Leukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid. The Tokyo Joshi-Idai Asthma Research Group.

abstract：RATIONALE:The activated leukocyte cell adhesion molecule (ALCAM) is a cluster of differentiation 6 ligand that is important for stabilizing the immunological synapse and inducing T-cell activation and proliferation. OBJECTIVES:In this study, we investigated the role of ALCAM in the development of inflammation in aller...

journal_title：American journal of respiratory and critical care medicine

authors： Kim MN,Hong JY,Shim DH,Sol IS,Kim YS,Lee JH,Kim KW,Lee JM,Sohn MH

更新日期：2018-04-15 00:00:00

abstract：:Possible mechanisms involved in inhaled sodium metabisulfite (MBS)-induced bronchoconstriction include cholinergic reflex and release of tachykinins from sensory nerve endings. Tachykinins are potent bronchoconstrictors cleaved and inactivated by neutral endopeptidase (NEP) in the airways. To investigate the role of t...

journal_title：American journal of respiratory and critical care medicine

authors： Bellofiore S,Caltagirone F,Pennisi A,Ciancio N,Mistretta A,Di Maria GU

更新日期：1994-09-01 00:00:00

abstract：:The objective of this study was to evaluate the effectiveness of an asthma education program on morbidity, knowledge, and compliance with inhaled corticosteroid treatment using a prospective, randomized, controlled, one-year-before/one-year-after protocol. After rigorous optimization of asthma therapy under the care o...

journal_title：American journal of respiratory and critical care medicine

authors： Coté J,Cartier A,Robichaud P,Boutin H,Malo JL,Rouleau M,Fillion A,Lavallée M,Krusky M,Boulet LP

更新日期：1997-05-01 00:00:00

abstract：:Pleural disease both before and after organ transplantation has important implications. Pleural effusions are common in candidates for heart, liver, and kidney transplantation. A thoracentesis is not mandatory in these patients, but it should be performed if clinical or radiologic features suggest that the effusion is...

journal_title：American journal of respiratory and critical care medicine

authors： Judson MA,Sahn SA

更新日期：1996-03-01 00:00:00

abstract：:In a previous study of older pulp and paper workers in Berlin, New Hampshire, decrements in spirometry results associated with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mill exposure and cigarette smoking. Many of those subjects were older and retired. A new study was ...

journal_title：American journal of respiratory and critical care medicine

authors： Henneberger PK,Lax MB,Ferris BG Jr

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Drug-resistant tuberculosis transmission in hospitals threatens staff and patient health. Surgical face masks used by patients with tuberculosis (TB) are believed to reduce transmission but have not been rigorously tested. OBJECTIVES:We sought to quantify the efficacy of surgical face masks when worn by pati...

journal_title：American journal of respiratory and critical care medicine

authors： Dharmadhikari AS,Mphahlele M,Stoltz A,Venter K,Mathebula R,Masotla T,Lubbe W,Pagano M,First M,Jensen PA,van der Walt M,Nardell EA

更新日期：2012-05-15 00:00:00

abstract：:Stimulation of the airways of asthmatic individuals causes severe bronchoconstriction, which is in part neurally mediated via the vagus nerve. Local anesthetics are commonly administered to prevent this reflex-induced bronchoconstriction. Therefore, in a double-blind, placebo-controlled prospective study, we tested th...

journal_title：American journal of respiratory and critical care medicine

authors： Groeben H,Foster WM,Brown RH

更新日期：1996-10-01 00:00:00

abstract：:To determine whether the diagnostic yield of transbronchial needle aspiration (TBNA) improves over time and to obtain insights about factors influencing its performance, we reviewed our experience during a 3-yr period. After serial multifaceted educational interventions directed toward bronchoscopists and their techni...

journal_title：American journal of respiratory and critical care medicine

authors： Haponik EF,Cappellari JO,Chin R,Adair NE,Lykens M,Alford PT,Bowton DL

更新日期：1995-06-01 00:00:00

abstract：:Normative spirometric values were derived from 5,042 white (of mainly European ancestry) and black (of mainly African ancestry) men and women paper plant workers who are never-smokers, with no respiratory symptoms or diagnoses and no history of occupational exposure to fibrogenic dusts or irritant chemicals. This coho...

journal_title：American journal of respiratory and critical care medicine

authors： Glindmeyer HW,Lefante JJ,McColloster C,Jones RN,Weill H

更新日期：1995-02-01 00:00:00

abstract：:This study aimed to examine the performance characteristics of four high-frequency oscillatory-type ventilators, using an in vitro model of the intubated neonatal respiratory system. Each ventilator was examined across its operative range of settings and at varying model lung compliance (C) and resistance. The oscilla...

journal_title：American journal of respiratory and critical care medicine

authors： Pillow JJ,Wilkinson MH,Neil HL,Ramsden CA

更新日期：2001-09-15 00:00:00

abstract：:Around 50% of patients with the sleep apnea/hypopnea syndrome (SAHS) are not obese: body mass index (BMI) < 30 kg/m2. We hypothesized that local fat deposition around the upper airway may be different in nonobese patients with SAHS from that in normal subjects with the same body mass. We therefore examined the relatio...

journal_title：American journal of respiratory and critical care medicine

authors： Mortimore IL,Marshall I,Wraith PK,Sellar RJ,Douglas NJ

更新日期：1998-01-01 00:00:00

abstract：:Previous studies suggest that lung function tests using monodisperse aerosols can help to identify early stages of lung diseases. We investigated intrapulmonary particle loss and aerosol bolus dispersion-a marker of convective gas transport-in 32 women with asymptomatic nonspecific bronchial hyperresponsiveness (BHR) ...

journal_title：American journal of respiratory and critical care medicine

authors： Kohlhäufl M,Brand P,Scheuch G,Meyer TS,Schulz H,Häussinger K,Heyder J

更新日期：1999-03-01 00:00:00

abstract：:Successful bronchodilator therapy with a metered-dose inhaler (MDI) in intubated, mechanically ventilated patients requires adequate delivery of aerosol to the lower respiratory tract. We determined the effect of ventilator mode, inspiratory flow pattern, humidity, and spontaneous respiratory effort on albuterol deliv...

journal_title：American journal of respiratory and critical care medicine

authors： Fink JB,Dhand R,Duarte AG,Jenne JW,Tobin MJ

更新日期：1996-08-01 00:00:00

abstract：:Regular short-acting inhaled beta-agonist therapy is of uncertain benefit in patients with chronic obstructive pulmonary disease (COPD). We conducted a randomized, concealed, double-blind, placebo-controlled crossover trial in two periods, each of 3-mo duration, involving 53 patients with a smoking history of > 20 pac...

journal_title：American journal of respiratory and critical care medicine

authors： Cook D,Guyatt G,Wong E,Goldstein R,Bedard M,Austin P,Ramsdale H,Jaeschke R,Sears M

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Respiratory syncytial virus (RSV) is the leading cause of childhood lower respiratory infection, yet viable therapies are lacking. Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immun...

journal_title：American journal of respiratory and critical care medicine

authors： DeVincenzo JP,Wilkinson T,Vaishnaw A,Cehelsky J,Meyers R,Nochur S,Harrison L,Meeking P,Mann A,Moane E,Oxford J,Pareek R,Moore R,Walsh E,Studholme R,Dorsett P,Alvarez R,Lambkin-Williams R

更新日期：2010-11-15 00:00:00

abstract：:Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Patients with Group 1 PAH were included from two national registries wit...

journal_title：American journal of respiratory and critical care medicine

authors： Karnes JH,Wiener HW,Schwantes-An TH,Natarajan B,Sweatt AJ,Chaturvedi A,Arora A,Batai K,Nair V,Steiner HE,Giles JB,Yu J,Hosseini M,Pauciulo MW,Lutz KA,Coleman AW,Feldman J,Vanderpool R,Tang H,Garcia JGN,Yuan JX,K

更新日期：2020-06-01 00:00:00

abstract：RATIONALE:Despite intensive research, sepsis displays the most prevalent cause of death on intensive care units. The hallmark of sepsis is an overshooting T-cell death that reduces host defense mechanisms and that is associated with poor patient survival. Previous in vitro studies revealed that the expression of the tr...

journal_title：American journal of respiratory and critical care medicine

authors： Schmidt MV,Paulus P,Kuhn AM,Weigert A,Morbitzer V,Zacharowski K,Kempf VA,Brüne B,von Knethen A

更新日期：2011-07-01 00:00:00

abstract：:Noninvasive and invasive diagnostic techniques have been shown to achieve comparable performances in the evaluation of suspected ventilator-associated pneumonia (VAP). We studied the impact of both approaches on outcome in a prospective, open, and randomized study in three intensive care units (ICUs) of a 1,000-bed te...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Torres A,Ewig S,Marcos MA,Alcón A,Lledó R,Asenjo MA,Maldonaldo A

更新日期：2000-07-01 00:00:00

abstract：:At the time of diagnosis, many sarcoidosis patients have no clinical indication for corticosteroid therapy, and prognostic parameters predicting deterioration are missing. In the present study, we investigated parameters derived from bronchoalveolar lavage (BAL) and serum in 77 patients with recently diagnosed sarcoid...

journal_title：American journal of respiratory and critical care medicine

authors： Ziegenhagen MW,Benner UK,Zissel G,Zabel P,Schlaak M,Müller-Quernheim J

更新日期：1997-11-01 00:00:00

abstract：:Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored.Objectives: To elucidate the role of TYKRIL (tyrosine kinase receptor-inducing lncRNA) as a regulator of p53/ PDGFRβ (platelet-derive...

journal_title：American journal of respiratory and critical care medicine

authors： Zehendner CM,Valasarajan C,Werner A,Boeckel JN,Bischoff FC,John D,Weirick T,Glaser SF,Rossbach O,Jaé N,Demolli S,Khassafi F,Yuan K,de Jesus Perez VA,Michalik KM,Chen W,Seeger W,Guenther A,Wasnick RM,Uchida S,Zeihe

更新日期：2020-11-15 00:00:00

abstract：:A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases. To find whether inactivation of surfactant could be prevented or reduced by nonionic p...

journal_title：American journal of respiratory and critical care medicine

authors： William Taeusch H,Lu KW,Goerke J,Clements JA

更新日期：1999-05-01 00:00:00

abstract：RATIONALE:As of April 2015, participants in the Danish Lung Cancer Screening Trial had been followed for at least 5 years since their last screening. OBJECTIVES:Mortality, causes of death, and lung cancer findings are reported to explore the effect of computed tomography (CT) screening. METHODS:A total of 4,104 parti...

journal_title：American journal of respiratory and critical care medicine

authors： Wille MM,Dirksen A,Ashraf H,Saghir Z,Bach KS,Brodersen J,Clementsen PF,Hansen H,Larsen KR,Mortensen J,Rasmussen JF,Seersholm N,Skov BG,Thomsen LH,Tønnesen P,Pedersen JH

更新日期：2016-03-01 00:00:00

abstract：:While signal transducer and activator of transcription protein 6 (STAT6) is important in interleukin-4 (IL-4)-induced commitment of CD4(+) T cells to the T helper cell, type 2 (Th2) phenotype and IgE isotype switching in B cells, its role in other IL-4-mediated events and their impact upon the allergic response is les...

journal_title：American journal of respiratory and critical care medicine

authors： Tomkinson A,Kanehiro A,Rabinovitch N,Joetham A,Cieslewicz G,Gelfand EW

更新日期：1999-10-01 00:00:00

abstract：RATIONALE:Airway mucous cell metaplasia and chronic inflammation are pathophysiological features that influence morbidity and mortality associated with asthma and other chronic pulmonary disorders. Elucidation of the molecular mechanisms regulating mucous metaplasia and hypersecretion provides the scientific basis for ...

journal_title：American journal of respiratory and critical care medicine

authors： Maeda Y,Chen G,Xu Y,Haitchi HM,Du L,Keiser AR,Howarth PH,Davies DE,Holgate ST,Whitsett JA

更新日期：2011-08-15 00:00:00

abstract：:Haemophilus influenzae and Streptococcus pneumoniae are common causes of respiratory tract infections. H. influenzae attach to receptor epitopes in mucins and in epithelial cell membranes. Attachment is followed by an epithelial cell cytokine response. Secreted cytokines then initiate inflammation, upset the integrity...

journal_title：American journal of respiratory and critical care medicine

authors： Håkansson A,Carlstedt I,Davies J,Mossberg AK,Sabharwal H,Svanborg C

更新日期：1996-10-01 00:00:00

abstract：:A 21-yr-old man with multiple pulmonary AV fistulae presented with moderate hypoxemia with chronic hyperventilation, which continued even after sufficient oxygenation by 100% O2 inhalation. The infusion of aminophylline, an adenosine receptor blocker, not only increased PaCO2 from 35 to 39 mm Hg but also depressed the...

journal_title：American journal of respiratory and critical care medicine

authors： Kobayashi S,Nishimura M,Nasuhara Y,Miyamoto K,Kawakami Y

更新日期：1994-12-01 00:00:00

abstract：:Stenotrophomonas maltophilia is a gram-negative bacterium that has been cultured with increasing prevalence from the sputum of patients with cystic fibrosis (CF). We conducted a cohort study, using the Cystic Fibrosis Foundation Registry, to assess the effect of S. maltophilia on survival. We studied all patients in t...

journal_title：American journal of respiratory and critical care medicine

authors： Goss CH,Otto K,Aitken ML,Rubenfeld GD

更新日期：2002-08-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with systemic hypertension. Either overnight intermittent hypoxia, or the recurrent arousals that occur in OSA, could cause the daytime increases in blood pressure (BP). OBJECTIVES:To establish the role of intermittent hypoxia in the increased morning BP in patient...

journal_title：American journal of respiratory and critical care medicine

authors： Turnbull CD,Sen D,Kohler M,Petousi N,Stradling JR

更新日期：2019-01-15 00:00:00

abstract：RATIONALE:Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in asthma pathogenesis, but it remains unknown how their phenotype, location, and activation relate to asthma severity. OBJECTIVES:To compare MC-related markers measured in bronchoscopically obtained samples with clinically relevant...

journal_title：American journal of respiratory and critical care medicine

authors： Balzar S,Fajt ML,Comhair SA,Erzurum SC,Bleecker E,Busse WW,Castro M,Gaston B,Israel E,Schwartz LB,Curran-Everett D,Moore CG,Wenzel SE

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood. OBJECTIVES:Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) ge...

journal_title：American journal of respiratory and critical care medicine

authors： Simpson A,Maniatis N,Jury F,Cakebread JA,Lowe LA,Holgate ST,Woodcock A,Ollier WE,Collins A,Custovic A,Holloway JW,John SL

更新日期：2005-07-01 00:00:00