Association study of the chromosomal region containing the FCER2 gene suggests it has a regulatory role in atopic disorders.

abstract：:Noninvasive and invasive diagnostic techniques have been shown to achieve comparable performances in the evaluation of suspected ventilator-associated pneumonia (VAP). We studied the impact of both approaches on outcome in a prospective, open, and randomized study in three intensive care units (ICUs) of a 1,000-bed te...

journal_title：American journal of respiratory and critical care medicine

authors： Ruiz M,Torres A,Ewig S,Marcos MA,Alcón A,Lledó R,Asenjo MA,Maldonaldo A

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:The effects of prenatal cigarette smoke (CS) exposure and hypoxemia on cardiorespiratory control have been investigated in full-term infants. However, few data are available in preterm infants, who form a particularly vulnerable population, with developmentally immature cardiorespiratory control. OBJECTIVES:...

journal_title：American journal of respiratory and critical care medicine

authors： Schneider J,Mitchell I,Singhal N,Kirk V,Hasan SU

更新日期：2008-09-01 00:00:00

abstract：RATIONALE:The around-the-clock presence of an in-house attending critical care physician (24/7 coverage) is purported to be associated with improved outcomes among high-risk children with critical illness. OBJECTIVES:To evaluate the association of 24/7 in-house coverage with outcomes in children with critical illness....

journal_title：American journal of respiratory and critical care medicine

authors： Gupta P,Rettiganti M,Rice TB,Wetzel RC

更新日期：2016-12-15 00:00:00

abstract：:Most of the studies linking chronic obstructive pulmonary disease (COPD) with oxidative stress are in vitro, using invasive techniques, or measuring systemic oxidative stress. The aim of this study was to quantify oxidative stress in the lungs in patients with COPD and in healthy smokers, as reflected by 8-isoprostane...

journal_title：American journal of respiratory and critical care medicine

authors： Montuschi P,Collins JV,Ciabattoni G,Lazzeri N,Corradi M,Kharitonov SA,Barnes PJ

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin this disease's complex pathophysiology, yet these cells have been little studied. OBJECTIVES:To examine the functional and transcriptional profiles of pa...

journal_title：American journal of respiratory and critical care medicine

authors： Juss JK,House D,Amour A,Begg M,Herre J,Storisteanu DM,Hoenderdos K,Bradley G,Lennon M,Summers C,Hessel EM,Condliffe A,Chilvers ER

更新日期：2016-10-15 00:00:00

abstract：RATIONALE:The association between aging and idiopathic pulmonary fibrosis is established. The associations between aging-related biomarkers and interstitial lung abnormalities (ILA) have not been comprehensively evaluated. OBJECTIVE:Evaluate associations between aging biomarkers, ILA, and all-cause mortality. METHODS...

journal_title：American journal of respiratory and critical care medicine

authors： Sanders JL,Putman RK,Dupuis J,Xu H,Murabito JM,Araki T,Nishino M,Benjamin EJ,Levy DL,Vasan RS,Washko GR,Curtis JL,Freeman CM,Bowler R,Hatabu H,O'Connor GT,Hunninghake GM

更新日期：2020-10-20 00:00:00

abstract：:Genes for the chemokine receptors CCR5 and CCR2 are characterized by polymorphisms resulting in a nonfunctional receptor expression. Ligands for CCR2 and CCR5 (chemokines monocyte chemotactic protein-1 [MCP-1] and RANTES) are implicated in the pathogenesis of sarcoidosis. We have, therefore, analyzed polymorphisms of ...

journal_title：American journal of respiratory and critical care medicine

authors： Petrek M,Drábek J,Kolek V,Zlámal J,Welsh KI,Bunce M,Weigl E,Du Bois R

更新日期：2000-09-01 00:00:00

abstract：:To determine the factors contributing to tuberculosis incidence in the U.S.-born and foreign-born populations in San Francisco, California, and to assess the effectiveness of tuberculosis control efforts in these populations, we performed a population-based molecular epidemiologic study using 367 patients with strains...

journal_title：American journal of respiratory and critical care medicine

authors： Chin DP,DeRiemer K,Small PM,de Leon AP,Steinhart R,Schecter GF,Daley CL,Moss AR,Paz EA,Jasmer RM,Agasino CB,Hopewell PC

更新日期：1998-12-01 00:00:00

abstract：:Transforming growth factor-beta1 (TGF-beta1) is a growth factor that is implicated in fibrosis of many organs. The purpose of this study was to determine the sequential levels of TGF-beta1 in the pleural fluid of rabbits that had undergone empyema induction, as fibrosis of the pleural space develops. Thirty-seven rabb...

journal_title：American journal of respiratory and critical care medicine

authors： Sasse SA,Jadus MR,Kukes GD

更新日期：2003-09-15 00:00:00

abstract：:Relaxation was examined in diaphragm muscle strips of cardiomyopathic Syrian hamsters and control hamsters. Isotonic lengthening velocity and isometric tension decay were analyzed over the load continuum in response to twitch. For each load level (P), we measured the maximum extent of shortening (deltaL), the peak len...

journal_title：American journal of respiratory and critical care medicine

authors： Coirault C,Chemla D,Pourny JC,Lambert F,Riou B,Lecarpentier Y

更新日期：1997-05-01 00:00:00

abstract：:Two distinct types of tumor necrosis factor receptors (TNF-R) have been identified (TNF-R55 and TNF-R75). Both TNF-R also exist in soluble forms (TNF-sR), resulting from the release of the extracellular domains (TNF-sR55 and TNF-sR75). TNF-sR may play an important role in vivo as they can bind to TNF alpha and prevent...

journal_title：American journal of respiratory and critical care medicine

authors： Humbert M,Roux-Lombard P,Cerrina J,Magnan A,Simonneau G,Dartevelle P,Galanaud P,Dayer JM,Emilie D

更新日期：1994-06-01 00:00:00

abstract：:We have studied intrasubject variability with respect to counts of immunostained inflammatory cells in snap frozen endobronchial biopsies from a group of patients with clinically mild to moderate stable asthma. Fiberoptic bronchoscopy was used to obtain endobronchial biopsies from the upper and lower lobes in 12 volun...

journal_title：American journal of respiratory and critical care medicine

authors： Richmond I,Booth H,Ward C,Walters EH

更新日期：1996-03-01 00:00:00

abstract：:Asthmaexpert, an expert system (ES), was produced at the special request of several clinicians in order to better understand the medical decisions made clinical experts in managing an asthmatic patient. We describe and evaluate this knowledge base, focusing mainly on assessment of the severity of asthma. After compili...

journal_title：American journal of respiratory and critical care medicine

authors： Redier H,Daures JP,Michel C,Proudhon H,Vervloet D,Charpin D,Marsac J,Dusser D,Brambilla C,Wallaert B

更新日期：1995-02-01 00:00:00

abstract：:Rationale: Decisions in medicine are made on the basis of knowledge and reasoning, often in shared conversations with patients and families in consideration of clinical practice guideline recommendations, individual preferences, and individual goals. Observational studies can provide valuable knowledge to inform guide...

journal_title：American journal of respiratory and critical care medicine

authors： Gershon AS,Lindenauer PK,Wilson KC,Rose L,Walkey AJ,Sadatsafavi M,Anstrom KJ,Au DH,Bender BG,Brookhart MA,Dweik RA,Han MK,Joo MJ,Lavergne V,Mehta AB,Miravitlles M,Mularski RA,Roche N,Oren E,Riekert KA,Schoenberg N

更新日期：2021-01-01 00:00:00

abstract：RATIONALE:Chronic hypoxia induces pulmonary vascular remodeling, pulmonary hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms driving these responses. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of transcription in hypoxic cells, up-regulating genes involved in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ball MK,Waypa GB,Mungai PT,Nielsen JM,Czech L,Dudley VJ,Beussink L,Dettman RW,Berkelhamer SK,Steinhorn RH,Shah SJ,Schumacker PT

更新日期：2014-02-01 00:00:00

abstract：RATIONALE:Smoking is the largest contributor to lung cancer risk, and those who continue to smoke after diagnosis have a worse survival. Screening for lung cancer with low-dose computed tomography (LDCT) reduces mortality in high-risk individuals. Smoking cessation is an essential component of a high-quality screening ...

journal_title：American journal of respiratory and critical care medicine

authors： Tanner NT,Kanodra NM,Gebregziabher M,Payne E,Halbert CH,Warren GW,Egede LE,Silvestri GA

更新日期：2016-03-01 00:00:00

abstract：:If lipid peroxidation (LP) contributes to organ dysfunction in sepsis rather than simply reflecting established injury, it should occur soon after the onset of the septic insult, and it may not progress uniformly in all organs. We assessed whether LP occurs within 90 min after onset of continuous intravenous endotoxin...

journal_title：American journal of respiratory and critical care medicine

authors： Clements NC Jr,Habib MP

更新日期：1995-03-01 00:00:00

abstract：RATIONALE:Lung transplant recipients are particularly at risk of complications from rhinovirus, the most frequent respiratory virus circulating in the community. OBJECTIVES:To determine whether lung transplant recipients can be chronically infected by rhinovirus and the potential clinical impact. METHODS:We first ide...

journal_title：American journal of respiratory and critical care medicine

authors： Kaiser L,Aubert JD,Pache JC,Deffernez C,Rochat T,Garbino J,Wunderli W,Meylan P,Yerly S,Perrin L,Letovanec I,Nicod L,Tapparel C,Soccal PM

更新日期：2006-12-15 00:00:00

abstract：:Used adjunctively during mechanical ventilation, tracheal gas insufflation (TGI) improves CO2 elimination, principally by decreasing effective anatomic dead space. Continuing lung deflation at end- expiration raises the end-expiratory C02 concentration within the proximal airway, and could theoretically reduce the eff...

journal_title：American journal of respiratory and critical care medicine

authors： Ravenscraft SA,Shapiro RS,Nahum A,Burke WC,Adams AB,Nakos G,Marini JJ

更新日期：1996-06-01 00:00:00

abstract：:We developed a bronchial provocation test (BPT) with a dry powder preparation of mannitol. The mannitol was inhaled from gelatin capsules containing 5, 10, 20, or 40 mg to a cumulative dose of 635 mg, and was delivered via an inhalator, Halermatic, or Dinkihaler device. We studied the airway sensitivity to inhaled man...

journal_title：American journal of respiratory and critical care medicine

authors： Anderson SD,Brannan J,Spring J,Spalding N,Rodwell LT,Chan K,Gonda I,Walsh A,Clark AR

更新日期：1997-09-01 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM), a disease that occurs primarily in women, is characterized by cystic lung lesions causing respiratory failure, which may require lung transplantation. Lung diffusion (DLCO) and/or FEV1 are decreased, but frequently not in parallel with each other. Because cardiopulmonary exercise testin...

journal_title：American journal of respiratory and critical care medicine

authors： Taveira-DaSilva AM,Stylianou MP,Hedin CJ,Kristof AS,Avila NA,Rabel A,Travis WD,Moss J

更新日期：2003-12-15 00:00:00

abstract：RATIONALE:Brief recurrent apneas in preterm infants and adults can precipitate rapid and severe arterial O(2) desaturation for reasons that remain unclear. OBJECTIVES:We tested a mathematically derived hypothesis that when breathing terminates apnea, mixed-venous hypoxemia continues into the subsequent apnea; as a res...

journal_title：American journal of respiratory and critical care medicine

authors： Sands SA,Edwards BA,Kelly VJ,Skuza EM,Davidson MR,Wilkinson MH,Berger PJ

更新日期：2010-10-01 00:00:00

abstract：:To investigate repair mechanisms in bleomycin-induced pulmonary fibrosis, we used mice deficient in gamma-glutamyl transpeptidase (GGT-/-), a key enzyme in glutathione (GSH) and cysteine metabolism. Seventy-two hours after bleomycin (0.03 U/g), GGT-/- mice displayed a different inflammatory response to wild-type mice ...

journal_title：American journal of respiratory and critical care medicine

authors： Pardo A,Ruiz V,Arreola JL,Ramírez R,Cisneros-Lira J,Gaxiola M,Barrios R,Kala SV,Lieberman MW,Selman M

更新日期：2003-03-15 00:00:00

abstract：RATIONALE:Obstructive sleep apnea (OSA) is associated with impaired renal function, but uncertainty exists over whether OSA treatment can influence renal outcomes. OBJECTIVES:To determine the effects of continuous positive airway pressure (CPAP) on renal function in subjects with coexisting OSA and cardiovascular dise...

journal_title：American journal of respiratory and critical care medicine

authors： Loffler KA,Heeley E,Freed R,Anderson CS,Brockway B,Corbett A,Chang CL,Douglas JA,Ferrier K,Graham N,Hamilton GS,Hlavac M,McArdle N,McLachlan J,Mukherjee S,Naughton MT,Thien F,Young A,Grunstein RR,Palmer LJ,Woodman

更新日期：2017-12-01 00:00:00

abstract：:Rationale: Lumacaftor-ivacaftor is a CFTR (cystic fibrosis transmembrane conductance regulator) modulator combination recently approved for patients with cystic fibrosis (CF) homozygous for the Phe508del mutation.Objectives: To evaluate the safety and effectiveness of lumacaftor-ivacaftor in adolescents (≥12 yr) and a...

journal_title：American journal of respiratory and critical care medicine

authors： Burgel PR,Munck A,Durieu I,Chiron R,Mely L,Prevotat A,Murris-Espin M,Porzio M,Abely M,Reix P,Marguet C,Macey J,Sermet-Gaudelus I,Corvol H,Bui S,Lemonnier L,Dehillotte C,Da Silva J,Paillasseur JL,Hubert D,French Cy

更新日期：2020-01-15 00:00:00

abstract：:Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease. We analyzed the power of lung hyperinflation as measured by the inspiratory capacity-to-total lung capacity ratio (IC/TLC) to predict mortality in a cohort of 689 patients with chronic obstructive pul...

journal_title：American journal of respiratory and critical care medicine

authors： Casanova C,Cote C,de Torres JP,Aguirre-Jaime A,Marin JM,Pinto-Plata V,Celli BR

更新日期：2005-03-15 00:00:00

abstract：RATIONALE:In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration. OBJECTIVES:To investigate how regional aeration, shunt, and perfusion are interrelated at different le...

journal_title：American journal of respiratory and critical care medicine

authors： Musch G,Bellani G,Vidal Melo MF,Harris RS,Winkler T,Schroeder T,Venegas JG

更新日期：2008-02-01 00:00:00

abstract：:Many persons say that they "don't know" whether they snore. The purpose of this study was to investigate the prevalence and correlates of such responses in an elderly population. Subjects were 1715 members (1,155 men, 560 women) of a previously defined cohort (Western Group Collaborative Study) followed prospectively ...

journal_title：American journal of respiratory and critical care medicine

authors： Bliwise DL,Swan GE,Carmelli D,La Rue A

更新日期：1999-12-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:Surfactant protein B (SP-B) is one of the essential constituents of the alveolar surfactant system, presenting mainly in the form of SP-B dimer. The measurement of this molecule in biologic samples has been hampered by its extreme hydrophobicity and intimate association with surfactant lipids. We developed a solid-pha...

journal_title：American journal of respiratory and critical care medicine

authors： Krämer HJ,Schmidt R,Günther A,Becker G,Suzuki Y,Seeger W

更新日期：1995-11-01 00:00:00