Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat.

abstract：:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocyte...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan BP,Michelson AD

更新日期：2006-03-01 00:00:00

abstract：:Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population dat...

journal_title：American journal of respiratory and critical care medicine

authors： Watson RS,Carcillo JA,Linde-Zwirble WT,Clermont G,Lidicker J,Angus DC

更新日期：2003-03-01 00:00:00

abstract：:We have previously shown (Am. J. Respir. Crit. Care Med. 1995;152:1248-1255) that in patients needing mechanical ventilation, the load imposed on the inspiratory muscles is excessive relative to their neuromuscular capacity. We have therefore hypothesized that weaning failure may occur because at the time of the trial...

journal_title：American journal of respiratory and critical care medicine

authors： Vassilakopoulos T,Zakynthinos S,Roussos C

更新日期：1998-08-01 00:00:00

abstract：:The potential role of atypical bacterial infection in the pathogenesis of asthma is a subject of continuing debate. There is an increasing body of literature concerning the association between the atypical bacteria Chlamydophila pneumoniae and Mycoplasma pneumoniae and asthma pathogenesis; however, many studies invest...

journal_title：American journal of respiratory and critical care medicine

authors： Johnston SL,Martin RJ

更新日期：2005-11-01 00:00:00

abstract：:At the time of diagnosis, many sarcoidosis patients have no clinical indication for corticosteroid therapy, and prognostic parameters predicting deterioration are missing. In the present study, we investigated parameters derived from bronchoalveolar lavage (BAL) and serum in 77 patients with recently diagnosed sarcoid...

journal_title：American journal of respiratory and critical care medicine

authors： Ziegenhagen MW,Benner UK,Zissel G,Zabel P,Schlaak M,Müller-Quernheim J

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Little is known about human club cells, dome-shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth-generation bronchi). OBJECTIVES:To define the ontogeny and biology of the human small airway epithelium club cell. METH...

journal_title：American journal of respiratory and critical care medicine

authors： Zuo WL,Shenoy SA,Li S,O'Beirne SL,Strulovici-Barel Y,Leopold PL,Wang G,Staudt MR,Walters MS,Mason C,Kaner RJ,Mezey JG,Crystal RG

更新日期：2018-12-01 00:00:00

abstract：:The nasal antiinflammatory effects produced by maintenance treatment with topical steroids include reduced production of cytokines. The present study explored nasal mucosal effects induced during the first 9 h after a single dose of topical budesonide. Nine subjects with allergic rhinitis due to birch or timothy polle...

journal_title：American journal of respiratory and critical care medicine

authors： Linden M,Svensson C,Andersson E,Andersson M,Greiff L,Persson CG

更新日期：2000-11-01 00:00:00

abstract：:The clinical significance of minimal acute rejection (grade A1) in lung transplant recipients is unknown. We prospectively analyzed 1,159 transbronchial lung biopsies in 184 patients. Two hundred seventy-nine biopsies in 128 participants confirmed A1 histology at a mean postoperative day of 229 +/- 340. Sixty four of ...

journal_title：American journal of respiratory and critical care medicine

authors： Hopkins PM,Aboyoun CL,Chhajed PN,Malouf MA,Plit ML,Rainer SP,Glanville AR

更新日期：2004-11-01 00:00:00

abstract：:The present study was designed to examine whether clenbuterol (CLEN) could reduce dexamethasone (DEX)-induced diaphragm dysfunction. We studied four groups of New Zealand white (NZW) rabbits, each receiving one of the following daily injections subcutaneously for 2 wk: saline (control), DEX 3 mg/kg, DEX 3 mg/kg + CLEN...

journal_title：American journal of respiratory and critical care medicine

authors： Jiang TX,Cairns A,Road JD,Wilcox PG

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Activin-A is up-regulated in various respiratory disorders. However, its precise role in pulmonary pathophysiology has not been adequately substantiated in vivo. OBJECTIVES:To investigate in vivo the consequences of dysregulated Activin-A expression in the lung and identify key Activin-A-induced processes th...

journal_title：American journal of respiratory and critical care medicine

authors： Apostolou E,Stavropoulos A,Sountoulidis A,Xirakia C,Giaglis S,Protopapadakis E,Ritis K,Mentzelopoulos S,Pasternack A,Foster M,Ritvos O,Tzelepis GE,Andreakos E,Sideras P

更新日期：2012-02-15 00:00:00

abstract：:Exhaled nitric oxide (eNO) is elevated in patients with inflammatory pulmonary diseases and it has attracted increasing interest as a simple, noninvasive marker of airway inflammation. Little is known, however, about factors that might affect eNO in healthy subjects. We measured eNO in 157 healthy 7- to 13-yr-old chil...

journal_title：American journal of respiratory and critical care medicine

authors： Franklin PJ,Taplin R,Stick SM

更新日期：1999-01-01 00:00:00

abstract：:Arousal from sleep produces transient increases in systemic blood pressure, leading to the suggestion that repeated arousals are associated with a sustained increase in daytime blood pressure. Using data from the Wisconsin Sleep Cohort Study, a population-based study, we tested the hypothesis that sleep fragmentation ...

journal_title：American journal of respiratory and critical care medicine

authors： Morrell MJ,Finn L,Kim H,Peppard PE,Badr MS,Young T

更新日期：2000-12-01 00:00:00

abstract：:The development of sensitization to inhaled allergens is determined by the interaction of multiple genetic and environmental influences. Occupational sensitization to low-molecular-weight chemicals allows a specific immunological response to an inhaled hapten to be studied in a well-defined population with characteriz...

journal_title：American journal of respiratory and critical care medicine

authors： Newman Taylor AJ,Cullinan P,Lympany PA,Harris JM,Dowdeswell RJ,du Bois RM

更新日期：1999-08-01 00:00:00

abstract：RATIONALE:Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH. OBJECTIVES:To assess the effect of the adrenergic receptor blocker carvedilol on ...

journal_title：American journal of respiratory and critical care medicine

authors： Bogaard HJ,Natarajan R,Mizuno S,Abbate A,Chang PJ,Chau VQ,Hoke NN,Kraskauskas D,Kasper M,Salloum FN,Voelkel NF

更新日期：2010-09-01 00:00:00

abstract：:Pneumonectomized rats develop pulmonary hypertension (PH) and pulmonary vascular neointimal formation 4 wk after monocrotaline (MCT) administration. Male Sprague-Dawley rats were injected with MCT (60 mg/kg) on Day 7 after left pneumonectomy. Three groups (n = 5) received 40-O-(2-hydroxyethyl)-rapamycin (RAD, 2.5 mg/k...

journal_title：American journal of respiratory and critical care medicine

authors： Nishimura T,Faul JL,Berry GJ,Veve I,Pearl RG,Kao PN

更新日期：2001-02-01 00:00:00

abstract：:A number of new observations have added to our understanding of mast cell biology and the relevance of this cell to the genesis of asthma. The purpose of this review has been to highlight this new information and to refer the reader to extensive reviews where previously documented and well-known data are available. Of...

journal_title：American journal of respiratory and critical care medicine

authors： Wasserman SI

更新日期：1994-11-01 00:00:00

abstract：:alpha-Tocopherol is a potent antioxidant that effectively protects biological membranes against oxidative injury through coordination with ascorbic acid. Because propofol has a phenolic structure similar to that of alpha-tocopherol, this intravenous anesthetic may also have similar antioxidant activity. To test this h...

journal_title：American journal of respiratory and critical care medicine

authors： Tsuchiya M,Asada A,Kasahara E,Sato EF,Shindo M,Inoue M

更新日期：2002-01-01 00:00:00

abstract：:Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate i...

journal_title：American journal of respiratory and critical care medicine

authors： Casaburi R,Bhasin S,Cosentino L,Porszasz J,Somfay A,Lewis MI,Fournier M,Storer TW

更新日期：2004-10-15 00:00:00

abstract：RATIONALE:The inadequacy of effector T-cell response in containment of tubercle bacilli is believed to result in the development of disseminated forms of tuberculosis (TB), such as miliary tuberculosis (MTB). Regulatory T cells (Treg) plausibly play a critical role in the immunopathogenesis of disseminated TB by suppre...

journal_title：American journal of respiratory and critical care medicine

authors： Sharma PK,Saha PK,Singh A,Sharma SK,Ghosh B,Mitra DK

更新日期：2009-06-01 00:00:00

abstract：:Until recently it was thought that age greater than 35 yr was the main risk factor for the development of drug-induced hepatitis (DIH) in patients receiving antituberculosis therapy. We conducted a study to determine whether infection with either the hepatitis C virus or the human immunodeficiency virus (HIV) were sig...

journal_title：American journal of respiratory and critical care medicine

authors： Ungo JR,Jones D,Ashkin D,Hollender ES,Bernstein D,Albanese AP,Pitchenik AE

更新日期：1998-06-01 00:00:00

abstract：RATIONALE:The degree to which chronic respiratory health effects caused by exposures to cotton dust and endotoxin is reversible after cessation of textile work is unknown. OBJECTIVES:To investigate changes in lung function and respiratory symptoms after cessation of textile work and to determine whether past exposure ...

journal_title：American journal of respiratory and critical care medicine

authors： Shi J,Hang JQ,Mehta AJ,Zhang HX,Dai HL,Su L,Eisen EA,Christiani DC

更新日期：2010-07-15 00:00:00

abstract：RATIONALE:The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. OB...

journal_title：American journal of respiratory and critical care medicine

authors： Linch SN,Danielson ET,Kelly AM,Tamakawa RA,Lee JJ,Gold JA

更新日期：2012-08-01 00:00:00

abstract：:In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do not change consistently following long-term anti-inflammatory trea...

journal_title：American journal of respiratory and critical care medicine

authors： Crimi E,Spanevello A,Neri M,Ind PW,Rossi GA,Brusasco V

更新日期：1998-01-01 00:00:00

abstract：:To test whether the leukotriene antagonist ONO-1078 (pranlukast) prevents asthma exacerbations during reduction of high-dose inhaled corticosteroid, we conducted a randomized, double-blind, placebo-controlled study in 79 asthma patients requiring high doses (1,500 microg/d or more) of inhaled beclomethasone dipropiona...

journal_title：American journal of respiratory and critical care medicine

authors： Tamaoki J,Kondo M,Sakai N,Nakata J,Takemura H,Nagai A,Takizawa T,Konno K

更新日期：1997-04-01 00:00:00

abstract：:We have previously reported differential impairment of pulmonary and systemic vascular contractility in hyperdynamic sepsis. The objectives of this study were (1) to determine whether the magnitude of this phenomenon depends on the control group chosen for comparison, and (2) to examine the role of nitric oxide (NO) i...

journal_title：American journal of respiratory and critical care medicine

authors： Yaghi A,Paterson NA,McCormack DG

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Although the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC-derived cells in lung disease models are missing. OBJECTIVES:We have tested the therapeuti...

journal_title：American journal of respiratory and critical care medicine

authors： Happle C,Lachmann N,Ackermann M,Mirenska A,Göhring G,Thomay K,Mucci A,Hetzel M,Glomb T,Suzuki T,Chalk C,Glage S,Dittrich-Breiholz O,Trapnell B,Moritz T,Hansen G

更新日期：2018-08-01 00:00:00

abstract：RATIONALE:Defective efferocytosis (phagocytic clearance of apoptotic cells) in the airway may perpetuate inflammation via secondary necrosis in chronic obstructive pulmonary disease (COPD). We have previously reported that low-dose azithromycin improved alveolar macrophage (AM) phagocytic function in vitro. OBJECTIVES...

journal_title：American journal of respiratory and critical care medicine

authors： Hodge S,Hodge G,Jersmann H,Matthews G,Ahern J,Holmes M,Reynolds PN

更新日期：2008-07-15 00:00:00

abstract：:In humans, respiratory viral infections lead to increased airway responsiveness and exacerbations of asthma. In the present study, the role of interleukin-5 (IL-5) in virus-induced airway hyperresponsiveness and inflammation was examined in guinea pigs. In animals treated with control antibody, parainfluenza-3 virus s...

journal_title：American journal of respiratory and critical care medicine

authors： van Oosterhout AJ,van Ark I,Folkerts G,van der Linde HJ,Savelkoul HF,Verheyen AK,Nijkamp FP

更新日期：1995-01-01 00:00:00

abstract：:Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and a...

journal_title：American journal of respiratory and critical care medicine

authors： Burgel PR,Munck A,Durieu I,Chiron R,Mely L,Prevotat A,Murris-Espin M,Porzio M,Abely M,Reix P,Marguet C,Macey J,Sermet-Gaudelus I,Corvol H,Bui S,Lemonnier L,Dehillotte C,Da Silva J,Paillasseur JL,Hubert D,French Cy

更新日期：2020-01-15 00:00:00

abstract：RATIONALE:Systemic sclerosis (SSc)-associated pulmonary arterial hypertension (PAH) portends worse outcome than other forms of PAH. Vasoconstrictive and vascular remodeling actions of endothelin (ET) 1 and angiotensin (Ang) II via endothelin receptor type A (ETAR) and Ang receptor type-1 (AT1R) activation are implicate...

journal_title：American journal of respiratory and critical care medicine

authors： Becker MO,Kill A,Kutsche M,Guenther J,Rose A,Tabeling C,Witzenrath M,Kühl AA,Heidecke H,Ghofrani HA,Tiede H,Schermuly RT,Nickel N,Hoeper MM,Lukitsch I,Gollasch M,Kuebler WM,Bock S,Burmester GR,Dragun D,Riemekasten

更新日期：2014-10-01 00:00:00