Localization of insulin-like growth factor-I in lung tissues of patients with fibroproliferative acute respiratory distress syndrome.

abstract：:The mechanism responsible for the increased air-space permeability in cigarette smokers is unknown. The aim of this study was to assess the acute and chronic effects of cigarette smoking on epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Fourteen cigarette smokers underwent 99mT...

journal_title：American journal of respiratory and critical care medicine

authors： Morrison D,Rahman I,Lannan S,MacNee W

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum. OBJECTIVES:To determine whether PARC/CCL-18 levels are elevated and modifiable in COPD an...

journal_title：American journal of respiratory and critical care medicine

authors： Sin DD,Miller BE,Duvoix A,Man SF,Zhang X,Silverman EK,Connett JE,Anthonisen NA,Wise RA,Tashkin D,Celli BR,Edwards LD,Locantore N,Macnee W,Tal-Singer R,Lomas DA,ECLIPSE Investigators.

更新日期：2011-05-01 00:00:00

abstract：:Asthma in adults may be associated with chronic airflow obstruction, possibly resulting from airway disease in early life and/or a greater rate of decline in lung function in adult life compared with those with asthma. Treatment and cigarette smoking may also influence the rate of decline of lung function. The aim of ...

journal_title：American journal of respiratory and critical care medicine

authors： James AL,Palmer LJ,Kicic E,Maxwell PS,Lagan SE,Ryan GF,Musk AW

更新日期：2005-01-15 00:00:00

abstract：:In a previous study of older pulp and paper workers in Berlin, New Hampshire, decrements in spirometry results associated with accidental exposures to high levels of irritant gases depended on cumulative levels of pulp mill exposure and cigarette smoking. Many of those subjects were older and retired. A new study was ...

journal_title：American journal of respiratory and critical care medicine

authors： Henneberger PK,Lax MB,Ferris BG Jr

更新日期：1996-01-01 00:00:00

abstract：RATIONALE:Lack of health insurance maybe an independent risk factor for mortality and differential treatment in critical illness. OBJECTIVES:To determine whether uninsured critically ill patients had differences in 30-day mortality and critical care service use compared with those with private insurance and to determi...

journal_title：American journal of respiratory and critical care medicine

authors： Lyon SM,Benson NM,Cooke CR,Iwashyna TJ,Ratcliffe SJ,Kahn JM

更新日期：2011-10-01 00:00:00

abstract：:Great emphasis is placed on educating asthmatics to use action plans to achieve better control of symptoms. The use of peak flow meters (PFM) has been recommended as an important part of self-management plans. We studied 92 (47 F) adult patients with asthma in a primary care setting to compare the effectiveness of act...

journal_title：American journal of respiratory and critical care medicine

authors： Turner MO,Taylor D,Bennett R,Fitzgerald JM

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:The effects of high positive end-expiratory pressure (PEEP) strictly depend on lung recruitability, which varies widely during acute respiratory distress syndrome (ARDS). Unfortunately, increasing PEEP may lead to opposing effects on two main factors potentially worsening the lung injury, that is, alveolar st...

journal_title：American journal of respiratory and critical care medicine

authors： Caironi P,Cressoni M,Chiumello D,Ranieri M,Quintel M,Russo SG,Cornejo R,Bugedo G,Carlesso E,Russo R,Caspani L,Gattinoni L

更新日期：2010-03-15 00:00:00

abstract：RATIONALE:Tidal volume and plateau pressure limitation decreases mortality in acute respiratory distress syndrome. Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation. OBJECTIVES:We hypothesized tha...

journal_title：American journal of respiratory and critical care medicine

authors： Terragni PP,Rosboch G,Tealdi A,Corno E,Menaldo E,Davini O,Gandini G,Herrmann P,Mascia L,Quintel M,Slutsky AS,Gattinoni L,Ranieri VM

更新日期：2007-01-15 00:00:00

abstract：:Phosphatidylglycerol (PG) and phosphatidylinositol (PI) are anionic phospholipids (APLs) present in lung surfactant of virtually all species studied, although their specific contribution to function is unknown. This study examines how APLs influence surfactant monolayer stability and adsorption under static and dynami...

journal_title：American journal of respiratory and critical care medicine

authors： Ingenito EP,Mora R,Mark L

更新日期：2000-03-01 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) is characterized by an extensive alveolar capillary leak, permitting contact between intra-alveolar factors and the endothelium. To investigate whether factors contained in the alveolar milieu induce cell death in human lung microvascular endothelial cells, we exposed these c...

journal_title：American journal of respiratory and critical care medicine

authors： Hamacher J,Lucas R,Lijnen HR,Buschke S,Dunant Y,Wendel A,Grau GE,Suter PM,Ricou B

更新日期：2002-09-01 00:00:00

abstract：:A number of new observations have added to our understanding of mast cell biology and the relevance of this cell to the genesis of asthma. The purpose of this review has been to highlight this new information and to refer the reader to extensive reviews where previously documented and well-known data are available. Of...

journal_title：American journal of respiratory and critical care medicine

authors： Wasserman SI

更新日期：1994-11-01 00:00:00

abstract：RATIONALE:The rate of progression of most interstitial lung diseases (ILD) is unpredictable. Fibrocytes are circulating bone marrow-derived cells that have been implicated in the pathogenesis of lung fibrosis. Hermansky-Pudlak syndrome (HPS), a genetic cause of ILD in early adulthood, allows for study of biomarkers of ...

journal_title：American journal of respiratory and critical care medicine

authors： Trimble A,Gochuico BR,Markello TC,Fischer R,Gahl WA,Lee JK,Kim Y,Burdick MD,Strieter RM,Mehrad B

更新日期：2014-12-15 00:00:00

abstract：:Genetic susceptibility to asthma is due to multiple genes that interact with each other and the environment. There are many known environmental influences, such as viral and other respiratory infections and exposure to allergens, air pollutants, and active or passive cigarette smoke (1). Genome-wide screens for asthma...

journal_title：American journal of respiratory and critical care medicine

authors： Bleecker ER,Postma DS,Meyers DA

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:The prevalence of vitamin D deficiency is increasing and has been linked to obstructive lung diseases including asthma and chronic obstructive pulmonary disease. Recent studies suggest that vitamin D deficiency is associated with reduced lung function. The relationship between vitamin D deficiency and lung fu...

journal_title：American journal of respiratory and critical care medicine

authors： Zosky GR,Berry LJ,Elliot JG,James AL,Gorman S,Hart PH

更新日期：2011-05-15 00:00:00

abstract：:Selected events in rhinovirus infection of the normal human airway can be regarded as occurring sequentially. Initial steps in rhinovirus pathogenesis are believed to include viral entry into the nose, mucociliary transport of virus to the posterior pharynx, and initiation of infection in ciliated and non-ciliated epi...

journal_title：American journal of respiratory and critical care medicine

authors： Gwaltney JM Jr

更新日期：1995-10-01 00:00:00

abstract：:The present prospective study was designed to determine the prevalence of pleural effusion at approximately 28 days after cardiac surgery and their subsequent course. This consecutive case study included 389 patients; 312 had only coronary artery bypass graft surgery (CABG) surgery, 37 had both valve and CABG surgery,...

journal_title：American journal of respiratory and critical care medicine

authors： Light RW,Rogers JT,Moyers JP,Lee YC,Rodriguez RM,Alford WC Jr,Ball SK,Burrus GR,Coltharp WH,Glassford DM Jr,Hoff SJ,Lea JW 4th,Nesbitt JC,Petracek MR,Starkey TD,Stoney WS,Tedder M

更新日期：2002-12-15 00:00:00

abstract：:The present studies were designed to assess the pattern of activity and the frequency of activation of the neck muscles in patients with chronic obstructive pulmonary disease (COPD). Using concentric needle electrodes, we thus recorded the electromyograms of the scalene, sternocleidomastoid, and trapezius muscles duri...

journal_title：American journal of respiratory and critical care medicine

authors： De Troyer A,Peche R,Yernault JC,Estenne M

更新日期：1994-07-01 00:00:00

abstract：:We derived reference values for slow vital capacity (VC) and flow-volume curve indexes (FVC, FEV(1), and flows) from the 1,185 tracings provided by 1,039 "normal" subjects who participated in one or both cross-sectional surveys of the Po River Delta study in 1980-1982 and in 1988-1991. Definition of "normal" was based...

journal_title：American journal of respiratory and critical care medicine

authors： Pistelli F,Bottai M,Viegi G,Di Pede F,Carrozzi L,Baldacci S,Pedreschi M,Giuntini C

更新日期：2000-03-01 00:00:00

abstract：:We describe two reliable methods for high-throughput screening of proteinase inhibitor (PI) S and PI Z alpha(1)-antitrypsin (alpha(1)-AT) deficiency alleles from dried blood spot (DBS) specimens using the LightCycler fluorimetric analyzer. The method was used to study 72 patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Rodriguez F,Jardí R,Costa X,Cotrina M,Galimany R,Vidal R,Miravitlles M

更新日期：2002-09-15 00:00:00

abstract：RATIONALE:End-tidal CO2 (EtCO2) is used to monitor cardiopulmonary resuscitation (CPR), but it can be affected by intrathoracic airway closure. Chest compressions induce oscillations in expired CO2, and this could reflect variable degrees of airway patency. OBJECTIVES:To understand the impact of airway closure during ...

journal_title：American journal of respiratory and critical care medicine

authors： Grieco DL,J Brochard L,Drouet A,Telias I,Delisle S,Bronchti G,Ricard C,Rigollot M,Badat B,Ouellet P,Charbonney E,Mancebo J,Mercat A,Savary D,Richard JM

更新日期：2019-03-15 00:00:00

abstract：:During exercise, children with congenital central hypoventilation syndrome (CCHS) demonstrate coupling of VE to exercise load, despite the absence of a VE response to changes in FICO2. To assess the effect of movement on VE, we studied six CCHS patients and six matched controls during passive motion in a motor-driven ...

journal_title：American journal of respiratory and critical care medicine

authors： Gozal D,Marcus CL,Ward SL,Keens TG

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:Low blood levels of 25-hydroxyvitamin D (25[OH]D) have been associated with a higher risk of respiratory infections in general populations and higher risk of exacerbations of lung disease in people with asthma. We hypothesized that low blood levels of 25(OH)D in patients with chronic obstructive pulmonary dis...

journal_title：American journal of respiratory and critical care medicine

authors： Kunisaki KM,Niewoehner DE,Connett JE,COPD Clinical Research Network.

更新日期：2012-02-01 00:00:00

abstract：:Elevated levels of ambient particulate matter (PM(10)) have been associated with increased cardiopulmonary morbidity and mortality. We previously showed that the deposition of particles in the lung induces a systemic inflammatory response that includes stimulation of the bone marrow. This marrow response is related to...

journal_title：American journal of respiratory and critical care medicine

authors： van Eeden SF,Tan WC,Suwa T,Mukae H,Terashima T,Fujii T,Qui D,Vincent R,Hogg JC

更新日期：2001-09-01 00:00:00

abstract：RATIONALE:In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration. OBJECTIVES:To investigate how regional aeration, shunt, and perfusion are interrelated at different le...

journal_title：American journal of respiratory and critical care medicine

authors： Musch G,Bellani G,Vidal Melo MF,Harris RS,Winkler T,Schroeder T,Venegas JG

更新日期：2008-02-01 00:00:00

abstract：RATIONALE:Endobronchial ultrasound (EBUS) and electromagnetic navigation bronchoscopy (ENB) have increased the diagnostic yield of bronchoscopic diagnosis of peripheral lung lesions. However, the role of combining these modalities to overcome each individual technique's limitations and, consequently, to further increas...

journal_title：American journal of respiratory and critical care medicine

authors： Eberhardt R,Anantham D,Ernst A,Feller-Kopman D,Herth F

更新日期：2007-07-01 00:00:00

abstract：:We used various ovalbumin sensitization and challenge protocols to determine the importance of the route of allergen administration and the genetic background in modulating the physiologic, inflammatory, and immunologic features characteristic of allergen-induced asthma. In BALB/c mice, induction of maximal airway hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,Lamm WJ,Albert RK,Chi EY,Henderson WR Jr,Lewis DB

更新日期：1997-02-01 00:00:00

abstract：:Although overproduction of proinflammatory 5-lipoxygenase (5-LO)-derived leukotrienes (LTs) has been demonstrated in the lungs of patients with pulmonary fibrosis, their causal involvement in this condition has not been established. Bleomycin-induced pulmonary fibrosis was studied in mice rendered LT deficient by knoc...

journal_title：American journal of respiratory and critical care medicine

authors： Peters-Golden M,Bailie M,Marshall T,Wilke C,Phan SH,Toews GB,Moore BB

更新日期：2002-01-15 00:00:00

abstract：RATIONALE:Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s. OBJECTIVES:To assess traffic-related pollution exposure and childhood lung function. METHODS:We geocoded addresses for 614 mother-child pa...

journal_title：American journal of respiratory and critical care medicine

authors： Rice MB,Rifas-Shiman SL,Litonjua AA,Oken E,Gillman MW,Kloog I,Luttmann-Gibson H,Zanobetti A,Coull BA,Schwartz J,Koutrakis P,Mittleman MA,Gold DR

更新日期：2016-04-15 00:00:00

abstract：:Cryptogenic fibrosing alveolitis has been reported to be associated with an increased risk of lung cancer. However, it has recently become apparent that cigarette smoking may be a risk factor for cryptogenic fibrosing alveolitis as well as for lung cancer, and so may confound the association between these conditions. ...

journal_title：American journal of respiratory and critical care medicine

authors： Hubbard R,Venn A,Lewis S,Britton J

更新日期：2000-01-01 00:00:00

abstract：:We evaluated positron emission tomographic imaging of pulmonary transgene expression, using an enhanced mutant herpes simplex virus-1 thymidine kinase as the reporter gene, in the lungs of normal rats. Sixteen rats were studied 3 days after an intratracheal administration of 5 x 10(9) to 1 x 10(11) viral particles of ...

journal_title：American journal of respiratory and critical care medicine

authors： Richard JC,Zhou Z,Ponde DE,Dence CS,Factor P,Reynolds PN,Luker GD,Sharma V,Ferkol T,Piwnica-Worms D,Schuster DP

更新日期：2003-05-01 00:00:00