Asthma exacerbations after glucocorticoid withdrawal reflects T cell recruitment to the airway.

abstract：RATIONALE:Previous studies have demonstrated a high prevalence of sleep apnea (SA) in patients with chronic heart failure (HF), which is associated with higher rates of morbidity, mortality, and health care use. OBJECTIVES:To investigate the reported incidence, treatment, outcomes, and economic cost of SA in new-onset...

journal_title：American journal of respiratory and critical care medicine

authors： Javaheri S,Caref EB,Chen E,Tong KB,Abraham WT

更新日期：2011-02-15 00:00:00

abstract：RATIONALE:Comorbidities contribute to disease severity and mortality in patients with chronic obstructive pulmonary disease (COPD). Comorbidities have been studied individually and were mostly based on self-reports. The coexistence of objectively identified comorbidities and the role of low-grade systemic inflammation ...

journal_title：American journal of respiratory and critical care medicine

authors： Vanfleteren LE,Spruit MA,Groenen M,Gaffron S,van Empel VP,Bruijnzeel PL,Rutten EP,Op 't Roodt J,Wouters EF,Franssen FM

更新日期：2013-04-01 00:00:00

abstract：:A respiratory therapist-driven weaning protocol incorporating daily screens, spontaneous breathing trials (SBT), and prompts to caregivers has been associated with superior outcomes in mechanically ventilated medical patients. To determine the effectiveness of this approach in neurosurgical (NSY) patients, we conducte...

journal_title：American journal of respiratory and critical care medicine

authors： Namen AM,Ely EW,Tatter SB,Case LD,Lucia MA,Smith A,Landry S,Wilson JA,Glazier SS,Branch CL,Kelly DL,Bowton DL,Haponik EF

更新日期：2001-03-01 00:00:00

abstract：:Cilomilast (Ariflo), a new oral phosphodiesterase-4 selective inhibitor, improves lung function in chronic obstructive pulmonary disease (COPD). We have evaluated its antiinflammatory effects in 59 patients with COPD randomized to receive cilomilast, 15 mg two times a day, or placebo for 12 weeks. Induced sputum diffe...

journal_title：American journal of respiratory and critical care medicine

authors： Gamble E,Grootendorst DC,Brightling CE,Troy S,Qiu Y,Zhu J,Parker D,Matin D,Majumdar S,Vignola AM,Kroegel C,Morell F,Hansel TT,Rennard SI,Compton C,Amit O,Tat T,Edelson J,Pavord ID,Rabe KF,Barnes NC,Jeffery PK

更新日期：2003-10-15 00:00:00

abstract：RATIONALE:The perception of dyspnea and pain show many similarities. Initial imaging studies suggested an important role of the insular cortex for the perception of both sensations. However, little is known about the cortical processing of dyspnea. OBJECTIVES:This study investigated the influence of lesions of the ins...

journal_title：American journal of respiratory and critical care medicine

authors： Schön D,Rosenkranz M,Regelsberger J,Dahme B,Büchel C,von Leupoldt A

更新日期：2008-12-01 00:00:00

abstract：:Men have higher prevalence rates of chronic obstructive pulmonary disease (COPD) than women, which has been attributed to the historically higher rates of cigarette smoking in males. However, the increased rates of cigarette smoking in females within the last several decades have been associated with steadily increasi...

journal_title：American journal of respiratory and critical care medicine

authors： Silverman EK,Weiss ST,Drazen JM,Chapman HA,Carey V,Campbell EJ,Denish P,Silverman RA,Celedon JC,Reilly JJ,Ginns LC,Speizer FE

更新日期：2000-12-01 00:00:00

abstract：:The role of strain difference in the response to cigarette smoke was investigated in mice. Mice of the strains DBA/2 and C57BL/6J responded to acute cigarette smoke with a decrease of the antioxidant defenses of their bronchoalveolar lavage (BAL) fluids. On the other hand, under these conditions ICR mice increased the...

journal_title：American journal of respiratory and critical care medicine

authors： Cavarra E,Bartalesi B,Lucattelli M,Fineschi S,Lunghi B,Gambelli F,Ortiz LA,Martorana PA,Lungarella G

更新日期：2001-09-01 00:00:00

abstract：:In this study, 12 male baboons were delivered by hysterotomy at 75% of gestation. The development of a nonlethal baboon model permitted a study of lung growth and development in long-term survivors. Control animals were ventilated with clinically appropriate oxygen for the 21 d study period. BPD animals were ventilate...

journal_title：American journal of respiratory and critical care medicine

authors： Coalson JJ,Winter V,deLemos RA

更新日期：1995-08-01 00:00:00

abstract：:The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as part of an inflammatory response, may play a pivotal role in the development of BPD. A neutrophil chemokine, cytokine-induced...

journal_title：American journal of respiratory and critical care medicine

authors： Yi M,Jankov RP,Belcastro R,Humes D,Copland I,Shek S,Sweezey NB,Post M,Albertine KH,Auten RL,Tanswell AK

更新日期：2004-12-01 00:00:00

abstract：:Little is known about the anti-asthmatic effects of powerful anti-inflammatory agents such as aspirin-like drugs. We compared the effects of two aspirin-like drugs with different pharmacologic activities, sodium salicylate (SSA) and indomethacin, with the effect of lysine acetylsalicylate (LASA), inhaled 30 min before...

journal_title：American journal of respiratory and critical care medicine

authors： Sestini P,Refini RM,Pieroni MG,Vaghi A,Robuschi M,Bianco S

更新日期：1999-04-01 00:00:00

abstract：:Asthma in children and young adults is strongly associated with immediate hypersensitivity to indoor allergens, notably those derived from the house dust mite. In addition, outdoor air pollution is considered to aggravate existing asthma. We investigated the prevalence of asthma and the pattern of allergen sensitizati...

journal_title：American journal of respiratory and critical care medicine

authors： Sporik R,Ingram JM,Price W,Sussman JH,Honsinger RW,Platts-Mills TA

更新日期：1995-05-01 00:00:00

abstract：:Sarcoidosis is a systemic granulomatous disease of unknown etiology that primarily affects the lungs. The etiology remains unclear; however, environmental, genetic, ethnic, and familial factors probably modify expression of the disease. As an example, African Americans are at greater risk of mortality and morbidity th...

journal_title：American journal of respiratory and critical care medicine

authors： Martin WJ 2nd,Iannuzzi MC,Gail DB,Peavy HH

更新日期：2004-09-01 00:00:00

abstract：RATIONALE:Tumor-infiltrating immune cells affect lung cancer outcome. However, the factors that influence the composition and function of the tumor immune environment remain poorly defined and need investigation, particularly in the era of immunotherapy. OBJECTIVES:To determine whether the tumoral immune environment i...

journal_title：American journal of respiratory and critical care medicine

authors： Mansuet-Lupo A,Alifano M,Pécuchet N,Biton J,Becht E,Goc J,Germain C,Ouakrim H,Régnard JF,Cremer I,Laurent-Puig P,Dieu-Nosjean MC,Blons H,Damotte D

更新日期：2016-12-01 00:00:00

abstract：RATIONALE:Congenital central hypoventilation syndrome (CCHS) is a genetic disorder mainly characterized by failure of automatic control of breathing, causing alveolar hypoventilation. Little is known regarding cough in CCHS. Parental reports indicate that patients cough normally during airway infections; however, previ...

journal_title：American journal of respiratory and critical care medicine

authors： Lavorini F,Fontana GA,Pantaleo T,Geri P,Piumelli R,Pistolesi M,Widdicombe J

更新日期：2007-10-15 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：RATIONALE:The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES:To identify novel asthma phenotypes using an unsupervised hierarchical clu...

journal_title：American journal of respiratory and critical care medicine

authors： Moore WC,Meyers DA,Wenzel SE,Teague WG,Li H,Li X,D'Agostino R Jr,Castro M,Curran-Everett D,Fitzpatrick AM,Gaston B,Jarjour NN,Sorkness R,Calhoun WJ,Chung KF,Comhair SA,Dweik RA,Israel E,Peters SP,Busse WW,Erzurum

更新日期：2010-02-15 00:00:00

abstract：RATIONALE:Dyspnea is the impairing cardinal symptom of asthma but its accurate perception is also crucial for timely initiation of treatment. However, the underlying brain mechanisms of perceived dyspnea in patients with asthma are unknown. OBJECTIVES:To study brain mechanisms of dyspnea in asthma. METHODS:By using f...

journal_title：American journal of respiratory and critical care medicine

authors： von Leupoldt A,Sommer T,Kegat S,Eippert F,Baumann HJ,Klose H,Dahme B,Büchel C

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:Long-term intermittent hypoxia (LTIH) exposure in adult mice, modeling oxygenation patterns of moderate-severe obstructive sleep apnea, results in lasting hypersomnolence and is associated with nitration and oxidation injuries in many brain regions, including wake-active regions. OBJECTIVES:We sought to dete...

journal_title：American journal of respiratory and critical care medicine

authors： Zhan G,Fenik P,Pratico D,Veasey SC

更新日期：2005-06-15 00:00:00

abstract：:We found that continuous eosinophilic inflammation after repeated antigen instillation into the nose was observed only in A/J mice, not in three other strains. Histologic analysis of tissues from A/J mice revealed features typical of airway remodeling, i.e., airway wall thickening and increased collagen depositions we...

journal_title：American journal of respiratory and critical care medicine

authors： Shinagawa K,Kojima M

更新日期：2003-10-15 00:00:00

abstract：:The aim of the study was to determine risk factors for severe community-acquired pneumonia (CAP) as well as to compare microbial patterns of severe CAP to a previous study from our respiratory intensive care unit (ICU) originating from 1984 to 1987. Patients admitted to the ICU according to clinical judgment were defi...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Ewig S,Torres A,Arancibia F,Marco F,Mensa J,Sanchez M,Martinez JA

更新日期：1999-09-01 00:00:00

abstract：:In a prospective, controlled, and randomized clinical trial, we examined the effects of treatment with vitamin D (1,000 IU/d), calcium (1 g/d), and ethane-1-hydroxy-1,1-diphosphonate (EHDP; 7.5 mg/kg body weight) on vertebral bone mass in fourteen asthmatics undergoing long-term treatment with systemically applied cor...

journal_title：American journal of respiratory and critical care medicine

authors： Worth H,Stammen D,Keck E

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poo...

journal_title：American journal of respiratory and critical care medicine

authors： Kiwamoto T,Ishii Y,Morishima Y,Yoh K,Maeda A,Ishizaki K,Iizuka T,Hegab AE,Matsuno Y,Homma S,Nomura A,Sakamoto T,Takahashi S,Sekizawa K

更新日期：2006-07-15 00:00:00

abstract：:We previously found that weight lifters could generate greater inspiratory pressures and had more diaphragm mass than control subjects. We postulated that the weight-lifting activity itself provided a strength-training stimulus to the diaphragm. To evaluate the extent to which the diaphragm is recruited during strenuo...

journal_title：American journal of respiratory and critical care medicine

authors： Al-Bilbeisi F,McCOOL FD

更新日期：2000-08-01 00:00:00

abstract：:Infection of the cystic fibrosis (CF) airways elicits an exaggerated, interleukin-8 (IL-8) mediated, neutrophil inflammatory response. Necrosing neutrophils release DNA and actin into the airways, increasing the viscoelasticity of airway secretions. Mucolytics aim to improve airway clearance by reducing this viscoelas...

journal_title：American journal of respiratory and critical care medicine

authors： Perks B,Shute JK

更新日期：2000-11-01 00:00:00

abstract：RATIONALE:In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration. OBJECTIVES:To investigate how regional aeration, shunt, and perfusion are interrelated at different le...

journal_title：American journal of respiratory and critical care medicine

authors： Musch G,Bellani G,Vidal Melo MF,Harris RS,Winkler T,Schroeder T,Venegas JG

更新日期：2008-02-01 00:00:00

abstract：:It has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity react...

journal_title：American journal of respiratory and critical care medicine

authors： Platts-Mills TA

更新日期：2001-10-15 00:00:00

abstract：RATIONALE:Despite intensive research, sepsis displays the most prevalent cause of death on intensive care units. The hallmark of sepsis is an overshooting T-cell death that reduces host defense mechanisms and that is associated with poor patient survival. Previous in vitro studies revealed that the expression of the tr...

journal_title：American journal of respiratory and critical care medicine

authors： Schmidt MV,Paulus P,Kuhn AM,Weigert A,Morbitzer V,Zacharowski K,Kempf VA,Brüne B,von Knethen A

更新日期：2011-07-01 00:00:00

abstract：:The distribution of ventilation-perfusion (VA/Q) ratios during bronchoconstriction measured with the multiple inert gases elimination technique is frequently bimodal. However, the topographic basis and the cause of that bimodality remain unknown. In this article, regional VA/Q is quantified by three-dimensional positr...

journal_title：American journal of respiratory and critical care medicine

authors： Melo MF,Harris RS,Layfield JD,Venegas JG

更新日期：2005-04-01 00:00:00

abstract：:Characterization of chemokine expression patterns in virus-infected epithelial cells provides important clues to the pathophysiology of such infections. The aim of this study was to determine the chemokine response pattern of respiratory epithelium when infected with respiratory syncytial virus (RSV). Macrophage infla...

journal_title：American journal of respiratory and critical care medicine

authors： Harrison AM,Bonville CA,Rosenberg HF,Domachowske JB

更新日期：1999-06-01 00:00:00

abstract：:Controversy exists regarding the clinical utility of pleural fluid pH, lactate dehydrogenase (LDH), and glucose for identifying complicated parapneumonic effusions that require drainage. In this report, we performed a meta-analysis of pertinent studies, using receiver operating characteristic (ROC) techniques, to asse...

journal_title：American journal of respiratory and critical care medicine

authors： Heffner JE,Brown LK,Barbieri C,DeLeo JM

更新日期：1995-06-01 00:00:00