbidity. The goal of the present study was to assess the validity of cardiac output measurement using transesophageal Doppler in critically ill patients. Forty-six patients from three diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Valtier B,Cholley BP,Belot JP,de la Coussaye JE,Mateo J,Payen DM

更新日期：1998-07-01 00:00:00

abstract：:Respiratory system compliance (Crs) in infants with cystic fibrosis (CF) has been reported as decreased or not different compared with healthy control subjects; however, the reported measurements of Crs were "quasi-static" or by the single-breath occlusion technique, with all measurements limited to tidal lung volume,...

journal_title：American journal of respiratory and critical care medicine

authors： Tepper RS,Weist A,Williams-Nkomo T,Kisling J

更新日期：2004-09-01 00:00:00