Association of minimal rejection in lung transplant recipients with obliterative bronchiolitis.

abstract：:Relaxation was examined in diaphragm muscle strips of cardiomyopathic Syrian hamsters and control hamsters. Isotonic lengthening velocity and isometric tension decay were analyzed over the load continuum in response to twitch. For each load level (P), we measured the maximum extent of shortening (deltaL), the peak len...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Chemla D,Pourny JC,Lambert F,Riou B,Lecarpentier Y

更新日期：1997-05-01 00:00:00

abstract：RATIONALE:Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions. However, the role of combining these modalities to overcome each individual technique's limitations and, consequently, to further increas...

journal_title：American journal of respiratory and critical care medicine

authors： Eberhardt R,Anantham D,Ernst A,Feller-Kopman D,Herth F

更新日期：2007-07-01 00:00:00

abstract：:Vitamin D receptor (VDR) polymorphisms have been associated with several immune-related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to chromosome 12q, near a region commonly linked to asthma. We evaluated VDR as part of a 12q positional candidate survey, and in response to observat...

journal_title：American journal of respiratory and critical care medicine

authors： Raby BA,Lazarus R,Silverman EK,Lake S,Lange C,Wjst M,Weiss ST

更新日期：2004-11-15 00:00:00

abstract：RATIONALE:As of April 2015, participants in the Danish Lung Cancer Screening Trial had been followed for at least 5 years since their last screening. OBJECTIVES:Mortality, causes of death, and lung cancer findings are reported to explore the effect of computed tomography (CT) screening. METHODS:A total of 4,104 parti...

journal_title：American journal of respiratory and critical care medicine

authors： Wille MM,Dirksen A,Ashraf H,Saghir Z,Bach KS,Brodersen J,Clementsen PF,Hansen H,Larsen KR,Mortensen J,Rasmussen JF,Seersholm N,Skov BG,Thomsen LH,Tønnesen P,Pedersen JH

更新日期：2016-03-01 00:00:00

abstract：:Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used...

journal_title：American journal of respiratory and critical care medicine

authors： Honarmand K,Lalli RS,Priestap F,Chen JL,McIntyre CW,Owen AM,Slessarev M

更新日期：2020-07-15 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is elevated in human fibrotic lung diseases and in animal models of pulmonary fibrosis, implicating IGF-I in the pathogenesis of fibrotic lung disease. We questioned whether IGF-I protein levels were enhanced in fibroproliferative acute respiratory distress syndrome (FP-ARDS). Seri...

journal_title：American journal of respiratory and critical care medicine

authors： Krein PM,Sabatini PJ,Tinmouth W,Green FH,Winston BW

更新日期：2003-01-01 00:00:00

abstract：:Background: This document provides evidence-based clinical practice guidelines on the management of adult patients with community-acquired pneumonia.Methods: A multidisciplinary panel conducted pragmatic systematic reviews of the relevant research and applied Grading of Recommendations, Assessment, Development, and Ev...

journal_title：American journal of respiratory and critical care medicine

authors： Metlay JP,Waterer GW,Long AC,Anzueto A,Brozek J,Crothers K,Cooley LA,Dean NC,Fine MJ,Flanders SA,Griffin MR,Metersky ML,Musher DM,Restrepo MI,Whitney CG

更新日期：2019-10-01 00:00:00

abstract：RATIONALE:Tissue resident memory T cells play a critical role in the defense against inhaled pathogens. The isolation and study of human lung tissue resident memory T cells and lung resident macrophages is limited by experimental constraints. OBJECTIVES:To characterize the spatial and functional relationship between l...

journal_title：American journal of respiratory and critical care medicine

authors： Snyder ME,Sembrat J,Noda K,Myerburg MM,Craig A,Mitash N,Harano T,Furukawa M,Pilewski J,McDyer J,Rojas M,Sanchez P

更新日期：2020-12-11 00:00:00

abstract：:To elucidate which cells are synthesizing tenascin in usual interstitial pneumonia (UIP) we have analyzed thoracoscopic or open lung biopsies from 30 patients with UIP by mRNA in situ hybridization, using (35)S-labeled tenascin RNA probes. The phenotype of the cells expressing tenascin mRNA was confirmed by immunohist...

journal_title：American journal of respiratory and critical care medicine

authors： Pääkkö P,Kaarteenaho-Wiik R,Pöllänen R,Soini Y

更新日期：2000-03-01 00:00:00

abstract：:Pulmonary infections are a significant cause of morbidity and mortality in patients with alcohol abuse and human immunodeficiency virus (HIV) infection, two immunocompromising conditions that frequently coexist. This study examined the separate and combined effects of in vivo lentiviral infection and in vitro alcohol ...

journal_title：American journal of respiratory and critical care medicine

authors： Stoltz DA,Nelson S,Kolls JK,Zhang P,Bohm RP Jr,Murphey-Corb M,Bagby GJ

更新日期：2000-01-01 00:00:00

abstract：:The present study was undertaken to assess the relationship between health-related quality of life (HRQOL) and bronchiolitis obliterans syndrome (BOS), as both represent important parameters of outcome after lung transplantation. HRQOL was measured both cross-sectionally and longitudinally by standardized patient self...

journal_title：American journal of respiratory and critical care medicine

authors： van Den BERG JW,Geertsma A,van Der BIJ W,Koëter GH,de BOER WJ,Postma DS,ten VERGERT EM

更新日期：2000-06-01 00:00:00

abstract：:We investigated ventilation inhomogeneity in patients with chronic obstructive pulmonary disease (COPD) through use of the multiple breath N2 washout test (MBW). From an alveolar slope analysis throughout the MBW, we derived two indices, S(cond) and S(acin), as a measure of ventilation inhomogeneity in conductive and ...

journal_title：American journal of respiratory and critical care medicine

authors： Verbanck S,Schuermans D,Van Muylem A,Melot C,Noppen M,Vincken W,Paiva M

更新日期：1998-05-01 00:00:00

abstract：:Several modalities of ventilatory support have been proposed to gradually withdraw patients from mechanical ventilation, but their respective effects on the outcome of weaning from mechanical ventilation are not known. We conducted a randomized trial in three intensive care units in mechanically ventilated patients wh...

journal_title：American journal of respiratory and critical care medicine

authors： Brochard L,Rauss A,Benito S,Conti G,Mancebo J,Rekik N,Gasparetto A,Lemaire F

更新日期：1994-10-01 00:00:00

abstract：:Obstructive sleep-disordered breathing is associated with cardiovascular disease in adults, and elevated C-reactive protein (CRP) has been proposed as a link between the two disorders. We hypothesized that children with sleep-disordered breathing have higher CRP values than do control subjects. CRP was measured in 39 ...

journal_title：American journal of respiratory and critical care medicine

authors： Kaditis AG,Alexopoulos EI,Kalampouka E,Kostadima E,Germenis A,Zintzaras E,Gourgoulianis K

更新日期：2005-02-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM), a disease that occurs primarily in women, is characterized by cystic lung lesions causing respiratory failure, which may require lung transplantation. Lung diffusion (DLCO) and/or FEV1 are decreased, but frequently not in parallel with each other. Because cardiopulmonary exercise testin...

journal_title：American journal of respiratory and critical care medicine

authors： Taveira-DaSilva AM,Stylianou MP,Hedin CJ,Kristof AS,Avila NA,Rabel A,Travis WD,Moss J

更新日期：2003-12-15 00:00:00

abstract：:To define the mechanisms by which inhaled glucocorticosteroid regulates allergen-induced airway inflammation, a double-blind, placebo-controlled, cross-over study with inhaled budesonide was conducted in 14 subjects with allergic asthma. After baseline bronchoscopy and bronchoalveolar lavage (BAL), subjects were rando...

journal_title：American journal of respiratory and critical care medicine

authors： Kelly EA,Busse WW,Jarjour NN

更新日期：2000-09-01 00:00:00

abstract：:Early experience suggests that lung volume reduction surgery improves exercise tolerance as measured by the 6-min walk distance in patients with emphysema. To identify the physiologic mechanism(s) by which lung volume reduction surgery improved exercise, we performed progressive cardiopulmonary exercise testing, inclu...

journal_title：American journal of respiratory and critical care medicine

authors： Benditt JO,Lewis S,Wood DE,Klima L,Albert RK

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with several pathophysiological deficits found in diabetic retinopathy (DR). Hence, it's plausible that OSA could play a role in the pathogenesis of sight-threatening DR (STDR). OBJECTIVES:To assess the relationship between OSA and DR in patients with type 2 diabet...

journal_title：American journal of respiratory and critical care medicine

authors： Altaf QA,Dodson P,Ali A,Raymond NT,Wharton H,Fellows H,Hampshire-Bancroft R,Shah M,Shepherd E,Miah J,Barnett AH,Tahrani AA

更新日期：2017-10-01 00:00:00

abstract：:Methodologies used to assess airway responsiveness (AR) in children administer the same dosage schedule to all children despite the great range in the size of subjects. The aim of this study was to examine the hypothesis that the level of AR is size dependent within same-age cohorts and between different ages. Among a...

journal_title：American journal of respiratory and critical care medicine

authors： Le Souëf PN,Sears MR,Sherrill D

更新日期：1995-08-01 00:00:00

abstract：:On the basis of studies with animal models, the gene for the low-affinity receptor for immunoglobulin E (IgE) (FCER2, CD23) has been implicated as a candidate for IgE-mediated allergic diseases and bronchial hyperreactivity, or related traits. Given evidence for genetic complexity in atopic disorders, we sought to stu...

journal_title：American journal of respiratory and critical care medicine

authors： Laitinen T,Ollikainen V,Lázaro C,Kauppi P,de Cid R,Antó JM,Estivill X,Lokki H,Mannila H,Laitinen LA,Kere J

更新日期：2000-03-01 00:00:00

abstract：:In patients with chronic obstructive pulmonary disease (COPD) the intensity of aerobic training is limited by dyspnea. Improving strength of the inspiratory muscles could enhance aerobic exercise training by reducing exercise-related dyspnea. We examined effects of home-based inspiratory muscle training (IMT) and cycl...

journal_title：American journal of respiratory and critical care medicine

authors： Larson JL,Covey MK,Wirtz SE,Berry JK,Alex CG,Langbein WE,Edwards L

更新日期：1999-08-01 00:00:00

abstract：RATIONALE:Diaphragm atrophy and dysfunction have been reported in humans during mechanical ventilation, but the prevalence, causes, and functional impact of changes in diaphragm thickness during routine mechanical ventilation for critically ill patients are unknown. OBJECTIVES:To describe the evolution of diaphragm th...

journal_title：American journal of respiratory and critical care medicine

authors： Goligher EC,Fan E,Herridge MS,Murray A,Vorona S,Brace D,Rittayamai N,Lanys A,Tomlinson G,Singh JM,Bolz SS,Rubenfeld GD,Kavanagh BP,Brochard LJ,Ferguson ND

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Venous thromboembolism is difficult to diagnose in critically ill patients and may increase morbidity and mortality. OBJECTIVES:To evaluate the cost-effectiveness of strategies to reduce morbidity from venous thromboembolism in critically ill patients. METHODS:A Markov decision analytic model to compare wee...

journal_title：American journal of respiratory and critical care medicine

authors： Sud S,Mittmann N,Cook DJ,Geerts W,Chan B,Dodek P,Gould MK,Guyatt G,Arabi Y,Fowler RA,Canadian Critical Care Trials Group.,E-PROTECT Investigators.

更新日期：2011-12-01 00:00:00

abstract：:The aim of this study was to determine the effects of maturation on crossbridge properties and myosin isoform composition in hamster diaphragm muscle. Diaphragm strips were obtained at postnatal Days 1 and 8 and in adults (10 to 12 wk). Peak isometric tension and maximum unloaded shortening velocity (Vmax) increased w...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Lambert F,Joseph T,Blanc FX,Chemla D,Lecarpentier Y

更新日期：1997-09-01 00:00:00

abstract：:Partial liquid ventilation (PLV) has been shown to be an effective means of improving oxygenation in the injured lung. However, little is known about how approach to ventilation during PLV affects gas exchange and pulmonary mechanics. We hypothesized that gas exchange and pulmonary mechanics would be best with positiv...

journal_title：American journal of respiratory and critical care medicine

authors： Fujino Y,Kirmse M,Hess D,Kacmarek RM

更新日期：1999-04-01 00:00:00

abstract：:Elevated levels of ambient particulate matter (PM(10)) have been associated with increased cardiopulmonary morbidity and mortality. We previously showed that the deposition of particles in the lung induces a systemic inflammatory response that includes stimulation of the bone marrow. This marrow response is related to...

journal_title：American journal of respiratory and critical care medicine

authors： van Eeden SF,Tan WC,Suwa T,Mukae H,Terashima T,Fujii T,Qui D,Vincent R,Hogg JC

更新日期：2001-09-01 00:00:00

abstract：:Glucocorticoids (GC) are the most effective anti-inflammatory drugs used in asthma. By a process called trans-activation, they increase the transcription of genes involved in either beneficial processes or certain side effects. Through trans-repression, they inhibit the transcription factors nuclear factor kappa B (NF...

journal_title：American journal of respiratory and critical care medicine

authors： Jaffuel D,Demoly P,Gougat C,Balaguer P,Mautino G,Godard P,Bousquet J,Mathieu M

更新日期：2000-07-01 00:00:00

abstract：:Patients with impaired pulmonary function are at increased risk for the development of postoperative complications. Recently exercise testing and predicted postoperative (ppo) function have gained increasing importance in the evaluation of lung resection candidates. We prospectively evaluated an algorithm for the preo...

journal_title：American journal of respiratory and critical care medicine

authors： Wyser C,Stulz P,Solèr M,Tamm M,Müller-Brand J,Habicht J,Perruchoud AP,Bolliger CT

更新日期：1999-05-01 00:00:00

abstract：:We described here an original device for laser Doppler (LD) flowmetry measurements of gastric mucosal perfusion, which was used here in healthy volunteers. A modified nasogastric tube containing the LD probe was inserted. Aspiration via a catheter, fixed in parallel to the probe, held the probe against the gastric wal...

journal_title：American journal of respiratory and critical care medicine

authors： Duranteau J,Sitbon P,Vicaut E,Descorps-Declère A,Vigue B,Samii K

更新日期：1996-12-01 00:00:00

abstract：:Alkaline phosphatase (ALP) in lung lavage fluids is a marker of tissue damage and type II cell proliferation. Type II pneumocytes are extensively involved in fibrosis. The aim of our study was to verify whether local ALP activity can be held as a marker of fibrosis in chronic interstitial lung disorders. ALP was deter...

journal_title：American journal of respiratory and critical care medicine

authors： Capelli A,Lusuardi M,Cerutti CG,Donner CF

更新日期：1997-01-01 00:00:00